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Seth Leo Alper, M.D., PH.D.

TitleProfessor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Med Ctr
Molecular Medicine, RW-763
330 Brookline Ave
Boston MA 02215
Phone617/667-2930
Fax617/667-8040

 Research 
 research resources
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in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Epithelial Cell Biology Core (CHB) - Core services (6) and Instruments (21)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Thomson R, Genovese G, Canon C, Kovacsics D, Higgins MK, Carrington M, Winkler CA, Kopp J, Rotimi C, Adeyemo A, Doumatey A, Ayodo G, Alper SL, Pollak MR, Friedman DJ, Raper J. Evolution of the primate trypanolytic factor APOL1. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):E2130-9.
    View in: PubMed
  2. Sharma AK, Zelikovic I, Alper SL. Molecular Dynamics Simulations of the STAS Domains of Rat Prestin and Human Pendrin Reveal Conformational Motions in Conserved Flexible Regions. Cell Physiol Biochem. 2014; 33(3):605-20.
    View in: PubMed
  3. Rozenfeld J, Tal O, Kladnitsky O, Adler L, Efrati E, Carrithers SL, Alper SL, Zelikovic I. Pendrin, a novel transcriptional target of the uroguanylin system. Cell Physiol Biochem. 2013; 32(7):221-37.
    View in: PubMed
  4. Celi LA, Scott DJ, Lee J, Nelson R, Alper SL, Mukamal KJ, Mark RG, Danziger J. Association of hypermagnesemia and blood pressure in the critically ill. J Hypertens. 2013 Nov; 31(11):2136-41; discussion 2141.
    View in: PubMed
  5. Samo S, Sherid M, Husein H, Sulaiman S, Brower JV, Alper S, Yungbluth M, Vainder JA. Metastatic infiltrating ductal carcinoma of the breast to the colon: a case report and literature review. Case Rep Gastrointest Med. 2013; 2013:603683.
    View in: PubMed
  6. Zhou C, Fitzharris G, Alper SL, Baltz JM. Na+/H+ exchange is inactivated during mouse oocyte meiosis, facilitating glycine accumulation that maintains embryo cell volume. J Cell Physiol. 2013 Oct; 228(10):2042-53.
    View in: PubMed
  7. Chattaraj P, Reimold FR, Muskett JA, Shmukler BE, Chien WW, Madeo AC, Pryor SP, Zalewski CK, Butman JA, Brewer CC, Kenna MA, Alper SL, Griffith AJ. Use of SLC26A4 mutation testing for unilateral enlargement of the vestibular aqueduct. JAMA Otolaryngol Head Neck Surg. 2013 Sep; 139(9):907-13.
    View in: PubMed
  8. Shmukler BE, Vandorpe DH, Rivera A, Auerbach M, Brugnara C, Alper SL. Dehydrated stomatocytic anemia due to the heterozygous mutation R2456H in the mechanosensitive cation channel PIEZO1: a case report. Blood Cells Mol Dis. 2014 Jan; 52(1):53-4.
    View in: PubMed
  9. Xu C, Chang A, Hack BK, Eadon MT, Alper SL, Cunningham PN. TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis. Kidney Int. 2014 Jan; 85(1):72-81.
    View in: PubMed
  10. Al-Samir S, Papadopoulos S, Scheibe RJ, Meißner JD, Cartron JP, Sly WS, Alper SL, Gros G, Endeward V. Activity and distribution of intracellular carbonic anhydrase II and their effects on the transport activity of anion exchanger AE1/SLC4A1. J Physiol. 2013 Oct 15; 591(Pt 20):4963-82.
    View in: PubMed
  11. Alper SL, Sharma AK. The SLC26 gene family of anion transporters and channels. Mol Aspects Med. 2013 Apr-Jun; 34(2-3):494-515.
    View in: PubMed
  12. Goldfarb-Rumyantzev AS, Alper SL. Short-term responses of the kidney to high altitude in mountain climbers. Nephrol Dial Transplant. 2014 Mar; 29(3):497-506.
    View in: PubMed
  13. Alper SL. Harnessing red cell membrane pathophysiology towards point-of-care diagnosis for sickle cell disease. J Physiol. 2013 Mar 15; 591(Pt 6):1403-4.
    View in: PubMed
  14. Rivera A, Zee RY, Alper SL, Peters LL, Brugnara C. Strain-specific variations in cation content and transport in mouse erythrocytes. Physiol Genomics. 2013 May 1; 45(9):343-50.
    View in: PubMed
  15. Andolfo I, Alper SL, De Franceschi L, Auriemma C, Russo R, De Falco L, Vallefuoco F, Esposito MR, Vandorpe DH, Shmukler BE, Narayan R, Montanaro D, D'Armiento M, Vetro A, Limongelli I, Zuffardi O, Glader BE, Schrier SL, Brugnara C, Stewart GW, Delaunay J, Iolascon A. Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1. Blood. 2013 May 9; 121(19):3925-35, S1-12.
    View in: PubMed
  16. Shmukler BE, Hsu A, Alves J, Trudel M, Rust MB, Hubner CA, Rivera A, Alper SL. N-ethylmaleimide activates a Cl(-)-independent component of K(+) flux in mouse erythrocytes. Blood Cells Mol Dis. 2013 Jun; 51(1):9-16.
    View in: PubMed
  17. Shmukler BE, Mukodzi S, Andres O, Eber S, Alper SL. Autosomal dominant overhydrated stomatocytosis associated with the heterozygous RhAG mutation F65S: a case of missed heterozygosity due to allelic dropout. Br J Haematol. 2013 May; 161(4):602-4.
    View in: PubMed
  18. Reimold FR, Braun N, Zsengellér ZK, Stillman IE, Karumanchi SA, Toka HR, Latus J, Fritz P, Biegger D, Segerer S, Alscher MD, Bhasin MK, Alper SL. Transcriptional patterns in peritoneal tissue of encapsulating peritoneal sclerosis, a complication of chronic peritoneal dialysis. PLoS One. 2013; 8(2):e56389.
    View in: PubMed
  19. Kirby A, Gnirke A, Jaffe DB, Barešová V, Pochet N, Blumenstiel B, Ye C, Aird D, Stevens C, Robinson JT, Cabili MN, Gat-Viks I, Kelliher E, Daza R, DeFelice M, Hulková H, Sovová J, Vylet'al P, Antignac C, Guttman M, Handsaker RE, Perrin D, Steelman S, Sigurdsson S, Scheinman SJ, Sougnez C, Cibulskis K, Parkin M, Green T, Rossin E, Zody MC, Xavier RJ, Pollak MR, Alper SL, Lindblad-Toh K, Gabriel S, Hart PS, Regev A, Nusbaum C, Kmoch S, Bleyer AJ, Lander ES, Daly MJ. Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing. Nat Genet. 2013 Mar; 45(3):299-303.
    View in: PubMed
  20. Coury F, Zenger S, Stewart AK, Stephens S, Neff L, Tsang K, Shull GE, Alper SL, Baron R, Aliprantis AO. SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts. Proc Natl Acad Sci U S A. 2013 Feb 5; 110(6):2163-8.
    View in: PubMed
  21. Braun N, Alscher MD, Fritz P, Latus J, Edenhofer I, Reimold F, Alper SL, Kimmel M, Biegger D, Lindenmeyer M, Cohen CD, Wüthrich RP, Segerer S. The spectrum of podoplanin expression in encapsulating peritoneal sclerosis. PLoS One. 2012; 7(12):e53382.
    View in: PubMed
  22. Reimold FR, Stewart AK, Stolpe K, Heneghan JF, Shmukler BE, Alper SL. Substitution of transmembrane domain Cys residues alters pH(o)-sensitive anion transport by AE2/SLC4A2 anion exchanger. Pflugers Arch. 2013 Jun; 465(6):839-51.
    View in: PubMed
  23. Andolfo I, Alper SL, Delaunay J, Auriemma C, Russo R, Asci R, Esposito MR, Sharma AK, Shmukler BE, Brugnara C, De Franceschi L, Iolascon A. Missense mutations in the ABCB6 transporter cause dominant familial pseudohyperkalemia. Am J Hematol. 2013 Jan; 88(1):66-72.
    View in: PubMed
  24. Hailey DW, Roberts B, Owens KN, Stewart AK, Linbo T, Pujol R, Alper SL, Rubel EW, Raible DW. Loss of Slc4a1b chloride/bicarbonate exchanger function protects mechanosensory hair cells from aminoglycoside damage in the zebrafish mutant persephone. PLoS Genet. 2012; 8(10):e1002971.
    View in: PubMed
  25. Huang J, Shan J, Kim D, Liao J, Evagelidis A, Alper SL, Hanrahan JW. Basolateral chloride loading by the anion exchanger type 2: role in fluid secretion by the human airway epithelial cell line Calu-3. J Physiol. 2012 Nov 1; 590(Pt 21):5299-316.
    View in: PubMed
  26. Shmukler BE, Rivera A, Vandorpe DH, Alves J, Bonfanti U, Paltrinieri S, Alper SL. Cation-leak stomatocytosis in standard schnauzers does not cosegregate with coding mutations in the RhAG, SLC4A1, or GLUT1 genes associated with human disease. Blood Cells Mol Dis. 2012 Apr 15; 48(4):219-25.
    View in: PubMed
  27. Song LJ, Liu RJ, Zeng Z, Alper SL, Cui HJ, Lu Y, Zheng L, Yan ZW, Fu GH. Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2, and P-ERK. J Mol Med (Berl). 2012 Jun; 90(6):707-18.
