Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Edward Thomas Ryan, D.T.M.&H., M.D.

Concepts

This page shows the publications Edward Ryan has written about Cholera.
Connection Strength

15.664
  1. Humans Surviving Cholera Develop Antibodies against Vibrio cholerae O-Specific Polysaccharide That Inhibit Pathogen Motility. mBio. 2020 11 17; 11(6).
    View in: PubMed
    Score: 0.555
  2. Immune responses to O-specific polysaccharide (OSP) in North American adults infected with Vibrio cholerae O1 Inaba. PLoS Negl Trop Dis. 2019 11; 13(11):e0007874.
    View in: PubMed
    Score: 0.518
  3. Cholera: recent updates. Curr Opin Infect Dis. 2018 10; 31(5):455-461.
    View in: PubMed
    Score: 0.478
  4. Plasma and memory B cell responses targeting O-specific polysaccharide (OSP) are associated with protection against Vibrio cholerae O1 infection among household contacts of cholera patients in Bangladesh. PLoS Negl Trop Dis. 2018 04; 12(4):e0006399.
    View in: PubMed
    Score: 0.464
  5. Anti-O-specific polysaccharide (OSP) immune responses following vaccination with oral cholera vaccine CVD 103-HgR correlate with protection against cholera after infection with wild-type Vibrio cholerae O1 El Tor Inaba in North American volunteers. PLoS Negl Trop Dis. 2018 04; 12(4):e0006376.
    View in: PubMed
    Score: 0.463
  6. Plasma and Mucosal Immunoglobulin M, Immunoglobulin A, and Immunoglobulin G Responses to the Vibrio cholerae O1 Protein Immunome in Adults With Cholera in Bangladesh. J Infect Dis. 2017 07 01; 216(1):125-134.
    View in: PubMed
    Score: 0.439
  7. O-Specific Polysaccharide-Specific Memory B Cell Responses in Young Children, Older Children, and Adults Infected with Vibrio cholerae O1 Ogawa in Bangladesh. Clin Vaccine Immunol. 2016 05; 23(5):427-435.
    View in: PubMed
    Score: 0.405
  8. A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice. PLoS Negl Trop Dis. 2015; 9(7):e0003881.
    View in: PubMed
    Score: 0.382
  9. Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh. Am J Trop Med Hyg. 2015 Aug; 93(2):244-249.
    View in: PubMed
    Score: 0.380
  10. Circulating mucosal associated invariant T cells are activated in Vibrio cholerae O1 infection and associated with lipopolysaccharide antibody responses. PLoS Negl Trop Dis. 2014 Aug; 8(8):e3076.
    View in: PubMed
    Score: 0.360
  11. Evaluation in mice of a conjugate vaccine for cholera made from Vibrio cholerae O1 (Ogawa) O-specific polysaccharide. PLoS Negl Trop Dis. 2014 Feb; 8(2):e2683.
    View in: PubMed
    Score: 0.347
  12. Impact of Ramadan on clinical and microbiologic parameters of patients seen at a diarrheal hospital in urban Dhaka, Bangladesh, 1996-2012. Am J Trop Med Hyg. 2014 Feb; 90(2):294-8.
    View in: PubMed
    Score: 0.345
  13. Eyes on the prize: lessons from the cholera wars for modern scientists, physicians, and public health officials. Am J Trop Med Hyg. 2013 Oct; 89(4):610-614.
    View in: PubMed
    Score: 0.338
  14. Immune responses to the O-specific polysaccharide antigen in children who received a killed oral cholera vaccine compared to responses following natural cholera infection in Bangladesh. Clin Vaccine Immunol. 2013 Jun; 20(6):780-8.
    View in: PubMed
    Score: 0.326
  15. Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera. Clin Vaccine Immunol. 2012 Nov; 19(11):1712-21.
