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Sahir Kalim, M.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK124453 (KALIM, SAHIR) May 14, 2020 - Feb 28, 2023
    Protein carbamylation and the progression and complications of CKD
    Role: Principal Investigator
  2. U01DK123818 (KALIM, SAHIR) Sep 24, 2019 - May 31, 2024
    Reducing chronic pain and opioid use in hemodialysis patients
    Role: Principal Investigator
  3. K23DK106479 (KALIM, SAHIR) Jul 30, 2015 - Jul 31, 2020
    The effects of protein carbamylation in end stage kidney disease
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wen D, Zheng Z, Surapaneni A, Yu B, Zhou L, Zhou W, Xie D, Shou H, Avila-Pacheco J, Kalim S, He J, Hsu CY, Parsa A, Rao P, Sondheimer J, Townsend R, Waikar SS, Rebholz CM, Denburg MR, Kimmel PL, Vasan RS, Clish CB, Coresh J, Feldman HI, Grams ME, Rhee EP. Metabolite profiling of CKD progression in the chronic renal insufficiency cohort (CRIC) study. JCI Insight. 2022 Sep 01. PMID: 36048534.
  2. Tang M, Kalim S. Novel Approaches for the Removal of Uremic Solutes. Clin J Am Soc Nephrol. 2022 08; 17(8):1113-1115. PMID: 35835517; PMCID: PMC9435973.
    Citations:    Fields:    
  3. Wen W, Portales-Castillo I, Seethapathy R, Krinsky S, Kroshinsky D, Kalim S, Goverman J, Nazarian RM, Chitalia V, Malhotra R, Kramann R, Malhotra CK, Nigwekar SU. Intravenous sodium thiosulphate for vascular calcification of hemodialysis patients - a systematic review and meta-analysis. Nephrol Dial Transplant. 2022 May 06. PMID: 35521751.
    Citations:    Fields:    
  4. Wulczyn KE, Zhao SH, Rhee EP, Kalim S, Shafi T. Trajectories of Uremic Symptom Severity and Kidney Function in Patients with Chronic Kidney Disease. Clin J Am Soc Nephrol. 2022 04; 17(4):496-506. PMID: 35246460; PMCID: PMC8993474.
    Citations: 1     Fields:    Translation:Humans
  5. Tang M, Kalim S. Avenues for post-translational protein modification prevention and therapy. Mol Aspects Med. 2022 08; 86:101083. PMID: 35227517; PMCID: PMC9378364.
    Citations:    Fields:    
  6. Halim A, Narayanan G, Hato T, Ho L, Wan D, Siedlecki AM, Rhee EP, Allegretti AS, Nigwekar SU, Zehnder D, Hiemstra TF, Bonventre JV, Charytan DM, Kalim S, Thadhani R, Lu T, Lim K. Myocardial Cytoskeletal Adaptations in Advanced Kidney Disease. J Am Heart Assoc. 2022 03; 11(5):e022991. PMID: 35179046; PMCID: PMC9075094.
    Citations:    Fields:    Translation:HumansCells
  7. Chewcharat A, Phipps EA, Bhatia K, Kalim S, Allegretti AS, Sise ME, Paunescu TG, Seethapathy R, Nigwekar SU. The association between olfactory and gustatory dysfunction and chronic kidney disease. BMC Nephrol. 2022 01 18; 23(1):36. PMID: 35042465; PMCID: PMC8767746.
    Citations:    Fields:    Translation:Humans
  8. Kalim S, Berg AH, Karumanchi SA, Thadhani R, Allegretti AS, Nigwekar S, Zhao S, Srivastava A, Raj D, Deo R, Frydrych A, Chen J, Sondheimer J, Shafi T, Weir M, Lash JP. Protein carbamylation and chronic kidney disease progression in the Chronic Renal Insufficiency Cohort Study. Nephrol Dial Transplant. 2021 12 31; 37(1):139-147. PMID: 33661286; PMCID: PMC8719615.
    Citations: 1     Fields:    Translation:HumansCells
  9. Berg AH, Tavasoli M, Lo AS, Burnett-Bowie SM, Bhan I, Karumanchi SA, Kalim S, Zhang D, Zhao S, Thadhani RI. Development and analytical validation of a novel bioavailable 25-hydroxyvitamin D assay. PLoS One. 2021; 16(7):e0254158. PMID: 34242315.
    Citations:    Fields:    Translation:Humans
  10. Shah NB, Nigwekar SU, Kalim S, Lelouvier B, Servant F, Dalal M, Krinsky S, Fasano A, Tolkoff-Rubin N, Allegretti AS. The Gut and Blood Microbiome in IgA Nephropathy and Healthy Controls. Kidney360. 2021 08 26; 2(8):1261-1274. PMID: 35369657; PMCID: PMC8676391.
    Citations: 1     Translation:Humans
  11. Allegretti AS, Parada XV, Endres P, Zhao S, Krinsky S, St Hillien SA, Kalim S, Nigwekar SU, Flood JG, Nixon A, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Regner KR, Belcher JM, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT. Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study. Clin Transl Gastroenterol. 2021 05 11; 12(5):e00359. PMID: 33979307.
    Citations: 7     Fields:    Translation:Humans
  12. Olaniran KO, Allegretti AS, Zhao SH, Nigwekar SU, Kalim S. Acute Kidney Injury among Black Patients with Sickle Cell Trait and Sickle Cell Disease. Clin J Am Soc Nephrol. 2021 03 08; 16(3):348-355. PMID: 33648973; PMCID: PMC8011026.
    Citations: 2     Fields:    Translation:Humans
  13. Kalim S, Lyons KS, Nigwekar SU. Opioids in Hemodialysis Patients. Semin Nephrol. 2021 01; 41(1):24-32. PMID: 33896471.
    Citations:    Fields:    Translation:Humans
  14. Battistone MA, Mendelsohn AC, Spallanzani RG, Allegretti AS, Liberman RN, Sesma J, Kalim S, Wall SM, Bonventre JV, Lazarowski ER, Brown D, Breton S. Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice. J Clin Invest. 2020 07 01; 130(7):3734-3749. PMID: 32287042; PMCID: PMC7324186.
    Citations: 21     Fields:    Translation:AnimalsCells
  15. Lundquist AL, Kalim S, Mojtahed A, Tomaszewski KJ. Case 13-2020: A 29-Year-Old Man with High Blood Pressure, Renal Insufficiency, and Hematuria. N Engl J Med. 2020 Apr 23; 382(17):1639-1647. PMID: 32320573.
    Citations:    Fields:    Translation:Humans
  16. Olaniran KO, Allegretti AS, Zhao SH, Achebe MM, Eneanya ND, Thadhani RI, Nigwekar SU, Kalim S. Kidney Function Decline among Black Patients with Sickle Cell Trait and Sickle Cell Disease: An Observational Cohort Study. J Am Soc Nephrol. 2020 02; 31(2):393-404. PMID: 31810990; PMCID: PMC7003305.
    Citations: 15     Fields:    Translation:Humans
  17. Olaniran KO, Seethapathy H, Zhao SH, Allegretti AS, Kalim S, Nigwekar SU. Validity of International Classification of Diseases Codes for Sickle Cell Trait and Sickle Cell Disease. J Gen Intern Med. 2020 04; 35(4):1323-1324. PMID: 31745854.
    Citations: 1     Fields:    Translation:Humans
  18. Lim K, Kalim S. The Role of Nonenzymatic Post-translational Protein Modifications in Uremic Vascular Calcification. Adv Chronic Kidney Dis. 2019 11; 26(6):427-436. PMID: 31831121.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  19. Nigwekar SU, Negri AL, Bajpai D, Allegretti A, Kalim S, Seethapathy H, Bhan I, Murthy K, Ayus JC. Chronic prolonged hyponatremia and risk of hip fracture in elderly patients with chronic kidney disease. Bone. 2019 10; 127:556-562. PMID: 31362067.
    Citations: 2     Fields:    Translation:Humans
  20. Shah NB, Allegretti AS, Nigwekar SU, Kalim S, Zhao S, Lelouvier B, Servant F, Serena G, Thadhani RI, Raj DS, Fasano A. Blood Microbiome Profile in CKD : A Pilot Study. Clin J Am Soc Nephrol. 2019 05 07; 14(5):692-701. PMID: 30962186.
    Citations: 32     Fields:    Translation:Humans
  21. Allegretti AS, Vela Parada X, Ortiz GA, Long J, Krinsky S, Zhao S, Fuchs BC, Sojoodi M, Zhang D, Karumanchi SA, Kalim S, Nigwekar SU, Thadhani RI, Parikh SM, Chung RT. Serum Angiopoietin-2 Predicts Mortality and Kidney Outcomes in Decompensated Cirrhosis. Hepatology. 2019 02; 69(2):729-741. PMID: 30141205.
    Citations: 8     Fields:    Translation:Humans
  22. Kalim S. Protein carbamylation in end stage renal disease: is there a mortality effect? Curr Opin Nephrol Hypertens. 2018 11; 27(6):454-462. PMID: 30148723; PMCID: PMC6235170.