    View in: PubMed
  28. Sharma AK, Ye L, Alper SL, Rigby AC. Guanine nucleotides differentially modulate backbone dynamics of the STAS domain of the SulP/SLC26 transport protein Rv1739c of Mycobacterium tuberculosis. FEBS J. 2012 Feb; 279(3):420-36.
    View in: PubMed
  29. Rozenfeld J, Tal O, Kladnitsky O, Adler L, Efrati E, Carrithers SL, Alper SL, Zelikovic I. The pendrin anion exchanger gene is transcriptionally regulated by uroguanylin: a novel enterorenal link. Am J Physiol Renal Physiol. 2012 Mar 1; 302(5):F614-24.
    View in: PubMed
  30. Ito T, Choi BY, King KA, Zalewski CK, Muskett J, Chattaraj P, Shawker T, Reynolds JC, Butman JA, Brewer CC, Wangemann P, Alper SL, Griffith AJ. SLC26A4 genotypes and phenotypes associated with enlargement of the vestibular aqueduct. Cell Physiol Biochem. 2011; 28(3):545-52.
    View in: PubMed
  31. Rozenfeld J, Efrati E, Adler L, Tal O, Carrithers SL, Alper SL, Zelikovic I. Transcriptional regulation of the pendrin gene. Cell Physiol Biochem. 2011; 28(3):385-96.
    View in: PubMed
  32. Reimold FR, Heneghan JF, Stewart AK, Zelikovic I, Vandorpe DH, Shmukler BE, Alper SL. Pendrin function and regulation in Xenopus oocytes. Cell Physiol Biochem. 2011; 28(3):435-50.
    View in: PubMed
  33. Sharma AK, Rigby AC, Alper SL. STAS domain structure and function. Cell Physiol Biochem. 2011; 28(3):407-22.
    View in: PubMed
  34. Heneghan JF, Alper SL. This, too, shall pass--like a kidney stone: a possible path to prophylaxis of nephrolithiasis? Focus on "Cholinergic signaling inhibits oxalate transport by human intestinal T84 cells". Am J Physiol Cell Physiol. 2012 Jan 1; 302(1):C18-20.
    View in: PubMed
  35. Stewart AK, Shmukler BE, Vandorpe DH, Rivera A, Heneghan JF, Li X, Hsu A, Karpatkin M, O'Neill AF, Bauer DE, Heeney MM, John K, Kuypers FA, Gallagher PG, Lux SE, Brugnara C, Westhoff CM, Alper SL. Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. Am J Physiol Cell Physiol. 2011 Dec; 301(6):C1325-43.
    View in: PubMed
  36. Ward HH, Brown-Glaberman U, Wang J, Morita Y, Alper SL, Bedrick EJ, Gattone VH, Deretic D, Wandinger-Ness A. A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1. Mol Biol Cell. 2011 Sep; 22(18):3289-305.
    View in: PubMed
  37. Stewart AK, Shmukler BE, Vandorpe DH, Reimold F, Heneghan JF, Nakakuki M, Akhavein A, Ko S, Ishiguro H, Alper SL. SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization. Am J Physiol Cell Physiol. 2011 Aug; 301(2):C289-303.
    View in: PubMed
  38. Stewart AK, Chebib FT, Akbar SW, Salas MJ, Sonik RA, Shmukler BE, Alper SL. Interactions of mouse glycophorin A with the dRTA-related mutant G719D of the mouse Cl-/HCO3- exchanger Ae1. Biochem Cell Biol. 2011 Apr; 89(2):224-35.
    View in: PubMed
  39. Choi BY, Muskett J, King KA, Zalewski CK, Shawker T, Reynolds JC, Butman JA, Brewer CC, Stewart AK, Alper SL, Griffith AJ. Hereditary hearing loss with thyroid abnormalities. Adv Otorhinolaryngol. 2011; 70:43-9.
    View in: PubMed
  40. Stewart AK, Kedar PS, Shmukler BE, Vandorpe DH, Hsu A, Glader B, Rivera A, Brugnara C, Alper SL. Functional characterization and modified rescue of novel AE1 mutation R730C associated with overhydrated cation leak stomatocytosis. Am J Physiol Cell Physiol. 2011 May; 300(5):C1034-46.
    View in: PubMed
  41. Sharma AK, Ye L, Baer CE, Shanmugasundaram K, Alber T, Alper SL, Rigby AC. Solution structure of the guanine nucleotide-binding STAS domain of SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. J Biol Chem. 2011 Mar 11; 286(10):8534-44.
    View in: PubMed
  42. Alper SL, Stewart AK, Vandorpe DH, Clark JS, Horack RZ, Simpson JE, Walker NM, Clarke LL. Native and recombinant Slc26a3 (downregulated in adenoma, Dra) do not exhibit properties of 2Cl-/1HCO3- exchange. Am J Physiol Cell Physiol. 2011 Feb; 300(2):C276-86.
    View in: PubMed
  43. Al Moamen NJ, Prasad V, Bodi I, Miller ML, Neiman ML, Lasko VM, Alper SL, Wieczorek DF, Lorenz JN, Shull GE. Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure. J Mol Cell Cardiol. 2011 Jan; 50(1):137-46.
    View in: PubMed
  44. Alper SL. Familial renal tubular acidosis. J Nephrol. 2010 Nov-Dec; 23 Suppl 16:S57-76.
    View in: PubMed
  45. Christov M, Alper SL. Tubular transport: core curriculum 2010. Am J Kidney Dis. 2010 Dec; 56(6):1202-17.
    View in: PubMed
  46. Shmukler BE, Kedar PS, Warang P, Desai M, Madkaikar M, Ghosh K, Colah RB, Alper SL. Hemolytic anemia and distal renal tubular acidosis in two Indian patients homozygous for SLC4A1/AE1 mutation A858D. Am J Hematol. 2010 Oct; 85(10):824-8.
    View in: PubMed
  47. Wu F, Saleem MA, Kampik NB, Satchwell TJ, Williamson RC, Blattner SM, Ni L, Toth T, White G, Young MT, Parker MD, Alper SL, Wagner CA, Toye AM. Anion exchanger 1 interacts with nephrin in podocytes. J Am Soc Nephrol. 2010 Sep; 21(9):1456-67.
    View in: PubMed
  48. Heneghan JF, Akhavein A, Salas MJ, Shmukler BE, Karniski LP, Vandorpe DH, Alper SL. Regulated transport of sulfate and oxalate by SLC26A2/DTDST. Am J Physiol Cell Physiol. 2010 Jun; 298(6):C1363-75.
    View in: PubMed
  49. Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE. AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon. Am J Physiol Gastrointest Liver Physiol. 2010 Apr; 298(4):G493-503.
    View in: PubMed
  50. Vandorpe DH, Xu C, Shmukler BE, Otterbein LE, Trudel M, Sachs F, Gottlieb PA, Brugnara C, Alper SL. Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One. 2010; 5(1):e8732.
    View in: PubMed
  51. Belenky MA, Sollars PJ, Mount DB, Alper SL, Yarom Y, Pickard GE. Cell-type specific distribution of chloride transporters in the rat suprachiasmatic nucleus. Neuroscience. 2010 Feb 17; 165(4):1519-37.
    View in: PubMed
  52. Stewart AK, Vandorpe DH, Heneghan JF, Chebib F, Stolpe K, Akhavein A, Edelman EJ, Maksimova Y, Gallagher PG, Alper SL. The GPA-dependent, spherostomatocytosis mutant AE1 E758K induces GPA-independent, endogenous cation transport in amphibian oocytes. Am J Physiol Cell Physiol. 2010 Feb; 298(2):C283-97.
    View in: PubMed
  53. Zhou C, Tiberi M, Liang B, Alper SL, Baltz JM. HCO3(-)/Cl(-) exchange inactivation and reactivation during mouse oocyte meiosis correlates with MEK/MAPK-regulated Ae2 plasma membrane localization. PLoS One. 2009; 4(10):e7417.
    View in: PubMed
  54. Choi BY, Stewart AK, Nishimura KK, Cha WJ, Seong MW, Park SS, Kim SW, Chun YS, Chung JW, Park SN, Chang SO, Kim CS, Alper SL, Griffith AJ, Oh SH. Efficient molecular genetic diagnosis of enlarged vestibular aqueducts in East Asians. Genet Test Mol Biomarkers. 2009 Oct; 13(5):679-87.
    View in: PubMed
  55. Xu J, Song P, Nakamura S, Miller M, Barone S, Alper SL, Riederer B, Bonhagen J, Arend LJ, Amlal H, Seidler U, Soleimani M. Deletion of the chloride transporter slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion. J Biol Chem. 2009 Oct 23; 284(43):29470-9.
    View in: PubMed
  56. Dai P, Stewart AK, Chebib F, Hsu A, Rozenfeld J, Huang D, Kang D, Lip V, Fang H, Shao H, Liu X, Yu F, Yuan H, Kenna M, Miller DT, Shen Y, Yang W, Zelikovic I, Platt OS, Han D, Alper SL, Wu BL. Distinct and novel SLC26A4/Pendrin mutations in Chinese and U.S. patients with nonsyndromic hearing loss. Physiol Genomics. 2009 Aug 7; 38(3):281-90.
    View in: PubMed
  57. Alper SL. Molecular physiology and genetics of Na+-independent SLC4 anion exchangers. J Exp Biol. 2009 Jun; 212(Pt 11):1672-83.
    View in: PubMed
  58. Feng J, Liu Y, Khabbaz KR, Sodha NR, Osipov RM, Hagberg R, Alper SL, Sellke FW. Large conductance calcium-activated potassium channels contribute to the reduced myogenic tone of peripheral microvasculature after cardiopulmonary bypass. J Surg Res. 2009 Nov; 157(1):123-8.