    View in: PubMed
    Score: 0.315
  16. Immune responses to cholera in children. Expert Rev Anti Infect Ther. 2012 Apr; 10(4):435-44.
    View in: PubMed
    Score: 0.305
  17. Memory B cell and other immune responses in children receiving two doses of an oral killed cholera vaccine compared to responses following natural cholera infection in Bangladesh. Clin Vaccine Immunol. 2012 May; 19(5):690-8.
    View in: PubMed
    Score: 0.304
  18. Haiti in the context of the current global cholera pandemic. Emerg Infect Dis. 2011 Nov; 17(11):2175-6.
    View in: PubMed
    Score: 0.296
  19. Cholera in the 21st century. Curr Opin Infect Dis. 2011 Oct; 24(5):472-7.
    View in: PubMed
    Score: 0.295
  20. Case records of the Massachusetts General Hospital. Case 20-2011. A 30-year-old man with diarrhea after a trip to the Dominican Republic. N Engl J Med. 2011 Jun 30; 364(26):2536-41.
    View in: PubMed
    Score: 0.289
  21. Comparison of memory B cell, antibody-secreting cell, and plasma antibody responses in young children, older children, and adults with infection caused by Vibrio cholerae O1 El Tor Ogawa in Bangladesh. Clin Vaccine Immunol. 2011 Aug; 18(8):1317-25.
    View in: PubMed
    Score: 0.289
  22. The cholera pandemic, still with us after half a century: time to rethink. PLoS Negl Trop Dis. 2011 Jan 25; 5(1):e1003.
    View in: PubMed
    Score: 0.281
  23. Severe, acute watery diarrhea in an adult. PLoS Negl Trop Dis. 2010 Nov 30; 4(11):e898.
    View in: PubMed
    Score: 0.278
  24. Informal urban settlements and cholera risk in Dar es Salaam, Tanzania. PLoS Negl Trop Dis. 2010 Mar 16; 4(3):e631.
    View in: PubMed
    Score: 0.265
  25. Transcutaneous immunization with toxin-coregulated pilin A induces protective immunity against Vibrio cholerae O1 El Tor challenge in mice. Infect Immun. 2006 Oct; 74(10):5834-9.
    View in: PubMed
    Score: 0.208
  26. Live attenuated oral cholera vaccines. Expert Rev Vaccines. 2006 Aug; 5(4):483-94.
    View in: PubMed
    Score: 0.206
  27. Gut Microbiota and Development of Vibrio cholerae-Specific Long-Term Memory B Cells in Adults after Whole-Cell Killed Oral Cholera Vaccine. Infect Immun. 2021 08 16; 89(9):e0021721.
    View in: PubMed
    Score: 0.146
  28. Local production of anti-vibrio cholerae mucosal antibody in reproductive tract tissues after cholera. J Infect Dis. 2001 Sep 01; 184(5):643-7.
    View in: PubMed
    Score: 0.146
  29. Vibrio cholerae Sialidase-Specific Immune Responses Are Associated with Protection against Cholera. mSphere. 2021 04 28; 6(2).
    View in: PubMed
    Score: 0.143
  30. Cholera vaccines. J Travel Med. 2001 Mar-Apr; 8(2):82-91.
    View in: PubMed
    Score: 0.141
  31. Predicting Vibrio cholerae Infection and Disease Severity Using Metagenomics in a Prospective Cohort Study. J Infect Dis. 2021 02 03; 223(2):342-351.
    View in: PubMed
    Score: 0.141
  32. Cholera vaccines. Clin Infect Dis. 2000 Aug; 31(2):561-5.
    View in: PubMed
    Score: 0.137
  33. Mortality, morbidity, and microbiology of endemic cholera among hospitalized patients in Dhaka, Bangladesh. Am J Trop Med Hyg. 2000 Jul-Aug; 63(1-2):12-20.
    View in: PubMed
    Score: 0.135
  34. Induction of systemic, mucosal and memory antibody responses targeting Vibrio cholerae O1 O-specific polysaccharide (OSP) in adults following oral vaccination with an oral killed whole cell cholera vaccine in Bangladesh. PLoS Negl Trop Dis. 2019 08; 13(8):e0007634.
