Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Edward Thomas Ryan, D.T.M.&H., M.D.

Co-Author

This page shows the publications co-authored by Edward Ryan and Richelle Charles.
Connection Strength

11.049
  1. Humans Surviving Cholera Develop Antibodies against Vibrio cholerae O-Specific Polysaccharide That Inhibit Pathogen Motility. mBio. 2020 11 17; 11(6).
    View in: PubMed
    Score: 0.945
  2. Plasma and Mucosal Immunoglobulin M, Immunoglobulin A, and Immunoglobulin G Responses to the Vibrio cholerae O1 Protein Immunome in Adults With Cholera in Bangladesh. J Infect Dis. 2017 07 01; 216(1):125-134.
    View in: PubMed
    Score: 0.747
  3. Immunoproteomic analysis of antibody in lymphocyte supernatant in patients with typhoid fever in Bangladesh. Clin Vaccine Immunol. 2014 Mar; 21(3):280-5.
    View in: PubMed
    Score: 0.586
  4. Identification of immunogenic Salmonella enterica serotype Typhi antigens expressed in chronic biliary carriers of S. Typhi in Kathmandu, Nepal. PLoS Negl Trop Dis. 2013; 7(8):e2335.
    View in: PubMed
    Score: 0.570
  5. Cholera in the 21st century. Curr Opin Infect Dis. 2011 Oct; 24(5):472-7.
    View in: PubMed
    Score: 0.502
  6. Characterization of anti-Salmonella enterica serotype Typhi antibody responses in bacteremic Bangladeshi patients by an immunoaffinity proteomics-based technology. Clin Vaccine Immunol. 2010 Aug; 17(8):1188-95.
    View in: PubMed
    Score: 0.459
  7. Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium. PLoS One. 2009 Sep 10; 4(9):e6994.
    View in: PubMed
    Score: 0.435
  8. Correction: Plasma and memory B cell responses targeting O-specific polysaccharide (OSP) are associated with protection against Vibrio cholerae O1 infection among household contacts of cholera patients in Bangladesh. PLoS Negl Trop Dis. 2021 Jul; 15(7):e0009616.
    View in: PubMed
    Score: 0.247
  9. Defining Polysaccharide-Specific Antibody Targets against Vibrio cholerae O139 in Humans following O139 Cholera and following Vaccination with a Commercial Bivalent Oral Cholera Vaccine, and Evaluation of Conjugate Vaccines Targeting O139. mSphere. 2021 Aug 25; 6(4):e0011421.
    View in: PubMed
    Score: 0.247
  10. Parenteral Vaccination with a Cholera Conjugate Vaccine Boosts Vibriocidal and Anti-OSP Responses in Mice Previously Immunized with an Oral Cholera Vaccine. Am J Trop Med Hyg. 2021 Apr 19.
    View in: PubMed
    Score: 0.243
  11. Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients. Sci Immunol. 2020 10 08; 5(52).
    View in: PubMed
    Score: 0.234
  12. Transcutaneous Vaccination with Conjugate Typhoid Vaccine Vi-DT Induces Systemic, Mucosal, and Memory Anti-Polysaccharide Responses. Am J Trop Med Hyg. 2020 09; 103(3):1032-1038.
    View in: PubMed
    Score: 0.233
  13. Dynamics and significance of the antibody response to SARS-CoV-2 infection. medRxiv. 2020 Jul 20.
    View in: PubMed
    Score: 0.231
  14. Evaluation of a Rapid Point-of-Care Multiplex Immunochromatographic Assay for the Diagnosis of Enteric Fever. mSphere. 2020 06 10; 5(3).
    View in: PubMed
    Score: 0.229
  15. Immune responses to O-specific polysaccharide (OSP) in North American adults infected with Vibrio cholerae O1 Inaba. PLoS Negl Trop Dis. 2019 11; 13(11):e0007874.
    View in: PubMed
    Score: 0.220
  16. Plasma Immunoglobulin A Responses Against 2 Salmonella Typhi Antigens Identify Patients With Typhoid Fever. Clin Infect Dis. 2019 03 05; 68(6):949-955.