    View in: PubMed
  59. Casula S, Zolotarev AS, Stuart-Tilley AK, Wilhelm S, Shmukler BE, Brugnara C, Alper SL. Chemical crosslinking studies with the mouse Kcc1 K-Cl cotransporter. Blood Cells Mol Dis. 2009 May-Jun; 42(3):233-40.
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  60. Bajmoczi M, Gadjeva M, Alper SL, Pier GB, Golan DE. Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa. Am J Physiol Cell Physiol. 2009 Aug; 297(2):C263-77.
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  61. Stewart AK, Yamamoto A, Nakakuki M, Kondo T, Alper SL, Ishiguro H. Functional coupling of apical Cl-/HCO3- exchange with CFTR in stimulated HCO3- secretion by guinea pig interlobular pancreatic duct. Am J Physiol Gastrointest Liver Physiol. 2009 Jun; 296(6):G1307-17.
    View in: PubMed
  62. Choi BY, Stewart AK, Madeo AC, Pryor SP, Lenhard S, Kittles R, Eisenman D, Kim HJ, Niparko J, Thomsen J, Arnos KS, Nance WE, King KA, Zalewski CK, Brewer CC, Shawker T, Reynolds JC, Butman JA, Karniski LP, Alper SL, Griffith AJ. Hypo-functional SLC26A4 variants associated with nonsyndromic hearing loss and enlargement of the vestibular aqueduct: genotype-phenotype correlation or coincidental polymorphisms? Hum Mutat. 2009 Apr; 30(4):599-608.
    View in: PubMed
  63. Sharma AK, Ye L, Zolotarev AS, Alper SL, Rigby AC. NMR assignment and secondary structure of the STAS domain of Rv1739c, a putative sulfate transporter of Mycobacterium tuberculosis. Biomol NMR Assign. 2009 Jun; 3(1):99-102.
    View in: PubMed
  64. Ertam I, Kitapcioglu G, Aksu K, Keser G, Ozaksar A, Elbi H, Unal I, Alper S. Quality of life and its relation with disease severity in Behçet's disease. Clin Exp Rheumatol. 2009 Mar-Apr; 27(2 Suppl 53):S18-22.
    View in: PubMed
  65. Xu C, Shmukler BE, Nishimura K, Kaczmarek E, Rossetti S, Harris PC, Wandinger-Ness A, Bacallao RL, Alper SL. Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai2+ signaling in human ADPKD cyst epithelial cells. Am J Physiol Renal Physiol. 2009 Jun; 296(6):F1464-76.
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  66. Stewart AK, Shmukler BE, Vandorpe DH, Alper SL. Molecular characterization of Slc26a3 and Slc26a6 anion transporters in guinea pig pancreatic duct. J Med Invest. 2009; 56 Suppl:329-31.
    View in: PubMed
  67. Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL. Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH. J Biol Chem. 2009 Mar 6; 284(10):6126-39.
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  68. Xu J, Song P, Miller ML, Borgese F, Barone S, Riederer B, Wang Z, Alper SL, Forte JG, Shull GE, Ehrenfeld J, Seidler U, Soleimani M. Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17955-60.
    View in: PubMed
  69. Feng J, Liu Y, Clements RT, Sodha NR, Khabbaz KR, Senthilnathan V, Nishimura KK, Alper SL, Sellke FW. Calcium-activated potassium channels contribute to human coronary microvascular dysfunction after cardioplegic arrest. Circulation. 2008 Sep 30; 118(14 Suppl):S46-51.
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  70. Alper SL. Let's look at cysts from both sides now. Kidney Int. 2008 Sep; 74(6):699-702.
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  71. Dereli T, Karaca N, Kilinc Karaarslan I, Akalin T, Alper S. A case of bullous pemphigoid clinically mimicking subcorneal pustular dermatosis. J Eur Acad Dermatol Venereol. 2009 May; 23(5):608-10.
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  72. Liu Y, Sellke EW, Feng J, Clements RT, Sodha NR, Khabbaz KR, Senthilnathan V, Alper SL, Sellke FW. Calcium-activated potassium channels contribute to human skeletal muscle microvascular endothelial dysfunction related to cardiopulmonary bypass. Surgery. 2008 Aug; 144(2):239-44.
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  73. Chernova MN, Stewart AK, Barry PN, Jennings ML, Alper SL. Mouse Ae1 E699Q mediates SO42-i/anion-o exchange with [SO42-]i-dependent reversal of wild-type pHo sensitivity. Am J Physiol Cell Physiol. 2008 Aug; 295(2):C302-12.
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  74. Alper SL, Vandorpe DH, Peters LL, Brugnara C. Reduced DIDS-sensitive chloride conductance in Ae1-/- mouse erythrocytes. Blood Cells Mol Dis. 2008 Jul-Aug; 41(1):22-34.
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  75. Kurschat CE, Shmukler BE, Jiang L, Hevi S, Kim EH, Stewart AK, Alper SL. Mouse strain-specific coding polymorphism in the Slc4a2/Ae2 gene encodes Ae2c2 variants differing in isoform-specific dominant negative activity. Exp Physiol. 2008 Apr; 93(4):458-67.
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  76. Clark JS, Vandorpe DH, Chernova MN, Heneghan JF, Stewart AK, Alper SL. Species differences in Cl- affinity and in electrogenicity of SLC26A6-mediated oxalate/Cl- exchange correlate with the distinct human and mouse susceptibilities to nephrolithiasis. J Physiol. 2008 Mar 1; 586(5):1291-306.
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  77. Zolotarev AS, Unnikrishnan M, Shmukler BE, Clark JS, Vandorpe DH, Grigorieff N, Rubin EJ, Alper SL. Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. Comp Biochem Physiol A Mol Integr Physiol. 2008 Mar; 149(3):255-66.
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  78. Shmukler BE, Clark JS, Hsu A, Vandorpe DH, Stewart AK, Kurschat CE, Choe SK, Zhou Y, Amigo J, Paw BH, Alper SL. Zebrafish ae2.2 encodes a second slc4a2 anion exchanger. Am J Physiol Regul Integr Comp Physiol. 2008 Mar; 294(3):R1081-91.
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  79. De Franceschi L, Ronzoni L, Cappellini MD, Cimmino F, Siciliano A, Alper SL, Servedio V, Pozzobon C, Iolascon A. K-CL co-transport plays an important role in normal and beta thalassemic erythropoiesis. Haematologica. 2007 Oct; 92(10):1319-26.
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  80. Gonzalez-Begne M, Nakamoto T, Nguyen HV, Stewart AK, Alper SL, Melvin JE. Enhanced formation of a HCO3- transport metabolon in exocrine cells of Nhe1-/- mice. J Biol Chem. 2007 Nov 30; 282(48):35125-32.
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  81. Stewart AK, Kurschat CE, Vaughan-Jones RD, Shmukler BE, Alper SL. Acute regulation of mouse AE2 anion exchanger requires isoform-specific amino acid residues from most of the transmembrane domain. J Physiol. 2007 Oct 1; 584(Pt 1):59-73.
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  82. Kanaan A, Douglas RM, Alper SL, Boron WF, Haddad GG. Effect of chronic elevated carbon dioxide on the expression of acid-base transporters in the neonatal and adult mouse. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 293(3):R1294-302.
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  83. Morgan PE, Pastoreková S, Stuart-Tilley AK, Alper SL, Casey JR. Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters. Am J Physiol Cell Physiol. 2007 Aug; 293(2):C738-48.
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  84. Ertam I, Biyikli SE, Yazkan FA, Aytimur D, Alper S. The frequency of nasal carriage in chronic urticaria patients. J Eur Acad Dermatol Venereol. 2007 Jul; 21(6):777-80.
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  85. Rust MB, Alper SL, Rudhard Y, Shmukler BE, Vicente R, Brugnara C, Trudel M, Jentsch TJ, Hübner CA. Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice. J Clin Invest. 2007 Jun; 117(6):1708-17.
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  86. Stehberger PA, Shmukler BE, Stuart-Tilley AK, Peters LL, Alper SL, Wagner CA. Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1). J Am Soc Nephrol. 2007 May; 18(5):1408-18.
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  87. Hsu YM, Chou CY, Chen HH, Lee WY, Chen YF, Lin PW, Alper SL, Ellory JC, Shen MR. IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness. J Cell Physiol. 2007 Mar; 210(3):626-36.
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  88. Stewart AK, Kurschat CE, Alper SL. Role of nonconserved charged residues of the AE2 transmembrane domain in regulation of anion exchange by pH. Pflugers Arch. 2007 Jun; 454(3):373-84.
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  89. Akel A, Wagner CA, Kovacikova J, Kasinathan RS, Kiedaisch V, Koka S, Alper SL, Bernhardt I, Wieder T, Huber SM, Lang F. Enhanced suicidal death of erythrocytes from gene-targeted mice lacking the Cl-/HCO(3)(-) exchanger AE1. Am J Physiol Cell Physiol. 2007 May; 292(5):C1759-67.
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  90. Malek AM, Xu C, Kim ES, Alper SL. Hypertonicity triggers RhoA-dependent assembly of myosin-containing striated polygonal actin networks in endothelial cells. Am J Physiol Cell Physiol. 2007 May; 292(5):C1645-59.
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  91. Xu C, Rossetti S, Jiang L, Harris PC, Brown-Glaberman U, Wandinger-Ness A, Bacallao R, Alper SL. Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling. Am J Physiol Renal Physiol. 2007 Mar; 292(3):F930-45.