    Citations: 1     Fields:    Translation:HumansCells
  23. Long J, Vela Parada X, Kalim S. Protein Carbamylation in Chronic Kidney Disease and Dialysis. Adv Clin Chem. 2018; 87:37-67. PMID: 30342712.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  24. Trottier C, Perl J, Freeman M, Thadhani R, Berg A, Kalim S. Protein Carbamylation in Peritoneal Dialysis and the Effect of Low Glucose Plus Amino Acid Solutions. Perit Dial Int. 2018 Mar-Apr; 38(2):149-152. PMID: 29563277.
    Citations: 3     Fields:    Translation:HumansCells
  25. Kalim S, Wald R, Yan AT, Goldstein MB, Kiaii M, Xu D, Berg AH, Clish C, Thadhani R, Rhee EP, Perl J. Extended Duration Nocturnal Hemodialysis and Changes in Plasma Metabolite Profiles. Clin J Am Soc Nephrol. 2018 03 07; 13(3):436-444. PMID: 29444900.
    Citations: 13     Fields:    Translation:Humans
  26. Tang M, Batty JA, Lin C, Fan X, Chan KE, Kalim S. Pulmonary Hypertension, Mortality, and Cardiovascular Disease in CKD and ESRD Patients: A Systematic Review and Meta-analysis. Am J Kidney Dis. 2018 07; 72(1):75-83. PMID: 29429751.
    Citations: 22     Fields:    Translation:Humans
  27. Kalim S, Rhee EP. Metabolomics and Kidney Precision Medicine. Clin J Am Soc Nephrol. 2017 11 07; 12(11):1726-1727. PMID: 28971981.
    Citations: 5     Fields:    Translation:Humans
  28. Nigwekar SU, Weiser JM, Kalim S, Xu D, Wibecan JL, Dougherty SM, Mercier-Lafond L, Corapi KM, Eneanya ND, Holbrook EH, Brown D, Thadhani RI, Paunescu TG. Characterization and Correction of Olfactory Deficits in Kidney Disease. J Am Soc Nephrol. 2017 Nov; 28(11):3395-3403. PMID: 28775001; PMCID: PMC5661283.
    Citations: 11     Fields:    Translation:Humans
  29. Fan X, Kalim S, Ye W, Zhao S, Ma J, Nigwekar SU, Chan KE, Cui J, Cai J, Wang L, Heng W, Zhou Y, Sun Y, Cui R, Zhang W, Wang B, Dai Q, Li X, Thadhani R, Li X. Urinary Stone Disease and Cardiovascular Disease Risk in a Rural Chinese Population. Kidney Int Rep. 2017 Nov; 2(6):1042-1049. PMID: 29270513; PMCID: PMC5733875.
    Citations: 5     
  30. Kalim S, Rhee EP. An overview of renal metabolomics. Kidney Int. 2017 01; 91(1):61-69. PMID: 27692817; PMCID: PMC5380230.
    Citations: 57     Fields:    Translation:HumansCells
  31. Allegretti AS, Ortiz G, Kalim S, Wibecan J, Zhang D, Shan HY, Xu D, Chung RT, Karumanchi SA, Thadhani RI. Siglec-7 as a Novel Biomarker to Predict Mortality in Decompensated Cirrhosis and Acute Kidney Injury. Dig Dis Sci. 2016 12; 61(12):3609-3620. PMID: 27655105; PMCID: PMC5106324.
    Citations: 2     Fields:    Translation:Humans
  32. Kalim S, Trottier CA, Wenger JB, Wibecan J, Ahmed R, Ankers E, Karumanchi SA, Thadhani R, Berg AH. Longitudinal Changes in Protein Carbamylation and Mortality Risk after Initiation of Hemodialysis. Clin J Am Soc Nephrol. 2016 10 07; 11(10):1809-1816. PMID: 27445162.
    Citations: 9     Fields:    Translation:HumansCells
  33. Perl J, Kalim S, Wald R, Goldstein MB, Yan AT, Noori N, Kiaii M, Wenger J, Chan C, Thadhani RI, Karumanchi SA, Berg AH. Reduction of carbamylated albumin by extended hemodialysis. Hemodial Int. 2016 10; 20(4):510-521. PMID: 27329430.
    Citations: 4     Fields:    Translation:Humans
  34. Chait Y, Kalim S, Horowitz J, Hollot CV, Ankers ED, Germain MJ, Thadhani RI. The greatly misunderstood erythropoietin resistance index and the case for a new responsiveness measure. Hemodial Int. 2016 07; 20(3):392-8. PMID: 26843352.
