Harvard Catalyst Profiles

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Colin Anthony Sieff, M.B.,B.Ch.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL064775 (SIEFF, COLIN A) Aug 15, 2001 - Jul 31, 2005
    NIH/NHLBI
    Genetic Heterogeneity and Protein Function in DBA
    Role: Principal Investigator
  2. P50HL054785 (NATHAN, DAVID G.) Sep 30, 1995 - Aug 31, 2005
    NIH/NHLBI
    STEM CELL THERAPY OF CONGENITAL DEFECTS IN HEMATOPOIESIS
    Role: Co-Principal Investigator
  3. R01HL055709 (SIEFF, COLIN A) Sep 30, 1995 - Aug 31, 1999
    NIH/NHLBI
    TRANSPLANT BIOLOGY, GENE TRANSFER, AND STEM CELL SOURCES
    Role: Principal Investigator
  4. R01DK042260 (SIEFF, COLIN A) Apr 15, 1989 - Mar 31, 1994
    NIH/NIDDK
    HUMAN IMMUNODEFICIENCY VIRUS AND HEMATOPOIESIS
    Role: Principal Investigator
  5. R01CA045559 (SIEFF, COLIN A) Sep 1, 1987 - Feb 28, 1997
    NIH/NCI
    SOURCES AND ACTIONS OF GM-CSF AND MULTI-CSF
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Joyce CE, Saadatpour A, Ruiz-Gutierrez M, Bolukbasi OV, Jiang L, Thomas DD, Young S, Hofmann I, Sieff C, Myers KC, Whangbo J, Libermann TA, Nusbaum C, Yuan GC, Shimamura A, Novina CD. TGFß signaling underlies hematopoietic dysfunction and bone marrow failure in Shwachman-Diamond Syndrome. J Clin Invest. 2019 Jun 18; 130. PMID: 31211692.
    Citations:    
  2. Gallagher PG, Maksimova Y, Lezon-Geyda K, Newburger PE, Medeiros D, Hanson RD, Rothman J, Israels S, Wall DA, Sidonio RF, Sieff C, Gowans LK, Mittal N, Rivera-Santiago R, Speicher DW, Baserga SJ, Schulz VP. Aberrant splicing contributes to severe a-spectrin-linked congenital hemolytic anemia. J Clin Invest. 2019 Apr 30; 130:2878-2887. PMID: 31038472.
    Citations:    
  3. Parsa A, Nazal MR, Stelzer JW, Sieff CA, Martin SD. A Successful Collaborative Approach to the Perioperative Management After Hip Arthroscopy of a Patient with Heterozygous Prothrombin G20210A Mutation: A Case Report. JBJS Case Connect. 2019 Apr-Jun; 9(2):e0376. PMID: 31085938.
    Citations:    
  4. Ulirsch JC, Verboon JM, Kazerounian S, Guo MH, Yuan D, Ludwig LS, Handsaker RE, Abdulhay NJ, Fiorini C, Genovese G, Lim ET, Cheng A, Cummings BB, Chao KR, Beggs AH, Genetti CA, Sieff CA, Newburger PE, Niewiadomska E, Matysiak M, Vlachos A, Lipton JM, Atsidaftos E, Glader B, Narla A, Gleizes PE, O'Donohue MF, Montel-Lehry N, Amor DJ, McCarroll SA, O'Donnell-Luria AH, Gupta N, Gabriel SB, MacArthur DG, Lander ES, Lek M, Da Costa L, Nathan DG, Korostelev AA, Do R, Sankaran VG, Gazda HT. The Genetic Landscape of Diamond-Blackfan Anemia. Am J Hum Genet. 2019 Feb 07; 104(2):356. PMID: 30735661.
    Citations:    
  5. Ulirsch JC, Verboon JM, Kazerounian S, Guo MH, Yuan D, Ludwig LS, Handsaker RE, Abdulhay NJ, Fiorini C, Genovese G, Lim ET, Cheng A, Cummings BB, Chao KR, Beggs AH, Genetti CA, Sieff CA, Newburger PE, Niewiadomska E, Matysiak M, Vlachos A, Lipton JM, Atsidaftos E, Glader B, Narla A, Gleizes PE, O'Donohue MF, Montel-Lehry N, Amor DJ, McCarroll SA, O'Donnell-Luria AH, Gupta N, Gabriel SB, MacArthur DG, Lander ES, Lek M, Da Costa L, Nathan DG, Korostelev AA, Do R, Sankaran VG, Gazda HT. The Genetic Landscape of Diamond-Blackfan Anemia. Am J Hum Genet. 2018 12 06; 103(6):930-947. PMID: 30503522.
    Citations:    Fields:    
  6. Sieff CA. Acquired and Inherited Bone Marrow Failure Syndromes. Hematol Oncol Clin North Am. 2018 08; 32(4):xiii-xiv. PMID: 30047424.
    Citations:    Fields:    
  7. Sieff CA. Introduction to Acquired and Inherited Bone Marrow Failure. Hematol Oncol Clin North Am. 2018 08; 32(4):569-580. PMID: 30047411.
