Harvard Catalyst Profiles

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Meredithe Lee Applebury, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03EY013771 (APPLEBURY, MEREDITHE L) Sep 30, 2002 - Jul 31, 2006
    NIH/NEI
    Human Retinal Progenitor Cells
    Role: Principal Investigator
  2. R01EY012954 (APPLEBURY, MEREDITHE L) Aug 5, 2001 - Jul 31, 2008
    NIH/NEI
    Opsin Patterning in Murine Cone Photoreceptors
    Role: Principal Investigator
  3. S10RR014635 (APPLEBURY, MEREDITHE L) Apr 14, 2000 - Apr 13, 2001
    NIH/NCRR
    A CONFOCAL MICROSCOPE FOR VISION AND AUDITORY RESEARCH
    Role: Principal Investigator
  4. R01EY004801 (APPLEBURY, MEREDITHE L) Jan 1, 1988 - Jun 30, 2000
    NIH/NEI
    PHOTORECEPTION AND TRANSDUCTION IN VISION
    Role: Principal Investigator
  5. C06EY007453 (APPLEBURY, MEREDITHE L) Sep 30, 1987 - Mar 31, 1989
    NIH/NEI
    ALTERATION &RENOVATION &INSTRUMENTATION: MOLEC BIO LAB
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Applebury ML, Farhangfar F, Glösmann M, Hashimoto K, Kage K, Robbins JT, Shibusawa N, Wondisford FE, Zhang H. Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis. Dev Dyn. 2007 May; 236(5):1203-12. PMID: 17436273.
    Citations: 27     Fields:    Translation:AnimalsCells
  2. Yaron O, Farhy C, Marquardt T, Applebury M, Ashery-Padan R. Notch1 functions to suppress cone-photoreceptor fate specification in the developing mouse retina. Development. 2006 Apr; 133(7):1367-78. PMID: 16510501.
    Citations: 65     Fields:    Translation:AnimalsCells
  3. Shibusawa N, Hashimoto K, Nikrodhanond AA, Liberman MC, Applebury ML, Liao XH, Robbins JT, Refetoff S, Cohen RN, Wondisford FE. Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo. J Clin Invest. 2003 Aug; 112(4):588-97. PMID: 12925699.
    Citations: 31     Fields:    Translation:AnimalsCells
  4. Fasick JI, Applebury ML, Oprian DD. Spectral tuning in the mammalian short-wavelength sensitive cone pigments. Biochemistry. 2002 May 28; 41(21):6860-5. PMID: 12022891.
    Citations: 35     Fields:    Translation:AnimalsCells
  5. Applebury ML, Antoch MP, Baxter LC, Chun LL, Falk JD, Farhangfar F, Kage K, Krzystolik MG, Lyass LA, Robbins JT. The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning. Neuron. 2000 Sep; 27(3):513-23. PMID: 11055434.
    Citations: 189     Fields:    Translation:AnimalsCells
  6. Johnston JP, Aparicio JG, Applebury ML. Purification and autophosphorylation of retinal guanylate cyclase. Methods Enzymol. 2000; 315:673-89. PMID: 10736733.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Johnston JP, Farhangfar F, Aparicio JG, Nam SH, Applebury ML. The bovine guanylate cyclase GC-E gene and 5' flanking region. Gene. 1997 Jul 09; 193(2):219-27. PMID: 9256080.
    Citations: 6     Fields:    Translation:AnimalsCells
  8. Wagner E, McCaffery P, Mey J, Farhangfar F, Applebury ML, Dräger UC. Retinoic aid increases arrestin mRNA levels in the mouse retina. FASEB J. 1997 Mar; 11(4):271-5. PMID: 9068616.
    Citations: 1     Fields:    Translation:Animals
  9. Aparicio JG, Applebury ML. The photoreceptor guanylate cyclase is an autophosphorylating protein kinase. J Biol Chem. 1996 Oct 25; 271(43):27083-9. PMID: 8900199.
    Citations: 11     Fields:    Translation:AnimalsCells
  10. Aparicio JG, Applebury ML. The bovine photoreceptor outer segment guanylate cyclase: purification, kinetic properties, and molecular size. Protein Expr Purif. 1995 Aug; 6(4):501-11. PMID: 8527937.
    Citations: 4     Fields:    Translation:AnimalsCells
  11. Max M, McKinnon PJ, Seidenman KJ, Barrett RK, Applebury ML, Takahashi JS, Margolskee RF. Pineal opsin: a nonvisual opsin expressed in chick pineal. Science. 1995 Mar 10; 267(5203):1502-6. PMID: 7878470.
    Citations: 20     Fields:    Translation:AnimalsCells
  12. Applebury ML. Relationships of G-protein-coupled receptors. A survey with the photoreceptor opsin subfamily. Soc Gen Physiol Ser. 1994; 49:235-48. PMID: 7939898.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Wilson CJ, Applebury ML. Arresting G-protein coupled receptor activity. Curr Biol. 1993 Oct 01; 3(10):683-6. PMID: 15335861.
