Cullin Proteins

"Cullin Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of structurally related proteins that were originally discovered for their role in cell-cycle regulation in CAENORHABDITIS ELEGANS. They play important roles in regulation of the CELL CYCLE and as components of UBIQUITIN-PROTEIN LIGASES.

Descriptor ID

D044842

MeSH Number(s)

D08.811.464.938.750.750.500

D12.776.167.175

Concept/Terms

Cullin Proteins

Below are MeSH descriptors whose meaning is more general than "Cullin Proteins".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Ligases [D08.811.464]
Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
Ubiquitin-Protein Ligases [D08.811.464.938.750]
SKP Cullin F-Box Protein Ligases [D08.811.464.938.750.750]
Cullin Proteins [D08.811.464.938.750.750.500]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Cell Cycle Proteins [D12.776.167]
Cullin Proteins [D12.776.167.175]

Below are MeSH descriptors whose meaning is related to "Cullin Proteins".

Below are MeSH descriptors whose meaning is more specific than "Cullin Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cullin Proteins" by people in Harvard Catalyst Profiles by year, and whether "Cullin Proteins" was a major or minor topic of these publication.

Bar chart showing 124 publications over 27 distinct years, with a maximum of 10 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
1998	3	0	3
1999	5	0	5
2000	1	0	1
2001	2	0	2
2002	4	0	4
2003	3	1	4
2004	3	3	6
2005	2	1	3
2006	6	1	7
2007	6	1	7
2008	3	3	6
2009	0	2	2
2010	5	0	5
2011	2	5	7
2012	6	1	7
2013	3	5	8
2014	4	6	10
2015	2	4	6
2016	1	4	5
2017	5	3	8
2018	0	3	3
2019	2	2	4
2020	0	1	1
2021	3	0	3
2022	1	3	4
2023	2	0	2

Below are the most recent publications written about "Cullin Proteins" by people in Profiles.

DCUN1D1 Is an Essential Regulator of Prostate Cancer Proliferation and Tumour Growth That Acts through Neddylation of Cullin 1, 3, 4A and 5 and Deregulation of Wnt/Catenin Pathway. Cells. 2023 07 31; 12(15).

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Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly. Free Radic Biol Med. 2023 08 01; 204:215-225.

View in: PubMed
Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation. Cancer Discov. 2022 10 05; 12(10):2434-2453.

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Adaptive exchange sustains cullin-RING ubiquitin ligase networks and proper licensing of DNA replication. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2205608119.

View in: PubMed
Post-translational control of beige fat biogenesis by PRDM16 stabilization. Nature. 2022 09; 609(7925):151-158.

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Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex. J Virol. 2022 09 14; 96(17):e0082622.

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ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2021 04 27; 118(17).

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Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis. Annu Rev Biochem. 2021 06 20; 90:403-429.

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CRL4ADTL degrades DNA-PKcs to modulate NHEJ repair and induce genomic instability and subsequent malignant transformation. Oncogene. 2021 03; 40(11):2096-2111.

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The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases. Mol Cell Proteomics. 2021; 20:100019.

View in: PubMed

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