Protein Tyrosine Phosphatase, Non-Receptor Type 12
"Protein Tyrosine Phosphatase, Non-Receptor Type 12" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.
MeSH Number(s)
D08.811.277.352.650.775.300.850
D12.644.360.585.850
D12.776.476.564.850
Concept/Terms
Protein Tyrosine Phosphatase, Non-Receptor Type 12- Protein Tyrosine Phosphatase, Non-Receptor Type 12
- Protein Tyrosine Phosphatase, Non Receptor Type 12
- PTP-PEST
- PEST-Enriched Phosphatase
- PEST Enriched Phosphatase
- Phosphatase, PEST-Enriched
- PEP Protein Tyrosine Phosphatase
- PEP PTPase
- PTPase, PEP
Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatase, Non-Receptor Type 12".
Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatase, Non-Receptor Type 12".
This graph shows the total number of publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 12" by people in Harvard Catalyst Profiles by year, and whether "Protein Tyrosine Phosphatase, Non-Receptor Type 12" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
Below are the most recent publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 12" by people in Profiles.
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Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A. Structure. 2019 01 02; 27(1):102-112.e4.
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The prognostic significance of tyrosine-protein phosphatase nonreceptor type 12 expression in nasopharyngeal carcinoma. Tumour Biol. 2015 Jul; 36(7):5201-8.
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Decreased expression of PTPN12 correlates with tumor recurrence and poor survival of patients with hepatocellular carcinoma. PLoS One. 2014; 9(1):e85592.
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PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling. Oncogene. 2014 Feb 20; 33(8):1047-54.
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Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 2011 Mar 04; 144(5):703-18.
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Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase. J Inorg Biochem. 2010 Mar; 104(3):268-73.
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Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes. J Med Chem. 2009 Nov 12; 52(21):6912-8.
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CD2BP1 modulates CD2-dependent T cell activation via linkage to protein tyrosine phosphatase (PTP)-PEST. J Immunol. 2006 May 15; 176(10):5898-907.
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The noncatalytic domain of protein-tyrosine phosphatase-PEST targets paxillin for dephosphorylation in vivo. J Biol Chem. 2000 Jan 14; 275(2):1405-13.
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A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion. EMBO J. 1998 Dec 15; 17(24):7320-36.