Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Isaac Chiu, Ph.D.

Co-Author

This page shows the publications co-authored by Isaac Chiu and I-Jen Chiu.
Connection Strength

18.554
  1. Chiu I, Rolls A. Editorial overview: Brain, gut and immune system interactions. Curr Opin Neurobiol. 2020 06; 62:iii-v.
    View in: PubMed
    Score: 0.988
  2. Lai NY, Musser MA, Pinho-Ribeiro FA, Baral P, Jacobson A, Ma P, Potts DE, Chen Z, Paik D, Soualhi S, Yan Y, Misra A, Goldstein K, Lagomarsino VN, Nordstrom A, Sivanathan KN, Wallrapp A, Kuchroo VK, Nowarski R, Starnbach MN, Shi H, Surana NK, An D, Wu C, Huh JR, Rao M, Chiu IM. Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. Cell. 2020 01 09; 180(1):33-49.e22.
    View in: PubMed
    Score: 0.955
  3. Pinho-Ribeiro FA, Chiu IM. Nociceptor nerves set the stage for skin immunity. Cell Res. 2019 11; 29(11):877-878.
    View in: PubMed
    Score: 0.949
  4. Baral P, Udit S, Chiu IM. Pain and immunity: implications for host defence. Nat Rev Immunol. 2019 07; 19(7):433-447.
    View in: PubMed
    Score: 0.927
  5. Blake KJ, Jiang XR, Chiu IM. Neuronal Regulation of Immunity in the Skin and Lungs. Trends Neurosci. 2019 08; 42(8):537-551.
    View in: PubMed
    Score: 0.925
  6. Voisin T, Chiu IM. Mast Cells Get on Your Nerves in Itch. Immunity. 2019 05 21; 50(5):1117-1119.
    View in: PubMed
    Score: 0.920
  7. Voisin T, Chiu IM. Molecular link between itch and atopic dermatitis. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):12851-12853.
    View in: PubMed
    Score: 0.893
  8. Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM. Author Correction: Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 Oct; 24(10):1625-1626.
    View in: PubMed
    Score: 0.881
  9. Pinho-Ribeiro FA, Baddal B, Haarsma R, O'Seaghdha M, Yang NJ, Blake KJ, Portley M, Verri WA, Dale JB, Wessels MR, Chiu IM. Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection. Cell. 2018 05 17; 173(5):1083-1097.e22.
    View in: PubMed
    Score: 0.857
  10. Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM. Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 05; 24(4):417-426.
    View in: PubMed
    Score: 0.846
  11. Blake KJ, Baral P, Voisin T, Lubkin A, Pinho-Ribeiro FA, Adams KL, Roberson DP, Ma YC, Otto M, Woolf CJ, Torres VJ, Chiu IM. Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314. Nat Commun. 2018 01 02; 9(1):37.
    View in: PubMed
    Score: 0.836
  12. Voisin T, Bouvier A, Chiu IM. Neuro-immune interactions in allergic diseases: novel targets for therapeutics. Int Immunol. 2017 06 01; 29(6):247-261.
    View in: PubMed
    Score: 0.803
  13. Chiu IM. Infection, Pain, and Itch. Neurosci Bull. 2018 Feb; 34(1):109-119.
    View in: PubMed
    Score: 0.785
  14. Yang NJ, Chiu IM. Bacterial Signaling to the Nervous System through Toxins and Metabolites. J Mol Biol. 2017 03 10; 429(5):587-605.
    View in: PubMed
    Score: 0.781
  15. Pinho-Ribeiro FA, Verri WA, Chiu IM. Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation. Trends Immunol. 2017 Jan; 38(1):5-19.
    View in: PubMed
    Score: 0.770
  16. Baral P, Mills K, Pinho-Ribeiro FA, Chiu IM. Pain and Itch: Beneficial or Harmful to Antimicrobial Defense? Cell Host Microbe. 2016 Jun 08; 19(6):755-9.
    View in: PubMed
    Score: 0.750
  17. Chiu IM, Pinho-Ribeiro FA, Woolf CJ. Pain and infection: pathogen detection by nociceptors. Pain. 2016 06; 157(6):1192-3.
    View in: PubMed
    Score: 0.749
  18. Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman GS, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf CJ. Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 2014 Dec 19; 3.
