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Hak Soo Choi, Ph.D.

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Available: 03/01/20, Expires: 03/31/22

My research is focused on the development of novel targeted agents for cancer diagnosis, staging, and treatment. Using invisible near-infrared fluorescence imaging, my laboratory has systematically defined the chemical, optical, and physiological properties required for organic and inorganic contrast agents such as nanoparticles and fluorophores. Our long-term goal is to provide oncologic surgeons with useful and specific contrast agents for image-guided cancer surgery.

This important theme started when Nature Biotechnology published our article “Renal clearance of quantum dots” in 2007 (Choi et al., 25:1165). In that article, which has already been cited over 1,000 times, we hypothesized that ultrasmall and zwitterionic nanoparticles could target tumors efficiently while eliminating unbound material from the body via renal clearance. Indeed, we proved this hypothesis in the following papers Nat Nanotechnol. 2010;5:42 and Nat Biotechnol. 2013; 31:148.

Most recently, we developed target-specific NIR fluorophores using the concept of “structure-inherent targeting.” That is, a new, ultra-compact, bifunctional molecule with both high affinity binding to a target as well as NIR fluorescence, i.e., targeting and imaging. This strategy appears to work well, at least with the fluorinated polymethine (Hyun et al. Nat Med. 2015, in press) and phenoxazine model systems employed. Our approach from the phenotypic tissue level screening to the microscopic observation to find cellular level targets (organelle localization) is rather practical because it is based on in silico quantitative structure-affinity relationship (QSAR) design and in vivo feedback. Since this has been an excellent strategy that has served us productively, we will continue to use this approach to find out detailed cellular targeting mechanisms and to prepare the first-in-human clinical trials of selected agents in the current application.

Students will work closely with chemists, engineers, and surgeons to develop and optimize new targeted contrast agents. Their responsibilities in the laboratory will include design of novel near-infrared fluorophores and targeting drugs including synthesis, purification, characterization, and conjugation with biomolecules. Students will be trained with cancer cell culture, cell-based assay, and most importantly, the use of contrast agents in image-guided surgery using mice, rats, and pigs.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL143020 (KIM, JONGHAN) Jan 1, 2021 - Aug 31, 2022
    Nanochelation Therapies for Iron Overload Disorders
    Role: Multi-PI/PD
  2. R21CA223270 (CHOI, HAK SOO) Sep 25, 2018 - Aug 31, 2021
    Image-Guided Drug Delivery and Treatment for GIST
    Role: Principal Investigator
  3. R01EB022230 (CHOI, HAK SOO) Sep 16, 2017 - Sep 21, 2021
    Image-Guided Drug Delivery for Pancreatic Neuroendocrine Tumor.
    Role: Principal Investigator
  4. R01EB010022 (FRANGIONI, JOHN V) Aug 1, 2010 - Jul 31, 2015
    Ultra-Low Background NIR Fluorophores for In Vivo Imaging and Image-Guided Surger
    Role: Multi-PI/PD
  5. R01EB011523 (CHOI, HAK SOO) Aug 1, 2010 - Apr 30, 2014
    Image-Guided Surgery of Endocrine Glands and Their Tumors using Near-Infrared Flu
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ji Y, Jones C, Baek Y, Park GK, Kashiwagi S, Choi HS. Near-infrared fluorescence imaging in immunotherapy. Adv Drug Deliv Rev. 2020 12; 167:121-134. PMID: 32579891.
    Citations:    Fields:    
  2. Park GK, Lee JH, Soriano E, Choi M, Bao K, Katagiri W, Kim DY, Paik JH, Yun SH, Frangioni JV, Clancy TE, Kashiwagi S, Henary M, Choi HS. Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors. iScience. 2020 Apr 24; 23(4):101006. PMID: 32268281.
  3. Choi HS, Kim HK. Multispectral image-guided surgery in patients. Nat Biomed Eng. 2020 03; 4(3):245-246. PMID: 32165731.
    Citations: 1     Fields:    Translation:Humans
  4. Katagiri W, Lee G, Tanushi A, Tsukada K, Choi HS, Kashiwagi S. High-throughput single-cell live imaging of photobiomodulation with multispectral near-infrared lasers in cultured T cells. J Biomed Opt. 2020 03; 25(3):1-18. PMID: 32193907.
    Citations: 3     Fields:    
  5. Kang H, Stiles WR, Baek Y, Nomura S, Bao K, Hu S, Park GK, Jo MJ, I H, Coll JL, Rubin BP, Choi HS. Renal Clearable Theranostic Nanoplatforms for Gastrointestinal Stromal Tumors. Adv Mater. 2020 Feb; 32(6):e1905899. PMID: 31854033.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  6. Kang H, Rho S, Stiles WR, Hu S, Baek Y, Hwang DW, Kashiwagi S, Kim MS, Choi HS. Size-Dependent EPR Effect of Polymeric Nanoparticles on Tumor Targeting. Adv Healthc Mater. 2020 01; 9(1):e1901223. PMID: 31794153.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  7. Lee JH, Jung SY, Park GK, Bao K, Hyun H, El Fakhri G, Choi HS. Fluorometric Imaging for Early Diagnosis and Prognosis of Rheumatoid Arthritis. Adv Sci (Weinh). 2020 Jan; 7(1):1902267. PMID: 31921569.
