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Hak Soo Choi, Ph.D.

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Overview

Mentoring
Available: 03/01/20, Expires: 03/31/22

My research is focused on the development of novel targeted agents for cancer diagnosis, staging, and treatment. Using invisible near-infrared fluorescence imaging, my laboratory has systematically defined the chemical, optical, and physiological properties required for organic and inorganic contrast agents such as nanoparticles and fluorophores. Our long-term goal is to provide oncologic surgeons with useful and specific contrast agents for image-guided cancer surgery.

This important theme started when Nature Biotechnology published our article “Renal clearance of quantum dots” in 2007 (Choi et al., 25:1165). In that article, which has already been cited over 1,000 times, we hypothesized that ultrasmall and zwitterionic nanoparticles could target tumors efficiently while eliminating unbound material from the body via renal clearance. Indeed, we proved this hypothesis in the following papers Nat Nanotechnol. 2010;5:42 and Nat Biotechnol. 2013; 31:148.

Most recently, we developed target-specific NIR fluorophores using the concept of “structure-inherent targeting.” That is, a new, ultra-compact, bifunctional molecule with both high affinity binding to a target as well as NIR fluorescence, i.e., targeting and imaging. This strategy appears to work well, at least with the fluorinated polymethine (Hyun et al. Nat Med. 2015, in press) and phenoxazine model systems employed. Our approach from the phenotypic tissue level screening to the microscopic observation to find cellular level targets (organelle localization) is rather practical because it is based on in silico quantitative structure-affinity relationship (QSAR) design and in vivo feedback. Since this has been an excellent strategy that has served us productively, we will continue to use this approach to find out detailed cellular targeting mechanisms and to prepare the first-in-human clinical trials of selected agents in the current application.