    Citations:    Fields:    
  8. Riley LG, Heeney MM, Rudinger-Thirion J, Frugier M, Campagna DR, Zhou R, Hale GA, Hilliard LM, Kaplan JA, Kwiatkowski JL, Sieff CA, Steensma DP, Rennings AJ, Simons A, Schaap N, Roodenburg RJ, Kleefstra T, Arenillas L, Fita-Torró J, Ahmed R, Abboud M, Bechara E, Farah R, Tamminga RYJ, Bottomley SS, Sanchez M, Huls G, Swinkels DW, Christodoulou J, Fleming MD. The phenotypic spectrum of germline YARS2 variants: from isolated sideroblastic anemia to mitochondrial myopathy, lactic acidosis and sideroblastic anemia 2. Haematologica. 2018 Dec; 103(12):2008-2015. PMID: 30026338.
    Citations:    
  9. Li H, Lodish HF, Sieff CA. Critical Issues in Diamond-Blackfan Anemia and Prospects for Novel Treatment. Hematol Oncol Clin North Am. 2018 Aug; 32(4):701-712. PMID: 30047421.
    Citations:    Fields:    
  10. Doulatov S, Vo LT, Macari ER, Wahlster L, Kinney MA, Taylor AM, Barragan J, Gupta M, McGrath K, Lee HY, Humphries JM, DeVine A, Narla A, Alter BP, Beggs AH, Agarwal S, Ebert BL, Gazda HT, Lodish HF, Sieff CA, Schlaeger TM, Zon LI, Daley GQ. Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors. Sci Transl Med. 2017 02 08; 9(376). PMID: 28179501.
    Citations: 12     Fields:    Translation:HumansCells
  11. Li H, Sieff C. Characteristic peripheral blood smear findings in disorders of cobalamin metabolism. Blood. 2016 11 24; 128(21):2584. PMID: 27884837.
    Citations:    Fields:    Translation:HumansCells
  12. Jabara HH, Boyden SE, Chou J, Ramesh N, Massaad MJ, Benson H, Bainter W, Fraulino D, Rahimov F, Sieff C, Liu ZJ, Alshemmari SH, Al-Ramadi BK, Al-Dhekri H, Arnaout R, Abu-Shukair M, Vatsayan A, Silver E, Ahuja S, Davies EG, Sola-Visner M, Ohsumi TK, Andrews NC, Notarangelo LD, Fleming MD, Al-Herz W, Kunkel LM, Geha RS. A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. Nat Genet. 2016 Jan; 48(1):74-8. PMID: 26642240.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  13. Ludwig LS, Gazda HT, Eng JC, Eichhorn SW, Thiru P, Ghazvinian R, George TI, Gotlib JR, Beggs AH, Sieff CA, Lodish HF, Lander ES, Sankaran VG. Altered translation of GATA1 in Diamond-Blackfan anemia. Nat Med. 2014 Jul; 20(7):748-53. PMID: 24952648.
    Citations: 58     Fields:    Translation:HumansCells
  14. Williams DA, Bennett C, Bertuch A, Bessler M, Coates T, Corey S, Dror Y, Huang J, Lipton J, Olson TS, Reiss UM, Rogers ZR, Sieff C, Vlachos A, Walkovich K, Wang W, Shimamura A. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): an initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC). Pediatr Blood Cancer. 2014 May; 61(5):869-74. PMID: 24285674.
    Citations: 4     Fields:    Translation:Humans
  15. Landowski M, O'Donohue MF, Buros C, Ghazvinian R, Montel-Lehry N, Vlachos A, Sieff CA, Newburger PE, Niewiadomska E, Matysiak M, Glader B, Atsidaftos E, Lipton JM, Beggs AH, Gleizes PE, Gazda HT. Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia. Hum Genet. 2013 Nov; 132(11):1265-74. PMID: 23812780.
    Citations: 37     Fields:    Translation:HumansCells
  16. Sankaran VG, Ghazvinian R, Do R, Thiru P, Vergilio JA, Beggs AH, Sieff CA, Orkin SH, Nathan DG, Lander ES, Gazda HT. Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. J Clin Invest. 2012 Jul; 122(7):2439-43. PMID: 22706301.
    Citations: 97     Fields:    Translation:HumansCells
  17. Gazda HT, Preti M, Sheen MR, O'Donohue MF, Vlachos A, Davies SM, Kattamis A, Doherty L, Landowski M, Buros C, Ghazvinian R, Sieff CA, Newburger PE, Niewiadomska E, Matysiak M, Glader B, Atsidaftos E, Lipton JM, Gleizes PE, Beggs AH. Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. Hum Mutat. 2012 Jul; 33(7):1037-44. PMID: 22431104.