  8. Kang H, Han M, Xue J, Baek Y, Chang J, Hu S, Nam H, Jo MJ, El Fakhri G, Hutchens MP, Choi HS, Kim J. Renal clearable nanochelators for iron overload therapy. Nat Commun. 2019 11 13; 10(1):5134. PMID: 31723130.
    Citations: 8     Fields:    Translation:Animals
  9. Yang C, Park GK, McDonald EJ, Choi HS. Targeted Near-Infrared Fluorescence Imaging for Regenerative Medicine. Tissue Eng Regen Med. 2019 10; 16(5):433-442. PMID: 31624699.
    Citations: 2     Translation:Humans
  10. Hwang DW, Jo MJ, Lee JH, Kang H, Bao K, Hu S, Baek Y, Moon HG, Lee DS, Kashiwagi S, Henary M, Choi HS. Chemical Modulation of Bioengineered Exosomes for Tissue-Specific Biodistribution. Adv Ther (Weinh). 2019 Nov; 2(11). PMID: 32318623.
    Citations: 1     
  11. Pal R, Kang H, Choi HS, Kumar ATN. Fluorescence Lifetime-Based Tumor Contrast Enhancement Using an EGFR Antibody-Labeled Near-Infrared Fluorophore. Clin Cancer Res. 2019 11 15; 25(22):6653-6661. PMID: 31481509.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  12. Das P, Santos S, Park GK, Hoseok I, Choi HS. Real-Time Fluorescence Imaging in Thoracic Surgery. Korean J Thorac Cardiovasc Surg. 2019 Aug; 52(4):205-220. PMID: 31403028.
    Citations: 1     
  13. Katagiri W, Lee JH, Tétrault MA, Kang H, Jeong S, Evans CL, Yokomizo S, Santos S, Jones C, Hu S, Fakhri GE, Tsukada K, Choi HS, Kashiwagi S. Real-Time Imaging of Vaccine Biodistribution Using Zwitterionic NIR Nanoparticles. Adv Healthc Mater. 2019 08; 8(15):e1900035. PMID: 31165556.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Park GK, Lee JH, Levitz A, El Fakhri G, Hwang NS, Henary M, Choi HS. Lysosome-Targeted Bioprobes for Sequential Cell Tracking from Macroscopic to Microscopic Scales. . 2019 Apr; 31(14):e1806216. PMID: 30740778.
    Citations: 3     Translation:HumansAnimalsCells
  15. Sajedi S, Sabet H, Choi HS. Intraoperative biophotonic imaging systems for image-guided interventions. Nanophotonics. 2019 Jan; 8(1):99-116. PMID: 31187017.
    Citations: 5     
  16. Kang H, Hu S, Cho MH, Hong SH, Choi Y, Choi HS. Theranostic Nanosystems for Targeted Cancer Therapy. Nano Today. 2018 Dec; 23:59-72. PMID: 31186672.
    Citations: 14     
  17. Wada H, Hyun H, Bao K, Lee JH, El Fakhri G, Choi Y, Choi HS. Multivalent Mannose-Decorated NIR Nanoprobes for Targeting Pan Lymph Nodes. Chem Eng J. 2018 May 15; 340:51-57. PMID: 29962899.
    Citations: 2     
  18. Tran BNN, Angelo JP, Lee JH, Ruan QZ, Laurence RG, Choi HS, Lee BT, Singhal D. A novel pilot animal model for the surgical prevention of lymphedema: the power of optical imaging. J Surg Res. 2018 01; 221:285-292. PMID: 29229140.
    Citations: 1     Fields:    Translation:Animals
  19. Valdes PA, Angelo JP, Choi HS, Gioux S. qF-SSOP: real-time optical property corrected fluorescence imaging. Biomed Opt Express. 2017 Aug 01; 8(8):3597-3605. PMID: 28856038.
    Citations: 13     
  20. Park GK, Kim GS, Hwang NS, Choi HS. Optical spectroscopic imaging for cell therapy and tissue engineering. Appl Spectrosc Rev. 2018; 53(2-4):360-375. PMID: 29563664.
    Citations: 8     
  21. Bao K, Lee JH, Kang H, Park GK, El Fakhri G, Choi HS. PSMA-targeted contrast agents for intraoperative imaging of prostate cancer. Chem Commun (Camb). 2017 Feb 04; 53(10):1611-1614. PMID: 28085163.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  22. Wada H, Hyun H, Kang H, Gravier J, Henary M, Bordo MW, Choi HS, Frangioni JV. Intraoperative Near-Infrared Fluorescence Imaging of Thymus in Preclinical Models. Ann Thorac Surg. 2017 Apr; 103(4):1132-1141. PMID: 27964920.
    Citations: 1     Fields:    Translation:Animals
  23. Koo H, Lee JH, Bao K, Wu Y, El Fakhri G, Henary M, Yun SH, Choi HS. Site-Specific In Vivo Bioorthogonal Ligation via Chemical Modulation. Adv Healthc Mater. 2016 10; 5(19):2510-2516. PMID: 27568818.
    Citations: 7     Fields:    Translation:AnimalsCells
  24. Ashitate Y, Levitz A, Park MH, Hyun H, Venugopal V, Park G, El Fakhri G, Henary M, Gioux S, Frangioni JV, Choi HS. Endocrine-specific NIR fluorophores for adrenal gland targeting. Chem Commun (Camb). 2016 Aug 11; 52(67):10305-8. PMID: 27476533.
    Citations: 7     Fields:    Translation:Humans
  25. Kang H, Gravier J, Bao K, Wada H, Lee JH, Baek Y, El Fakhri G, Gioux S, Rubin BP, Coll JL, Choi HS. Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery. . 2016 Oct; 28(37):8162-8168. PMID: 27414255.
    Citations: 23     
  26. Owens EA, Hyun H, Dost TL, Lee JH, Park G, Pham DH, Park MH, Choi HS, Henary M. Near-Infrared Illumination of Native Tissues for Image-Guided Surgery. J Med Chem. 2016 06 09; 59(11):5311-23. PMID: 27100476.
    Citations: 17     Fields:    Translation:AnimalsCells
  27. Zhao Y, Liang M, Li X, Fan K, Xiao J, Li Y, Shi H, Wang F, Choi HS, Cheng D, Yan X. Bioengineered Magnetoferritin Nanoprobes for Single-Dose Nuclear-Magnetic Resonance Tumor Imaging. ACS Nano. 2016 04 26; 10(4):4184-91. PMID: 26959856.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  28. Hyun H, Henary M, Gao T, Narayana L, Owens EA, Lee JH, Park G, Wada H, Ashitate Y, Frangioni JV, Choi HS. 700-nm Zwitterionic Near-Infrared Fluorophores for Dual-Channel Image-Guided Surgery. Mol Imaging Biol. 2016 Feb; 18(1):52-61. PMID: 26084246.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  29. Yeo SJ, Choi K, Cuc BT, Hong NN, Bao DT, Ngoc NM, Le MQ, Hang Nle K, Thach NC, Mallik SK, Kim HS, Chong CK, Choi HS, Sung HW, Yu K, Park H. Smartphone-Based Fluorescent Diagnostic System for Highly Pathogenic H5N1 Viruses. Theranostics. 2016; 6(2):231-42. PMID: 26877781.
    Citations: 21     Fields:    Translation:HumansCells
  30. Kang H, Mintri S, Menon AV, Lee HY, Choi HS, Kim J. Pharmacokinetics, pharmacodynamics and toxicology of theranostic nanoparticles. Nanoscale. 2015 Dec 07; 7(45):18848-62. PMID: 26528835.
    Citations: 25     Fields:    Translation:HumansAnimals
  31. Kim KS, Hyun H, Yang JA, Lee MY, Kim H, Yun SH, Choi HS, Hahn SK. Bioimaging of Hyaluronate-Interferon a Conjugates Using a Non-Interfering Zwitterionic Fluorophore. Biomacromolecules. 2015 Sep 14; 16(9):3054-61. PMID: 26258264.
    Citations: 7     Fields:    Translation:HumansCells
  32. Wang J, Choi HS, Wáng YX. Exponential growth of publications on carbon nanodots by Chinese authors. J Thorac Dis. 2015 Jul; 7(7):E201-5. PMID: 26380753.
    Citations: 3     
  33. Hyun H, Owens EA, Wada H, Levitz A, Park G, Park MH, Frangioni JV, Henary M, Choi HS. Cartilage-Specific Near-Infrared Fluorophores for Biomedical Imaging. Angew Chem Int Ed Engl. 2015 Jul 20; 54(30):8648-52. PMID: 26095685.
    Citations: 31     Fields:    Translation:Animals
  34. Wada H, Hyun H, Vargas C, Genega EM, Gravier J, Gioux S, Frangioni JV, Choi HS. Sentinel Lymph Node Mapping of Liver. Ann Surg Oncol. 2015 Dec; 22 Suppl 3:S1147-55. PMID: 25968620.
    Citations: 10     Fields:    Translation:Animals
  35. Owens EA, Hyun H, Tawney JG, Choi HS, Henary M. Correlating molecular character of NIR imaging agents with tissue-specific uptake. J Med Chem. 2015 May 28; 58(10):4348-56. PMID: 25923454.
    Citations: 19     Fields:    Translation:Animals
  36. Bordo MW, Oketokoun R, Cross CJ, Bao K, Lee JH, Feygin I, Chang AB, Frangioni JV, Choi HS. High-Throughput Sorting and Placement of One-Bead-One-Compound (OBOC) Libraries from Bulk to Single Wells in Organic Solvent. ACS Comb Sci. 2015 May 11; 17(5):303-9. PMID: 25879633.
    Citations:    Fields:    
  37. Njiojob CN, Owens EA, Narayana L, Hyun H, Choi HS, Henary M. Tailored near-infrared contrast agents for image guided surgery. J Med Chem. 2015 Mar 26; 58(6):2845-54. PMID: 25711712.