    View in: PubMed
    Score: 0.210
  17. Extensively Drug-Resistant Typhoid - Are Conjugate Vaccines Arriving Just in Time? N Engl J Med. 2018 Oct 18; 379(16):1493-1495.
    View in: PubMed
    Score: 0.204
  18. Plasma and memory B cell responses targeting O-specific polysaccharide (OSP) are associated with protection against Vibrio cholerae O1 infection among household contacts of cholera patients in Bangladesh. PLoS Negl Trop Dis. 2018 04; 12(4):e0006399.
    View in: PubMed
    Score: 0.198
  19. Anti-O-specific polysaccharide (OSP) immune responses following vaccination with oral cholera vaccine CVD 103-HgR correlate with protection against cholera after infection with wild-type Vibrio cholerae O1 El Tor Inaba in North American volunteers. PLoS Negl Trop Dis. 2018 04; 12(4):e0006376.
    View in: PubMed
    Score: 0.197
  20. A magneto-DNA nanoparticle system for the rapid and sensitive diagnosis of enteric fever. Sci Rep. 2016 09 08; 6:32878.
    View in: PubMed
    Score: 0.177
  21. O-Specific Polysaccharide-Specific Memory B Cell Responses in Young Children, Older Children, and Adults Infected with Vibrio cholerae O1 Ogawa in Bangladesh. Clin Vaccine Immunol. 2016 05; 23(5):427-435.
    View in: PubMed
    Score: 0.172
  22. A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice. PLoS Negl Trop Dis. 2015; 9(7):e0003881.
    View in: PubMed
    Score: 0.163
  23. Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh. Am J Trop Med Hyg. 2015 Aug; 93(2):244-249.
    View in: PubMed
    Score: 0.162
  24. Circulating mucosal associated invariant T cells are activated in Vibrio cholerae O1 infection and associated with lipopolysaccharide antibody responses. PLoS Negl Trop Dis. 2014 Aug; 8(8):e3076.
    View in: PubMed
    Score: 0.153
  25. Salmonella chronic carriage: epidemiology, diagnosis, and gallbladder persistence. Trends Microbiol. 2014 Nov; 22(11):648-55.
    View in: PubMed
    Score: 0.152
  26. Immunogenicity of a killed bivalent (O1 and O139) whole cell oral cholera vaccine, Shanchol, in Haiti. PLoS Negl Trop Dis. 2014 May; 8(5):e2828.
    View in: PubMed
    Score: 0.150
  27. Cellular and cytokine responses to Salmonella enterica serotype Typhi proteins in patients with typhoid fever in Bangladesh. Am J Trop Med Hyg. 2014 Jun; 90(6):1024-1030.
    View in: PubMed
    Score: 0.149
  28. Evaluation in mice of a conjugate vaccine for cholera made from Vibrio cholerae O1 (Ogawa) O-specific polysaccharide. PLoS Negl Trop Dis. 2014 Feb; 8(2):e2683.
    View in: PubMed
    Score: 0.148
  29. Immune responses to the O-specific polysaccharide antigen in children who received a killed oral cholera vaccine compared to responses following natural cholera infection in Bangladesh. Clin Vaccine Immunol. 2013 Jun; 20(6):780-8.
    View in: PubMed
    Score: 0.139
  30. Identification of in vivo-induced bacterial proteins during human infection with Salmonella enterica serotype Paratyphi A. Clin Vaccine Immunol. 2013 May; 20(5):712-9.
    View in: PubMed
    Score: 0.139
  31. Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera. Clin Vaccine Immunol. 2012 Nov; 19(11):1712-21.
    View in: PubMed
    Score: 0.134
  32. Memory B cell and other immune responses in children receiving two doses of an oral killed cholera vaccine compared to responses following natural cholera infection in Bangladesh. Clin Vaccine Immunol. 2012 May; 19(5):690-8.
    View in: PubMed
    Score: 0.130
  33. In vivo expression of Salmonella enterica serotype Typhi genes in the blood of patients with typhoid fever in Bangladesh. PLoS Negl Trop Dis. 2011 Dec; 5(12):e1419.
    View in: PubMed
    Score: 0.127
  34. Interferon-? and proliferation responses to Salmonella enterica Serotype Typhi proteins in patients with S. Typhi Bacteremia in Dhaka, Bangladesh. PLoS Negl Trop Dis. 2011 Jun; 5(6):e1193.
