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Ryan Carroll, M.D.

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Overview
My research and development interests combine investigations into the pathophysiology of severe and cerebral malaria, pediatric critical care capacity building, and appropriate medical technology development for low- and middle-income countries. I work with the MassGen Hospital for Children (MGHfC) divisions of Pediatric Global Health and Pediatric Critical Care, developing didactics and a robust training platform for domestic and international trainees, in addition to building pediatric critical care services in several global locations.

Mentoring
Available: 04/05/22, Expires: 06/01/23

1. Inhaled high-dose nitric oxide as an anti-microbial therapy for bacterial pulmonary infections and SARS-CoV-2. 2. SARS-CoV-2 infection in children presenting to the PICU (local and national) 3. Assessing the use of non-invasive respiratory therapies (HFNC, CPAP, BiPAP) in the PICU. 4. Developing novel BiPAP and ventilatory support devices.


Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hobbs CV, Woodworth K, Young CC, Jackson AM, Newhams MM, Dapul H, Maamari M, Hall MW, Maddux AB, Singh AR, Schuster JE, Rowan CM, Fitzgerald JC, Irby K, Kong M, Mack EH, Staat MA, Cvijanovich NZ, Bembea MM, Coates BM, Halasa NB, Walker TC, McLaughlin GE, Babbitt CJ, Nofziger RA, Loftis LL, Bradford TT, Campbell AP, Patel MM, Randolph AG. Frequency, Characteristics and Complications of COVID-19 in Hospitalized Infants. Pediatr Infect Dis J. 2022 03 01; 41(3):e81-e86. PMID: 34955519.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  2. Yonker LM, Swank Z, Gilboa T, Senussi Y, Kenyon V, Papadakis L, Boribong BP, Carroll RW, Walt DR, Fasano A. Zonulin Antagonist, Larazotide (AT1001), As an Adjuvant Treatment for Multisystem Inflammatory Syndrome in Children: A Case Series. Crit Care Explor. 2022 Feb; 10(2):e0641. PMID: 35211683.
    Citations:    
  3. Di Fenza R, Yu B, Carroll RW, Berra L. Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds. J Vis Exp. 2022 02 16; (180). PMID: 35253799.
    Citations:    Fields:    
  4. Kamenshchikov NO, Berra L, Carroll RW. Therapeutic Effects of Inhaled Nitric Oxide Therapy in COVID-19 Patients. Biomedicines. 2022 Feb 03; 10(2). PMID: 35203578.
    Citations:    
  5. Miloslavsky EM, Besche HC, Calderwood SB, Chang BS, Dienstag JL, King RW, Mitchell RN, Schwartzstein RM, Thomas H, Hundert EM, Flanagan JG. Advanced Integrated Science Courses: Building a Skill Set to Engage With the Interface of Research and Medicine. Acad Med. 2022 Feb 01. PMID: 35108233.
    Citations:    Fields:    
  6. Naber CE, Fernandes ND, Lahoud-Rahme M, Doucette D, Goldstein AM, Yager PH, Cummings BM, Carroll RW. Operational Innovation in the Provision of Pediatric Extracorporeal Membrane Oxygenation for Multisystem Inflammatory Syndrome in Children. Health Secur. 2022 Jan-Feb; 20(1):50-57. PMID: 35020494.
    Citations:    Fields:    Translation:HumansCells
  7. Sessions KL, Smith AG, Holmberg PJ, Wahl B, Mvalo T, Chisti MJ, Carroll RW, McCollum ED. Continuous positive airway pressure for children in resource-limited settings, effect on mortality and adverse events: systematic review and meta-analysis. Arch Dis Child. 2021 Dec 08. PMID: 34880003.
    Citations:    Fields:    
  8. Geva A, Patel MM, Newhams MM, Young CC, Son MBF, Kong M, Maddux AB, Hall MW, Riggs BJ, Singh AR, Giuliano JS, Hobbs CV, Loftis LL, McLaughlin GE, Schwartz SP, Schuster JE, Babbitt CJ, Halasa NB, Gertz SJ, Doymaz S, Hume JR, Bradford TT, Irby K, Carroll CL, McGuire JK, Tarquinio KM, Rowan CM, Mack EH, Cvijanovich NZ, Fitzgerald JC, Spinella PC, Staat MA, Clouser KN, Soma VL, Dapul H, Maamari M, Bowens C, Havlin KM, Mourani PM, Heidemann SM, Horwitz SM, Feldstein LR, Tenforde MW, Newburger JW, Mandl KD, Randolph AG. Data-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescents. EClinicalMedicine. 2021 Oct; 40:101112. PMID: 34485878.
