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Alice Weaver Flaherty, M.D., Ph.D.

TitleAssociate Professor of Neurology
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMassachusetts General Hospital
Dept of Neurology, ACC 729B
15 Parkman Street
Boston MA 02114
Phone617/724-9234
Other Positions
TitleAssociate Professor of Psychiatry
InstitutionMassachusetts General Hospital
DepartmentPsychiatry


 Mentoring 
 completed student projects
Investigating the effect of deep brain stimulation on neural circuits perturbed in obsessive compulsive disorder: Neural activity during an avoidance-reward competition task
Summer, 06/14/10 - 08/20/10

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, Gomperts SN, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Hyman BT, Sudarsky LR, Growdon JH, Scherzer CR. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology. 2013 Oct 22; 81(17):1531-7.
    View in: PubMed
  2. Patel SR, Sheth SA, Martinez-Rubio C, Mian MK, Asaad WF, Gerrard JL, Kwon CS, Dougherty DD, Flaherty AW, Greenberg BD, Gale JT, Williams ZM, Eskandar EN. Studying task-related activity of individual neurons in the human brain. Nat Protoc. 2013 Apr 18; 8(5):949-57.
    View in: PubMed
  3. Ding H, Sarokhan AK, Roderick SS, Bakshi R, Maher NE, Ashourian P, Kan CG, Chang S, Santarlasci A, Swords KE, Ravina BM, Hayes MT, Sohur US, Wills AM, Flaherty AW, Unni VK, Hung AY, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Sudarsky LR, Growdon JH, Ivinson AJ, Hyman BT, Scherzer CR. Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study. Mov Disord. 2011 Oct; 26(12):2283-6.
    View in: PubMed
  4. Shields DC, Flaherty AW, Eskandar EN, Williams ZM. Ventral intermediate thalamic stimulation for monoclonal gammopathy-associated tremor: case report. Neurosurgery. 2011 May; 68(5):E1464-7.
    View in: PubMed
  5. LeWitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, Kostyk SK, Thomas K, Sarkar A, Siddiqui MS, Tatter SB, Schwalb JM, Poston KL, Henderson JM, Kurlan RM, Richard IH, Van Meter L, Sapan CV, During MJ, Kaplitt MG, Feigin A. AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial. Lancet Neurol. 2011 Apr; 10(4):309-19.
    View in: PubMed
  6. Flaherty AW. Brain illness and creativity: mechanisms and treatment risks. Can J Psychiatry. 2011 Mar; 56(3):132-43.
    View in: PubMed
  7. Brown HE, Flaherty AW, Goff DC, Freudenreich O. A case of dramatic improvement of severe tardive dyskinesia after switch to aripiprazole. Prim Care Companion CNS Disord. 2011; 13(6).
    View in: PubMed
  8. Ducharme S, Flaherty AW, Seiner SJ, Dougherty DD, Morales OG. Temporary interruption of deep brain stimulation for Parkinson's disease during outpatient electroconvulsive therapy for major depression: a novel treatment strategy. J Neuropsychiatry Clin Neurosci. 2011; 23(2):194-7.
    View in: PubMed
  9. Quinn DK, Flaherty AW, Herman JB, Kleinschmidt TL. Over the rainbow: a case of traumatic brain injury. Harv Rev Psychiatry. 2010; 18(1):56-66.
    View in: PubMed
  10. Shields DC, Asaad W, Eskandar EN, Jain FA, Cosgrove GR, Flaherty AW, Cassem EH, Price BH, Rauch SL, Dougherty DD. Prospective assessment of stereotactic ablative surgery for intractable major depression. Biol Psychiatry. 2008 Sep 15; 64(6):449-54.
    View in: PubMed
  11. Flaherty AW. Movement disorders. In Stern TA, Rosenbaum JF, Fava M, Biederman J, Rauch S, eds., Massachusetts General Hospital Comprehensive Clinical Psychiatry, CD-ROM edition. 2008.
  12. Flaherty, AW. Movement disorders. Stern TA, Rosenbaum JF, Fava M, Biederman J, Rauch S, eds., Massachusetts General Hospital Comprehensive Clinical Psychiatry. 2008.