    Citations: 44     Fields:    Translation:HumansCells
  18. Crétien A, Proust A, Delaunay J, Rincé P, Leblanc T, Ducrocq R, Simansour M, Marie I, Tamary H, Meerpohl J, Niemeyer C, Gazda H, Sieff C, Ball S, Tchernia G, Mohandas N, Da Costa L. Genetic variants in the noncoding region of RPS19 gene in Diamond-Blackfan anemia: potential implications for phenotypic heterogeneity. Am J Hematol. 2010 Feb; 85(2):111-6. PMID: 20054847.
    Citations: 5     Fields:    Translation:Humans
  19. Doherty L, Sheen MR, Vlachos A, Choesmel V, O'Donohue MF, Clinton C, Schneider HE, Sieff CA, Newburger PE, Ball SE, Niewiadomska E, Matysiak M, Glader B, Arceci RJ, Farrar JE, Atsidaftos E, Lipton JM, Gleizes PE, Gazda HT. Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. Am J Hum Genet. 2010 Feb 12; 86(2):222-8. PMID: 20116044.
    Citations: 77     Fields:    Translation:HumansCells
  20. Sieff CA, Yang J, Merida-Long LB, Lodish HF. Pathogenesis of the erythroid failure in Diamond Blackfan anaemia. Br J Haematol. 2010 Feb; 148(4):611-22. PMID: 19958353.
    Citations: 21     Fields:    Translation:HumansCells
  21. Gazda HT, Sheen MR, Vlachos A, Choesmel V, O'Donohue MF, Schneider H, Darras N, Hasman C, Sieff CA, Newburger PE, Ball SE, Niewiadomska E, Matysiak M, Zaucha JM, Glader B, Niemeyer C, Meerpohl JJ, Atsidaftos E, Lipton JM, Gleizes PE, Beggs AH. Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. Am J Hum Genet. 2008 Dec; 83(6):769-80. PMID: 19061985.
    Citations: 136     Fields:    Translation:HumansCells
  22. Farrar JE, Nater M, Caywood E, McDevitt MA, Kowalski J, Takemoto CM, Talbot CC, Meltzer P, Esposito D, Beggs AH, Schneider HE, Grabowska A, Ball SE, Niewiadomska E, Sieff CA, Vlachos A, Atsidaftos E, Ellis SR, Lipton JM, Gazda HT, Arceci RJ. Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia. Blood. 2008 Sep 01; 112(5):1582-92. PMID: 18535205.
    Citations: 88     Fields:    Translation:HumansCells
  23. Gazda HT, Grabowska A, Merida-Long LB, Latawiec E, Schneider HE, Lipton JM, Vlachos A, Atsidaftos E, Ball SE, Orfali KA, Niewiadomska E, Da Costa L, Tchernia G, Niemeyer C, Meerpohl JJ, Stahl J, Schratt G, Glader B, Backer K, Wong C, Nathan DG, Beggs AH, Sieff CA. Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia. Am J Hum Genet. 2006 Dec; 79(6):1110-8. PMID: 17186470.
    Citations: 99     Fields:    Translation:HumansCells
  24. Gazda HT, Sieff CA. Recent insights into the pathogenesis of Diamond-Blackfan anaemia. Br J Haematol. 2006 Oct; 135(2):149-57. PMID: 16942586.
    Citations: 18     Fields:    Translation:HumansAnimals
  25. Gazda HT, Kho AT, Sanoudou D, Zaucha JM, Kohane IS, Sieff CA, Beggs AH. Defective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia. Stem Cells. 2006 Sep; 24(9):2034-44. PMID: 16741228.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  26. Quigley JG, Gazda H, Yang Z, Ball S, Sieff CA, Abkowitz JL. Investigation of a putative role for FLVCR, a cytoplasmic heme exporter, in Diamond-Blackfan anemia. Blood Cells Mol Dis. 2005 Sep-Oct; 35(2):189-92. PMID: 15996880.
    Citations: 12     Fields:    Translation:HumansCells
  27. Ebert BL, Lee MM, Pretz JL, Subramanian A, Mak R, Golub TR, Sieff CA. An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray. Blood. 2005 Jun 15; 105(12):4620-6. PMID: 15755903.
    Citations: 33     Fields:    Translation:HumansCells
  28. Shikama Y, Shichishima T, Matsuoka I, Jubinsky PT, Sieff CA, Maruyama Y. Accumulation of an intron-retained mRNA for granulocyte macrophage-colony stimulating factor receptor common beta chain in neutrophils of myelodysplastic syndromes. J Leukoc Biol. 2005 May; 77(5):811-9. PMID: 15728248.
    Citations: 3     Fields:    Translation:HumansCells
  29. Gazda HT, Zhong R, Long L, Niewiadomska E, Lipton JM, Ploszynska A, Zaucha JM, Vlachos A, Atsidaftos E, Viskochil DH, Niemeyer CM, Meerpohl JJ, Rokicka-Milewska R, Pospisilova D, Wiktor-Jedrzejczak W, Nathan DG, Beggs AH, Sieff CA. RNA and protein evidence for haplo-insufficiency in Diamond-Blackfan anaemia patients with RPS19 mutations. Br J Haematol. 2004 Oct; 127(1):105-13. PMID: 15384984.