    View in: PubMed
    Score: 0.677
  19. Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 2013 Sep 05; 501(7465):52-7.
    View in: PubMed
    Score: 0.618
  20. Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O'Keeffe S, Phatnani HP, Muratet M, Carroll MC, Levy S, Tavazoie S, Myers RM, Maniatis T. A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Rep. 2013 Jul 25; 4(2):385-401.
    View in: PubMed
    Score: 0.613
  21. Chiu IM, von Hehn CA, Woolf CJ. Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology. Nat Neurosci. 2012 Jul 26; 15(8):1063-7.
    View in: PubMed
    Score: 0.574
  22. Chiu IM, Phatnani H, Kuligowski M, Tapia JC, Carrasco MA, Zhang M, Maniatis T, Carroll MC. Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20960-5.
    View in: PubMed
    Score: 0.476
  23. Chiu IM, Chen A, Zheng Y, Kosaras B, Tsiftsoglou SA, Vartanian TK, Brown RH, Carroll MC. T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17913-8.
    View in: PubMed
    Score: 0.443
  24. Wang K, Yaghi OK, Spallanzani RG, Chen X, Zemmour D, Lai N, Chiu IM, Benoist C, Mathis D. Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5402-5408.
    View in: PubMed
    Score: 0.061
  25. Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, Gonçalves WA, Shwartz Y, Fast EM, Su Y, Zon LI, Regev A, Buenrostro JD, Cunha TM, Chiu IM, Fisher DE, Hsu YC. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020 01; 577(7792):676-681.
    View in: PubMed
    Score: 0.060
  26. Wallrapp A, Burkett PR, Riesenfeld SJ, Kim SJ, Christian E, Abdulnour RE, Thakore PI, Schnell A, Lambden C, Herbst RH, Khan P, Tsujikawa K, Xavier RJ, Chiu IM, Levy BD, Regev A, Kuchroo VK. Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses. Immunity. 2019 10 15; 51(4):709-723.e6.
    View in: PubMed
    Score: 0.059
  27. Leyva-Castillo JM, Galand C, Kam C, Burton O, Gurish M, Musser MA, Goldsmith JD, Hait E, Nurko S, Brombacher F, Dong C, Finkelman FD, Lee RT, Ziegler S, Chiu I, Austen KF, Geha RS. Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 2019 05 21; 50(5):1262-1275.e4.
    View in: PubMed
    Score: 0.057
  28. Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. 2017 09 21; 549(7672):351-356.
    View in: PubMed
    Score: 0.051
  29. Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D, Benoist C. An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk. Cell. 2017 03 09; 168(6):1135-1148.e12.
    View in: PubMed
    Score: 0.049
  30. Ghasemlou N, Chiu IM, Julien JP, Woolf CJ. CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):E6808-17.
    View in: PubMed
    Score: 0.045
  31. Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 2015 Jul 15; 87(2):341-54.
    View in: PubMed
    Score: 0.044
  32. Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan; 18(1):17-24.
    View in: PubMed
    Score: 0.042
  33. Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lü J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol. 2006 Oct 23; 175(2):209-15.
    View in: PubMed
    Score: 0.024
  34. Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC. Identification of the target self-antigens in reperfusion injury. J Exp Med. 2006 Jan 23; 203(1):141-52.
    View in: PubMed
    Score: 0.023
  35. Deng LW, Chiu I, Strominger JL. MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression. Proc Natl Acad Sci U S A. 2004 Jan 20; 101(3):757-62.
    View in: PubMed
    Score: 0.020
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.