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Benedikt L Proffen, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sanborn RM, Badger GJ, Yen YM, Murray MM, Christino MA, Proffen B, Sant N, Barnett S, Fleming BC, Kramer DE, Micheli LJ. Psychological Readiness to Return to Sport at 6 Months Is Higher After Bridge-Enhanced ACL Restoration Than Autograft ACL Reconstruction: Results of a Prospective Randomized Clinical Trial. Orthop J Sports Med. 2022 Feb; 10(2):23259671211070542. PMID: 35155707.
  2. Barnett SC, Murray MM, Flannery SW, Menghini D, Fleming BC, Kiapour AM, Proffen B, Sant N, Portilla G, Sanborn R, Freiberger C, Henderson R, Ecklund K, Yen YM, Kramer D, Micheli L. ACL Size, but Not Signal Intensity, Is Influenced by Sex, Body Size, and Knee Anatomy. Orthop J Sports Med. 2021 Dec; 9(12):23259671211063836. PMID: 34988237.
  3. Barnett SC, Murray MM, Badger GJ, Yen YM, Kramer DE, Sanborn R, Kiapour A, Proffen B, Sant N, Fleming BC, Micheli LJ. Earlier Resolution of Symptoms and Return of Function After Bridge-Enhanced Anterior Cruciate Ligament Repair As Compared With Anterior Cruciate Ligament Reconstruction. Orthop J Sports Med. 2021 Nov; 9(11):23259671211052530. PMID: 34778483.
    Citations: 1     
  4. Kiapour AM, Flannery SW, Murray MM, Miller PE, Proffen BL, Sant N, Portilla G, Sanborn R, Freiberger C, Henderson R, Barnett S, Ecklund K, Yen YM, Kramer DE, Micheli LJ, Fleming BC. Regional Differences in Anterior Cruciate Ligament Signal Intensity After Surgical Treatment. Am J Sports Med. 2021 12; 49(14):3833-3841. PMID: 34668789.
    Citations:    Fields:    Translation:Humans
  5. Sant NJ, Proffen BL, Murray MM. Effects of radiation dose and nitrogen purge on collagen scaffold properties. J Biomater Appl. 2022 01; 36(6):1011-1018. PMID: 34607497.
    Citations:    Fields:    
  6. Costa MQ, Murray MM, Sieker JT, Karamchedu NP, Proffen BL, Fleming BC. Peripheral shift in the viable chondrocyte population of the medial femoral condyle after anterior cruciate ligament injury in the porcine knee. PLoS One. 2021; 16(8):e0256765. PMID: 34437631.
    Citations:    Fields:    Translation:AnimalsCells
  7. Karamchedu NP, Fleming BC, Donnenfield JI, Proffen BL, Costa MQ, Molino J, Murray MM. Enrichment of inflammatory mediators in the synovial fluid is associated with slower progression of mild to moderate osteoarthritis in the porcine knee. Am J Transl Res. 2021; 13(7):7667-7676. PMID: 34377243.
  8. Karamchedu NP, Fleming BC, Proffen BL, Sant NJ, Portilla G, Parola LR, Molino J, Murray MM. Terminal sterilization influences the efficacy of an extracellular matrix-blood composite for treating posttraumatic osteoarthritis in the rat model. J Orthop Res. 2022 Mar; 40(3):573-583. PMID: 33913543.
    Citations:    Fields:    
  9. Karamchedu NP, Murray MM, Sieker JT, Proffen BL, Portilla G, Costa MQ, Molino J, Fleming BC. Bridge-Enhanced Anterior Cruciate Ligament Repair Leads to Greater Limb Asymmetry and Less Cartilage Damage Than Untreated ACL Transection or ACL Reconstruction in the Porcine Model. Am J Sports Med. 2021 03; 49(3):667-674. PMID: 33534613.
    Citations: 4     Fields:    Translation:Animals
  10. Freiberger C, Kiapour AM, Liu S, Henderson RN, Barnett S, Sant NJ, Proffen BL, Fleming BC, Ecklund K, Kramer DE, Micheli LJ, Murray MM, Yen YM. Higher Physiologic Platelet Counts in Whole Blood Are Not Associated With Improved ACL Cross-sectional Area or Signal Intensity 6 Months After Bridge-Enhanced ACL Repair. Orthop J Sports Med. 2020 Jul; 8(7):2325967120927655. PMID: 32656289.