    View in: PubMed
    Score: 0.123
  35. Analysis of Salmonella enterica serotype paratyphi A gene expression in the blood of bacteremic patients in Bangladesh. PLoS Negl Trop Dis. 2010 Dec 07; 4(12):e908.
    View in: PubMed
    Score: 0.119
  36. An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates. Cell Host Microbe. 2021 Aug 07.
    View in: PubMed
    Score: 0.062
  37. Vibrio cholerae Sialidase-Specific Immune Responses Are Associated with Protection against Cholera. mSphere. 2021 04 28; 6(2).
    View in: PubMed
    Score: 0.061
  38. Impact of Immunoglobulin Isotype and Epitope on the Functional Properties of Vibrio cholerae O-Specific Polysaccharide-Specific Monoclonal Antibodies. mBio. 2021 04 20; 12(2).
    View in: PubMed
    Score: 0.061
  39. Humoral signatures of protective and pathological SARS-CoV-2 infection in children. Nat Med. 2021 03; 27(3):454-462.
    View in: PubMed
    Score: 0.060
  40. Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates. bioRxiv. 2021 Jan 19.
    View in: PubMed
    Score: 0.060
  41. Ultra-Sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease. Clin Chem. 2020 12 01; 66(12):1562-1572.
    View in: PubMed
    Score: 0.059
  42. Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality. Cell. 2020 12 10; 183(6):1508-1519.e12.
    View in: PubMed
    Score: 0.059
  43. Antibody responses after COVID-19 infection in patients who are mildly symptomatic or asymptomatic in Bangladesh. Int J Infect Dis. 2020 Dec; 101:220-225.
    View in: PubMed
    Score: 0.059
  44. Ultrasensitive high-resolution profiling of early seroconversion in patients with COVID-19. Nat Biomed Eng. 2020 12; 4(12):1180-1187.
    View in: PubMed
    Score: 0.058
  45. Evolution of Early SARS-CoV-2 and Cross-Coronavirus Immunity. mSphere. 2020 09 02; 5(5).
    View in: PubMed
    Score: 0.058
  46. Clinical sensitivity and interpretation of PCR and serological COVID-19 diagnostics for patients presenting to the hospital. FASEB J. 2020 10; 34(10):13877-13884.
    View in: PubMed
    Score: 0.058
  47. Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. Nat Biotechnol. 2020 10; 38(10):1174-1183.
    View in: PubMed
    Score: 0.058
  48. Distinct Early Serological Signatures Track with SARS-CoV-2 Survival. Immunity. 2020 09 15; 53(3):524-532.e4.
    View in: PubMed
    Score: 0.058
  49. Test performance evaluation of SARS-CoV-2 serological assays. medRxiv. 2020 May 17.
    View in: PubMed
    Score: 0.057
  50. Ultra-Sensitive High-Resolution Profiling of Anti-SARS-CoV-2 Antibodies for Detecting Early Seroconversion in COVID-19 Patients. medRxiv. 2020 May 02.
    View in: PubMed
    Score: 0.057
  51. Posttranslational Regulation of IL-23 Production Distinguishes the Innate Immune Responses to Live Toxigenic versus Heat-Inactivated Vibrio cholerae. mSphere. 2019 08 21; 4(4).
    View in: PubMed
    Score: 0.054
  52. Induction of systemic, mucosal and memory antibody responses targeting Vibrio cholerae O1 O-specific polysaccharide (OSP) in adults following oral vaccination with an oral killed whole cell cholera vaccine in Bangladesh. PLoS Negl Trop Dis. 2019 08; 13(8):e0007634.
    View in: PubMed
    Score: 0.054
  53. Bivalent oral cholera vaccination induces a memory B cell response to the V. cholerae O1-polysaccharide antigen in Haitian adults. PLoS Negl Trop Dis. 2019 01; 13(1):e0007057.
    View in: PubMed
    Score: 0.052
  54. Defining endemic cholera at three levels of spatiotemporal resolution within Bangladesh. Nat Genet. 2018 07; 50(7):951-955.