    Citations: 5     
  9. Gianni S, Fenza RD, Morais CCA, Fakhr BS, Mueller AL, Yu B, Carroll RW, Ichinose F, Zapol WM, Berra L. High-Dose Nitric Oxide From Pressurized Cylinders and Nitric Oxide Produced by an Electric Generator From Air. Respir Care. 2022 02; 67(2):201-208. PMID: 34413210.
    Citations: 1     Fields:    Translation:HumansCells
  10. Safaee Fakhr B, Di Fenza R, Gianni S, Wiegand SB, Miyazaki Y, Araujo Morais CC, Gibson LE, Chang MG, Mueller AL, Rodriguez-Lopez JM, Ackman JB, Arora P, Scott LK, Bloch DB, Zapol WM, Carroll RW, Ichinose F, Berra L. Inhaled high dose nitric oxide is a safe and effective respiratory treatment in spontaneous breathing hospitalized patients with COVID-19 pneumonia. Nitric Oxide. 2021 11 01; 116:7-13. PMID: 34400339.
    Citations: 4     Fields:    Translation:Humans
  11. Chisti MJ, Harris JB, Carroll RW, Shahunja KM, Shahid ASMSB, Moschovis PP, Schenkel SR, Hasibur Rahman ASMM, Shahrin L, Faruk T, Kabir F, Ahmed D, Ahmed T. Antibiotic-Resistant Bacteremia in Young Children Hospitalized With Pneumonia in Bangladesh Is Associated With a High Mortality Rate. Open Forum Infect Dis. 2021 Jul; 8(7):ofab260. PMID: 34277885.
    Citations: 1     
  12. Son MBF, Murray N, Friedman K, Young CC, Newhams MM, Feldstein LR, Loftis LL, Tarquinio KM, Singh AR, Heidemann SM, Soma VL, Riggs BJ, Fitzgerald JC, Kong M, Doymaz S, Giuliano JS, Keenaghan MA, Hume JR, Hobbs CV, Schuster JE, Clouser KN, Hall MW, Smith LS, Horwitz SM, Schwartz SP, Irby K, Bradford TT, Maddux AB, Babbitt CJ, Rowan CM, McLaughlin GE, Yager PH, Maamari M, Mack EH, Carroll CL, Montgomery VL, Halasa NB, Cvijanovich NZ, Coates BM, Rose CE, Newburger JW, Patel MM, Randolph AG. Multisystem Inflammatory Syndrome in Children - Initial Therapy and Outcomes. N Engl J Med. 2021 07 01; 385(1):23-34. PMID: 34133855.
    Citations: 32     Fields:    Translation:HumansPHPublic Health
  13. Gianni S, Carroll RW, Kacmarek RM, Berra L. Inhaled Nitric Oxide Delivery Systems for Mechanically Ventilated and Nonintubated Patients: A Review. Respir Care. 2021 Jun; 66(6):1021-1028. PMID: 34039761.
    Citations: 1     Fields:    Translation:Humans
  14. Payne AB, Gilani Z, Godfred-Cato S, Belay ED, Feldstein LR, Patel MM, Randolph AG, Newhams M, Thomas D, Magleby R, Hsu K, Burns M, Dufort E, Maxted A, Pietrowski M, Longenberger A, Bidol S, Henderson J, Sosa L, Edmundson A, Tobin-D'Angelo M, Edison L, Heidemann S, Singh AR, Giuliano JS, Kleinman LC, Tarquinio KM, Walsh RF, Fitzgerald JC, Clouser KN, Gertz SJ, Carroll RW, Carroll CL, Hoots BE, Reed C, Dahlgren FS, Oster ME, Pierce TJ, Curns AT, Langley GE, Campbell AP, Balachandran N, Murray TS, Burkholder C, Brancard T, Lifshitz J, Leach D, Charpie I, Tice C, Coffin SE, Perella D, Jones K, Marohn KL, Yager PH, Fernandes ND, Flori HR, Koncicki ML, Walker KS, Di Pentima MC, Li S, Horwitz SM, Gaur S, Coffey DC, Harwayne-Gidansky I, Hymes SR, Thomas NJ, Ackerman KG, Cholette JM. Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2. JAMA Netw Open. 2021 06 01; 4(6):e2116420. PMID: 34110391.
