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I-Cheng Ho, M.D., Ph.D.

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Overview
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Dr. I-Cheng Ho's laboratory has two major research focuses.
1. Pathogenesis and translational research of rheumatoid arthritis. Ho lab is investigating how genetic/environmental risk factors contribute to the autoimmune process of rheumatoid arthritis. The lab is also identifying biomarkers and developing bioassays for predicting response to various treatments, hoping to bring personalized medicine to rheumatoid arthritis.
2. Roles of protein citrullination in regulating the function of immune and non-immune cells. Citrullination is a unique form of post-translational modification of proteins, and hypercitrullination is associated with several major risk factors of rheumatoid arthritis. Ho lab is investigating how citrullination affects the function of immune cells, such as lymphocytes, and non-immune cells, such as fibroblasts, in the context of autoimmune diseases and development.
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Research
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL158601 (HO, I-CHENG) Apr 15, 2022 - Mar 31, 2026
    NIH
    Regulatory roles of peptidylarginine deimination in elastogenisis
    Role: Principal Investigator
  2. R21AI169191 (HO, I-CHENG) Feb 1, 2022 - Jan 31, 2024
    NIH
    Functional analysis of SIRPG, a T cell-specific autoimmune gene
    Role: Principal Investigator
  3. R21AI165967 (HO, I-CHENG) Sep 22, 2021 - Aug 31, 2023
    NIH
    Proteome-wide assessment of the impact of citrullination on the activityof transcription factors in Th2 cells
    Role: Principal Investigator
  4. R03AI155935 (HO, I-CHENG) Nov 17, 2020 - Oct 31, 2022
    NIH
    Detecting RORgt Citrullination
    Role: Principal Investigator
  5. R21AR074788 (HO, I-CHENG) Sep 7, 2018 - Aug 31, 2021
    NIH
    Utilizing the RA signature to predict TNFi response
    Role: Principal Investigator

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© 2024 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.