Protein Tyrosine Phosphatase, Non-Receptor Type 6
"Protein Tyrosine Phosphatase, Non-Receptor Type 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Src-homology domain-containing protein tyrosine phosphatase found in the CYTOSOL of hematopoietic cells. It plays a role in signal transduction by dephosphorylating signaling proteins that are activated or inactivated by PROTEIN-TYROSINE KINASES.
MeSH Number(s)
D08.811.277.352.650.775.300.600
D08.811.277.352.650.775.700.200
D12.644.360.585.600
D12.644.360.800.200
D12.776.476.564.600
D12.776.476.800.200
Concept/Terms
Protein Tyrosine Phosphatase, Non-Receptor Type 6- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatase, Non Receptor Type 6
- Hematopoietic Cell Phosphatase
- Cell Phosphatase, Hematopoietic
- Phosphatase, Hematopoietic Cell
- Hematopoietic Cell-Specific Tyrosine Phosphatase SHP-1
- Hematopoietic Cell Specific Tyrosine Phosphatase SHP 1
- Protein Tyrosine Phosphatase 1C
- Protein Tyrosine Phosphatase, Nonreceptor Type 6
- SHP-1 Protein-Tyrosine Phosphatase
- Phosphatase, SHP-1 Protein-Tyrosine
- Protein-Tyrosine Phosphatase, SHP-1
- SHP 1 Protein Tyrosine Phosphatase
- SHP-1 Tyrosine Phosphatase
- Phosphatase, SHP-1 Tyrosine
- SHP 1 Tyrosine Phosphatase
- Tyrosine Phosphatase, SHP-1
- SHP1 Phosphatase
- Phosphatase, SHP1
- SHP1 Protein Tyrosine Phosphatase
- Haematopoietic Cell Phosphatase
- Cell Phosphatase, Haematopoietic
- Phosphatase, Haematopoietic Cell
- SHP-1 Phosphatase
- Phosphatase, SHP-1
- SHP 1 Phosphatase
Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatase, Non-Receptor Type 6".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Esterases [D08.811.277.352]
- Phosphoric Monoester Hydrolases [D08.811.277.352.650]
- Protein Tyrosine Phosphatases [D08.811.277.352.650.775]
- Protein Tyrosine Phosphatases, Non-Receptor [D08.811.277.352.650.775.300]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D08.811.277.352.650.775.300.600]
- SH2 Domain-Containing Protein Tyrosine Phosphatases [D08.811.277.352.650.775.700]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D08.811.277.352.650.775.700.200]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Protein Tyrosine Phosphatases, Non-Receptor [D12.644.360.585]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D12.644.360.585.600]
- SH2 Domain-Containing Protein Tyrosine Phosphatases [D12.644.360.800]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D12.644.360.800.200]
- Proteins [D12.776]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Protein Tyrosine Phosphatases, Non-Receptor [D12.776.476.564]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D12.776.476.564.600]
- SH2 Domain-Containing Protein Tyrosine Phosphatases [D12.776.476.800]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D12.776.476.800.200]
Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatase, Non-Receptor Type 6".
This graph shows the total number of publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 6" by people in Harvard Catalyst Profiles by year, and whether "Protein Tyrosine Phosphatase, Non-Receptor Type 6" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 3 | 3 |
| 1995 | 0 | 4 | 4 |
| 1996 | 0 | 6 | 6 |
| 1997 | 0 | 8 | 8 |
| 1998 | 0 | 5 | 5 |
| 1999 | 0 | 6 | 6 |
| 2000 | 0 | 11 | 11 |
| 2001 | 0 | 10 | 10 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 3 | 3 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 2 | 3 |
| 2009 | 2 | 3 | 5 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 1 | 1 | 2 |
| 2015 | 2 | 0 | 2 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 2 | 3 |
| 2018 | 0 | 1 | 1 |
| 2019 | 2 | 1 | 3 |
| 2020 | 0 | 3 | 3 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 2 | 2 |
Below are the most recent publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 6" by people in Profiles.
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SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses. Nat Immunol. 2023 01; 24(1):55-68.
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SHP-1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription. EMBO J. 2022 10 04; 41(19):e109720.
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Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation. Nat Metab. 2021 04; 3(4):513-522.
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Signalling input from divergent pathways subverts B cell transformation. Nature. 2020 07; 583(7818):845-851.
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Unraveling the Signaling Balance of Activation and Exhaustion of CAR T Cells. Cancer Cell. 2020 02 10; 37(2):143-144.
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Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis. Nat Nanotechnol. 2020 02; 15(2):154-161.
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Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation. Nat Immunol. 2020 01; 21(1):54-64.
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Sunitinib promotes myogenic regeneration and mitigates disease progression in the mdx mouse model of Duchenne muscular dystrophy. Hum Mol Genet. 2019 07 01; 28(13):2120-2132.
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Inhibition of SYK or BTK augments venetoclax sensitivity in SHP1-negative/BCL-2-positive diffuse large B-cell lymphoma. Leukemia. 2019 10; 33(10):2416-2428.
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Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans. Nat Commun. 2018 08 17; 9(1):3287.