    Citations: 30     Fields:    Translation:HumansCells
  15. Pinciroli R, Traeger L, Fischbach A, Gianni S, Morais CCA, Fakhr BS, Di Fenza R, Robinson D, Carroll R, Zapol WM, Berra L. A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects. J Vis Exp. 2021 05 04; (171). PMID: 34028428.
    Citations: 1     Fields:    Translation:HumansCells
  16. LaRovere KL, Riggs BJ, Poussaint TY, Young CC, Newhams MM, Maamari M, Walker TC, Singh AR, Dapul H, Hobbs CV, McLaughlin GE, Son MBF, Maddux AB, Clouser KN, Rowan CM, McGuire JK, Fitzgerald JC, Gertz SJ, Shein SL, Munoz AC, Thomas NJ, Irby K, Levy ER, Staat MA, Tenforde MW, Feldstein LR, Halasa NB, Giuliano JS, Hall MW, Kong M, Carroll CL, Schuster JE, Doymaz S, Loftis LL, Tarquinio KM, Babbitt CJ, Nofziger RA, Kleinman LC, Keenaghan MA, Cvijanovich NZ, Spinella PC, Hume JR, Wellnitz K, Mack EH, Michelson KN, Flori HR, Patel MM, Randolph AG. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome. JAMA Neurol. 2021 05 01; 78(5):536-547. PMID: 33666649.
    Citations: 46     Fields:    Translation:Humans
  17. Olson KR, Nimkin K, Carroll RW, Stathatos N, Ordulu Z. Case 9-2021: A 16-Year-Old Boy with Headache, Abdominal Pain, and Hypertension. N Engl J Med. 2021 Mar 25; 384(12):1145-1155. PMID: 33761211.
    Citations: 1     Fields:    Translation:Humans
  18. Feldstein LR, Tenforde MW, Friedman KG, Newhams M, Rose EB, Dapul H, Soma VL, Maddux AB, Mourani PM, Bowens C, Maamari M, Hall MW, Riggs BJ, Giuliano JS, Singh AR, Li S, Kong M, Schuster JE, McLaughlin GE, Schwartz SP, Walker TC, Loftis LL, Hobbs CV, Halasa NB, Doymaz S, Babbitt CJ, Hume JR, Gertz SJ, Irby K, Clouser KN, Cvijanovich NZ, Bradford TT, Smith LS, Heidemann SM, Zackai SP, Wellnitz K, Nofziger RA, Horwitz SM, Carroll RW, Rowan CM, Tarquinio KM, Mack EH, Fitzgerald JC, Coates BM, Jackson AM, Young CC, Son MBF, Patel MM, Newburger JW, Randolph AG. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. 2021 03 16; 325(11):1074-1087. PMID: 33625505.
    Citations: 114     Fields:    Translation:Humans
  19. Fernandes ND, Cummings BM, Naber CE, Salt MD, Lok J, Yager PH, Carroll RW. Adult COVID-19 Patients Cared for in a Pediatric ICU Embedded in a Regional Biothreat Center: Disease Severity and Outcomes. Health Secur. 2021 Jul-Aug; 19(4):442-446. PMID: 33326301.
    Citations: 1     Fields:    Translation:Humans
  20. Wiegand SB, Traeger L, Nguyen HK, Rouillard KR, Fischbach A, Zadek F, Ichinose F, Schoenfisch MH, Carroll RW, Bloch DB, Zapol WM. Antimicrobial effects of nitric oxide in murine models of Klebsiella pneumonia. Redox Biol. 2021 02; 39:101826. PMID: 33352464.