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  92. Kilinc Karaarslan I, Girgin Sagin F, Ertam I, Alper S, Ozturk G, Yildirim Sozmen E. Broad-band ultraviolet B phototherapy is associated with elevated serum thiobarbituric acid reactive substance and nitrite-nitrate levels in psoriatic patients. J Eur Acad Dermatol Venereol. 2006 Nov; 20(10):1226-31.
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  93. Stewart AK, Kurschat CE, Burns D, Banger N, Vaughan-Jones RD, Alper SL. Transmembrane domain histidines contribute to regulation of AE2-mediated anion exchange by pH. Am J Physiol Cell Physiol. 2007 Feb; 292(2):C909-18.
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  94. Alper SL, Stewart AK, Chernova MN, Zolotarev AS, Clark JS, Vandorpe DH. Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides. Novartis Found Symp. 2006; 273:107-19; discussion 119-25, 261-4.
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  95. Kurschat CE, Shmukler BE, Jiang L, Wilhelm S, Kim EH, Chernova MN, Kinne RK, Stewart AK, Alper SL. Alkaline-shifted pHo sensitivity of AE2c1-mediated anion exchange reveals novel regulatory determinants in the AE2 N-terminal cytoplasmic domain. J Biol Chem. 2006 Jan 27; 281(4):1885-96.
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  96. De Franceschi L, Villa-Moruzzi E, Biondani A, Siciliano A, Brugnara C, Alper SL, Lowell CA, Berton G. Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes. Pflugers Arch. 2006 Mar; 451(6):760-8.
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  97. Alper SL. Molecular physiology of SLC4 anion exchangers. Exp Physiol. 2006 Jan; 91(1):153-61.
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  98. Chernova MN, Vandorpe DH, Clark JS, Williams JI, Zasloff MA, Jiang L, Alper SL. Apparent receptor-mediated activation of Ca2+-dependent conductive Cl- transport by shark-derived polyaminosterols. Am J Physiol Regul Integr Comp Physiol. 2005 Dec; 289(6):R1644-58.
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  99. Ertam I, Unal I, Alper S. Erythromelanosis follicularis faciei et colli: report of involvement in two female patients. Dermatol Online J. 2005; 11(2):23.
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  100. Chernova MN, Vandorpe DH, Clark JS, Alper SL. Expression of the polycystin-1 C-terminal cytoplasmic tail increases Cl channel activity in Xenopus oocytes. Kidney Int. 2005 Aug; 68(2):632-41.
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  101. Shmukler BE, Kurschat CE, Ackermann GE, Jiang L, Zhou Y, Barut B, Stuart-Tilley AK, Zhao J, Zon LI, Drummond IA, Vandorpe DH, Paw BH, Alper SL. Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F835-49.
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  102. Sherman T, Chernova MN, Clark JS, Jiang L, Alper SL, Nehrke K. The abts and sulp families of anion transporters from Caenorhabditis elegans. Am J Physiol Cell Physiol. 2005 Aug; 289(2):C341-51.
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  103. Quentin F, Eladari D, Frische S, Cambillau M, Nielsen S, Alper SL, Paillard M, Chambrey R. Regulation of the Cl-/HCO3- exchanger AE2 in rat thick ascending limb of Henle's loop in response to changes in acid-base and sodium balance. J Am Soc Nephrol. 2004 Dec; 15(12):2988-97.
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  104. Davies SL, Roussa E, Le Rouzic P, Thévenod F, Alper SL, Best L, Brown PD. Expression of K+-Cl- cotransporters in the alpha-cells of rat endocrine pancreas. Biochim Biophys Acta. 2004 Nov 17; 1667(1):7-14.
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  105. Chernova MN, Jiang L, Friedman DJ, Darman RB, Lohi H, Kere J, Vandorpe DH, Alper SL. Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity. J Biol Chem. 2005 Mar 4; 280(9):8564-80.
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  106. Stewart AK, Kerr N, Chernova MN, Alper SL, Vaughan-Jones RD. Acute pH-dependent regulation of AE2-mediated anion exchange involves discrete local surfaces of the NH2-terminal cytoplasmic domain. J Biol Chem. 2004 Dec 10; 279(50):52664-76.
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  107. Begenisich T, Nakamoto T, Ovitt CE, Nehrke K, Brugnara C, Alper SL, Melvin JE. Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4. J Biol Chem. 2004 Nov 12; 279(46):47681-7.
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  108. Shen MR, Lin AC, Hsu YM, Chang TJ, Tang MJ, Alper SL, Ellory JC, Chou CY. Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells. J Biol Chem. 2004 Sep 17; 279(38):40017-25.
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  109. Gawenis LR, Ledoussal C, Judd LM, Prasad V, Alper SL, Stuart-Tilley A, Woo AL, Grisham C, Sanford LP, Doetschman T, Miller ML, Shull GE. Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydric. J Biol Chem. 2004 Jul 16; 279(29):30531-9.
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  110. Shayakul C, Alper SL. Defects in processing and trafficking of the AE1 Cl-/HCO3- exchanger associated with inherited distal renal tubular acidosis. Clin Exp Nephrol. 2004 Mar; 8(1):1-11.
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  111. Shayakul C, Jarolim P, Zachlederova M, Prabakaran D, Cortez-Campeao D, Kalabova D, Stuart-Tilley AK, Ideguchi H, Haller C, Alper SL. Characterization of a highly polymorphic marker adjacent to the SLC4A1 gene and of kidney immunostaining in a family with distal renal tubular acidosis. Nephrol Dial Transplant. 2004 Feb; 19(2):371-9.
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  112. Frische S, Zolotarev AS, Kim YH, Praetorius J, Alper S, Nielsen S, Wall SM. AE2 isoforms in rat kidney: immunohistochemical localization and regulation in response to chronic NH4Cl loading. Am J Physiol Renal Physiol. 2004 Jun; 286(6):F1163-70.
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  113. Aki S, Eskiyurt N, Akarirmak U, Tüzün F, Eryavuz M, Alper S, Arpacioglu O, Atalay F, Kavuncu V, Kokino S, Kuru O, Nas K, Ozerbil O, Savas G, Sendur OF, Soy D, Akyüz G. Gastrointestinal side effect profile due to the use of alendronate in the treatment of osteoporosis. Yonsei Med J. 2003 Dec 30; 44(6):961-7.
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  114. Rufo PA, Lin PW, Andrade A, Jiang L, Rameh L, Flexner C, Alper SL, Lencer WI. Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling. Am J Physiol Cell Physiol. 2004 May; 286(5):C998-C1008.
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  115. Nguyen HV, Stuart-Tilley A, Alper SL, Melvin JE. Cl(-)/HCO(3)(-) exchange is acetazolamide sensitive and activated by a muscarinic receptor-induced [Ca(2+)](i) increase in salivary acinar cells. Am J Physiol Gastrointest Liver Physiol. 2004 Feb; 286(2):G312-20.
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  116. Dahl NK, Jiang L, Chernova MN, Stuart-Tilley AK, Shmukler BE, Alper SL. Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomer. J Biol Chem. 2003 Nov 7; 278(45):44949-58.
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  117. Shen MR, Chou CY, Hsu KF, Hsu YM, Chiu WT, Tang MJ, Alper SL, Ellory JC. KCl cotransport is an important modulator of human cervical cancer growth and invasion. J Biol Chem. 2003 Oct 10; 278(41):39941-50.
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  118. Alper S, Temiz Arpaci O, Sener Aki E, Yalçin I. Some new bi- and ter-benzimidazole derivatives as topoisomerase I inhibitors. Farmaco. 2003 Jul; 58(7):497-507.
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  119. Petrovic S, Ju X, Barone S, Seidler U, Alper SL, Lohi H, Kere J, Soleimani M. Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells. Am J Physiol Gastrointest Liver Physiol. 2003 Jun; 284(6):G1093-103.
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  120. Paw BH, Davidson AJ, Zhou Y, Li R, Pratt SJ, Lee C, Trede NS, Brownlie A, Donovan A, Liao EC, Ziai JM, Drejer AH, Guo W, Kim CH, Gwynn B, Peters LL, Chernova MN, Alper SL, Zapata A, Wickramasinghe SN, Lee MJ, Lux SE, Fritz A, Postlethwait JH, Zon LI. Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet. 2003 May; 34(1):59-64.
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  121. Douglas RM, Xue J, Chen JY, Haddad CG, Alper SL, Haddad GG. Chronic intermittent hypoxia decreases the expression of Na/H exchangers and HCO3-dependent transporters in mouse CNS. J Appl Physiol (1985). 2003 Jul; 95(1):292-9.
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  122. Tietz PS, Marinelli RA, Chen XM, Huang B, Cohn J, Kole J, McNiven MA, Alper S, LaRusso NF. Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes. J Biol Chem. 2003 May 30; 278(22):20413-9.
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  123. Chernova MN, Jiang L, Shmukler BE, Schweinfest CW, Blanco P, Freedman SD, Stewart AK, Alper SL. Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes. J Physiol. 2003 May 15; 549(Pt 1):3-19.
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  124. Ceylan C, Oztürk G, Alper S. Non-melanoma skin cancers between the years of 1990 and 1999 in Izmir, Turkey: demographic and clinicopathological characteristics. J Dermatol. 2003 Feb; 30(2):123-31.
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  125. Chernova MN, Stewart AK, Jiang L, Friedman DJ, Kunes YZ, Alper SL. Structure-function relationships of AE2 regulation by Ca(i)(2+)-sensitive stimulators NH(4+) and hypertonicity. Am J Physiol Cell Physiol. 2003 May; 284(5):C1235-46.