    Citations: 9     Fields:    Translation:Humans
  35. Allegretti AS, Ortiz G, Wenger J, Deferio JJ, Wibecan J, Kalim S, Tamez H, Chung RT, Karumanchi SA, Thadhani RI. Prognosis of Acute Kidney Injury and Hepatorenal Syndrome in Patients with Cirrhosis: A Prospective Cohort Study. Int J Nephrol. 2015; 2015:108139. PMID: 26266048; PMCID: PMC4525763.
    Citations: 26     
  36. Kalim S, Clish CB, Deferio JJ, Ortiz G, Moffet AS, Gerszten RE, Thadhani R, Rhee EP. Cross-sectional examination of metabolites and metabolic phenotypes in uremia. BMC Nephrol. 2015 Jul 07; 16:98. PMID: 26149577.
    Citations: 9     Fields:    Translation:Humans
  37. Bhan I, Dobens D, Tamez H, Deferio JJ, Li YC, Warren HS, Ankers E, Wenger J, Tucker JK, Trottier C, Pathan F, Kalim S, Nigwekar SU, Thadhani R. Nutritional vitamin D supplementation in dialysis: a randomized trial. Clin J Am Soc Nephrol. 2015 Apr 07; 10(4):611-9. PMID: 25770176.
    Citations: 27     Fields:    Translation:Humans
  38. Kalim S, Ortiz G, Trottier CA, Deferio JJ, Karumanchi SA, Thadhani RI, Berg AH. The Effects of Parenteral Amino Acid Therapy on Protein Carbamylation in Maintenance Hemodialysis Patients. J Ren Nutr. 2015 Jul; 25(4):388-92. PMID: 25753604; PMCID: PMC4469570.
    Citations: 7     Fields:    Translation:Humans
  39. Drechsler C, Kalim S, Wenger JB, Suntharalingam P, Hod T, Thadhani RI, Karumanchi SA, Wanner C, Berg AH. Protein carbamylation is associated with heart failure and mortality in diabetic patients with end-stage renal disease. Kidney Int. 2015 Jun; 87(6):1201-8. PMID: 25671766; PMCID: PMC4449819.
    Citations: 24     Fields:    Translation:Humans
  40. Kalim S, Karumanchi SA, Thadhani RI, Berg AH. Protein carbamylation in kidney disease: pathogenesis and clinical implications. Am J Kidney Dis. 2014 Nov; 64(5):793-803. PMID: 25037561; PMCID: PMC4209336.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  41. Kalim S, Clish CB, Wenger J, Elmariah S, Yeh RW, Deferio JJ, Pierce K, Deik A, Gerszten RE, Thadhani R, Rhee EP. A plasma long-chain acylcarnitine predicts cardiovascular mortality in incident dialysis patients. J Am Heart Assoc. 2013 Dec 05; 2(6):e000542. PMID: 24308938.
    Citations: 66     Fields:    Translation:Humans
  42. Kalim S, Tamez H, Wenger J, Ankers E, Trottier CA, Deferio JJ, Berg AH, Karumanchi SA, Thadhani RI. Carbamylation of serum albumin and erythropoietin resistance in end stage kidney disease. Clin J Am Soc Nephrol. 2013 Nov; 8(11):1927-34. PMID: 23970130.
    Citations: 16     Fields:    Translation:HumansCells
  43. Berg AH, Drechsler C, Wenger J, Buccafusca R, Hod T, Kalim S, Ramma W, Parikh SM, Steen H, Friedman DJ, Danziger J, Wanner C, Thadhani R, Karumanchi SA. Carbamylation of serum albumin as a risk factor for mortality in patients with kidney failure. Sci Transl Med. 2013 Mar 06; 5(175):175ra29. PMID: 23467560; PMCID: PMC3697767.
    Citations: 59     Fields:    Translation:Humans
  44. Tamez H, Kalim S, Thadhani RI. Does vitamin D modulate blood pressure? Curr Opin Nephrol Hypertens. 2013 Mar; 22(2):204-9. PMID: 23299053.
    Citations: 29     Fields:    Translation:HumansAnimals
  45. Camill P, Chihara L, Adams B, Andreassi C, Barry A, Kalim S, Limmer J, Mandell M, Rafert G. Early life history transitions and recruitment of Picea mariana in thawed boreal permafrost peatlands. Ecology. 2010 Feb; 91(2):448-59. PMID: 20392010.
    Citations: 1     Fields:    Translation:AnimalsCells
  46. Kalim S, Szczech LA, Wyatt CM. Acute kidney injury in HIV-infected patients. Semin Nephrol. 2008 Nov; 28(6):556-62. PMID: 19013326.
    Citations: 15     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.