    View in: PubMed
    Score: 0.127
  35. Oral immunization with a probiotic cholera vaccine induces broad protective immunity against Vibrio cholerae colonization and disease in mice. PLoS Negl Trop Dis. 2019 05; 13(5):e0007417.
    View in: PubMed
    Score: 0.125
  36. Synthesis of glycocluster-containing conjugates for a vaccine against cholera. Org Biomol Chem. 2019 04 17; 17(16):4049-4060.
    View in: PubMed
    Score: 0.124
  37. Estimating cholera incidence with cross-sectional serology. Sci Transl Med. 2019 02 20; 11(480).
    View in: PubMed
    Score: 0.123
  38. Bivalent oral cholera vaccination induces a memory B cell response to the V. cholerae O1-polysaccharide antigen in Haitian adults. PLoS Negl Trop Dis. 2019 01; 13(1):e0007057.
    View in: PubMed
    Score: 0.122
  39. Cognate T and B cell interaction and association of follicular helper T cells with B cell responses in Vibrio cholerae O1 infected Bangladeshi adults. Microbes Infect. 2019 Apr - May; 21(3-4):176-183.
    View in: PubMed
    Score: 0.121
  40. Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection. J Infect Dis. 2018 07 13; 218(4):645-653.
    View in: PubMed
    Score: 0.118
  41. Defining endemic cholera at three levels of spatiotemporal resolution within Bangladesh. Nat Genet. 2018 07; 50(7):951-955.
    View in: PubMed
    Score: 0.117
  42. Development of a new dipstick (Cholkit) for rapid detection of Vibrio cholerae O1 in acute watery diarrheal stools. PLoS Negl Trop Dis. 2018 03; 12(3):e0006286.
    View in: PubMed
    Score: 0.115
  43. Dried Blood Spots for Measuring Vibrio cholerae-specific Immune Responses. PLoS Negl Trop Dis. 2018 01; 12(1):e0006196.
    View in: PubMed
    Score: 0.114
  44. Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways. Infect Immun. 2018 02; 86(2).
    View in: PubMed
    Score: 0.114
  45. Vibrio cholerae genomic diversity within and between patients. Microb Genom. 2017 12; 3(12).
    View in: PubMed
    Score: 0.113
  46. Assessing antigen specific HLA-DR+ antibody secreting cell (DR+ASC) responses in whole blood in enteric infections using an ELISPOT technique. Microbes Infect. 2018 02; 20(2):122-129.
    View in: PubMed
    Score: 0.112
  47. Recommendations of the Advisory Committee on Immunization Practices for Use of Cholera Vaccine. MMWR Morb Mortal Wkly Rep. 2017 May 12; 66(18):482-485.
    View in: PubMed
    Score: 0.109
  48. Single-Cell Analysis of the Plasmablast Response to Vibrio cholerae Demonstrates Expansion of Cross-Reactive Memory B Cells. mBio. 2016 12 20; 7(6).
    View in: PubMed
    Score: 0.106
  49. Biomarkers of Environmental Enteropathy are Positively Associated with Immune Responses to an Oral Cholera Vaccine in Bangladeshi Children. PLoS Negl Trop Dis. 2016 Nov; 10(11):e0005039.
    View in: PubMed
    Score: 0.105
  50. Immune Responses to an Oral Cholera Vaccine in Internally Displaced Persons in South Sudan. Sci Rep. 2016 10 24; 6:35742.
    View in: PubMed
    Score: 0.105
  51. Antibody Secreting Cell Responses following Vaccination with Bivalent Oral Cholera Vaccine among Haitian Adults. PLoS Negl Trop Dis. 2016 06; 10(6):e0004753.
    View in: PubMed
    Score: 0.102
  52. Vibrio cholerae Serogroup O139: Isolation from Cholera Patients and Asymptomatic Household Family Members in Bangladesh between 2013 and 2014. PLoS Negl Trop Dis. 2015 Nov; 9(11):e0004183.