    Citations: 2     
  11. Barnett S, Badger GJ, Kiapour A, Yen YM, Henderson R, Freiberger C, Proffen B, Sant N, Trainor B, Fleming BC, Micheli LJ, Murray MM, Kramer DE. Females Have Earlier Muscle Strength and Functional Recovery After Bridge-Enhanced Anterior Cruciate Ligament Repair. Tissue Eng Part A. 2020 07; 26(13-14):702-711. PMID: 32589515.
    Citations: 1     Fields:    Translation:Humans
  12. Murray MM, Fleming BC, Badger GJ, Freiberger C, Henderson R, Barnett S, Kiapour A, Ecklund K, Proffen B, Sant N, Kramer DE, Micheli LJ, Yen YM. Bridge-Enhanced Anterior Cruciate Ligament Repair Is Not Inferior to Autograft Anterior Cruciate Ligament Reconstruction at 2 Years: Results of a Prospective Randomized Clinical Trial. Am J Sports Med. 2020 05; 48(6):1305-1315. PMID: 32298131.
    Citations: 22     Fields:    Translation:Humans
  13. Ayturk UM, Sieker JT, Haslauer CM, Proffen BL, Weissenberger MH, Warman ML, Fleming BC, Murray MM. Proteolysis and cartilage development are activated in the synovium after surgical induction of post traumatic osteoarthritis. PLoS One. 2020; 15(2):e0229449. PMID: 32107493.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. O'Keefe RJ, Tuan RS, Lane NE, Awad HA, Barry F, Bunnell BA, Colnot C, Drake MT, Drissi H, Dyment NA, Fortier LA, Guldberg RE, Kandel R, Little DG, Marshall MF, Mao JJ, Nakamura N, Proffen BL, Rodeo SA, Rosen V, Thomopoulos S, Schwarz EM, Serra R. American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies - Secondary Publication. J Orthop Res. 2020 03; 38(3):485-502. PMID: 31994782.
    Citations: 3     Fields:    
  15. O'Keefe RJ, Tuan RS, Lane NE, Awad HA, Barry F, Bunnell BA, Colnot C, Drake MT, Drissi H, Dyment NA, Fortier LA, Guldberg RE, Kandel R, Little DG, Marshall MF, Mao JJ, Nakamura N, Proffen BL, Rodeo SA, Rosen V, Thomopoulos S, Schwarz EM, Serra R. American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies. J Bone Miner Res. 2020 01; 35(1):3-17. PMID: 31545883.
    Citations: 7     Fields:    Translation:Humans
  16. Beveridge JE, Proffen BL, Karamchedu NP, Chin KE, Sieker JT, Badger GJ, Kiapour AM, Murray MM, Fleming BC. Cartilage Damage Is Related to ACL Stiffness in a Porcine Model of ACL Repair. J Orthop Res. 2019 10; 37(10):2249-2257. PMID: 31125133.
    Citations: 4     Fields:    Translation:Animals
  17. Murray MM, Kalish LA, Fleming BC, Flutie B, Freiberger C, Henderson RN, Perrone GS, Thurber LG, Proffen BL, Ecklund K, Kramer DE, Yen YM, Micheli LJ. Bridge-Enhanced Anterior Cruciate Ligament Repair: Two-Year Results of a First-in-Human Study. Orthop J Sports Med. 2019 Mar; 7(3):2325967118824356. PMID: 30923725.
    Citations: 36     
  18. Kiapour AM, Sieker JT, Proffen BL, Lam TT, Fleming BC, Murray MM. Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: Proteomics analysis of porcine knee synovial fluid. PLoS One. 2019; 14(3):e0212662. PMID: 30822327.
    Citations: 2     Fields:    Translation:Animals
  19. Sieker JT, Proffen BL, Waller KA, Chin KE, Karamchedu NP, Akelman MR, Perrone GS, Kiapour AM, Konrad J, Fleming BC, Murray MM. Transcriptional profiling of synovium in a porcine model of early post-traumatic osteoarthritis. J Orthop Res. 2018 Feb 20. PMID: 29460983.
    Citations: 6     Fields:    
  20. Beveridge JE, Machan JT, Walsh EG, Kiapour AM, Karamchedu NP, Chin KE, Proffen BL, Sieker JT, Murray MM, Fleming BC. Magnetic resonance measurements of tissue quantity and quality using T2 * relaxometry predict temporal changes in the biomechanical properties of the healing ACL. J Orthop Res. 2018 06; 36(6):1701-1709. PMID: 29227559.
    Citations: 15     Fields:    Translation:Animals
  21. Sieker JT, Proffen BL, Waller KA, Chin KE, Karamchedu NP, Akelman MR, Perrone GS, Kiapour AM, Konrad J, Murray MM, Fleming BC. Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis. J Orthop Res. 2018 01; 36(1):318-329. PMID: 28671352.