Students will work closely with chemists, engineers, and surgeons to develop and optimize new targeted contrast agents. Their responsibilities in the laboratory will include design of novel near-infrared fluorophores and targeting drugs including synthesis, purification, characterization, and conjugation with biomolecules. Students will be trained with cancer cell culture, cell-based assay, and most importantly, the use of contrast agents in image-guided surgery using mice, rats, and pigs.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL143020 (KIM, JONGHAN) Jan 1, 2021 - Aug 31, 2022
    NIH
    Nanochelation Therapies for Iron Overload Disorders
    Role: Multi-PI/PD
  2. R21CA223270 (CHOI, HAK SOO) Sep 25, 2018 - Aug 31, 2021
    NIH
    Image-Guided Drug Delivery and Treatment for GIST
    Role: Principal Investigator
  3. R01EB022230 (CHOI, HAK SOO) Sep 16, 2017 - Sep 21, 2021
    NIH
    Image-Guided Drug Delivery for Pancreatic Neuroendocrine Tumor.
    Role: Principal Investigator
  4. R01EB010022 (FRANGIONI, JOHN V) Aug 1, 2010 - Jul 31, 2015
    NIH/NIBIB
    Ultra-Low Background NIR Fluorophores for In Vivo Imaging and Image-Guided Surger
    Role: Multi-PI/PD
  5. R01EB011523 (CHOI, HAK SOO) Aug 1, 2010 - Apr 30, 2014
    NIH/NIBIB
    Image-Guided Surgery of Endocrine Glands and Their Tumors using Near-Infrared Flu
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Han HH, Kang H, Kim SJ, Pal R, Kumar ATN, Choi HS, Hahn SK. Fluorescent nanodiamond - hyaluronate conjugates for target-specific molecular imaging. RSC Adv. 2021; 11(37):23073-23081. PMID: 34262698.
    Citations:    
  2. Yang C, Wang H, Yokomizo S, Hickey M, Chang H, Kang H, Fukuda T, Song MY, Lee SY, Park JW, Bao K, Choi HS. ZW800-PEG: A Renal Clearable Zwitterionic Near-Infrared Fluorophore for Potential Clinical Translation. Angew Chem Int Ed Engl. 2021 06 14; 60(25):13847-13852. PMID: 33857346.
    Citations:    Fields:    Translation:Humans
  3. Kim SH, Kwon JS, Cho JG, Park KG, Lim TH, Kim MS, Choi HS, Park CH, Lee SJ. Non-invasive in vivo monitoring of transplanted stem cells in 3D-bioprinted constructs using near-infrared fluorescent imaging. Bioeng Transl Med. 2021 May; 6(2):e10216. PMID: 34027098.
    Citations:    
  4. Lee H, An YH, Kim TK, Ryu J, Park GK, Park MJ, Ko J, Kim H, Choi HS, Hwang NS, Park TH. Enhancement of Wound Healing Efficacy by Increasing the Stability and Skin-Penetrating Property of bFGF Using 30Kc19a-Based Fusion Protein. Adv Biol (Weinh). 2021 01; 5(1):e2000176. PMID: 33724733.
    Citations:    
  5. Baart VM, Deken MM, Bordo MW, Bhairosingh SS, Salvatori DCF, Hyun H, Henary M, Choi HS, Sier CFM, Kuppen PJK, van Scheltinga AGTT, March TL, Valentijn ARPM, Frangioni JV, Vahrmeijer AL. Small Molecules for Multi-Wavelength Near-Infrared Fluorescent Mapping of Regional and Sentinel Lymph Nodes in Colorectal Cancer Staging. Front Oncol. 2020; 10:586112. PMID: 33392081.
    Citations:    
  6. Suh YJ, Lim TH, Choi HS, Kim MS, Lee SJ, Kim SH, Park CH. 3D Printing and NIR Fluorescence Imaging Techniques for the Fabrication of Implants. Materials (Basel). 2020 Oct 28; 13(21). PMID: 33126650.
    Citations:    
  7. Pham XH, Hahm E, Kim TH, Kim HM, Lee SH, Lee SC, Kang H, Lee HY, Jeong DH, Choi HS, Jun BH. Enzyme-amplified SERS immunoassay with Ag-Au bimetallic SERS hot spots. Nano Res. 2020; 13:3338-3346. View Publication.
  8. Yadav Y, Owens E, Nomura S, Fukuda T, Baek Y, Kashiwagi S, Choi HS, Henary M. Ultrabright and Serum-Stable Squaraine Dyes. J Med Chem. 2020 09 10; 63(17):9436-9445. PMID: 32787096.
    Citations:    Fields:    Translation:AnimalsCells
  9. Kim SH, Park JH, Kwon JS, Cho JG, Park KG, Park CH, Yoo JJ, Atala A, Choi HS, Kim MS, Lee SJ. NIR fluorescence for monitoring in vivo scaffold degradation along with stem cell tracking in bone tissue engineering. Biomaterials. 2020 11; 258:120267. PMID: 32781325.
    Citations: 3     Fields:    Translation:AnimalsCells
  10. Ju HJ, Park M, Park JH, Shin GR, Choi HS, Suh MW, Kim MS. In Vivo Imaging of Click-Crosslinked Hydrogel Depots Following Intratympanic Injection. Materials (Basel). 2020 Jul 09; 13(14). PMID: 32660032.
    Citations: 2     
  11. Ji Y, Jones C, Baek Y, Park GK, Kashiwagi S, Choi HS. Near-infrared fluorescence imaging in immunotherapy. Adv Drug Deliv Rev. 2020 12; 167:121-134. PMID: 32579891.
    Citations: 3     Fields:    
  12. Kilian HI, Kang H, Nyayapathi N, Fukuda T, Adluru E, Zhang H, Quinn B, Xia J, Choi HS, Lovell JF. Facile formulation of a long-wavelength cyanine for optical imaging in the second near-infrared window. Biomater Sci. 2020 Aug 07; 8(15):4199-4205. PMID: 32515752.
    Citations: 2     Fields:    Translation:Animals
  13. Jones G, Goswami SK, Kang H, Choi HS, Kim J. Combating iron overload: a case for deferoxamine-based nanochelators. Nanomedicine (Lond). 2020 May 20. PMID: 32429801.
    Citations:    Fields:    
  14. Park GK, Lee JH, Soriano E, Choi M, Bao K, Katagiri W, Kim DY, Paik JH, Yun SH, Frangioni JV, Clancy TE, Kashiwagi S, Henary M, Choi HS. Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors. iScience. 2020 Apr 24; 23(4):101006. PMID: 32268281.
    Citations:    
  15. Wang P, Liu S, Hu M, Zhang H, Duan D, He J, Hong J, Lv R, Choi HS, Yan X, Liang M. Peroxidase-like nanozymes induce a novel form of cell death and inhibit tumor growth in vivo. Adv Funct Mater. 2020; 30(21):2000647. View Publication.
  16. Choi HS, Kim HK. Multispectral image-guided surgery in patients. Nat Biomed Eng. 2020 03; 4(3):245-246. PMID: 32165731.
    Citations: 1     Fields:    Translation:Humans
  17. Katagiri W, Lee G, Tanushi A, Tsukada K, Choi HS, Kashiwagi S. High-throughput single-cell live imaging of photobiomodulation with multispectral near-infrared lasers in cultured T cells. J Biomed Opt. 2020 03; 25(3):1-18. PMID: 32193907.
    Citations: 3     Fields:    Translation:AnimalsCells
  18. Mannan MMN, Kamran MA, Kang S, Choi HS, Jeong MY. A Hybrid Speller Design Using Eye Tracking and SSVEP Brain-Computer Interface. Sensors (Basel). 2020 Feb 07; 20(3). PMID: 32046131.
    Citations: 4     Fields:    Translation:Humans
  19. Kim H, Choi HS, Eom JB, Choi Y. Mini-Platform for Off-On Near-Infrared Fluorescence Imaging Using Peptide-Targeting Ligands. Bioconjug Chem. 2020 03 18; 31(3):721-728. PMID: 31895549.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  20. Usama SM, Park GK, Nomura S, Baek Y, Choi HS, Burgess K. Role of Albumin in Accumulation and Persistence of Tumor-Seeking Cyanine Dyes. Bioconjug Chem. 2020 02 19; 31(2):248-259. PMID: 31909595.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  21. Kang H, Stiles WR, Baek Y, Nomura S, Bao K, Hu S, Park GK, Jo MJ, I H, Coll JL, Rubin BP, Choi HS. Renal Clearable Theranostic Nanoplatforms for Gastrointestinal Stromal Tumors. Adv Mater. 2020 Feb; 32(6):e1905899. PMID: 31854033.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  22. Kang H, Rho S, Stiles WR, