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Yuyu Song, M.D.,Ph.D.

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Biography
1999 - 2004
Various Distiguished Awards in Academic Studies (including the President's Awards)
2003
Outstanding Honor in Medical Education and Clinical Practice
2003
"National 'Challenge Cup' Academic Research Competition" Winner-3rd place
2008
Graduate Student Travel Award, American Society for Mass Spectrometry
2009
Chancellor's Award for Leadership and Community Service
2009 - 2010
Various Graduate School Presenting Awards for Posters and Talks
2010
Travel Award and Selected Abstract Presentation, Gordon Research Conference
2010
Provost's W.C. and May Preble Deiss Grant for Biomedical Research
2010
Best Thesis of the Year at University of Illinois
2010
Best Poster Award at Chicago Cytoskeleton Meeting
2010
Young Investigator Award, American Society of Neurochemistry
2010
Postdoctoral Travel Award, American Society for Cell Biology
2010
Travel Award and Invited Speaker, European Science Foundation
2011
Nomination for 2011 CGS/University Microfilms International Distinguished Dissertation Award
2011
Travel Award and Invited Speaker at Emerging Concept of Neuronal Cytoskeleton Conference
2011
Best Poster Award at International Society of Neurochemistry Advanced School
2011 - 2012
"Fight for Sight" Postdoctoral Research Grant
2014
Grass Fellowship
2015
"Advanced Imaging Center" Research Grant, HHMI/Janelia Research Campus

Overview
Trained as both a physician and a basic research scientist, Yuyu Song has a primary interest in research projects related to adult-onset neurodegenerative diseases, with a focus on Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s Disease (AD). This interest was first stimulated by her clinical experiences and eventually led to graduate work that explored topics related to both normal neural development and neurodegeneration including: 1) specializations of the neuronal cytoskeleton that are essential for normal neuronal structure and function; and 2) molecular mechanisms underlying adult-onset neurodegenerative diseases. This includes AD, ALS, Huntington’s Disease (HD), Parkinson’s Disease (PD), and HIV neuropathy. Inspired by the possibility of conducting translational neuroscience research, Dr. Song obtained postdoctoral training at Boston Children’s Hospital/Harvard Medical School, where she studied childhood neurological diseases caused by tubulin mutations. This work explored the puzzle of selective vulnerability of neurons in various neuromotor disorders and led her to Dr. Arthur Horwich’s laboratory at HHMI/Yale School of Medicine. There she examined the molecular mechanism of ALS via three areas that might provide insights into the puzzle: 1) protein misfolding/quality control and molecular chaperones; 2) axonal transport deficits and altered motor protein behavior; and 3) synaptic dysfunction and aberrant Ca2+ influx. Her work revealed signaling pathways that connect these three aspects of disease pathology, and that may also involve the innate immune response and neuroinflammation. As the intertwined and multifactorial pathogenesis of these diseases emerged and suggested potential therapeutic approaches, Dr. Song joined the Laboratory of Systems Pharmacology at the Harvard Medical School. Here she aims to develop new drugs and/or repurpose and modify existing ones, that target the signaling pathway components and neuronal cytoskeletal disruptions observed in neurodegenerative diseases.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Song Y. Synaptic Actions of Amyotrophic Lateral Sclerosis-Associated G85R-SOD1 in the Squid Giant Synapse. eNeuro. 2020 Mar/Apr; 7(2). PMID: 32188708.
    Citations:    
  2. Song Y, Subramanian K, Berberich MJ, Rodriguez S, Latorre IJ, Luria CM, Everley R, Albers MW, Mitchison TJ, Sorger PK. A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line. Sci Data. 2019 02 19; 6:190016. PMID: 30778261.
    Citations:    
  3. Pineda JJ, Miller MA, Song Y, Kuhn H, Mikula H, Tallapragada N, Weissleder R, Mitchison TJ. Site occupancy calibration of taxane pharmacology in live cells and tissues. Proc Natl Acad Sci U S A. 2018 11 27; 115(48):E11406-E11414. PMID: 30429313.
    Citations:    Fields:    
  4. Shimada K, Reznik E, Stokes ME, Krishnamoorthy L, Bos PH, Song Y, Quartararo CE, Pagano NC, Carpizo DR, deCarvalho AC, Lo DC, Stockwell BR. Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells. Cell Chem Biol. 2018 05 17; 25(5):585-594.e7. PMID: 29576531.
    Citations:    Fields:    
  5. Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF. Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2. PLoS One. 2017; 12(12):e0188340. PMID: 29261664.
    Citations:    
  6. Leo L, Weissmann C, Burns M, Kang M, Song Y, Qiang L, Brady ST, Baas PW, Morfini G. Mutant spastin proteins promote deficits in axonal transport through an isoform-specific mechanism involving casein kinase 2 activation. Hum Mol Genet. 2017 06 15; 26(12):2321-2334. PMID: 28398512.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  7. Sama RR, Fallini C, Gatto R, McKeon JE, Song Y, Rotunno MS, Penaranda S, Abdurakhmanov I, Landers JE, Morfini G, Brady ST, Bosco DA. ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation. Sci Rep. 2017 03 08; 7(1):115. PMID: 28273913.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  8. Barry JF, Turner MJ, Schloss JM, Glenn DR, Song Y, Lukin MD, Park H, Walsworth RL. Optical magnetic detection of single-neuron action potentials using quantum defects in diamond. Proc Natl Acad Sci U S A. 2016 12 06; 113(49):14133-14138. PMID: 27911765.