    Citations: 17     Fields:    Translation:Animals
  38. Bao K, Nasr KA, Hyun H, Lee JH, Gravier J, Gibbs SL, Choi HS. Charge and hydrophobicity effects of NIR fluorophores on bone-specific imaging. Theranostics. 2015; 5(6):609-17. PMID: 25825600.
    Citations: 13     Fields:    Translation:Animals
  39. Owens EA, Lee S, Choi J, Henary M, Choi HS. NIR fluorescent small molecules for intraoperative imaging. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 Nov-Dec; 7(6):828-38. PMID: 25645081.
    Citations: 24     Fields:    Translation:HumansAnimals
  40. Hyun H, Park MH, Owens EA, Wada H, Henary M, Handgraaf HJ, Vahrmeijer AL, Frangioni JV, Choi HS. Structure-inherent targeting of near-infrared fluorophores for parathyroid and thyroid gland imaging. Nat Med. 2015 Feb; 21(2):192-7. PMID: 25559343.
    Citations: 52     Fields:    Translation:Animals
  41. Wada H, Hyun H, Vargas C, Gravier J, Park G, Gioux S, Frangioni JV, Henary M, Choi HS. Pancreas-targeted NIR fluorophores for dual-channel image-guided abdominal surgery. Theranostics. 2015; 5(1):1-11. PMID: 25553094.
    Citations: 16     Fields:    Translation:Animals
  42. Lee JH, Bao K, Frangioni JV, Choi HS. Screening of Small Molecule Microarrays for Ligands Targeted to the Extracellular Epitopes of Living Cells. Microarrays (Basel). 2015; 4(1):53-63. PMID: 26435848.
    Citations: 2     
  43. Jee JE, Lim J, Hyun H, Oon J, Ong YS, Massif C, Chang YT, Choi HS, Lee SS. Investigating fluorescent dyes in fluorescence-assisted screenings. Chem Commun (Camb). 2014 Dec 14; 50(96):15220-3. PMID: 25340456.
    Citations: 1     Fields:    Translation:HumansCells
  44. Inoue K, Gibbs SL, Liu F, Lee JH, Xie Y, Ashitate Y, Fujii H, Frangioni JV, Choi HS. Microscopic validation of macroscopic in vivo images enabled by same-slide optical and nuclear fusion. J Nucl Med. 2014 Nov; 55(11):1899-904. PMID: 25324521.
    Citations: 1     Fields:    Translation:HumansAnimals
  45. Salim MM, Owens EA, Gao T, Lee JH, Hyun H, Choi HS, Henary M. Hydroxylated near-infrared BODIPY fluorophores as intracellular pH sensors. Analyst. 2014 Oct 07; 139(19):4862-73. PMID: 25105177.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  46. Chung JE, Tan S, Gao SJ, Yongvongsoontorn N, Kim SH, Lee JH, Choi HS, Yano H, Zhuo L, Kurisawa M, Ying JY. Self-assembled micellar nanocomplexes comprising green tea catechin derivatives and protein drugs for cancer therapy. Nat Nanotechnol. 2014 Nov; 9(11):907-912. PMID: 25282044.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  47. Yeo SJ, Huong DT, Hong NN, Li CY, Choi K, Yu K, Choi DY, Chong CK, Choi HS, Mallik SK, Kim HS, Sung HW, Park H. Rapid and quantitative detection of zoonotic influenza A virus infection utilizing coumarin-derived dendrimer-based fluorescent immunochromatographic strip test (FICT). Theranostics. 2014; 4(12):1239-49. PMID: 25285172.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  48. Hyun H, Wada H, Bao K, Gravier J, Yadav Y, Laramie M, Henary M, Frangioni JV, Choi HS. Phosphonated near-infrared fluorophores for biomedical imaging of bone. Angew Chem Int Ed Engl. 2014 Sep 26; 53(40):10668-72. PMID: 25139079.
    Citations: 31     Fields:    Translation:Animals
  49. Park MH, Hyun H, Ashitate Y, Wada H, Park G, Lee JH, Njiojob C, Henary M, Frangioni JV, Choi HS. Prototype nerve-specific near-infrared fluorophores. Theranostics. 2014; 4(8):823-33. PMID: 24955143.
    Citations: 33     Fields:    Translation:Animals
  50. Ashitate Y, Hyun H, Kim SH, Lee JH, Henary M, Frangioni JV, Choi HS. Simultaneous mapping of pan and sentinel lymph nodes for real-time image-guided surgery. Theranostics. 2014; 4(7):693-700. PMID: 24883119.
    Citations: 19     Fields:    Translation:Animals
  51. Verbeek FP, van der Vorst JR, Tummers QR, Boonstra MC, de Rooij KE, Löwik CW, Valentijn AR, van de Velde CJ, Choi HS, Frangioni JV, Vahrmeijer AL. Near-infrared fluorescence imaging of both colorectal cancer and ureters using a low-dose integrin targeted probe. Ann Surg Oncol. 2014 Dec; 21 Suppl 4:S528-37. PMID: 24515567.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  52. Choi HS. Nanoparticle assembly: building blocks for tumour delivery. Nat Nanotechnol. 2014 Feb; 9(2):93-4. PMID: 24463360.