    Citations: 2     Fields:    Translation:AnimalsCells
  21. Safaee Fakhr B, Wiegand SB, Pinciroli R, Gianni S, Morais CCA, Ikeda T, Miyazaki Y, Marutani E, Di Fenza R, Larson GM, Parcha V, Gibson LE, Chang MG, Arora P, Carroll RW, Kacmarek RM, Ichinose F, Barth WH, Kaimal A, Hohmann EL, Zapol WM, Berra L. High Concentrations of Nitric Oxide Inhalation Therapy in Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19). Obstet Gynecol. 2020 12; 136(6):1109-1113. PMID: 32852324.
    Citations: 18     Fields:    Translation:HumansCellsPHPublic Health
  22. Wiegand SB, Safaee Fakhr B, Carroll RW, Zapol WM, Kacmarek RM, Berra L. Rescue Treatment With High-Dose Gaseous Nitric Oxide in Spontaneously Breathing Patients With Severe Coronavirus Disease 2019. Crit Care Explor. 2020 Nov; 2(11):e0277. PMID: 33225304.
    Citations: 5     
  23. Gianni S, Morais CCA, Larson G, Pinciroli R, Carroll R, Yu B, Zapol WM, Berra L. Ideation and assessment of a nitric oxide delivery system for spontaneously breathing subjects. Nitric Oxide. 2020 11 01; 104-105:29-35. PMID: 32835810.
    Citations: 4     Fields:    Translation:Humans
  24. Bartley BL, Gardner KJ, Spina S, Hurley BP, Campeau D, Berra L, Yonker LM, Carroll RW. High-Dose Inhaled Nitric Oxide as Adjunct Therapy in Cystic Fibrosis Targeting Burkholderia multivorans. Case Rep Pediatr. 2020; 2020:1536714. PMID: 32685229.
    Citations: 7     
  25. Fernandes ND, Chung E, Salt MD, Ejiofor B, Carroll RW, Kacmarek RM. Measured CPAP in a Noninvasive Pediatric Airway and Lung Model. Respir Care. 2021 Jan; 66(1):87-94. PMID: 32576707.
    Citations:    Fields:    Translation:Humans
  26. Krezanoski PJ, Santorino D, Agaba A, Dorsey G, Bangsberg DR, Carroll RW. How Are Insecticide-Treated Bednets Used in Ugandan Households? A Comprehensive Characterization of Bednet Adherence Using a Remote Monitor. Am J Trop Med Hyg. 2019 08; 101(2):404-411. PMID: 31287045.
    Citations: 3     Fields:    Translation:Humans
  27. Ejiofor BD, Carroll RW, Bortcosh W, Kacmarek RM. PEEP Generated by High-Flow Nasal Cannula in a Pediatric Model. Respir Care. 2019 Oct; 64(10):1240-1249. PMID: 31088986.
    Citations: 7     Fields:    Translation:Humans
  28. Cieslak TJ, Evans L, Kortepeter MG, Grindle A, Aigbivbalu L, Boulter K, Carroll RW, Cumplido S, Danforth AG, Fry C, Gaensbauer J, Hume JR, Husain A, Kelleher A, Kratochvil CJ, Kunrath C, Morgan JS, Schwedhelm MM, Shane AL, Tennill P, Yager PH, Davies HD. Perspectives on the Management of Children in a Biocontainment Unit: Report of the NETEC Pediatric Workgroup. Health Secur. 2019 Jan/Feb; 17(1):11-17. PMID: 30779612.
    Citations:    Fields:    Translation:HumansPHPublic Health
  29. Otani IM, Carroll RW, Yager P, Kroshinsky D, Murphy S, Hornick JL, Akin C, Castells M, Walter JE. Diffuse cutaneous mastocytosis with novel somatic KIT mutation K509I and association with tuberous sclerosis. Clin Case Rep. 2018 Sep; 6(9):1834-1840. PMID: 30214774.
    Citations: 2     
  30. Bennett DJ, Carroll RW, Kacmarek RM. Evaluation of a Low-Cost Bubble CPAP System Designed for Resource-Limited Settings. Respir Care. 2018 Apr; 63(4):395-403. PMID: 29382795.
