Wade Harper, PH.D.
|Title||Bert and Natalie Vallee Professor of Molecular Pathology|
|Institution||Harvard Medical School|
|Address||Harvard Medical School|
Pathology - Harper Lab, NRB 940e
77 Avenue Louis Pasteur
Boston MA 02115
Available: 11/26/12, Expires: 11/28/14
Tumor suppressors can function to maintain cell proliferation control pathways in an inactive state by suppressing positively acting growth regulators. Such growth control pathways can be viewed as constellations of protein complexes that assemble into a series of inter-connected sub-networks. The Hippo pathway is a protein kinase driven phosphorylation cascade containing multiple tumor suppressors that negatively control cell growth and is deactivated in many cancer types, such as breast, kidney, and liver cancers. The project will utilize emerging quantitative proteomic methods to define a comprehensive network map of Hippo pathway organization and dynamics in normal cells and in cells lacking critical upstream tumor suppressors. These studies aim to uncover crucial architectural elements in the Hippo pathway that promote tumorigenesis.
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