    View in: PubMed
    Score: 0.098
  53. Enumeration of Gut-Homing ß7-Positive, Pathogen-Specific Antibody-Secreting Cells in Whole Blood from Enterotoxigenic Escherichia coli- and Vibrio cholerae-Infected Patients, Determined Using an Enzyme-Linked Immunosorbent Spot Assay Technique. Clin Vaccine Immunol. 2016 01; 23(1):27-36.
    View in: PubMed
    Score: 0.098
  54. The increased severity in patients presenting to hospital with diarrhea in Dhaka, Bangladesh since the emergence of the hybrid strain of Vibrio cholerae O1 is not unique to cholera patients. Int J Infect Dis. 2015 Nov; 40:9-14.
    View in: PubMed
    Score: 0.097
  55. Cholera in pregnancy: Clinical and immunological aspects. Int J Infect Dis. 2015 Oct; 39:20-4.
    View in: PubMed
    Score: 0.096
  56. Gut microbial succession follows acute secretory diarrhea in humans. mBio. 2015 May 19; 6(3):e00381-15.
    View in: PubMed
    Score: 0.095
  57. Immunogenicity of the Bivalent Oral Cholera Vaccine Shanchol in Haitian Adults With HIV Infection. J Infect Dis. 2015 Sep 01; 212(5):779-83.
    View in: PubMed
    Score: 0.093
  58. Comparative proteomic analysis reveals activation of mucosal innate immune signaling pathways during cholera. Infect Immun. 2015 Mar; 83(3):1089-103.
    View in: PubMed
    Score: 0.092
  59. Household Transmission of Vibrio cholerae in Bangladesh. PLoS Negl Trop Dis. 2014 Nov; 8(11):e3314.
    View in: PubMed
    Score: 0.092
  60. Evaluation of matrix-assisted laser desorption ionization-time of flight mass spectrometry for identification of Vibrio cholerae. J Clin Microbiol. 2015 Jan; 53(1):329-31.
    View in: PubMed
    Score: 0.091
  61. Bacterial shedding in household contacts of cholera patients in Dhaka, Bangladesh. Am J Trop Med Hyg. 2014 Oct; 91(4):738-42.
    View in: PubMed
    Score: 0.090
  62. Immunogenicity of a killed bivalent (O1 and O139) whole cell oral cholera vaccine, Shanchol, in Haiti. PLoS Negl Trop Dis. 2014 May; 8(5):e2828.
    View in: PubMed
    Score: 0.088
  63. Immune responses to O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 Ogawa in adult Bangladeshi recipients of an oral killed cholera vaccine and comparison to responses in patients with cholera. Am J Trop Med Hyg. 2014 May; 90(5):873-81.
    View in: PubMed
    Score: 0.088
  64. Antibody-secreting cell responses after Vibrio cholerae O1 infection and oral cholera vaccination in adults in Bangladesh. Clin Vaccine Immunol. 2013 Oct; 20(10):1592-8.
    View in: PubMed
    Score: 0.084
  65. Natural selection in a bangladeshi population from the cholera-endemic ganges river delta. Sci Transl Med. 2013 Jul 03; 5(192):192ra86.
    View in: PubMed
    Score: 0.083
  66. High depth, whole-genome sequencing of cholera isolates from Haiti and the Dominican Republic. BMC Genomics. 2012 Sep 11; 13:468.
    View in: PubMed
    Score: 0.079
  67. Frequency of reexposure to Vibrio cholerae O1 evaluated by subsequent vibriocidal titer rise after an episode of severe cholera in a highly endemic area in Bangladesh. Am J Trop Med Hyg. 2012 Nov; 87(5):921-6.
    View in: PubMed
    Score: 0.079
  68. Cholera. Lancet. 2012 Jun 30; 379(9835):2466-2476.
    View in: PubMed
    Score: 0.078
  69. Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera. Clin Vaccine Immunol. 2012 Aug; 19(8):1304-11.