    Citations: 8     Fields:    
  9. Berth SH, Mesnard-Hoaglin N, Wang B, Kim H, Song Y, Sapar M, Morfini G, Brady ST. HIV Glycoprotein Gp120 Impairs Fast Axonal Transport by Activating Tak1 Signaling Pathways. ASN Neuro. 2016 12; 8(6). PMID: 27872270.
    Citations:    Fields:    Translation:AnimalsCells
  10. Song Y, Kang M, Morfini G, Brady ST. Fast axonal transport in isolated axoplasm from the squid giant axon. Methods Cell Biol. 2016; 131:331-48. PMID: 26794522.
    Citations: 8     Fields:    Translation:AnimalsCells
  11. Kang M, Baker L, Song Y, Brady ST, Morfini G. Biochemical analysis of axon-specific phosphorylation events using isolated squid axoplasms. Methods Cell Biol. 2016; 131:199-216. PMID: 26794515.
    Citations: 3     Fields:    Translation:AnimalsCells
  12. Song Y, Brady ST. Post-translational modifications of tubulin: pathways to functional diversity of microtubules. Trends Cell Biol. 2015 Mar; 25(3):125-36. PMID: 25468068.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  13. Song Y, Brady ST. Stabilization of neuronal connections and the axonal cytoskeleton. Bioarchitecture. 2014 Jan-Feb; 4(1):22-4. PMID: 24492417.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Morfini GA, Bosco DA, Brown H, Gatto R, Kaminska A, Song Y, Molla L, Baker L, Marangoni MN, Berth S, Tavassoli E, Bagnato C, Tiwari A, Hayward LJ, Pigino GF, Watterson DM, Huang CF, Banker G, Brown RH, Brady ST. Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase. PLoS One. 2013; 8(6):e65235. PMID: 23776455.
    Citations: 27     Fields:    Translation:AnimalsCells
  15. Cantuti Castelvetri L, Givogri MI, Hebert A, Smith B, Song Y, Kaminska A, Lopez-Rosas A, Morfini G, Pigino G, Sands M, Brady ST, Bongarzone ER. The sphingolipid psychosine inhibits fast axonal transport in Krabbe disease by activation of GSK3ß and deregulation of molecular motors. J Neurosci. 2013 Jun 12; 33(24):10048-56. PMID: 23761900.
    Citations: 23     Fields:    Translation:AnimalsCells
  16. Song Y, Kirkpatrick LL, Schilling AB, Helseth DL, Chabot N, Keillor JW, Johnson GV, Brady ST. Transglutaminase and polyamination of tubulin: posttranslational modification for stabilizing axonal microtubules. Neuron. 2013 Apr 10; 78(1):109-23. PMID: 23583110.
    Citations: 38     Fields:    Translation:AnimalsCells
  17. Song Y, Nagy M, Ni W, Tyagi NK, Fenton WA, López-Giráldez F, Overton JD, Horwich AL, Brady ST. Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5428-33. PMID: 23509252.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  18. Song Y, Brady ST. Analysis of microtubules in isolated axoplasm from the squid giant axon. Methods Cell Biol. 2013; 115:125-37. PMID: 23973070.
    Citations: 4     Fields:    Translation:AnimalsCells
  19. Cederquist GY, Luchniak A, Tischfield MA, Peeva M, Song Y, Menezes MP, Chan WM, Andrews C, Chew S, Jamieson RV, Gomes L, Flaherty M, Grant PE, Gupta ML, Engle EC. An inherited TUBB2B mutation alters a kinesin-binding site and causes polymicrogyria, CFEOM and axon dysinnervation. Hum Mol Genet. 2012 Dec 15; 21(26):5484-99. PMID: 23001566.
    Citations: 31     Fields:    Translation:HumansCells
  20. Pigino G., Song Y., Kirkpatrick LL., Brady ST. . Basic Neurochemistry: Principles of Molecular, Cellular and Medical Neurobiology. The Cytoskeleton of Neurons and Glia. 2012; 101-118.
  21. Song Y., Brady ST. Basic Neurochemistry: Principles of Molecular, Cellular and Medical Neurobiology. Tubulin Mutations and Neurological Diseases. 2012; 115-116.
  22. Kanaan NM, Morfini G, Pigino G, LaPointe NE, Andreadis A, Song Y, Leitman E, Binder LI, Brady ST. Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport. Neurobiol Aging. 2012 Apr; 33(4):826.e15-30. PMID: 21794954.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  23. Kanaan NM, Morfini GA, LaPointe NE, Pigino GF, Patterson KR, Song Y, Andreadis A, Fu Y, Brady ST, Binder LI. Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. J Neurosci. 2011 Jul 06; 31(27):9858-68. PMID: 21734277.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  24. Bosco DA, Morfini G, Karabacak NM, Song Y, Gros-Louis F, Pasinelli P, Goolsby H, Fontaine BA, Lemay N, McKenna-Yasek D, Frosch MP, Agar JN, Julien JP, Brady ST, Brown RH. Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nat Neurosci. 2010 Nov; 13(11):1396-403. PMID: 20953194.
    Citations: 205     Fields:    Translation:HumansCells
  25. Song Y. Stabilization of neuronal microtubules by polyamines and transglutaminase: Its roles in brain function. 2010.
  26. Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, Pigino G, Brady ST. Axonal transport defects in neurodegenerative diseases. J Neurosci. 2009 Oct 14; 29(41):12776-86. PMID: 19828789.
    Citations: 168     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.