    Citations: 36     Fields:    Translation:HumansCells
  30. Gazda H, Lipton JM, Willig TN, Ball S, Niemeyer CM, Tchernia G, Mohandas N, Daly MJ, Ploszynska A, Orfali KA, Vlachos A, Glader BE, Rokicka-Milewska R, Ohara A, Baker D, Pospisilova D, Webber A, Viskochil DH, Nathan DG, Beggs AH, Sieff CA. Evidence for linkage of familial Diamond-Blackfan anemia to chromosome 8p23.3-p22 and for non-19q non-8p disease. Blood. 2001 Apr 01; 97(7):2145-50. PMID: 11264183.
    Citations: 10     Fields:    Translation:HumansCells
  31. Sieff CA, Nisbet-Brown E, Nathan DG. Congenital bone marrow failure syndromes. Br J Haematol. 2000 Oct; 111(1):30-42. PMID: 11091180.
    Citations: 4     Fields:    Translation:Humans
  32. Willig TN, Gazda H, Sieff CA. Diamond-Blackfan anemia. Curr Opin Hematol. 2000 Mar; 7(2):85-94. PMID: 10698294.
    Citations: 16     Fields:    Translation:Humans
  33. Kung AL, Rebel VI, Bronson RT, Ch'ng LE, Sieff CA, Livingston DM, Yao TP. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev. 2000 Feb 01; 14(3):272-7. PMID: 10673499.
    Citations: 125     Fields:    Translation:Animals
  34. Rebel VI, Hartnett S, Denham J, Chan M, Finberg R, Sieff CA. Maturation and lineage-specific expression of the coxsackie and adenovirus receptor in hematopoietic cells. Stem Cells. 2000; 18(3):176-82. PMID: 10840070.
    Citations: 9     Fields:    Translation:HumansCells
  35. Rebel VI, Hartnett S, Hill GR, Lazo-Kallanian SB, Ferrara JL, Sieff CA. Essential role for the p55 tumor necrosis factor receptor in regulating hematopoiesis at a stem cell level. J Exp Med. 1999 Nov 15; 190(10):1493-504. PMID: 10562323.
    Citations: 27     Fields:    Translation:AnimalsCells
  36. Nathan DG, Sieff CA. Pure red-cell aplasia. N Engl J Med. 1999 Jun 24; 340(25):2004; author reply 2005. PMID: 10383281.
    Citations:    Fields:    Translation:HumansCells
  37. Rebel VI, Tanaka M, Lee JS, Hartnett S, Pulsipher M, Nathan DG, Mulligan RC, Sieff CA. One-day ex vivo culture allows effective gene transfer into human nonobese diabetic/severe combined immune-deficient repopulating cells using high-titer vesicular stomatitis virus G protein pseudotyped retrovirus. Blood. 1999 Apr 01; 93(7):2217-24. PMID: 10090930.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  38. Taylor DS, Lee Y, Sieff CA, Homans A, Garrison L, Guinan EC. Phase I/II trial of PIXY321 (granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein) for treatment of inherited and acquired marrow failure syndromes. Br J Haematol. 1998 Nov; 103(2):304-7. PMID: 9827896.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  39. Pulsipher M, Kupfer GM, Naf D, Suliman A, Lee JS, Jakobs P, Grompe M, Joenje H, Sieff C, Guinan E, Mulligan R, D'Andrea AD. Subtyping analysis of Fanconi anemia by immunoblotting and retroviral gene transfer. Mol Med. 1998 Jul; 4(7):468-79. PMID: 9713825.
    Citations: 11     Fields:    Translation:HumansCells
  40. Aiuti A, Friedrich C, Sieff CA, Gutierrez-Ramos JC. Identification of distinct elements of the stromal microenvironment that control human hematopoietic stem/progenitor cell growth and differentiation. Exp Hematol. 1998 Feb; 26(2):143-57. PMID: 9472804.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  41. Krijanovski OI, Sieff CA. Diamond-Blackfan anemia. Hematol Oncol Clin North Am. 1997 Dec; 11(6):1061-77. PMID: 9443046.
    Citations: 2     Fields:    Translation:Humans
  42. Goodell MA, Rosenzweig M, Kim H, Marks DF, DeMaria M, Paradis G, Grupp SA, Sieff CA, Mulligan RC, Johnson RP. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med. 1997 Dec; 3(12):1337-45. PMID: 9396603.
    Citations: 223     Fields:    Translation:HumansAnimalsCells
  43. Jubinsky PT, Krijanovski OI, Nathan DG, Tavernier J, Sieff CA. The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor. Blood. 1997 Sep 01; 90(5):1867-73. PMID: 9292519.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  44. Benjamin RJ, Linsley L, Fountain D, Churchill WH, Sieff C, Cannon ME, Uhl L, Gaynes L, Antin JH, Wheeler C. Preapheresis peripheral blood CD34+ mononuclear cell counts as predictors of progenitor cell yield. Transfusion. 1997 Jan; 37(1):79-85. PMID: 9024494.