    View in: PubMed
    Score: 0.050
  55. Development of a new dipstick (Cholkit) for rapid detection of Vibrio cholerae O1 in acute watery diarrheal stools. PLoS Negl Trop Dis. 2018 03; 12(3):e0006286.
    View in: PubMed
    Score: 0.049
  56. Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways. Infect Immun. 2018 02; 86(2).
    View in: PubMed
    Score: 0.049
  57. Vibrio cholerae genomic diversity within and between patients. Microb Genom. 2017 12; 3(12).
    View in: PubMed
    Score: 0.048
  58. Nanomagnetic System for Rapid Diagnosis of Acute Infection. ACS Nano. 2017 11 28; 11(11):11425-11432.
    View in: PubMed
    Score: 0.048
  59. Single-Cell Analysis of the Plasmablast Response to Vibrio cholerae Demonstrates Expansion of Cross-Reactive Memory B Cells. mBio. 2016 12 20; 7(6).
    View in: PubMed
    Score: 0.045
  60. Antibody Secreting Cell Responses following Vaccination with Bivalent Oral Cholera Vaccine among Haitian Adults. PLoS Negl Trop Dis. 2016 06; 10(6):e0004753.
    View in: PubMed
    Score: 0.043
  61. Comparison of the Performance of the TPTest, Tubex, Typhidot and Widal Immunodiagnostic Assays and Blood Cultures in Detecting Patients with Typhoid Fever in Bangladesh, Including Using a Bayesian Latent Class Modeling Approach. PLoS Negl Trop Dis. 2016 Apr; 10(4):e0004558.
    View in: PubMed
    Score: 0.043
  62. Fluorescence Polarization Based Nucleic Acid Testing for Rapid and Cost-Effective Diagnosis of Infectious Disease. Chemistry. 2015 Nov 09; 21(46):16359-63.
    View in: PubMed
    Score: 0.041
  63. Typhoid fever in young children in Bangladesh: clinical findings, antibiotic susceptibility pattern and immune responses. PLoS Negl Trop Dis. 2015 Apr; 9(4):e0003619.
    View in: PubMed
    Score: 0.040
  64. Immunogenicity of the Bivalent Oral Cholera Vaccine Shanchol in Haitian Adults With HIV Infection. J Infect Dis. 2015 Sep 01; 212(5):779-83.
    View in: PubMed
    Score: 0.040
  65. Bacterial shedding in household contacts of cholera patients in Dhaka, Bangladesh. Am J Trop Med Hyg. 2014 Oct; 91(4):738-42.
    View in: PubMed
    Score: 0.038
  66. Immune responses to O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 Ogawa in adult Bangladeshi recipients of an oral killed cholera vaccine and comparison to responses in patients with cholera. Am J Trop Med Hyg. 2014 May; 90(5):873-81.
    View in: PubMed
    Score: 0.037
  67. Evaluation of a typhoid/paratyphoid diagnostic assay (TPTest) detecting anti-Salmonella IgA in secretions of peripheral blood lymphocytes in patients in Dhaka, Bangladesh. PLoS Negl Trop Dis. 2013; 7(7):e2316.
    View in: PubMed
    Score: 0.035
  68. Frequency of reexposure to Vibrio cholerae O1 evaluated by subsequent vibriocidal titer rise after an episode of severe cholera in a highly endemic area in Bangladesh. Am J Trop Med Hyg. 2012 Nov; 87(5):921-6.
    View in: PubMed
    Score: 0.033
  69. Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera. Clin Vaccine Immunol. 2012 Aug; 19(8):1304-11.
    View in: PubMed
    Score: 0.033
  70. Simple, direct conjugation of bacterial O-SP-core antigens to proteins: development of cholera conjugate vaccines. Bioconjug Chem. 2011 Oct 19; 22(10):2179-85.
    View in: PubMed
    Score: 0.031
  71. Salmonella enterica serovar Typhi-specific immunoglobulin A antibody responses in plasma and antibody in lymphocyte supernatant specimens in Bangladeshi patients with suspected typhoid fever. Clin Vaccine Immunol. 2009 Nov; 16(11):1587-94.
    View in: PubMed
    Score: 0.027
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.