    Citations: 5     Fields:    Translation:Animals
  53. Hyun H, Owens EA, Narayana L, Wada H, Gravier J, Bao K, Frangioni JV, Choi HS, Henary M. Central C-C Bonding Increases Optical and Chemical Stability of NIR Fluorophores. RSC Adv. 2014 Jan 01; 4(102):58762-58768. PMID: 25530846.
    Citations: 18     
  54. Lee D, Bae S, Ke Q, Lee J, Song B, Karumanchi SA, Khang G, Choi HS, Kang PM. Hydrogen peroxide-responsive copolyoxalate nanoparticles for detection and therapy of ischemia-reperfusion injury. J Control Release. 2013 Dec 28; 172(3):1102-10. PMID: 24096013.
    Citations: 14     Fields:    Translation:AnimalsCells
  55. Huang X, Zhang F, Zhu L, Choi KY, Guo N, Guo J, Tackett K, Anilkumar P, Liu G, Quan Q, Choi HS, Niu G, Sun YP, Lee S, Chen X. Effect of injection routes on the biodistribution, clearance, and tumor uptake of carbon dots. ACS Nano. 2013 Jul 23; 7(7):5684-93. PMID: 23731122.
    Citations: 31     Fields:    Translation:Animals
  56. Lee JH, Park S, Hyun H, Bordo MW, Oketokoun R, Nasr KA, Frangioni JV, Choi HS. High-throughput screening of small molecule ligands targeted to live bacteria surface. Anal Chem. 2013 Apr 02; 85(7):3508-14. PMID: 23461528.
    Citations: 4     Fields:    Translation:HumansCells
  57. Ashitate Y, Lee BT, Laurence RG, Lunsford E, Hutteman M, Oketokoun R, Choi HS, Frangioni JV. Intraoperative prediction of postoperative flap outcome using the near-infrared fluorophore methylene blue. Ann Plast Surg. 2013 Mar; 70(3):360-5. PMID: 22395044.
    Citations: 5     Fields:    Translation:Animals
  58. Kim SH, Lee JH, Hyun H, Ashitate Y, Park G, Robichaud K, Lunsford E, Lee SJ, Khang G, Choi HS. Near-infrared fluorescence imaging for noninvasive trafficking of scaffold degradation. Sci Rep. 2013; 3:1198. PMID: 23386968.
    Citations: 18     Fields:    Translation:Animals
  59. Ashitate Y, Lee BT, Ngo LH, Laurence RG, Hutteman M, Oketokoun R, Lunsford E, Soo Choi H, Frangioni JV. Quantitative assessment of nipple perfusion with near-infrared fluorescence imaging. Ann Plast Surg. 2013 Feb; 70(2):149-53. PMID: 21862913.
    Citations: 5     Fields:    Translation:Animals
  60. Owens EA, Hyun H, Kim SH, Lee JH, Park G, Ashitate Y, Choi J, Hong GH, Alyabyev S, Lee SJ, Khang G, Henary M, Choi HS. Highly charged cyanine fluorophores for trafficking scaffold degradation. Biomed Mater. 2013 Feb; 8(1):014109. PMID: 23353870.
    Citations: 11     Fields:    Translation:Animals
  61. Kim SH, Park G, Hyun H, Lee JH, Ashitate Y, Choi J, Hong GH, Owens EA, Henary M, Choi HS. Near-infrared lipophilic fluorophores for tracing tissue growth. Biomed Mater. 2013 Feb; 8(1):014110. PMID: 23353894.
    Citations: 18     Fields:    Translation:AnimalsCells
  62. Choi HS, Gibbs SL, Lee JH, Kim SH, Ashitate Y, Liu F, Hyun H, Park G, Xie Y, Bae S, Henary M, Frangioni JV. Targeted zwitterionic near-infrared fluorophores for improved optical imaging. Nat Biotechnol. 2013 Feb; 31(2):148-53. PMID: 23292608.
    Citations: 146     Fields:    Translation:HumansAnimalsCells
  63. Huang X, Zhang F, Wang H, Niu G, Choi KY, Swierczewska M, Zhang G, Gao H, Wang Z, Zhu L, Choi HS, Lee S, Chen X. Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery. Biomaterials. 2013 Feb; 34(7):1772-80. PMID: 23228423.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  64. Lee JH, Park G, Hong GH, Choi J, Choi HS. Design considerations for targeted optical contrast agents. Quant Imaging Med Surg. 2012 Dec; 2(4):266-73. PMID: 23289086.
    Citations: 32     
  65. Hyun H, Bordo MW, Nasr K, Feith D, Lee JH, Kim SH, Ashitate Y, Moffitt LA, Rosenberg M, Henary M, Choi HS, Frangioni JV. cGMP-Compatible preparative scale synthesis of near-infrared fluorophores. Contrast Media Mol Imaging. 2012 Nov-Dec; 7(6):516-24. PMID: 22991318.
    Citations: 24     Fields:    Translation:Animals
  66. Zhu L, Guo N, Li Q, Ma Y, Jacboson O, Lee S, Choi HS, Mansfield JR, Niu G, Chen X. Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe. Theranostics. 2012; 2(8):746-56. PMID: 22916074.