    View in: PubMed
    Score: 0.078
  70. Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in Bangladesh. Clin Vaccine Immunol. 2012 Jun; 19(6):842-8.
    View in: PubMed
    Score: 0.076
  71. Individuals with Le(a+b-) blood group have increased susceptibility to symptomatic vibrio cholerae O1 infection. PLoS Negl Trop Dis. 2011 Dec; 5(12):e1413.
    View in: PubMed
    Score: 0.075
  72. Simple, direct conjugation of bacterial O-SP-core antigens to proteins: development of cholera conjugate vaccines. Bioconjug Chem. 2011 Oct 19; 22(10):2179-85.
    View in: PubMed
    Score: 0.074
  73. Vibrio cholerae O1 infection induces proinflammatory CD4+ T-cell responses in blood and intestinal mucosa of infected humans. Clin Vaccine Immunol. 2011 Aug; 18(8):1371-7.
    View in: PubMed
    Score: 0.072
  74. Meeting cholera's challenge to Haiti and the world: a joint statement on cholera prevention and care. PLoS Negl Trop Dis. 2011; 5(5):e1145.
    View in: PubMed
    Score: 0.072
  75. Antigen-specific memory B-cell responses in Bangladeshi adults after one- or two-dose oral killed cholera vaccination and comparison with responses in patients with naturally acquired cholera. Clin Vaccine Immunol. 2011 May; 18(5):844-50.
    View in: PubMed
    Score: 0.071
  76. Mucosal immunologic responses in cholera patients in Bangladesh. Clin Vaccine Immunol. 2011 Mar; 18(3):506-12.
    View in: PubMed
    Score: 0.070
  77. Concomitant enterotoxigenic Escherichia coli infection induces increased immune responses to Vibrio cholerae O1 antigens in patients with cholera in Bangladesh. Infect Immun. 2010 May; 78(5):2117-24.
    View in: PubMed
    Score: 0.066
  78. Comparison of clinical features and immunological parameters of patients with dehydrating diarrhoea infected with Inaba or Ogawa serotypes of Vibrio cholerae O1. Scand J Infect Dis. 2010; 42(1):48-56.
    View in: PubMed
    Score: 0.065
  79. Familial aggregation of Vibrio cholerae-associated infection in Matlab, Bangladesh. J Health Popul Nutr. 2009 Dec; 27(6):733-8.
    View in: PubMed
    Score: 0.065
  80. Clinical outcomes in household contacts of patients with cholera in Bangladesh. Clin Infect Dis. 2009 Nov 15; 49(10):1473-9.
    View in: PubMed
    Score: 0.065
  81. Development of immunoglobulin M memory to both a T-cell-independent and a T-cell-dependent antigen following infection with Vibrio cholerae O1 in Bangladesh. Infect Immun. 2010 Jan; 78(1):253-9.
    View in: PubMed
    Score: 0.064
  82. Memory T-cell responses to Vibrio cholerae O1 infection. Infect Immun. 2009 Nov; 77(11):5090-6.
    View in: PubMed
    Score: 0.064
  83. Antigen-specific memory B-cell responses to Vibrio cholerae O1 infection in Bangladesh. Infect Immun. 2009 Sep; 77(9):3850-6.
    View in: PubMed
    Score: 0.063
  84. Immunologic responses to Vibrio cholerae in patients co-infected with intestinal parasites in Bangladesh. PLoS Negl Trop Dis. 2009; 3(3):e403.
    View in: PubMed
    Score: 0.062
  85. A variant in long palate, lung and nasal epithelium clone 1 is associated with cholera in a Bangladeshi population. Genes Immun. 2009 Apr; 10(3):267-72.
    View in: PubMed
    Score: 0.061
  86. A comparison of clinical and immunologic features in children and older patients hospitalized with severe cholera in Bangladesh. Pediatr Infect Dis J. 2008 Nov; 27(11):986-92.