    Citations: 16     Fields:    Translation:Animals
  22. Perrone GS, Proffen BL, Kiapour AM, Sieker JT, Fleming BC, Murray MM. Bench-to-bedside: Bridge-enhanced anterior cruciate ligament repair. J Orthop Res. 2017 12; 35(12):2606-2612. PMID: 28608618.
    Citations: 11     Fields:    Translation:HumansAnimals
  23. Murray MM, Flutie BM, Kalish LA, Ecklund K, Fleming BC, Proffen BL, Micheli LJ. The Bridge-Enhanced Anterior Cruciate Ligament Repair (BEAR) Procedure: An Early Feasibility Cohort Study. Orthop J Sports Med. 2016 Nov; 4(11):2325967116672176. PMID: 27900338.
    Citations: 48     
  24. Chin KE, Karamchedu NP, Patel TK, Badger GJ, Akelman MR, Moore DC, Proffen BL, Murray MM, Fleming BC. Comparison of micro-CT post-processing methods for evaluating the trabecular bone volume fraction in a rat ACL-transection model. J Biomech. 2016 10 03; 49(14):3559-3563. PMID: 27594677.
    Citations: 2     Fields:    Translation:Animals
  25. Sieker JT, Ayturk UM, Proffen BL, Weissenberger MH, Kiapour AM, Murray MM. Immediate Administration of Intraarticular Triamcinolone Acetonide After Joint Injury Modulates Molecular Outcomes Associated With Early Synovitis. Arthritis Rheumatol. 2016 07; 68(7):1637-47. PMID: 26866935.
    Citations: 18     Fields:    Translation:Animals
  26. Proffen BL, Sieker JT, Murray MM, Akelman MR, Chin KE, Perrone GS, Patel TK, Fleming BC. Extracellular matrix-blood composite injection reduces post-traumatic osteoarthritis after anterior cruciate ligament injury in the rat. J Orthop Res. 2016 06; 34(6):995-1003. PMID: 26629963.
    Citations: 4     Fields:    Translation:Animals
  27. Kelly BA, Proffen BL, Haslauer CM, Murray MM. Platelets and plasma stimulate sheep rotator cuff tendon tenocytes when cultured in an extracellular matrix scaffold. J Orthop Res. 2016 Apr; 34(4):623-9. PMID: 26419602.
    Citations: 6     Fields:    Translation:AnimalsCells
  28. Proffen BL, Perrone GS, Fleming BC, Sieker JT, Kramer J, Hawes ML, Murray MM. Effect of low-temperature ethylene oxide and electron beam sterilization on the in vitro and in vivo function of reconstituted extracellular matrix-derived scaffolds. J Biomater Appl. 2015 Oct; 30(4):435-49. PMID: 26088294.
    Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
  29. Kiapour AM, Fleming BC, Proffen BL, Murray MM. Sex Influences the Biomechanical Outcomes of Anterior Cruciate Ligament Reconstruction in a Preclinical Large Animal Model. Am J Sports Med. 2015 Jul; 43(7):1623-31. PMID: 25939612.
    Citations: 14     Fields:    Translation:Animals
  30. Proffen BL, Perrone GS, Fleming BC, Sieker JT, Kramer J, Hawes ML, Badger GJ, Murray MM. Electron beam sterilization does not have a detrimental effect on the ability of extracellular matrix scaffolds to support in vivo ligament healing. J Orthop Res. 2015 Jul; 33(7):1015-23. PMID: 25676876.
    Citations: 12     Fields:    Translation:AnimalsCellsPHPublic Health
  31. Biercevicz AM, Proffen BL, Murray MM, Walsh EG, Fleming BC. T2* relaxometry and volume predict semi-quantitative histological scoring of an ACL bridge-enhanced primary repair in a porcine model. J Orthop Res. 2015 Aug; 33(8):1180-7. PMID: 25764143.
    Citations: 16     Fields:    Translation:Animals
  32. Proffen BL, Perrone GS, Roberts G, Murray MM. Bridge-enhanced ACL repair: A review of the science and the pathway through FDA investigational device approval. Ann Biomed Eng. 2015 Mar; 43(3):805-18. PMID: 25631206.
    Citations: 13     Fields:    Translation:HumansAnimalsPHPublic Health
  33. Proffen BL, Sieker JT, Murray MM. Bio-enhanced repair of the anterior cruciate ligament. Arthroscopy. 2015 May; 31(5):990-7. PMID: 25595694.