    Citations: 3     Fields:    Translation:HumansCells
  45. Chen L, Pulsipher M, Chen D, Sieff C, Elias A, Fine HA, Kufe DW. Selective transgene expression for detection and elimination of contaminating carcinoma cells in hematopoietic stem cell sources. J Clin Invest. 1996 Dec 01; 98(11):2539-48. PMID: 8958216.
    Citations: 9     Fields:    Translation:HumansCells
  46. Jubinsky PT, Shikama Y, Laurie A, Nathan DG, Carroll M, Sieff CA. The beta c component of the granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin 3 (IL-3)/IL-5 receptor interacts with a hybrid GM-CSF/erythropoietin receptor to influence proliferation and beta-globin mRNA expression. Mol Med. 1996 Nov; 2(6):766-73. PMID: 8972491.
    Citations:    Fields:    Translation:HumansAnimalsCells
  47. Shikama Y, Barber DL, D'Andrea AD, Sieff CA. A constitutively activated chimeric cytokine receptor confers factor-independent growth in hematopoietic cell lines. Blood. 1996 Jul 15; 88(2):455-64. PMID: 8695792.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  48. Gribben JG, Guinan EC, Boussiotis VA, Ke XY, Linsley L, Sieff C, Gray GS, Freeman GJ, Nadler LM. Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft-versus-host disease and extend the donor pool. Blood. 1996 Jun 01; 87(11):4887-93. PMID: 8639863.
    Citations: 17     Fields:    Translation:HumansCells
  49. Pratt JC, Weiss M, Sieff CA, Shoelson SE, Burakoff SJ, Ravichandran KS. Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor. J Biol Chem. 1996 May 24; 271(21):12137-40. PMID: 8647804.
    Citations: 14     Fields:    Translation:AnimalsCells
  50. Benjamin RJ, Linsley L, Axelrod JD, Churchill WH, Sieff C, Shulman LN, Elias A, Ayash L, Malachowski ME, Uhl L, et al. The collection and evaluation of peripheral blood progenitor cells sufficient for repetitive cycles of high-dose chemotherapy support. Transfusion. 1995 Oct; 35(10):837-44. PMID: 7570914.
    Citations:    Fields:    Translation:HumansCells
  51. Blobel GA, Sieff CA, Orkin SH. Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor. Mol Cell Biol. 1995 Jun; 15(6):3147-53. PMID: 7760810.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  52. Busque L, Gilliland DG, Prchal JT, Sieff CA, Weinstein HJ, Sokol JM, Belickova M, Wayne AS, Zuckerman KS, Sokol L, et al. Clonality in juvenile chronic myelogenous leukemia. Blood. 1995 Jan 01; 85(1):21-30. PMID: 7803795.
    Citations: 7     Fields:    Translation:HumansCells
  53. Jubinsky PT, Laurie AS, Nathan DG, Yetz-Aldepe J, Sieff CA. Expression and function of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit. Blood. 1994 Dec 15; 84(12):4174-85. PMID: 7994031.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  54. Sieff CA. Hematopoietic cell proliferation and differentiation. Curr Opin Hematol. 1994 Jul; 1(4):310-20. PMID: 9371298.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  55. Neben S, Donaldson D, Sieff C, Mauch P, Bodine D, Ferrara J, Yetz-Aldape J, Turner K. Synergistic effects of interleukin-11 with other growth factors on the expansion of murine hematopoietic progenitors and maintenance of stem cells in liquid culture. Exp Hematol. 1994 Apr; 22(4):353-9. PMID: 8150033.
    Citations: 3     Fields:    Translation:AnimalsCells
  56. Nathan DH, Sieff CA. [Regulation of hematopoiesis]. Gematol Transfuziol. 1994 Mar-Apr; 39(2):3-10. PMID: 8026686.
    Citations:    Fields:    Translation:HumansCells
  57. Weiss M, Yokoyama C, Shikama Y, Naugle C, Druker B, Sieff CA. Human granulocyte-macrophage colony-stimulating factor receptor signal transduction requires the proximal cytoplasmic domains of the alpha and beta subunits. Blood. 1993 Dec 01; 82(11):3298-306. PMID: 8241501.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  58. Sieff C, Guinan E. In vitro enhancement of erythropoiesis by steel factor in Diamond-Blackfan anemia and treatment of other congenital cytopenias with recombinant interleukin 3/granulocyte-macrophage colony stimulating factor. Stem Cells. 1993 Jul; 11 Suppl 2:113-22. PMID: 7691316.
    Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
  59. Jubinsky PT, Nathan DG, Wilson DJ, Sieff CA. A low-affinity human granulocyte-macrophage colony-stimulating factor/murine erythropoietin hybrid receptor functions in murine cell lines. Blood. 1993 Feb 01; 81(3):587-91. PMID: 8427955.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  60. Sieff CA, Yokoyama CT, Zsebo KM, Trammell J, Andersen JW, Nathan DG, Williams DA. The production of steel factor mRNA in Diamond-Blackfan anaemia long-term cultures and interactions of steel factor with erythropoietin and interleukin-3. Br J Haematol. 1992 Dec; 82(4):640-7. PMID: 1282827.