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  126. Stewart AK, Chernova MN, Shmukler BE, Wilhelm S, Alper SL. Regulation of AE2-mediated Cl- transport by intracellular or by extracellular pH requires highly conserved amino acid residues of the AE2 NH2-terminal cytoplasmic domain. J Gen Physiol. 2002 Nov; 120(5):707-22.
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  127. Ceylan C, Alper S, Kilinç I. Leser-Trelat sign. Int J Dermatol. 2002 Oct; 41(10):687-8.
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  128. Alper S, Kenyon C. The zinc finger protein REF-2 functions with the Hox genes to inhibit cell fusion in the ventral epidermis of C. elegans. Development. 2002 Jul; 129(14):3335-48.
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  129. Duman S, Töz H, Asçi G, Alper S, Ozkahya M, Unal I, Celik A, Ok E, Basçi A. Successful treatment of post-transplant Kaposi's sarcoma by reduction of immunosuppression. Nephrol Dial Transplant. 2002 May; 17(5):892-6.
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  130. Ceylan C, Erboz S, Ozdemir F, Alper S. Topical photodynamic therapy for intraepidermal epithelioma. J Eur Acad Dermatol Venereol. 2002 May; 16(3):292-4.
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  131. Roussa E, Shmukler BE, Wilhelm S, Casula S, Stuart-Tilley AK, Thévenod F, Alper SL. Immunolocalization of potassium-chloride cotransporter polypeptides in rat exocrine glands. Histochem Cell Biol. 2002 Apr; 117(4):335-44.
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  132. Alper SL, Darman RB, Chernova MN, Dahl NK. The AE gene family of Cl/HCO3- exchangers. J Nephrol. 2002 Mar-Apr; 15 Suppl 5:S41-53.
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  133. Vandorpe DH, Wilhelm S, Jiang L, Ibraghimov-Beskrovnaya O, Chernova MN, Stuart-Tilley AK, Alper SL. Cation channel regulation by COOH-terminal cytoplasmic tail of polycystin-1: mutational and functional analysis. Physiol Genomics. 2002 Feb 28; 8(2):87-98.
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  134. Alper SL. Genetic diseases of acid-base transporters. Annu Rev Physiol. 2002; 64:899-923.
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  135. Ramchandran R, Karumanchi SA, Hanai J, Alper SL, Sukhatme VP. Cellular actions and signaling by endostatin. Crit Rev Eukaryot Gene Expr. 2002; 12(3):175-91.
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  136. Alper SL, Chernova MN, Stewart AK. How pH regulates a pH regulator: a regulatory hot spot in the N-terminal cytoplasmic domain of the AE2 anion exchanger. Cell Biochem Biophys. 2002; 36(2-3):123-36.
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  137. Goss GG, Jiang L, Vandorpe DH, Kieller D, Chernova MN, Robertson M, Alper SL. Role of JNK in hypertonic activation of Cl(-)-dependent Na(+)/H(+) exchange in Xenopus oocytes. Am J Physiol Cell Physiol. 2001 Dec; 281(6):C1978-90.
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  138. De Franceschi L, Villa-Moruzzi E, Fumagalli L, Brugnara C, Turrini F, Motta R, Veghini E, Corato C, Alper SL, Berton G. K-Cl cotransport modulation by intracellular Mg in erythrocytes from mice bred for low and high Mg levels. Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1385-95.
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  139. Stewart AK, Chernova MN, Kunes YZ, Alper SL. Regulation of AE2 anion exchanger by intracellular pH: critical regions of the NH(2)-terminal cytoplasmic domain. Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1344-54.
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  140. Gaxiola RA, Li J, Undurraga S, Dang LM, Allen GJ, Alper SL, Fink GR. Drought- and salt-tolerant plants result from overexpression of the AVP1 H+-pump. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11444-9.
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  141. Casula S, Shmukler BE, Wilhelm S, Stuart-Tilley AK, Su W, Chernova MN, Brugnara C, Alper SL. A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. J Biol Chem. 2001 Nov 9; 276(45):41870-8.
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  142. Rossmann H, Bachmann O, Wang Z, Shull GE, Obermaier B, Stuart-Tilley A, Alper SL, Seidler U. Differential expression and regulation of AE2 anion exchanger subtypes in rabbit parietal and mucous cells. J Physiol. 2001 Aug 1; 534(Pt 3):837-48.
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  143. Alper SL, Chernova MN, Stewart AK. Regulation of Na+-independent Cl-/HCO3- exchangers by pH. JOP. 2001 Jul; 2(4 Suppl):171-5.
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  144. Alper S, Kenyon C. REF-1, a protein with two bHLH domains, alters the pattern of cell fusion in C. elegans by regulating Hox protein activity. Development. 2001 May; 128(10):1793-804.
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  145. Jiang L, Jha V, Dhanabal M, Sukhatme VP, Alper SL. Intracellular Ca(2+) signaling in endothelial cells by the angiogenesis inhibitors endostatin and angiostatin. Am J Physiol Cell Physiol. 2001 May; 280(5):C1140-50.
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  146. Brugnara C, De Franceschi L, Bennekou P, Alper SL, Christophersen P. Novel therapies for prevention of erythrocyte dehydration in sickle cell anemia. Drug News Perspect. 2001 May; 14(4):208-20.
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  147. Karumanchi SA, Jiang L, Knebelmann B, Stuart-Tilley AK, Alper SL, Sukhatme VP. VHL tumor suppressor regulates Cl-/HCO3- exchange and Na+/H+ exchange activities in renal carcinoma cells. Physiol Genomics. 2001 Apr 2; 5(3):119-28.
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  148. Roussa E, Alper SL, Thévenod F. Immunolocalization of anion exchanger AE2, Na(+)/H(+) exchangers NHE1 and NHE4, and vacuolar type H(+)-ATPase in rat pancreas. J Histochem Cytochem. 2001 Apr; 49(4):463-74.
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  149. Shmukler BE, Bond CT, Wilhelm S, Bruening-Wright A, Maylie J, Adelman JP, Alper SL. Structure and complex transcription pattern of the mouse SK1 K(Ca) channel gene, KCNN1. Biochim Biophys Acta. 2001 Mar 19; 1518(1-2):36-46.
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  150. Alper SL. Sporadic cases of Liddle's syndrome: clues to essential hypertension? Am J Kidney Dis. 2001 Mar; 37(3):632-5.
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  151. Papageorgiou P, Shmukler BE, Stuart-Tilley AK, Jiang L, Alper SL. AE anion exchangers in atrial tumor cells. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H937-45.
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  152. Walsh PJ, Grosell M, Goss GG, Bergman HL, Bergman AN, Wilson P, Laurent P, Alper SL, Smith CP, Kamunde C, Wood CM. Physiological and molecular characterization of urea transport by the gills of the Lake Magadi tilapia (Alcolapia grahami). J Exp Biol. 2001 Feb; 204(Pt 3):509-20.
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  153. Rajendran VM, Black J, Ardito TA, Sangan P, Alper SL, Schweinfest C, Kashgarian M, Binder HJ. Regulation of DRA and AE1 in rat colon by dietary Na depletion. Am J Physiol Gastrointest Liver Physiol. 2000 Nov; 279(5):G931-42.
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  154. Vandorpe DH, Chernova MN, Jiang L, Sellin LK, Wilhelm S, Stuart-Tilley AK, Walz G, Alper SL. The cytoplasmic C-terminal fragment of polycystin-1 regulates a Ca2+-permeable cation channel. J Biol Chem. 2001 Feb 9; 276(6):4093-101.
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  155. Loffing J, Moyer BD, Reynolds D, Shmukler BE, Alper SL, Stanton BA. Functional and molecular characterization of an anion exchanger in airway serous epithelial cells. Am J Physiol Cell Physiol. 2000 Oct; 279(4):C1016-23.
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  156. Shayakul C, Alper SL. Inherited renal tubular acidosis. Curr Opin Nephrol Hypertens. 2000 Sep; 9(5):541-6.
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  157. Counillon L, Touret N, Bidet M, Peterson-Yantorno K, Coca-Prados M, Stuart-Tilley A, Wilhelm S, Alper SL, Civan MM. Na+/H+ and CI-/HCO3-antiporters of bovine pigmented ciliary epithelial cells. Pflugers Arch. 2000 Sep; 440(5):667-78.
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  158. Shmukler BE, Brugnara C, Alper SL. Structure and genetic polymorphism of the mouse KCC1 gene. Biochim Biophys Acta. 2000 Jul 24; 1492(2-3):353-61.
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  159. Klein M, Seeger P, Schuricht B, Alper SL, Schwab A. Polarization of Na(+)/H(+) and Cl(-)/HCO (3)(-) exchangers in migrating renal epithelial cells. J Gen Physiol. 2000 May; 115(5):599-608.
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  160. Ozdemir F, Erboz S, Unal I, Alper S, Aytimur D, Ozol A, Aytimur M. Generalized Trichophyton rubrum infection in a subject with pemphigus vulgaris. J Eur Acad Dermatol Venereol. 2000 May; 14(3):228-30.
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  161. Schmit J, Alper S, Raschke D, Ryndak D. Effects of using a photographic cueing package during routine school transitions with a child who has autism. Ment Retard. 2000 Apr; 38(2):131-7.
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  162. Rossmann H, Alper SL, Nader M, Wang Z, Gregor M, Seidler U. Three 5'-variant mRNAs of anion exchanger AE2 in stomach and intestine of mouse, rabbit, and rat. Ann N Y Acad Sci. 2000; 915:81-91.