    Citations: 6     Fields:    
  14. Pierce ME, Sheshberadaran H, Zhang Z, Fox LE, Applebury ML, Takahashi JS. Circadian regulation of iodopsin gene expression in embryonic photoreceptors in retinal cell culture. Neuron. 1993 Apr; 10(4):579-84. PMID: 8476610.
    Citations: 44     Fields:    Translation:AnimalsCells
  15. Bowes C, Li T, Frankel WN, Danciger M, Coffin JM, Applebury ML, Farber DB. Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. Proc Natl Acad Sci U S A. 1993 Apr 01; 90(7):2955-9. PMID: 8385352.
    Citations: 45     Fields:    Translation:AnimalsCells
  16. Lem J, Flannery JG, Li T, Applebury ML, Farber DB, Simon MI. Retinal degeneration is rescued in transgenic rd mice by expression of the cGMP phosphodiesterase beta subunit. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4422-6. PMID: 1350091.
    Citations: 22     Fields:    Translation:AnimalsCells
  17. Applebury ML. Variations in retinal degenerations. Curr Biol. 1992 Mar; 2(3):113-5. PMID: 15335982.
    Citations: 1     Fields:    
  18. Bateman JB, Klisak I, Kojis T, Mohandas T, Sparkes RS, Li TS, Applebury ML, Bowes C, Farber DB. Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16. Genomics. 1992 Mar; 12(3):601-3. PMID: 1313787.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  19. Applebury ML. Molecular determinants of visual pigment function. Curr Opin Neurobiol. 1991 Aug; 1(2):263-9. PMID: 1840362.
    Citations: 1     Fields:    Translation:AnimalsCells
  20. Lem J, Applebury ML, Falk JD, Flannery JG, Simon MI. Tissue-specific and developmental regulation of rod opsin chimeric genes in transgenic mice. Neuron. 1991 Feb; 6(2):201-10. PMID: 1825171.
    Citations: 55     Fields:    Translation:AnimalsCells
  21. Leser GP, Nicoll DA, Applebury ML. Distinctive properties of the purified Na-Ca exchanger from rod outer segments. Ann N Y Acad Sci. 1991; 639:222-33. PMID: 1785848.
    Citations: 2     Fields:    Translation:AnimalsCells
  22. Bowes C, Li T, Danciger M, Baxter LC, Applebury ML, Farber DB. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. Nature. 1990 Oct 18; 347(6294):677-80. PMID: 1977087.
    Citations: 224     Fields:    Translation:AnimalsCells
  23. Lipkin VM, Khramtsov NV, Vasilevskaya IA, Atabekova NV, Muradov KG, Gubanov VV, Li T, Johnston JP, Volpp KJ, Applebury ML. Beta-subunit of bovine rod photoreceptor cGMP phosphodiesterase. Comparison with the phosphodiesterase family. J Biol Chem. 1990 Aug 05; 265(22):12955-9. PMID: 2165490.
    Citations: 16     Fields:    Translation:AnimalsCells
  24. Danciger M, Kozak CA, Li T, Applebury ML, Farber DB. Genetic mapping demonstrates that the alpha-subunit of retinal cGMP-phosphodiesterase is not the site of the rd mutation. Exp Eye Res. 1990 Aug; 51(2):185-9. PMID: 2167232.
    Citations: 9     Fields:    Translation:Animals
  25. Applebury ML. Molecular genetics. Insight into blindness. Nature. 1990 Jan 25; 343(6256):316-7. PMID: 2137199.
    Citations:    Fields:    Translation:HumansCells
  26. Li TS, Volpp K, Applebury ML. Bovine cone photoreceptor cGMP phosphodiesterase structure deduced from a cDNA clone. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):293-7. PMID: 2153291.
    Citations: 24     Fields:    Translation:AnimalsCells
  27. Nicoll DA, Applebury ML. Purification of the bovine rod outer segment Na+/Ca2+ exchanger. J Biol Chem. 1989 Sep 25; 264(27):16207-13. PMID: 2777786.
    Citations: 6     Fields:    Translation:AnimalsCells
  28. Applebury ML. Neurosensory signalling. Biochemical puzzles about the cyclic-GMP-dependent channel. Nature. 1987 Apr 9-15; 326(6113):546-7. PMID: 2436054.
    Citations: 1     Fields:    Translation:Cells
  29. Martin RL, Wood C, Baehr W, Applebury ML. Visual pigment homologies revealed by DNA hybridization. Science. 1986 Jun 06; 232(4755):1266-9. PMID: 3010467.
    Citations: 6     Fields:    Translation:AnimalsCells
  30. Applebury ML, Hargrave PA. Molecular biology of the visual pigments. Vision Res. 1986; 26(12):1881-95. PMID: 3303660.
    Citations: 38     Fields:    Translation:AnimalsCells
  31. Roof DJ, Applebury ML, Sternweis PC. Relationships within the family of GTP-binding proteins isolated from bovine central nervous system. J Biol Chem. 1985 Dec 25; 260(30):16242-9. PMID: 2999152.