    Citations: 2     Fields:    Translation:HumansCells
  61. McCarthy PL, Abhyankar S, Neben S, Newman G, Sieff C, Thompson RC, Burakoff SJ, Ferrara JL. Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease. Blood. 1991 Oct 15; 78(8):1915-8. PMID: 1832996.
    Citations: 23     Fields:    Translation:Animals
  62. Antin JH, Bierer BE, Smith BR, Ferrara J, Guinan EC, Sieff C, Golan DE, Macklis RM, Tarbell NJ, Lynch E, et al. Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies. Blood. 1991 Oct 15; 78(8):2139-49. PMID: 1717080.
    Citations: 9     Fields:    Translation:HumansCells
  63. Sieff CA. New hats for hematopoietic hormones. Exp Hematol. 1991 Oct; 19(9):857-60. PMID: 1893960.
    Citations: 1     Fields:    
  64. Crosier KE, Wong GG, Mathey-Prevot B, Nathan DG, Sieff CA. A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7744-8. PMID: 1715577.
    Citations: 9     Fields:    Translation:HumansCells
  65. Ezekowitz RA, Sieff CA, Dinauer MC, Nathan DG, Orkin SH, Newburger PE. Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell. Blood. 1990 Dec 15; 76(12):2443-8. PMID: 2176110.
    Citations: 5     Fields:    Translation:HumansCells
  66. Guinan EC, Sieff CA, Oette DH, Nathan DG. A phase I/II trial of recombinant granulocyte-macrophage colony-stimulating factor for children with aplastic anemia. Blood. 1990 Sep 15; 76(6):1077-82. PMID: 2205306.
    Citations: 4     Fields:    Translation:HumansCells
  67. Sieff CA. Biology and clinical aspects of the hematopoietic growth factors. Annu Rev Med. 1990; 41:483-96. PMID: 2184746.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  68. Niemeyer CM, Sieff CA, Smith BR, Ault KA, Nathan DG. Hematopoiesis in vitro coexists with natural killer lymphocytes. Blood. 1989 Nov 15; 74(7):2376-82. PMID: 2529928.
    Citations: 3     Fields:    Translation:HumansCells
  69. Wimperis JZ, Niemeyer CM, Sieff CA, Mathey-Prevot B, Nathan DG, Arceci RJ. Granulocyte-macrophage colony-stimulating factor and interleukin-3 mRNAs are produced by a small fraction of blood mononuclear cells. Blood. 1989 Oct; 74(5):1525-30. PMID: 2676015.
    Citations: 4     Fields:    Translation:HumansCells
  70. Niemeyer CM, Sieff CA, Mathey-Prevot B, Wimperis JZ, Bierer BE, Clark SC, Nathan DG. Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines. Blood. 1989 Mar; 73(4):945-51. PMID: 2645952.
    Citations: 15     Fields:    Translation:HumansCells
  71. Sieff CA, Ekern SC, Nathan DG, Anderson JW. Combinations of recombinant colony-stimulating factors are required for optimal hematopoietic differentiation in serum-deprived culture. Blood. 1989 Feb 15; 73(3):688-93. PMID: 2644985.
    Citations: 7     Fields:    Translation:Humans
  72. Sieff CA, Niemeyer CM, Mentzer SJ, Faller DV. Interleukin-1, tumor necrosis factor, and the production of colony-stimulating factors by cultured mesenchymal cells. Blood. 1988 Oct; 72(4):1316-23. PMID: 2458780.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  73. Sieff CA, Niemeyer CM. The biology of the colony stimulating factors. Behring Inst Mitt. 1988 Aug; (83):93-7. PMID: 3266467.
    Citations:    Fields:    Translation:HumansAnimalsCells
  74. Sieff CA, Ekern S, Nathan DG. Combinations of purified recombinant colony-stimulating factors are required for optimal hematopoietic differentiation. Trans Assoc Am Physicians. 1988; 101:282-7. PMID: 2480018.
    Citations:    Fields:    Translation:HumansCells
  75. Sieff CA, Niemeyer CM, Faller DV. Human colony-stimulating factors and stromal cell function. Soc Gen Physiol Ser. 1988; 43:47-55. PMID: 3077558.
    Citations: 1     Fields:    Translation:HumansCells
  76. Sieff CA. The sources and actions of the human colony stimulating factors. Mead Johnson Symp Perinat Dev Med. 1988; (32):21-7. PMID: 2485454.
    Citations:    Fields:    Translation:HumansAnimalsCells
  77. Emerson SG, Sieff CA, Gross RG, Rozans MK, Miller RA, Rappeport JM, Nathan DG. Decreased hematopoietic accessory cell function following bone marrow transplantation. Exp Hematol. 1987 Nov; 15(10):1013-21. PMID: 2959495.