    View in: PubMed
    Score: 0.060
  87. Cholera toxin-specific memory B cell responses are induced in patients with dehydrating diarrhea caused by Vibrio cholerae O1. J Infect Dis. 2008 Oct 01; 198(7):1055-61.
    View in: PubMed
    Score: 0.060
  88. Proteomic analysis of Vibrio cholerae in human stool. Infect Immun. 2008 Sep; 76(9):4145-51.
    View in: PubMed
    Score: 0.059
  89. Susceptibility to Vibrio cholerae infection in a cohort of household contacts of patients with cholera in Bangladesh. PLoS Negl Trop Dis. 2008 Apr 09; 2(4):e221.
    View in: PubMed
    Score: 0.058
  90. Complexity of rice-water stool from patients with Vibrio cholerae plays a role in the transmission of infectious diarrhea. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):19091-6.
    View in: PubMed
    Score: 0.056
  91. Postgenomic approaches to cholera vaccine development. Expert Rev Vaccines. 2006 Jun; 5(3):337-46.
    View in: PubMed
    Score: 0.051
  92. Blood group, immunity, and risk of infection with Vibrio cholerae in an area of endemicity. Infect Immun. 2005 Nov; 73(11):7422-7.
    View in: PubMed
    Score: 0.049
  93. Reduction in capsular content and enhanced bacterial susceptibility to serum killing of Vibrio cholerae O139 associated with the 2002 cholera epidemic in Bangladesh. Infect Immun. 2005 Oct; 73(10):6577-83.
    View in: PubMed
    Score: 0.049
  94. Hyperinfectivity of human-passaged Vibrio cholerae can be modeled by growth in the infant mouse. Infect Immun. 2005 Oct; 73(10):6674-9.
    View in: PubMed
    Score: 0.049
  95. Transcriptional profiling of Vibrio cholerae recovered directly from patient specimens during early and late stages of human infection. Infect Immun. 2005 Aug; 73(8):4488-93.
    View in: PubMed
    Score: 0.048
  96. Incomplete correlation of serum vibriocidal antibody titer with protection from Vibrio cholerae infection in urban Bangladesh. J Infect Dis. 2004 Jun 15; 189(12):2318-22.
    View in: PubMed
    Score: 0.044
  97. Antigen-specific immunoglobulin A antibodies secreted from circulating B cells are an effective marker for recent local immune responses in patients with cholera: comparison to antibody-secreting cell responses and other immunological markers. Infect Immun. 2003 Aug; 71(8):4808-14.
    View in: PubMed
    Score: 0.042
  98. Use of in vivo-induced antigen technology (IVIAT) to identify genes uniquely expressed during human infection with Vibrio cholerae. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8508-13.
    View in: PubMed
    Score: 0.042
  99. Conjugate Vaccines from Bacterial Antigens by Squaric Acid Chemistry: A Closer Look. Chembiochem. 2017 04 18; 18(8):799-815.
    View in: PubMed
    Score: 0.027
  100. Development of a germfree mouse model of Vibrio cholerae infection. Infect Immun. 1996 Oct; 64(10):4373-7.
    View in: PubMed
    Score: 0.026
  101. Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nat Chem Biol. 2016 Apr; 12(4):268-274.
    View in: PubMed
    Score: 0.025
  102. Study of avidity of antigen-specific antibody as a means of understanding development of long-term immunological memory after Vibrio cholerae O1 infection. Clin Vaccine Immunol. 2013 Jan; 20(1):17-23.
    View in: PubMed
    Score: 0.020
  103. Relatedness of Vibrio cholerae O1/O139 isolates from patients and their household contacts, determined by multilocus variable-number tandem-repeat analysis. J Bacteriol. 2010 Sep; 192(17):4367-76.
    View in: PubMed
    Score: 0.017
  104. The major subunit of the toxin-coregulated pilus TcpA induces mucosal and systemic immunoglobulin A immune responses in patients with cholera caused by Vibrio cholerae O1 and O139. Infect Immun. 2004 Aug; 72(8):4448-54.
    View in: PubMed
    Score: 0.011
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.