    Citations: 15     Fields:    Translation:HumansAnimals
  34. Proffen BL, Vavken P, Haslauer CM, Fleming BC, Harris CE, Machan JT, Murray MM. Addition of autologous mesenchymal stem cells to whole blood for bioenhanced ACL repair has no benefit in the porcine model. Am J Sports Med. 2015 Feb; 43(2):320-30. PMID: 25549633.
    Citations: 8     Fields:    Translation:AnimalsCells
  35. Haslauer CM, Proffen BL, Johnson VM, Hill A, Murray MM. Gene expression of catabolic inflammatory cytokines peak before anabolic inflammatory cytokines after ACL injury in a preclinical model. J Inflamm (Lond). 2014; 11(1):34. PMID: 25400511.
    Citations: 12     
  36. Bennike T, Ayturk U, Haslauer CM, Froehlich JW, Proffen BL, Barnaby O, Birkelund S, Murray MM, Warman ML, Stensballe A, Steen H. A normative study of the synovial fluid proteome from healthy porcine knee joints. J Proteome Res. 2014 Oct 03; 13(10):4377-87. PMID: 25160569.
    Citations: 28     Fields:    Translation:AnimalsCells
  37. Proffen BL, Nielson JH, Zurakowski D, Micheli LJ, Curtis C, Murray MM. The Effect of Perioperative Ketorolac on the Clinical Failure Rate of Meniscal Repair. Orthop J Sports Med. 2014 May 01; 2(5). PMID: 25401118.
    Citations: 3     
  38. Fleming BC, Proffen BL, Vavken P, Shalvoy MR, Machan JT, Murray MM. Increased platelet concentration does not improve functional graft healing in bio-enhanced ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2015 Apr; 23(4):1161-70. PMID: 24633008.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  39. Haslauer CM, Proffen BL, Johnson VM, Murray MM. Expression of modulators of extracellular matrix structure after anterior cruciate ligament injury. Wound Repair Regen. 2014 Jan-Feb; 22(1):103-10. PMID: 24393158.
    Citations: 10     Fields:    Translation:AnimalsCells
  40. Proffen BL, Fleming BC, Murray MM. Histologic Predictors of Maximum Failure Loads Differ between the Healing ACL and ACL Grafts after 6 and 12 Months In Vivo. Orthop J Sports Med. 2013 Nov; 1(6). PMID: 25343145.
    Citations: 18     
  41. Haslauer CM, Elsaid KA, Fleming BC, Proffen BL, Johnson VM, Murray MM. Loss of extracellular matrix from articular cartilage is mediated by the synovium and ligament after anterior cruciate ligament injury. Osteoarthritis Cartilage. 2013 Dec; 21(12):1950-7. PMID: 24036379.
    Citations: 31     Fields:    Translation:AnimalsCells
  42. Proffen B, Vavken P, Dorotka R. Surgical management of osteoarthritis. Wien Med Wochenschr. 2013 May; 163(9-10):243-50. PMID: 23620196.
    Citations: 3     Fields:    Translation:Humans
  43. Vavken P, Proffen B, Peterson C, Fleming BC, Machan JT, Murray MM. Effects of suture choice on biomechanics and physeal status after bioenhanced anterior cruciate ligament repair in skeletally immature patients: a large-animal study. Arthroscopy. 2013 Jan; 29(1):122-32. PMID: 23200845.
    Citations: 13     Fields:    Translation:Animals
  44. Proffen BL, Haslauer CM, Harris CE, Murray MM. Mesenchymal stem cells from the retropatellar fat pad and peripheral blood stimulate ACL fibroblast migration, proliferation, and collagen gene expression. Connect Tissue Res. 2013; 54(1):14-21. PMID: 22839298.
    Citations: 9     Fields:    Translation:AnimalsCells
  45. Proffen B, von Keudell A, Vavken P. [Evidence-based therapy for cartilage lesions in the knee - regenerative treatment options]. Z Orthop Unfall. 2012 Jun; 150(3):280-9. PMID: 22723070.
    Citations: 3     Fields:    Translation:HumansCells
  46. Proffen BL, McElfresh M, Fleming BC, Murray MM. A comparative anatomical study of the human knee and six animal species. Knee. 2012 Aug; 19(4):493-9. PMID: 21852139.
    Citations: 113     Fields:    Translation:HumansAnimals
  47. Steinert AF, Proffen B, Kunz M, Hendrich C, Ghivizzani SC, Nöth U, Rethwilm A, Eulert J, Evans CH. Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer. Arthritis Res Ther. 2009; 11(5):R148. PMID: 19799789.
    Citations: 57     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.