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  163. Shmukler BE, Wilhelm S, Alper SL. Short sequence repeat polymorphism in the mouse slc4al gene encoding the AE1 Cl-/HCO3-exchanger. DNA Seq. 2000; 11(5):447-50.
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  164. Malek AM, Alper SL, Izumo S. Hemodynamic shear stress and its role in atherosclerosis. JAMA. 1999 Dec 1; 282(21):2035-42.
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  165. Mourre C, Chernova MN, Martin-Eauclaire MF, Bessone R, Jacquet G, Gola M, Alper SL, Crest M. Distribution in rat brain of binding sites of kaliotoxin, a blocker of Kv1.1 and Kv1.3 alpha-subunits. J Pharmacol Exp Ther. 1999 Dec; 291(3):943-52.
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  166. Roussa E, Romero MF, Schmitt BM, Boron WF, Alper SL, Thévenod F. Immunolocalization of anion exchanger AE2 and Na(+)-HCO(-)(3) cotransporter in rat parotid and submandibular glands. Am J Physiol. 1999 Dec; 277(6 Pt 1):G1288-96.
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  167. Su W, Shmukler BE, Chernova MN, Stuart-Tilley AK, de Franceschi L, Brugnara C, Alper SL. Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation. Am J Physiol. 1999 Nov; 277(5 Pt 1):C899-912.
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  168. Jensen LJ, Stuart-Tilley AK, Peters LL, Lux SE, Alper SL, Breton S. Immunolocalization of AE2 anion exchanger in rat and mouse epididymis. Biol Reprod. 1999 Oct; 61(4):973-80.
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  169. Shayakul C, Breton S, Brown D, Alper SL. Gene therapy of inherited renal tubular disease. Am J Kidney Dis. 1999 Aug; 34(2):374-9.
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  170. Malek AM, Izumo S, Alper SL. Modulation by pathophysiological stimuli of the shear stress-induced up-regulation of endothelial nitric oxide synthase expression in endothelial cells. Neurosurgery. 1999 Aug; 45(2):334-44; discussion 344-5.
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  171. Alper SL, Rossmann H, Wilhelm S, Stuart-Tilley AK, Shmukler BE, Seidler U. Expression of AE2 anion exchanger in mouse intestine. Am J Physiol. 1999 Aug; 277(2 Pt 1):G321-32.
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  172. Zolotarev AS, Shmukler BE, Alper SL. AE2 anion exchanger polypeptide is a homooligomer in pig gastric membranes: a chemical cross-linking study. Biochemistry. 1999 Jun 29; 38(26):8521-31.
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  173. Gaxiola RA, Rao R, Sherman A, Grisafi P, Alper SL, Fink GR. The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast. Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1480-5.
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  174. Malek AM, Zhang J, Jiang J, Alper SL, Izumo S. Endothelin-1 gene suppression by shear stress: pharmacological evaluation of the role of tyrosine kinase, intracellular calcium, cytoskeleton, and mechanosensitive channels. J Mol Cell Cardiol. 1999 Feb; 31(2):387-99.
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  175. Malek AM, Jiang L, Lee I, Sessa WC, Izumo S, Alper SL. Induction of nitric oxide synthase mRNA by shear stress requires intracellular calcium and G-protein signals and is modulated by PI 3 kinase. Biochem Biophys Res Commun. 1999 Jan 8; 254(1):231-42.
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  176. Iigenli T, Varol A, Alper S, Kandemir S. Periodontal lesions in lipoid proteinosis. Periodontal Clin Investig. 1999; 21(1):21-3.
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  177. Lencer WI, Alper SL. The potassium channel and how it works. Gastroenterology. 1999 Jan; 116(1):216-7.
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  178. Tanphaichitr VS, Sumboonnanonda A, Ideguchi H, Shayakul C, Brugnara C, Takao M, Veerakul G, Alper SL. Novel AE1 mutations in recessive distal renal tubular acidosis. Loss-of-function is rescued by glycophorin A. J Clin Invest. 1998 Dec 15; 102(12):2173-9.
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  179. Malek AM, Goss GG, Jiang L, Izumo S, Alper SL. Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells. Stroke. 1998 Dec; 29(12):2631-40.
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  180. Mhatre AN, Charachon G, Alper SL, Lalwani AK. The guinea pig cochlear AE2 anion exchanger: cDNA cloning and in situ localization within the cochlea. Biochim Biophys Acta. 1998 Nov 11; 1414(1-2):1-15.
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  181. Eladari D, Blanchard A, Leviel F, Paillard M, Stuart-Tilley AK, Alper SL, Podevin RA. Functional and molecular characterization of luminal and basolateral Cl-/HCO-3 exchangers of rat thick limbs. Am J Physiol. 1998 Sep; 275(3 Pt 2):F334-42.
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  182. Vandorpe DH, Shmukler BE, Jiang L, Lim B, Maylie J, Adelman JP, de Franceschi L, Cappellini MD, Brugnara C, Alper SL. cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation. J Biol Chem. 1998 Aug 21; 273(34):21542-53.
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  183. Merlin D, Jiang L, Strohmeier GR, Nusrat A, Alper SL, Lencer WI, Madara JL. Distinct Ca2+- and cAMP-dependent anion conductances in the apical membrane of polarized T84 cells. Am J Physiol. 1998 Aug; 275(2 Pt 1):C484-95.
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  184. Tofukuji M, Metais C, Wang SY, Alper SL, Sellke FW. Clotrimazole is a potent vasodilator of the rat coronary microcirculation. J Surg Res. 1998 Jun; 77(1):6-10.
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  185. Stuart-Tilley AK, Shmukler BE, Brown D, Alper SL. Immunolocalization and tissue-specific splicing of AE2 anion exchanger in mouse kidney. J Am Soc Nephrol. 1998 Jun; 9(6):946-59.
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  186. Jarolim P, Shayakul C, Prabakaran D, Jiang L, Stuart-Tilley A, Rubin HL, Simova S, Zavadil J, Herrin JT, Brouillette J, Somers MJ, Seemanova E, Brugnara C, Guay-Woodford LM, Alper SL. Autosomal dominant distal renal tubular acidosis is associated in three families with heterozygosity for the R589H mutation in the AE1 (band 3) Cl-/HCO3- exchanger. J Biol Chem. 1998 Mar 13; 273(11):6380-8.
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  187. Alper S, Tjosvold D, Law KS. Interdependence and Controversy in Group Decision Making: Antecedents to Effective Self-Managing Teams. Organ Behav Hum Decis Process. 1998 Apr; 74(1):33-52.
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  188. Alper SL, Chernova MN, Williams J, Zasloff M, Law FY, Knauf PA. Differential inhibition of AE1 and AE2 anion exchangers by oxonol dyes and by novel polyaminosterol analogs of the shark antibiotic squalamine. Biochem Cell Biol. 1998; 76(5):799-806.
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  189. Rufo PA, Merlin D, Riegler M, Ferguson-Maltzman MH, Dickinson BL, Brugnara C, Alper SL, Lencer WI. The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera. J Clin Invest. 1997 Dec 15; 100(12):3111-20.
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  190. Brosius FC, Pisoni RL, Cao X, Deshmukh G, Yannoukakos D, Stuart-Tilley AK, Haller C, Alper SL. AE anion exchanger mRNA and protein expression in vascular smooth muscle cells, aorta, and renal microvessels. Am J Physiol. 1997 Dec; 273(6 Pt 2):F1039-47.
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  191. Stankovic KM, Brown D, Alper SL, Adams JC. Localization of pH regulating proteins H+ATPase and Cl-/HCO3- exchanger in the guinea pig inner ear. Hear Res. 1997 Dec; 114(1-2):21-34.
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  192. Malek AM, Lee IW, Alper SL, Izumo S. Regulation of endothelin-1 gene expression by cell shape and the microfilament network in vascular endothelium. Am J Physiol. 1997 Nov; 273(5 Pt 1):C1764-74.
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  193. Chernova MN, Humphreys BD, Robinson DH, Stuart-Tilley AK, Garcia AM, Brosius FC, Alper SL. Functional consequences of mutations in the transmembrane domain and the carboxy-terminus of the murine AE1 anion exchanger. Biochim Biophys Acta. 1997 Oct 2; 1329(1):111-23.
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  194. Alper SL, Stuart-Tilley AK, Biemesderfer D, Shmukler BE, Brown D. Immunolocalization of AE2 anion exchanger in rat kidney. Am J Physiol. 1997 Oct; 273(4 Pt 2):F601-14.
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  195. De Franceschi L, Bachir D, Galacteros F, Tchernia G, Cynober T, Alper S, Platt O, Beuzard Y, Brugnara C. Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease. J Clin Invest. 1997 Oct 1; 100(7):1847-52.
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  196. Zhao Y, Doroshenko PA, Alper SL, Baltz JM. Routes of Cl- transport across the trophectoderm of the mouse blastocyst. Dev Biol. 1997 Sep 1; 189(1):148-60.
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  197. Nozik-Grayck E, Piantadosi CA, van Adelsberg J, Alper SL, Huang YC. Protection of perfused lung from oxidant injury by inhibitors of anion exchange. Am J Physiol. 1997 Aug; 273(2 Pt 1):L296-304.
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  198. Rittenhouse AR, Parker C, Brugnara C, Morgan KG, Alper SL. Inhibition of maxi-K currents in ferret portal vein smooth muscle cells by the antifungal clotrimazole. Am J Physiol. 1997 Jul; 273(1 Pt 1):C45-56.