    Citations: 3     Fields:    Translation:HumansCells
  78. Sieff CA, Niemeyer CM, Nathan DG, Ekern SC, Bieber FR, Yang YC, Wong G, Clark SC. Stimulation of human hematopoietic colony formation by recombinant gibbon multi-colony-stimulating factor or interleukin 3. J Clin Invest. 1987 Sep; 80(3):818-23. PMID: 3497952.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  79. Miller BA, Perrine SP, Antognetti G, Perlmutter DH, Emerson SG, Sieff C, Faller DV. Gamma-interferon alters globin gene expression in neonatal and adult erythroid cells. Blood. 1987 Jun; 69(6):1674-81. PMID: 2437981.
    Citations: 2     Fields:    Translation:HumansCells
  80. Sieff CA. Hematopoietic growth factors. J Clin Invest. 1987 Jun; 79(6):1549-57. PMID: 3034976.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  81. Tsai S, Patel V, Beaumont E, Lodish HF, Nathan DG, Sieff CA. Differential binding of erythroid and myeloid progenitors to fibroblasts and fibronectin. Blood. 1987 Jun; 69(6):1587-94. PMID: 3580569.
    Citations: 12     Fields:    Translation:HumansCells
  82. Sieff CA, Niemeyer CM, Faller DV. The role of endothelial cells in hematopoiesis. Prog Clin Biol Res. 1987; 251:13-21. PMID: 3501586.
    Citations: 1     Fields:    Translation:HumansCells
  83. Sieff CA, Niemeyer CM, Faller DV. The production of hematopoietic growth factors by endothelial accessory cells. Blood Cells. 1987; 13(1-2):65-74. PMID: 3499195.
    Citations: 1     Fields:    Translation:HumansCells
  84. Sieff CA, Tsai S, Faller DV. Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor. J Clin Invest. 1987 Jan; 79(1):48-51. PMID: 3491839.
    Citations: 33     Fields:    Translation:HumansCells
  85. Nathan DG, Sieff CA. The biological activities and uses of recombinant granulocyte-macrophage and multi-colony stimulating factors. Prog Hematol. 1987; 15:1-18. PMID: 3332387.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  86. Arnaout MA, Wang EA, Clark SC, Sieff CA. Human recombinant granulocyte-macrophage colony-stimulating factor increases cell-to-cell adhesion and surface expression of adhesion-promoting surface glycoproteins on mature granulocytes. J Clin Invest. 1986 Aug; 78(2):597-601. PMID: 3090106.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  87. Tsai S, Sieff CA, Nathan DG. Stromal cell-associated erythropoiesis. Blood. 1986 May; 67(5):1418-26. PMID: 3516256.
    Citations: 6     Fields:    Translation:HumansCells
  88. Tsai S, Emerson SG, Sieff CA, Nathan DG. Isolation of a human stromal cell strain secreting hemopoietic growth factors. J Cell Physiol. 1986 Apr; 127(1):137-45. PMID: 3514636.
    Citations: 7     Fields:    Translation:HumansCells
  89. Morgan G, Linch DC, Knott LT, Davies EG, Sieff C, Chessells JM, Hale G, Waldmann H, Levinsky RJ. Successful haploidentical mismatched bone marrow transplantation in severe combined immunodeficiency: T cell removal using CAMPATH-I monoclonal antibody and E-rosetting. Br J Haematol. 1986 Mar; 62(3):421-30. PMID: 3513818.
    Citations: 1     Fields:    Translation:HumansCells
  90. Sieff CA. Membrane antigen expression during hemopoietic differentiation. Crit Rev Oncol Hematol. 1986; 5(1):1-36. PMID: 3006941.
    Citations:    Fields:    Translation:HumansAnimalsCells
  91. Sieff CA, Emerson SG, Mufson A, Gesner TG, Nathan DG. Dependence of highly enriched human bone marrow progenitors on hemopoietic growth factors and their response to recombinant erythropoietin. J Clin Invest. 1986 Jan; 77(1):74-81. PMID: 3511093.
    Citations: 15     Fields:    Translation:HumansCells
  92. Sieff CA, Emerson SG, Donahue RE, Nathan DG, Wang EA, Wong GG, Clark SC. Human recombinant granulocyte-macrophage colony-stimulating factor: a multilineage hematopoietin. Science. 1985 Dec 06; 230(4730):1171-3. PMID: 3877981.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  93. Emerson SG, Sieff CA, Wang EA, Wong GG, Clark SC, Nathan DG. Purification of fetal hematopoietic progenitors and demonstration of recombinant multipotential colony-stimulating activity. J Clin Invest. 1985 Sep; 76(3):1286-90. PMID: 3876355.
    Citations: 29     Fields:    Translation:HumansCells
  94. Greaves MF, Katz FE, Myers CD, Davies L, Sieff C. Selective expression of cell surface antigens on human haemopoietic progenitor cells. Prog Clin Biol Res. 1985; 184:301-15. PMID: 3863145.