  13. Flaherty AW. Playing doctor well. Neurology. 2008 Mar 11; 70(11):826-7.
    View in: PubMed
  14. Flaherty AW. Interdisciplinary inspiration. Nature. 2008; 451(7176):246.
  15. Flaherty AW. Video edition of The Luck of the Loch Ness Monster. 2008.
  16. Patel S. Hester T, Hughes R, Huggins N, Flaherty A, Standaert D, Growdon J, Bonato P. Processing wearable sensor data to optimize deep-brain stimulation. IEEE Pervasive Computing. 2008; 7:56-61.
  17. Flaherty A. A brief proposal, 150 words. Nature. 2007 Dec 20; 450(7173):1156.
    View in: PubMed
  18. Shields DC, Cheng ML, Flaherty AW, Gale JT, Eskandar EN. Microelectrode-guided deep brain stimulation for Tourette syndrome: within-subject comparison of different stimulation sites. Stereotact Funct Neurosurg. 2008; 86(2):87-91.
    View in: PubMed
  19. Flaherty AW, Jacobs A, Lethem J, Levy F, Oppenhiem L, Reyes P,. Hypergraphia and Hypographia, "Diseases" of the Written Word," 2-hour video of roundtable discussion. 2007.
  20. Gale JT, Amirnovin R, Williams ZM, Flaherty AW, Eskandar EN. From symphony to cacophony: pathophysiology of the human basal ganglia in Parkinson disease. Neurosci Biobehav Rev. 2008; 32(3):378-87.
    View in: PubMed
  21. Kraft E, Chen AW, Flaherty AW, Blood AJ, Kwong KK, Jenkins BG. The role of the basal ganglia in bimanual coordination. Brain Res. 2007 Jun 2; 1151:62-73.
    View in: PubMed
  22. Flaherty AW, Rost NS. . . The Massachusetts General Hospital Handbook of Neurology, 2nd expanded edition. 2007.
  23. Flaherty AW. Psychosocial effects of deep brain stimulation, or the perils of getting well. Journal Watch Neurology. 2007.
  24. Flaherty AW, illus. Magoon S. The Luck of the Loch Ness Monster. 2007.
  25. Flaherty AW, Magoon S. The Luck of the Loch Ness Monster: A Tale of Picky Eating. 2007.
  26. Flaherty AW. All the rage. The Harvard Medical School Bulletin. 2006; autumn.
  27. Flaherty AW. The proctologist wears Prada. The Harvard Medical School Bulletin. 2006; spring.
  28. Flaherty, AW. Trans: Yoshida T. [Japanese trans. of TMD]. 2006.
  29. Koss AM, Tramo MJ, Flaherty AW, Young AB. Effect of auditory stimulation with popular music on visuomotor integration and gait in Parkinson’ s disease. American Academy of Neurology Annual Meeting. 2006.
  30. Flaherty AW. Frontotemporal and dopaminergic control of idea generation and creative drive. J Comp Neurol. 2005 Dec 5; 493(1):147-53.
    View in: PubMed
  31. Flaherty, AW. Just got to write this down. The New Scientist. 2005; 48-49.
  32. Flaherty AW, Williams ZM, Amirnovin R, Kasper E, Rauch SL, Cosgrove GR, Eskandar EN. Deep brain stimulation of the anterior internal capsule for the treatment of Tourette syndrome: technical case report. Neurosurgery. 2005 Oct; 57(4 Suppl):E403; discussion E403.
    View in: PubMed
  33. Flaherty AW. Bedside manners. The Harvard Medical School Bulletin. 2005; autumn.
  34. Flaherty AW, trans. Fleckenstein K. Die Mitternachtskrankheit - Warum Schriftsteller schreiben müssen. Schreibzwang - Schreibrausch - Schreibblockade und das kreative Gehirn. [German trans. of TMD]. 2004.
  35. Blood AJ, Flaherty AW, Choi JK, Hochberg FH, Greve DN, Bonmassar G, Rosen BR, Jenkins BG. Basal ganglia activity remains elevated after movement in focal hand dystonia. Ann Neurol. 2004 May; 55(5):744-8.
    View in: PubMed
  36. Flaherty AW. Mood and creative state influences on temporal perception. International Psychoanalytical Association Biannual Meeting. 2004.
  37. Flaherty AW. The Midnight Disease: The Drive to Write, Writer's Block, and the Creative Brain. 2004.
  38. Flaherty, AW. Monkey business. The Harvard Medical School Bulletin. 2004; autumn.
  39. Flaherty, AW, Akbarian S, MA Samuels. Stroke. T. A. Stern and J. B. Herman, eds., Psychiatry: Update and Board Preparation, 2nd ed. 2004.
