Protein Tyrosine Phosphatase, Non-Receptor Type 22
"Protein Tyrosine Phosphatase, Non-Receptor Type 22" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.
MeSH Number(s)
D08.811.277.352.650.775.300.930
D12.644.360.585.930
D12.776.476.564.930
Concept/Terms
Protein Tyrosine Phosphatase, Non-Receptor Type 22- Protein Tyrosine Phosphatase, Non-Receptor Type 22
- Protein Tyrosine Phosphatase, Non Receptor Type 22
- Protein-Tyrosine Phosphatase Lyp
- Protein Tyrosine Phosphatase Lyp
- Tyrosine Protein Phosphatase, Non-Receptor Type 22
- Tyrosine Protein Phosphatase, Non Receptor Type 22
- Lymphoid Phosphatase
- PTPase Lyp
Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatase, Non-Receptor Type 22".
Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatase, Non-Receptor Type 22".
This graph shows the total number of publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 22" by people in Harvard Catalyst Profiles by year, and whether "Protein Tyrosine Phosphatase, Non-Receptor Type 22" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 1 | 2 | 3 |
| 2008 | 3 | 1 | 4 |
| 2009 | 0 | 1 | 1 |
| 2010 | 2 | 0 | 2 |
| 2012 | 2 | 0 | 2 |
| 2013 | 2 | 1 | 3 |
| 2014 | 1 | 0 | 1 |
| 2015 | 3 | 1 | 4 |
| 2016 | 3 | 1 | 4 |
| 2017 | 1 | 0 | 1 |
| 2019 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 22" by people in Profiles.
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Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice. BMC Med. 2023 07 13; 21(1):252.
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Whole Exome Sequencing Reveals Clustering of Variants of Known Vitiligo Genes in Multiplex Consanguineous Pakistani Families. Genes (Basel). 2023 05 22; 14(5).
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Validation of a Bioassay for Predicting Response to Tumor Necrosis Factor Inhibitors in Rheumatoid Arthritis. Arthritis Rheumatol. 2021 06; 73(6):1086-1087.
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Genome-wide Study Identifies Association between HLA-B*55:01 and Self-Reported Penicillin Allergy. Am J Hum Genet. 2020 10 01; 107(4):612-621.
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Regulation of B cell homeostasis by Ptpn22 contributes to type 1 diabetes in NOD mice. Endocrine. 2020 03; 67(3):535-543.
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Utilizing a PTPN22 gene signature to predict response to targeted therapies in rheumatoid arthritis. J Autoimmun. 2019 07; 101:121-130.
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Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis. Arthritis Rheumatol. 2017 05; 69(5):1054-1066.
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The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors. Cell Rep. 2016 12 06; 17(10):2776-2788.
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A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22. JCI Insight. 2016 Oct 20; 1(17):e90045.
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Major histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis. Sci Rep. 2016 04 25; 6:25014.