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  199. Joannidis M, Cantley LG, Spokes K, Stuart-Tilley AK, Alper SL, Epstein FH. Modulation of c-fos and egr-1 expression in the isolated perfused kidney by agents that alter tubular work. Kidney Int. 1997 Jul; 52(1):130-9.
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  200. Husain M, Jiang L, See V, Bein K, Simons M, Alper SL, Rosenberg RD. Regulation of vascular smooth muscle cell proliferation by plasma membrane Ca(2+)-ATPase. Am J Physiol. 1997 Jun; 272(6 Pt 1):C1947-59.
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  201. Malek AM, Izumo S, Alper SL. Quantitative densitometric analysis using a commercially available handheld CCD digital camera. Biotechniques. 1997 Jun; 22(6):1150-3.
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  202. Rittenhouse AR, Vandorpe DH, Brugnara C, Alper SL. The antifungal imidazole clotrimazole and its major in vivo metabolite are potent blockers of the calcium-activated potassium channel in murine erythroleukemia cells. J Membr Biol. 1997 May 15; 157(2):177-91.
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  203. Husain M, Bein K, Jiang L, Alper SL, Simons M, Rosenberg RD. c-Myb-dependent cell cycle progression and Ca2+ storage in cultured vascular smooth muscle cells. Circ Res. 1997 May; 80(5):617-26.
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  204. Perrone RD, Grubman SA, Murray SL, Lee DW, Alper SL, Jefferson DM. Autosomal dominant polycystic kidney disease decreases anion exchanger activity. Am J Physiol. 1997 May; 272(5 Pt 1):C1748-56.
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  205. Humphreys BD, Chernova MN, Jiang L, Zhang Y, Alper SL. NH4Cl activates AE2 anion exchanger in Xenopus oocytes at acidic pHi. Am J Physiol. 1997 Apr; 272(4 Pt 1):C1232-40.
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  206. Caroppo R, Debellis L, Valenti G, Alper S, Frömter E, Curci S. Is resting state HCO3- secretion in frog gastric fundus mucosa mediated by apical Cl(-)-HCO3- exchange? J Physiol. 1997 Mar 15; 499 ( Pt 3):763-71.
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  207. Chernova MN, Jiang L, Crest M, Hand M, Vandorpe DH, Strange K, Alper SL. Electrogenic sulfate/chloride exchange in Xenopus oocytes mediated by murine AE1 E699Q. J Gen Physiol. 1997 Mar; 109(3):345-60.
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  208. Jiang L, Chernova MN, Alper SL. Secondary regulatory volume increase conferred on Xenopus oocytes by expression of AE2 anion exchanger. Am J Physiol. 1997 Jan; 272(1 Pt 1):C191-202.
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  209. Shmukler B, Sun T, Brugnara C, Alper SL. Reinterpretation of the RACTK1 K+ channel. Am J Physiol. 1997 Jan; 272(1 Pt 1):C350-4.
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  210. He X, Tse CM, Donowitz M, Alper SL, Gabriel SE, Baum BJ. Polarized distribution of key membrane transport proteins in the rat submandibular gland. Pflugers Arch. 1997 Jan; 433(3):260-8.
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  211. Sabolic I, Brown D, Gluck SL, Alper SL. Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis. Kidney Int. 1997 Jan; 51(1):125-37.
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  212. Rufo PA, Jiang L, Moe SJ, Brugnara C, Alper SL, Lencer WI. The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells. J Clin Invest. 1996 Nov 1; 98(9):2066-75.
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  213. Peters LL, Shivdasani RA, Liu SC, Hanspal M, John KM, Gonzalez JM, Brugnara C, Gwynn B, Mohandas N, Alper SL, Orkin SH, Lux SE. Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Cell. 1996 Sep 20; 86(6):917-27.
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  214. Zolotarev AS, Chernova MN, Yannoukakos D, Alper SL. Proteolytic cleavage sites of native AE2 anion exchanger in gastric mucosal membranes. Biochemistry. 1996 Aug 13; 35(32):10367-76.
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  215. Zolotarev AS, Townsend RR, Stuart-Tilley A, Alper SL. HCO3(-)-dependent conformational change in gastric parietal cell AE2, a glycoprotein naturally lacking sialic acid. Am J Physiol. 1996 Aug; 271(2 Pt 1):G311-21.
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  216. Alper S, Dufour A, Garsin DA, Duncan L, Losick R. Role of adenosine nucleotides in the regulation of a stress-response transcription factor in Bacillus subtilis. J Mol Biol. 1996 Jul 12; 260(2):165-77.
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  217. Duncan L, Alper S, Losick R. SpoIIAA governs the release of the cell-type specific transcription factor sigma F from its anti-sigma factor SpoIIAB. J Mol Biol. 1996 Jul 12; 260(2):147-64.
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  218. Resnekov O, Alper S, Losick R. Subcellular localization of proteins governing the proteolytic activation of a developmental transcription factor in Bacillus subtilis. Genes Cells. 1996 Jun; 1(6):529-42.
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  219. Simon JS, Deshmukh G, Couch FJ, Merajver SD, Weber BL, Van Vooren P, Tissil F, Szpirer J, Szpirer C, Alper SL, Jacob HJ, Brosius FC. Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3. Mamm Genome. 1996 May; 7(5):380-2.
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  220. Arigoni F, Duncan L, Alper S, Losick R, Stragier P. SpoIIE governs the phosphorylation state of a protein regulating transcription factor sigma F during sporulation in Bacillus subtilis. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3238-42.
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  221. Brown D, Lydon J, McLaughlin M, Stuart-Tilley A, Tyszkowski R, Alper S. Antigen retrieval in cryostat tissue sections and cultured cells by treatment with sodium dodecyl sulfate (SDS). Histochem Cell Biol. 1996 Apr; 105(4):261-7.
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  222. Zhang Y, Chernova MN, Stuart-Tilley AK, Jiang L, Alper SL. The cytoplasmic and transmembrane domains of AE2 both contribute to regulation of anion exchange by pH. J Biol Chem. 1996 Mar 8; 271(10):5741-9.
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  223. Armsby CC, Stuart-Tilley AK, Alper SL, Brugnara C. Resistance to osmotic lysis in BXD-31 mouse erythrocytes: association with upregulated K-Cl cotransport. Am J Physiol. 1996 Mar; 270(3 Pt 1):C866-77.
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  224. Brugnara C, Gee B, Armsby CC, Kurth S, Sakamoto M, Rifai N, Alper SL, Platt OS. Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease. J Clin Invest. 1996 Mar 1; 97(5):1227-34.
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  225. de Franceschi L, Rouyer-Fessard P, Alper SL, Jouault H, Brugnara C, Beuzard Y. Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a beta thalassemic mouse: a model for human therapy. Blood. 1996 Feb 1; 87(3):1188-95.
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  226. Coupry I, Armsby CC, Alper SL, Brugnara C, Parini A. Clotrimazole and efaroxan inhibit red cell Gardos channel independently of imidazoline I1 and I2 binding sites. Eur J Pharmacol. 1996 Jan 4; 295(1):109-12.
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  227. Breton S, Alper SL, Gluck SL, Sly WS, Barker JE, Brown D. Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice. Am J Physiol. 1995 Dec; 269(6 Pt 2):F761-74.
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  228. Chernova MN, Jarolim P, Palek J, Alper SL. Overexpression of AE1 Prague, but not of AE1 SAO, inhibits wild-type AE1 trafficking in Xenopus oocytes. J Membr Biol. 1995 Nov; 148(2):203-10.
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  229. Duncan L, Alper S, Arigoni F, Losick R, Stragier P. Activation of cell-specific transcription by a serine phosphatase at the site of asymmetric division. Science. 1995 Oct 27; 270(5236):641-4.
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  230. Zhao Y, Chauvet PJ, Alper SL, Baltz JM. Expression and function of bicarbonate/chloride exchangers in the preimplantation mouse embryo. J Biol Chem. 1995 Oct 13; 270(41):24428-34.
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  231. Brosius FC, Nguyen K, Stuart-Tilley AK, Haller C, Briggs JP, Alper SL. Regional and segmental localization of AE2 anion exchanger mRNA and protein in rat kidney. Am J Physiol. 1995 Oct; 269(4 Pt 2):F461-8.
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  232. Brugnara C, Armsby CC, De Franceschi L, Crest M, Euclaire MF, Alper SL. Ca(2+)-activated K+ channels of human and rabbit erythrocytes display distinctive patterns of inhibition by venom peptide toxins. J Membr Biol. 1995 Sep; 147(1):71-82.
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  233. Moisa RB, Zeldis SM, Alper SA, Scott WC. Aortic regurgitation in coronary artery bypass grafting: implications for cardioplegia administration. Ann Thorac Surg. 1995 Sep; 60(3):665-8.
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  234. Coupry I, Armsby CC, Alper S, Parini A, Brugnara C. Inhibition of red cell Ca(2+)-activated K+ transport by clotrimazole does not take place via imidazoline binding sites. Ann N Y Acad Sci. 1995 Jul 12; 763:287-9.
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  235. Brugnara C, De Franceschi L, Armsby CC, Saadane N, Trudel M, Beuzard Y, Rittenhouse A, Rifai N, Platt O, Alper SL. A new therapeutic approach for sickle cell disease. Blockade of the red cell Ca(2+)-activated K+ channel by clotrimazole. Ann N Y Acad Sci. 1995 Jul 12; 763:262-71.
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  236. Brugnara C, Armsby CC, Sakamoto M, Rifai N, Alper SL, Platt O. Oral administration of clotrimazole and blockade of human erythrocyte Ca(++)-activated K+ channel: the imidazole ring is not required for inhibitory activity. J Pharmacol Exp Ther. 1995 Apr; 273(1):266-72.