    Citations:    Fields:    Translation:HumansCells
  95. Sieff C. Pure red cell aplasia. Br J Haematol. 1983 Jul; 54(3):331-6. PMID: 6860587.
    Citations: 1     Fields:    Translation:HumansCells
  96. Greaves MF, Sieff C, Edwards PA. Monoclonal antiglycophorin as a probe for erythroleukemias. Blood. 1983 Apr; 61(4):645-51. PMID: 6572533.
    Citations: 7     Fields:    Translation:Humans
  97. Sieff CA, Chessells JM, Levinsky RJ, Pritchard J, Rogers DW, Casey A, Muller K, Hall CM. Allogeneic bone-marrow transplantation in infantile malignant osteopetrosis. Lancet. 1983 Feb 26; 1(8322):437-41. PMID: 6131166.
    Citations: 10     Fields:    Translation:Humans
  98. Sieff C, Bicknell D, Caine G, Edwards PA, Greaves M. Antigen expression on normal and leukaemic erythroid precursors. Haematol Blood Transfus. 1983; 28:397-402. PMID: 6574959.
    Citations:    Fields:    Translation:HumansCells
  99. Chessells JM, Sieff CA, Rankin A. Acute myeloid leukaemia in childhood: treatment in the United Kingdom. Haematol Blood Transfus. 1983; 28:51-5. PMID: 6345293.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  100. Sieff C, Bicknell D, Caine G, Robinson J, Lam G, Greaves MF. Changes in cell surface antigen expression during hemopoietic differentiation. Blood. 1982 Sep; 60(3):703-13. PMID: 6286014.
    Citations: 31     Fields:    Translation:HumansCells
  101. Purtilo DT, Sakamoto K, Saemundsen AK, Sullivan JL, Synnerholm AC, Anvret M, Pritchard J, Sloper C, Sieff C, Pincott J, Pachman L, Rich K, Cruzi F, Cornet JA, Collins R, Barnes N, Knight J, Sandstedt B, Klein G. Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative diseases by clinical, virological, and immunopathological studies. Cancer Res. 1981 Nov; 41(11 Pt 1):4226-36. PMID: 6272967.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  102. Masucci MG, Szigeti R, Ernberg I, Masucci G, Klein G, Chessels J, Sieff C, Lie S, Glomstein A, Businco L, Henle W, Henle G, Pearson G, Sakamoto K, Purtilo DT. Cellular immune defects to Epstein-Barr virus-determined antigens in young males. Cancer Res. 1981 Nov; 41(11 Pt 1):4284-91. PMID: 6171337.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  103. Sieff CA, Chessells JM, Harvey BA, Pickthall VJ, Lawler SD. Monosomy 7 in childhood: a myeloproliferative disorder. Br J Haematol. 1981 Oct; 49(2):235-49. PMID: 6945867.
    Citations: 11     Fields:    Translation:HumansCells
  104. Greaves M, Robinson J, Delia D, Sutherland R, Newman R, Sieff C. Mapping cell surface antigen expression of haemopoietic progenitor cells using monoclonal antibodies. Ciba Found Symp. 1981; 84:109-29. PMID: 6168448.
    Citations:    Fields:    Translation:HumansAnimalsCells
  105. Robinson J, Sieff C, Delia D, Edwards PA, Greaves M. Expression of cell-surface HLA-DR, HLA-ABC and glycophorin during erythroid differentiation. Nature. 1981 Jan 01; 289(5793):68-71. PMID: 6161308.
    Citations: 22     Fields:    Translation:HumansCells
  106. Linch DC, Cawley JC, MacDonald SM, Masters G, Roberts BE, Antonis AH, Waters AK, Sieff C, Lydyard PM. Acquired pure red-cell aplasia associated with an increase of T cells bearing receptors for the Fc of IgG. Acta Haematol. 1981; 65(4):270-4. PMID: 6789590.
    Citations: 4     Fields:    Translation:HumansCells
  107. Greaves MF, Robinson JB, Delia D, Ritz J, Schlossman S, Sieff C, Goldstein G, Kung P, Bollum FJ, Edwards PA. Comparative antigenic phenotypes of normal and leukemic hemopoietic precursor cells analysed with a "library" of monoclonal antibodies. Haematol Blood Transfus. 1981; 26:296-304. PMID: 6947934.
    Citations:    Fields:    Translation:HumansCells
  108. Sieff CA, Malleson P. Familial myelofibrosis. Arch Dis Child. 1980 Nov; 55(11):888-93. PMID: 7436463.
    Citations: 3     Fields:    Translation:Humans
  109. Sieff CA, Chessells JM. The response of a child with primary sideroblastic anemia to cyclophosphamide. Blood. 1980 Aug; 56(2):323. PMID: 7397385.
    Citations:    Fields:    Translation:Humans
  110. Torok-Storb BJ, Sieff C, Storb R, Adamson J, Thomas ED. In vitro tests for distinguishing possible immune-mediated aplastic anemia from transfusion-induced sensitization. Blood. 1980 Feb; 55(2):211-5. PMID: 7353071.
    Citations: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.