    Citations: 5     Fields:    Translation:Humans
  31. Lee GQ, Bangsberg DR, Mo T, Lachowski C, Brumme CJ, Zhang W, Lima VD, Boum Y, Mwebesa BB, Muzoora C, Andia I, Mbalibulha Y, Kembabazi A, Carroll R, Siedner MJ, Haberer JE, Mocello AR, Kigozi SH, Hunt PW, Martin JN, Harrigan PR. Prevalence and clinical impacts of HIV-1 intersubtype recombinants in Uganda revealed by near-full-genome population and deep sequencing approaches. AIDS. 2017 11 13; 31(17):2345-2354. PMID: 28832407.
    Citations: 12     Fields:    Translation:HumansCells
  32. Bortcosh W, Siedner M, Carroll RW. Utility of the urine reagent strip leucocyte esterase assay for the diagnosis of meningitis in resource-limited settings: meta-analysis. Trop Med Int Health. 2017 09; 22(9):1072-1080. PMID: 28627004.
    Citations: 3     Fields:    Translation:HumansCells
  33. Carroll RW, Katz ML, Paul E, Jüppner H. Case 17-2017. A 14-Year-Old Boy with Acute Fear of Choking while Swallowing. N Engl J Med. 2017 06 08; 376(23):2266-2275. PMID: 28591527.
    Citations:    Fields:    Translation:HumansCells
  34. Mwanga-Amumpaire J, Carroll RW, Baudin E, Kemigisha E, Nampijja D, Mworozi K, Santorino D, Nyehangane D, Nathan DI, De Beaudrap P, Etard JF, Feelisch M, Fernandez BO, Berssenbrugge A, Bangsberg D, Bloch KD, Boum Y, Zapol WM. Inhaled Nitric Oxide as an Adjunctive Treatment for Cerebral Malaria in Children: A Phase II Randomized Open-Label Clinical Trial. Open Forum Infect Dis. 2015 Sep; 2(3):ofv111. PMID: 26309894.
    Citations: 18     
  35. Sundararajan R, Mwanga-Amumpaire J, Adrama H, Tumuhairwe J, Mbabazi S, Mworozi K, Carroll R, Bangsberg D, Boum Y, Ware NC. Sociocultural and structural factors contributing to delays in treatment for children with severe malaria: a qualitative study in southwestern Uganda. Am J Trop Med Hyg. 2015 May; 92(5):933-940. PMID: 25802438.
    Citations: 16     Fields:    Translation:Humans
  36. DePasse JW, Carroll R, Ippolito A, Yost A, Santorino D, Chu Z, Olson KR. Less noise, more hacking: how to deploy principles from MIT's hacking medicine to accelerate health care. Int J Technol Assess Health Care. 2014 Jul; 30(3):260-4. PMID: 25096225.
    Citations: 20     Fields:    Translation:Humans
  37. Rogers DJ, Collins C, Carroll R, Yager P, Cummings B, Raol N, Setlur J, Maturo S, Tremblay S, Quinones E, Noviski N, Hartnick CJ. Operation airway: the first sustainable, multidisciplinary, pediatric airway surgical mission. Ann Otol Rhinol Laryngol. 2014 Oct; 123(10):726-33. PMID: 24835243.
    Citations: 1     Fields:    Translation:Humans
  38. Bergmark B, Bergmark R, Beaudrap PD, Boum Y, Mwanga-Amumpaire J, Carroll R, Zapol W. Inhaled nitric oxide and cerebral malaria: basis of a strategy for buying time for pharmacotherapy. Pediatr Infect Dis J. 2012 Dec; 31(12):e250-4. PMID: 22760538.
    Citations: 8     Fields:    Translation:Humans
  39. Ackerman HC, Carroll RW, Casals-Pascual C. A better biomarker for cerebral malaria: in the eye of the beheld?*. Crit Care Med. 2012 Mar; 40(3):1018-20. PMID: 22343865.
    Citations: 1     Fields:    Translation:Animals
  40. Carroll RW, Wainwright MS, Kim KY, Kidambi T, Gómez ND, Taylor T, Haldar K. A rapid murine coma and behavior scale for quantitative assessment of murine cerebral malaria. PLoS One. 2010 Oct 01; 5(10). PMID: 20957049.
    Citations: 58     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.