  40. Flaherty AW. The Midnight Disease: The Drive to Write, Writer's Block, and the Creative Brain. 2004.
  41. Flaherty, AW, Akbarian S, MA Samuels. Movement disorders. T. A. Stern and J. B. Herman, eds., Psychiatry: Update and Board Preparation, 2nd ed. 2004.
  42. Eskandar EN, Flaherty A, Cosgrove GR, Shinobu LA, Barker FG. Surgery for Parkinson disease in the United States, 1996 to 2000: practice patterns, short-term outcomes, and hospital charges in a nationwide sample. J Neurosurg. 2003 Nov; 99(5):863-71.
    View in: PubMed
  43. Flaherty AW. Writing like crazy: a word on the brain. Chronicle of Higher Education. 2003; 50(13):1-6.
  44. Flaherty AW. CD-ROM edition of The Massachusetts General Hospital Handbook of Neurology. 2002.
  45. Flaherty AW. PDA edition of The Massachusetts General Hospital Handbook of Neurology. 2002.
  46. Flaherty, AW. Neurologia [Spanish trans. of TMGHHN]. 2001.
  47. Flaherty AW. [Japanese trans. of TMGHHN]. 2001.
  48. Flaherty, A. W. , J. Lester, S. Prady, L. H. Schwamm (2001). . Baker Educational Colloquium: The Harvard WEB-MED Project and The MGH Handbook of Neurology. 2001.
  49. Flaherty AW, Lester J, Prady S, Schwamm LS. An interactive portable neurological tool. American Academy of Neurology Annual Meeting. 2001.
  50. Scholz VH, Flaherty AW, Kraft E, Keltner JR, Kwong KK, Chen YI, Rosen BR, Jenkins BG. Laterality, somatotopy and reproducibility of the basal ganglia and motor cortex during motor tasks. Brain Res. 2000 Oct 6; 879(1-2):204-15.
    View in: PubMed
  51. Flaherty AW. The Massachusetts General Hospital Handbook of Neurology. 2000.
  52. Flaherty AW, Graybiel AM. Motor and somatosensory corticostriatal projection magnifications in the squirrel monkey. J Neurophysiol. 1995 Dec; 74(6):2638-48.
    View in: PubMed
  53. Graybiel AM, Aosaki T, Flaherty AW, Kimura M. The basal ganglia and adaptive motor control. Science. 1994 Sep 23; 265(5180):1826-31.
    View in: PubMed
  54. Flaherty AW, Graybiel AM. Input-output organization of the sensorimotor striatum in the squirrel monkey. J Neurosci. 1994 Feb; 14(2):599-610.
    View in: PubMed
  55. Flaherty AW, Graybiel AM. Anatomy of the basal ganglia. Marsden CD, Fahn S, eds. Movement Disorders, III. 1994; 3-28.
  56. Flaherty AW. Contributions of motor and somatosensory cortex to movement control in the primate striatum. 1994.
  57. Flaherty AW, Graybiel AM. Output architecture of the primate putamen. J Neurosci. 1993 Aug; 13(8):3222-37.
    View in: PubMed
  58. Flaherty AW, Graybiel AM. Two input systems for body representations in the primate striatal matrix: experimental evidence in the squirrel monkey. J Neurosci. 1993 Mar; 13(3):1120-37.
    View in: PubMed
  59. Flaherty AW. Multiple stages of sensorimotor processing in the primate basal ganglia. 1992.
  60. Flaherty AW, Graybiel AM. Corticostriatal transformations in the primate somatosensory system. Projections from physiologically mapped body-part representations. J Neurophysiol. 1991 Oct; 66(4):1249-63.
    View in: PubMed
  61. Graybiel AM, Flaherty AW, Gimenez-Amaya JM. Striosomes and matrisomes. Bernardi G, Carpenter MB, Di Chiari G, eds. The Basal Ganglia, III. 1991.
  62. Flaherty AW . Standard laboratory methods. Beck WS, ed. Hematology, fifth ed. 1991.
  63. Flaherty AW. Mirror, mirror .. Science. 1989 Aug 18; 245(4919):693.
    View in: PubMed
  64. Godley BF, Flaherty AW, Wurtman RJ. The effects of light on retinal dopamine in the ra. Annals of the New York Academy of Sciences. 1985; 453:383-384.
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