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  237. Armsby CC, Brugnara C, Alper SL. Cation transport in mouse erythrocytes: role of K(+)-Cl- cotransport in regulatory volume decrease. Am J Physiol. 1995 Apr; 268(4 Pt 1):C894-902.
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  238. Jarolim P, Rubin HL, Brabec V, Chrobak L, Zolotarev AS, Alper SL, Brugnara C, Wichterle H, Palek J. Mutations of conserved arginines in the membrane domain of erythroid band 3 lead to a decrease in membrane-associated band 3 and to the phenotype of hereditary spherocytosis. Blood. 1995 Feb 1; 85(3):634-40.
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  239. Humphreys BD, Jiang L, Chernova MN, Alper SL. Hypertonic activation of AE2 anion exchanger in Xenopus oocytes via NHE-mediated intracellular alkalinization. Am J Physiol. 1995 Jan; 268(1 Pt 1):C201-9.
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  240. Haller C, Alper SL. Erratum Assessment of heterologous membrane protein polarity in transiently transfected MDCK cells. Cytotechnology. 1995 Jan; 18(3):235-48.
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  241. Haller C, Alper SL. Assessment of heterologous membrane protein polarity in transiently transfected MDCK cells. Cytotechnology. 1995 Jan; 17(2):71-82.
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  242. White RA, Geissler EN, Adkison LR, Dowler LL, Alper SL, Lux SE. Chromosomal location of the murine anion exchanger genes encoding AE2 and AE3. Mamm Genome. 1994 Dec; 5(12):827-9.
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  243. Humphreys BD, Jiang L, Chernova MN, Alper SL. Functional characterization and regulation by pH of murine AE2 anion exchanger expressed in Xenopus oocytes. Am J Physiol. 1994 Nov; 267(5 Pt 1):C1295-307.
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  244. Duncan L, Alper S, Losick R. Establishment of cell type specific gene transcription during sporulation in Bacillus subtilis. Curr Opin Genet Dev. 1994 Oct; 4(5):630-6.
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  245. Yannoukakos D, Stuart-Tilley A, Fernandez HA, Fey P, Duyk G, Alper SL. Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart. Circ Res. 1994 Oct; 75(4):603-14.
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  246. Jiang L, Stuart-Tilley A, Parkash J, Alper SL. pHi and serum regulate AE2-mediated Cl-/HCO3- exchange in CHOP cells of defined transient transfection status. Am J Physiol. 1994 Sep; 267(3 Pt 1):C845-56.
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  247. Jayne D, Schloss PJ, Alper S, Menscher S. Reducing disruptive behaviors by training students to request assistance. Behav Modif. 1994 Jul; 18(3):320-38.
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  248. Caliskan MK, Türkün M, Alper S. Allergy to sodium hypochlorite during root canal therapy: a case report. Int Endod J. 1994 May; 27(3):163-7.
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  249. Alper S, Duncan L, Losick R. An adenosine nucleotide switch controlling the activity of a cell type-specific transcription factor in B. subtilis. Cell. 1994 Apr 22; 77(2):195-205.
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  250. De Franceschi L, Saadane N, Trudel M, Alper SL, Brugnara C, Beuzard Y. Treatment with oral clotrimazole blocks Ca(2+)-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease. J Clin Invest. 1994 Apr; 93(4):1670-6.
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  251. Alper SL, Stuart-Tilley A, Simmons CF, Brown D, Drenckhahn D. The fodrin-ankyrin cytoskeleton of choroid plexus preferentially colocalizes with apical Na+K(+)-ATPase rather than with basolateral anion exchanger AE2. J Clin Invest. 1994 Apr; 93(4):1430-8.
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  252. Frangioni JV, Moghal N, Stuart-Tilley A, Neel BG, Alper SL. The DNA binding domain of retinoic acid receptor beta is required for ligand-dependent suppression of proliferation. Application of general purpose mammalian coexpression vectors. J Cell Sci. 1994 Apr; 107 ( Pt 4):827-38.
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  253. Trammel DL, Schloss PJ, Alper S. Using self-recording, evaluation, and graphing to increase completion of homework assignments. J Learn Disabil. 1994 Feb; 27(2):75-81.
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  254. Stuart-Tilley A, Sardet C, Pouyssegur J, Schwartz MA, Brown D, Alper SL. Immunolocalization of anion exchanger AE2 and cation exchanger NHE-1 in distinct adjacent cells of gastric mucosa. Am J Physiol. 1994 Feb; 266(2 Pt 1):C559-68.
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  255. Jarolim P, Rubin HL, Liu SC, Cho MR, Brabec V, Derick LH, Yi SJ, Saad ST, Alper S, Brugnara C, et al. Duplication of 10 nucleotides in the erythroid band 3 (AE1) gene in a kindred with hereditary spherocytosis and band 3 protein deficiency (band 3PRAGUE). J Clin Invest. 1994 Jan; 93(1):121-30.
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  256. Haller C, Alper SL. Nonpolarized surface distribution and delivery of human CD7 in polarized MDCK cells. Am J Physiol. 1993 Oct; 265(4 Pt 1):C1069-79.
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  257. Brugnara C, de Franceschi L, Alper SL. Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives. J Clin Invest. 1993 Jul; 92(1):520-6.
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  258. Alper S, Parker K, Schloss P, Wisniewski L. Extended school year programs: a community-driven curriculum model. Ment Retard. 1993 Jun; 31(3):163-70.
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  259. Brugnara C, De Franceschi L, Alper SL. Ca(2+)-activated K+ transport in erythrocytes. Comparison of binding and transport inhibition by scorpion toxins. J Biol Chem. 1993 Apr 25; 268(12):8760-8.
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  260. Ercolani L, Brown D, Stuart-Tilley A, Alper SL. Colocalization of GAPDH and band 3 (AE1) proteins in rat erythrocytes and kidney intercalated cell membranes. Am J Physiol. 1992 May; 262(5 Pt 2):F892-6.
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  261. Zhang R, Alper SL, Thorens B, Verkman AS. Evidence from oocyte expression that the erythrocyte water channel is distinct from band 3 and the glucose transporter. J Clin Invest. 1991 Nov; 88(5):1553-8.
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  262. Alper SL. The band 3-related anion exchanger (AE) gene family. Annu Rev Physiol. 1991; 53:549-64.
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  263. Alper SL, Natale J, Gluck S, Lodish HF, Brown D. Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase. Proc Natl Acad Sci U S A. 1989 Jul; 86(14):5429-33.
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  264. Brosius FC, Alper SL, Garcia AM, Lodish HF. The major kidney band 3 gene transcript predicts an amino-terminal truncated band 3 polypeptide. J Biol Chem. 1989 May 15; 264(14):7784-7.
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  265. Charron MJ, Brosius FC, Alper SL, Lodish HF. A glucose transport protein expressed predominately in insulin-responsive tissues. Proc Natl Acad Sci U S A. 1989 Apr; 86(8):2535-9.
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  266. Alper SL, Kopito RR, Libresco SM, Lodish HF. Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line. J Biol Chem. 1988 Nov 15; 263(32):17092-9.
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  267. Alper SL, Kopito RR, Lodish HF. A molecular biological approach to the study of anion transport. Kidney Int Suppl. 1987 Dec; 23:S117-33.
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  268. Alper SL. Molecular biology of renal function: methods and applications. Semin Nephrol. 1987 Mar; 7(1):3-19.
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  269. Palfrey HC, Alper SL, Greengard P. Protein phosphorylation and the regulation of cation cotransport. J Exp Biol. 1980 Dec; 89:103-15.
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  270. Alper SL, Palfrey HC, DeRiemer SA, Greengard P. Hormonal control of protein phosphorylation in turkey erythrocytes. Phosphorylation by cAMP-dependent and Ca2+-dependent protein kinases of distinct sites in goblin, a high molecular weight protein of the plasma membrane. J Biol Chem. 1980 Nov 25; 255(22):11029-39.
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  271. Alper SL, Beam KG, Greengard P. Hormonal control of Na+-K+ co-transport in turkey erythrocytes. Multiple site phosphorylation of goblin, a high molecular weight protein of the plasma membrane. J Biol Chem. 1980 May 25; 255(10):4864-71.
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  272. Beam KG, Alper SL, Palade GE, Greengard P. Hormonally regulated phosphoprotein of turkey erythrocytes: localization to plasma membrane. J Cell Biol. 1979 Oct; 83(1):1-15.
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  273. Sieghart W, Theoharides TC, Alper SL, Douglas WW, Greengard P. Calcium-dependent protein phosphorylation during secretion by exocytosis in the mast cell. Nature. 1978 Sep 28; 275(5678):329-31.
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  274. Alper S, Retish PM. The influence of academic information on teachers' judgments of vocational potential. Except Child. 1978 Apr; 44(7):537-8.
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  275. Kosslyn SM, Alper SN. On the pictorial properties of visual images: effects of image size on memory for words. Can J Psychol. 1977 Mar; 31(1):32-40.
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  276. Alper S, Algozzine B. The effects of a seven day camping experience on volunteer student counselors. Adolescence. 1977; 12(48):533-40.
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  277. Blank ML, Wykle RL, Alper S, Snyder F. Microsomal synthesis of the ether analogs of triacylglycerols. Acyl CoA:alkylacylglycerol and acyl CoA:alk-i-enylacylglycerol acyltransferases in tumors and liver. Biochim Biophys Acta. 1974 Jun 26; 348(3):397-403.
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