    Citations: 14     Fields:    
  67. Ashitate Y, Vooght CS, Hutteman M, Oketokoun R, Choi HS, Frangioni JV. Simultaneous assessment of luminal integrity and vascular perfusion of the gastrointestinal tract using dual-channel near-infrared fluorescence. Mol Imaging. 2012 Jul-Aug; 11(4):301-8. PMID: 22954146.
    Citations: 8     Fields:    Translation:Animals
  68. Liu F, Lunsford EP, Tong J, Ashitate Y, Gibbs SL, Yu J, Choi HS, Henske EP, Frangioni JV. Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex. PLoS One. 2012; 7(6):e38589. PMID: 22719903.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  69. Ashitate Y, Kim SH, Tanaka E, Henary M, Choi HS, Frangioni JV, Flaumenhaft R. Two-wavelength near-infrared fluorescence for the quantitation of drug antiplatelet effects in large animal model systems. J Vasc Surg. 2012 Jul; 56(1):171-80. PMID: 22503225.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  70. Huang X, Zhang F, Lee S, Swierczewska M, Kiesewetter DO, Lang L, Zhang G, Zhu L, Gao H, Choi HS, Niu G, Chen X. Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes. Biomaterials. 2012 Jun; 33(17):4370-8. PMID: 22425023.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  71. Lee JH, Hyun H, Cross CJ, Henary M, Nasr KA, Oketokoun R, Choi HS, Frangioni JV. Rapid and Facile Microwave-Assisted Surface Chemistry for Functionalized Microarray Slides. Adv Funct Mater. 2012 Feb 22; 22(4):872-878. PMID: 23467787.
    Citations: 4     
  72. Kim KH, Lee EN, Park JK, Lee JR, Kim JH, Choi HJ, Kim BS, Lee HW, Lee KS, Yoon S. Curcumin attenuates TNF-a-induced expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and proinflammatory cytokines in human endometriotic stromal cells. Phytother Res. 2012 Jul; 26(7):1037-47. PMID: 22183741.
    Citations: 9     Fields:    Translation:HumansCells
  73. Ashitate Y, Stockdale A, Choi HS, Laurence RG, Frangioni JV. Real-time simultaneous near-infrared fluorescence imaging of bile duct and arterial anatomy. J Surg Res. 2012 Jul; 176(1):7-13. PMID: 21816414.
    Citations: 32     Fields:    Translation:Animals
  74. Lee JH, Choi HS, Nasr KA, Ha M, Kim Y, Frangioni JV. High-throughput small molecule identification using MALDI-TOF and a nanolayered substrate. Anal Chem. 2011 Jul 01; 83(13):5283-9. PMID: 21651231.
    Citations: 7     Fields:    Translation:Cells
  75. Choi HS, Nasr K, Alyabyev S, Feith D, Lee JH, Kim SH, Ashitate Y, Hyun H, Patonay G, Strekowski L, Henary M, Frangioni JV. Synthesis and in vivo fate of zwitterionic near-infrared fluorophores. Angew Chem Int Ed Engl. 2011 Jul 04; 50(28):6258-63. PMID: 21656624.
    Citations: 113     Fields:    Translation:Animals
  76. Ashitate Y, Tanaka E, Stockdale A, Choi HS, Frangioni JV. Near-infrared fluorescence imaging of thoracic duct anatomy and function in open surgery and video-assisted thoracic surgery. J Thorac Cardiovasc Surg. 2011 Jul; 142(1):31-8.e1-2. PMID: 21477818.
    Citations: 20     Fields:    Translation:Animals
  77. Mieog JS, Troyan SL, Hutteman M, Donohoe KJ, van der Vorst JR, Stockdale A, Liefers GJ, Choi HS, Gibbs-Strauss SL, Putter H, Gioux S, Kuppen PJ, Ashitate Y, Löwik CW, Smit VT, Oketokoun R, Ngo LH, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer. Ann Surg Oncol. 2011 Sep; 18(9):2483-91. PMID: 21360250.
    Citations: 98     Fields:    Translation:HumansAnimals
  78. Choi HS, Frangioni JV. Nanoparticles for biomedical imaging: fundamentals of clinical translation. Mol Imaging. 2010 Dec; 9(6):291-310. PMID: 21084027.
    Citations: 94     Fields:    Translation:Humans
  79. Hutteman M, Choi HS, Mieog JS, van der Vorst JR, Ashitate Y, Kuppen PJ, van Groningen MC, Löwik CW, Smit VT, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Clinical translation of ex vivo sentinel lymph node mapping for colorectal cancer using invisible near-infrared fluorescence light. Ann Surg Oncol. 2011 Apr; 18(4):1006-14. PMID: 21080086.
    Citations: 28     Fields:    Translation:HumansAnimals
  80. Choi HS, Ashitate Y, Lee JH, Kim SH, Matsui A, Insin N, Bawendi MG, Semmler-Behnke M, Frangioni JV, Tsuda A. Rapid translocation of nanoparticles from the lung airspaces to the body. Nat Biotechnol. 2010 Dec; 28(12):1300-3. PMID: 21057497.