    Citations: 19     Fields:    Translation:AnimalsCells
  32. O'Tousa JE, Baehr W, Martin RL, Hirsh J, Pak WL, Applebury ML. The Drosophila ninaE gene encodes an opsin. Cell. 1985 Apr; 40(4):839-50. PMID: 2985266.
    Citations: 120     Fields:    Translation:AnimalsCells
  33. Applebury ML. Dynamic processes of visual transduction. Vision Res. 1984; 24(11):1445-54. PMID: 6533979.
    Citations: 4     Fields:    Translation:AnimalsCells
  34. Swanson RJ, Applebury ML. Methylation of proteins in photoreceptor rod outer segments. J Biol Chem. 1983 Sep 10; 258(17):10599-605. PMID: 6309808.
    Citations: 10     Fields:    Translation:AnimalsCells
  35. Spalink JD, Reynolds AH, Rentzepis PM, Sperling W, Applebury ML. Bathorhodopsin intermediates from 11-cis-rhodopsin and 9-cis-rhodopsin. Proc Natl Acad Sci U S A. 1983 Apr; 80(7):1887-91. PMID: 6572950.
    Citations: 13     Fields:    Translation:AnimalsCells
  36. Baehr W, Morita EA, Swanson RJ, Applebury ML. Characterization of bovine rod outer segment G-protein. J Biol Chem. 1982 Jun 10; 257(11):6452-60. PMID: 7076677.
    Citations: 42     Fields:    Translation:AnimalsCells
  37. Applebury ML, Rentzepis PM. Picosecond spectroscopy of visual pigments. Methods Enzymol. 1982; 81:354-68. PMID: 7098880.
    Citations: 2     Fields:    Translation:Animals
  38. Applebury ML. The primary processes of vision: a view from the experimental side. Photochem Photobiol. 1980 Oct; 32(4):425-31. PMID: 6256784.
    Citations: 2     Fields:    Translation:AnimalsCells
  39. Baehr W, Devlin MJ, Applebury ML. Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments. J Biol Chem. 1979 Nov 25; 254(22):11669-77. PMID: 227876.
    Citations: 91     Fields:    Translation:AnimalsCells
  40. Applebury ML, Peters KS, Rentzepis PM. Primary intermediates in the photochemical cycle of bacteriorhodopsin. Biophys J. 1978 Sep; 23(3):375-82. PMID: 698342.
    Citations: 22     Fields:    
  41. Whinston M, Applebury ML. The unsolved mysteries of retinitis pigmentosa and retinal degeneration. J Nurs Care. 1978 Jan; 11(1):28-9, 34-5. PMID: 306607.
    Citations:    Fields:    Translation:Humans
  42. Peters K, Applebury ML, Rentzepis PM. Primary photochemical event in vision: proton translocation. Proc Natl Acad Sci U S A. 1977 Aug; 74(8):3119-23. PMID: 20620.
    Citations: 44     Fields:    Translation:AnimalsCells
  43. Sundstrom V, Rentzepis PM, Peters K, Applebury ML. Kinetics of rhodopsin at room temperature measured by picosecond spectroscopy. Nature. 1977 Jun 16; 267(5612):645-6. PMID: 559949.
    Citations: 5     Fields:    Translation:Animals
  44. Applebury ML, Zuckerman DM, Lamola AA, Jovin TM. Rhodopsin. Purification and recombination with phospholipids assayed by the metarhodopsin I leads to metarhodopsin II transition. Biochemistry. 1974 Aug 13; 13(17):3448-58. PMID: 4846291.
    Citations: 36     Fields:    Translation:AnimalsCells
  45. Taylor JS, Lau CY, Applebury ML, Coleman JE. Escherichia coli Co(II) alkaline phosphatase. Absorption, circular dichroism, and magnetic circular dichroism of the d-d electronic transitions. J Biol Chem. 1973 Sep 10; 248(17):6216-20. PMID: 4580054.
    Citations: 2     Fields:    Translation:Cells
  46. Busch GE, Applebury ML, Lamola AA, Rentzepis PM. Formation and decay of prelumirhodopsin at room temperatures. Proc Natl Acad Sci U S A. 1972 Oct; 69(10):2802-6. PMID: 4507603.
    Citations: 36     Fields:    Translation:Animals
  47. Applebury ML, Johnson BP, Coleman JE. Phosphate binding to alkaline phosphatase. Metal ion dependence. J Biol Chem. 1970 Oct 10; 245(19):4968-76. PMID: 4319108.
    Citations: 14     Fields:    Translation:Cells
  48. Applebury ML, Coleman JE. Escherichia coli co (II) alkaline phsophatase. J Biol Chem. 1969 Feb 25; 244(4):709-18. PMID: 4889861.
    Citations: 4     Fields:    Translation:Cells
  49. Applebury ML, Coleman JE. Escherichia coli alkaline phosphatase. Metal binding, protein conformation, and quaternary structure. J Biol Chem. 1969 Jan 25; 244(2):308-18. PMID: 4886432.
    Citations: 11     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.