    Citations: 173     Fields:    Translation:Animals
  81. Gioux S, Choi HS, Frangioni JV. Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation. Mol Imaging. 2010 Oct; 9(5):237-55. PMID: 20868625.
    Citations: 185     Fields:    Translation:Humans
  82. Gioux S, Lomnes SJ, Choi HS, Frangioni JV. Low-frequency wide-field fluorescence lifetime imaging using a high-power near-infrared light-emitting diode light source. J Biomed Opt. 2010 Mar-Apr; 15(2):026005. PMID: 20459250.
    Citations: 7     Fields:    
  83. Matsui A, Tanaka E, Choi HS, Winer JH, Kianzad V, Gioux S, Laurence RG, Frangioni JV. Real-time intra-operative near-infrared fluorescence identification of the extrahepatic bile ducts using clinically available contrast agents. Surgery. 2010 Jul; 148(1):87-95. PMID: 20117813.
    Citations: 47     Fields:    Translation:Animals
  84. Matsui A, Tanaka E, Choi HS, Kianzad V, Gioux S, Lomnes SJ, Frangioni JV. Real-time, near-infrared, fluorescence-guided identification of the ureters using methylene blue. Surgery. 2010 Jul; 148(1):78-86. PMID: 20117811.
    Citations: 41     Fields:    Translation:Animals
  85. Winer JH, Choi HS, Gibbs-Strauss SL, Ashitate Y, Colson YL, Frangioni JV. Intraoperative localization of insulinoma and normal pancreas using invisible near-infrared fluorescent light. Ann Surg Oncol. 2010 Apr; 17(4):1094-100. PMID: 20033320.
    Citations: 33     Fields:    Translation:Animals
  86. Choi HS, Liu W, Liu F, Nasr K, Misra P, Bawendi MG, Frangioni JV. Design considerations for tumour-targeted nanoparticles. Nat Nanotechnol. 2010 Jan; 5(1):42-7. PMID: 19893516.
    Citations: 214     Fields:    Translation:HumansAnimalsCells
  87. Choi HS, Ipe BI, Misra P, Lee JH, Bawendi MG, Frangioni JV. Tissue- and organ-selective biodistribution of NIR fluorescent quantum dots. . 2009 Jun; 9(6):2354-9. PMID: 19422261.
    Citations: 83     Translation:Animals
  88. Yuan TL, Choi HS, Matsui A, Benes C, Lifshits E, Luo J, Frangioni JV, Cantley LC. Class 1A PI3K regulates vessel integrity during development and tumorigenesis. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9739-44. PMID: 18621722.
    Citations: 35     Fields:    Translation:Animals
  89. Tanaka E, Choi HS, Humblet V, Ohnishi S, Laurence RG, Frangioni JV. Real-time intraoperative assessment of the extrahepatic bile ducts in rats and pigs using invisible near-infrared fluorescent light. Surgery. 2008 Jul; 144(1):39-48. PMID: 18571583.
    Citations: 31     Fields:    Translation:Animals
  90. Gioux S, Kianzad V, Ciocan R, Choi HS, Nelson C, Thumm J, Filkins RJ, Lomnes SJ, Frangioni JV. A low-cost, linear, DC - 35 MHz, high-power LED driver for continuous wave (CW) and fluorescence lifetime imaging (FLIM). Proc SPIE Int Soc Opt Eng. 2008; 6848:684807. PMID: 19655029.
    Citations: 4     
  91. Liu W, Choi HS, Zimmer JP, Tanaka E, Frangioni JV, Bawendi M. Compact cysteine-coated CdSe(ZnCdS) quantum dots for in vivo applications. J Am Chem Soc. 2007 Nov 28; 129(47):14530-1. PMID: 17983223.
    Citations: 64     Fields:    Translation:AnimalsCells
  92. Choi HS, Liu W, Misra P, Tanaka E, Zimmer JP, Itty Ipe B, Bawendi MG, Frangioni JV. Renal clearance of quantum dots. Nat Biotechnol. 2007 Oct; 25(10):1165-70. PMID: 17891134.
    Citations: 845     Fields:    Translation:Animals
  93. Tanaka E, Ohnishi S, Laurence RG, Choi HS, Humblet V, Frangioni JV. Real-time intraoperative ureteral guidance using invisible near-infrared fluorescence. J Urol. 2007 Nov; 178(5):2197-202. PMID: 17870110.
    Citations: 34     Fields:    Translation:Animals
  94. Tanaka E, Choi HS, Fujii H, Bawendi MG, Frangioni JV. Image-guided oncologic surgery using invisible light: completed pre-clinical development for sentinel lymph node mapping. Ann Surg Oncol. 2006 Dec; 13(12):1671-81. PMID: 17009138.
    Citations: 112     Fields:    Translation:Animals
  95. Loethen S, Ooya T, Choi HS, Yui N, Thompson DH. Synthesis, characterization, and pH-triggered dethreading of alpha-cyclodextrin-poly(ethylene glycol) polyrotaxanes bearing cleavable endcaps. Biomacromolecules. 2006 Sep; 7(9):2501-6. PMID: 16961310.
    Citations: 6     Fields:    Translation:Cells
  96. Choi HS, Takahashi A, Ooya T, Yui N. Molecular-recognition and binding properties of cyclodextrin-conjugated polyrotaxanes. Chemphyschem. 2006 Aug 11; 7(8):1668-70. PMID: 16807959.
    Citations: 1     Fields:    Translation:Cells
  97. Choi HS, Hirasawa A, Ooya T, Kajihara D, Hohsaka T, Yui N. pH-sensitive locomotion of cyclodextrins in a block-selective mobile polyrotaxane. Chemphyschem. 2006 Aug 11; 7(8):1671-3. PMID: 16832804.
    Citations: 1     Fields:    
  98. Ooya T, Inoue D, Choi HS, Kobayashi Y, Loethen S, Thompson DH, Ko YH, Kim K, Yui N. pH-responsive movement of cucurbit[7]uril in a diblock polypseudorotaxane containing dimethyl beta-cyclodextrin and cucurbit[7]uril. Org Lett. 2006 Jul 20; 8(15):3159-62. PMID: 16836355.
    Citations: 2     Fields:    Translation:Cells
  99. Choi HS, Ooya T, Yui N. One-pot synthesis of a polyrotaxane via selective threading of a PEI-b-PEG-b-PEI copolymer. Macromol Biosci. 2006 Jun 16; 6(6):420-4. PMID: 16761273.
    Citations: 2     Fields:    
  100. Ooya T, Choi HS, Yamashita A, Yui N, Sugaya Y, Kano A, Maruyama A, Akita H, Ito R, Kogure K, Harashima H. Biocleavable polyrotaxane-plasmid DNA polyplex for enhanced gene delivery. J Am Chem Soc. 2006 Mar 29; 128(12):3852-3. PMID: 16551060.
    Citations: 34     Fields:    Translation:Cells
  101. Yamashita A, Choi HS, Ooya T, Yui N, Akita H, Kogure K, Harashima H. Improved cell viability of linear polyethylenimine through gamma-cyclodextrin inclusion for effective gene delivery. Chembiochem. 2006 Feb; 7(2):297-302. PMID: 16408311.
    Citations: 1     Fields:    Translation:AnimalsCells
  102. Choi HS, Yamashita A, Ooya T, Yui N, Akita H, Kogure K, Ito R, Harashima H. Sunflower-shaped cyclodextrin-conjugated poly(epsilon-lysine) polyplex as a controlled intracellular trafficking device. Chembiochem. 2005 Nov; 6(11):1986-90. PMID: 16222730.
    Citations: 4     Fields:    Translation:AnimalsCells
  103. Choi HS, Yamamoto K, Ooya T, Yui N. Synthesis of poly(epsilon-lysine)-grafted dextrans and their pH- and thermosensitive hydrogelation with cyclodextrins. Chemphyschem. 2005 Jun 13; 6(6):1081-6. PMID: 15937894.
    Citations: 2     Fields:    
  104. Choi HS, Ooya T, Huh KM, Yui N. pH-triggered changes in assembling properties of beta-cyclodextrin-conjugated poly(epsilon-lysine) complexes. Biomacromolecules. 2005 May-Jun; 6(3):1200-4. PMID: 15877334.
    Citations: 1     Fields:    
  105. Choi HS, Ooya T, Sasaki S, Yui N, Kurisawa M, Uyama H, Kobayashi S. Spontaneous change of physical state from hydrogels to crystalline precipitates during poly-pseudorotaxane formation. Chemphyschem. 2004 Sep 20; 5(9):1431-4. PMID: 15499862.
    Citations: 1     Fields:    
  106. Chun T, Choi HJ, Chung YH. Two different forms of human CTLA-4 proteins following peripheral T cell activation. Immunol Lett. 2004 Feb 15; 91(2-3):213-20. PMID: 15019292.
    Citations: 1     Fields:    Translation:HumansCells
  107. Choi HS, Huh KM, Ooya T, Yui N. pH- and thermosensitive supramolecular assembling system: rapidly responsive properties of beta-cyclodextrin-conjugated poly(epsilon-lysine). J Am Chem Soc. 2003 May 28; 125(21):6350-1. PMID: 12785758.
    Citations: 5     Fields:    
  108. Seo SA, Choi HS, Khang G, Rhee JM, Lee HB. A local delivery system for fentanyl based on biodegradable poly(L-lactide-co-glycolide) oligomer. Int J Pharm. 2002 Jun 04; 239(1-2):93-101. PMID: 12052694.
    Citations: 2     Fields:    
  109. Choi HS, Seo SA, Khang G, Rhee JM, Lee HB. Preparation and characterization of fentanyl-loaded PLGA microspheres: in vitro release profiles. Int J Pharm. 2002 Mar 02; 234(1-2):195-203. PMID: 11839450.
    Citations: 5     Fields:    
  110. Choi HS, Shin HC, Khang G, Rhee JM, Lee HB. Quantitative analysis of fentanyl in rat plasma by gas chromatography with nitrogen-phosphorus detection. J Chromatogr B Biomed Sci Appl. 2001 Dec 05; 765(1):63-9. PMID: 11817311.
    Citations:    Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.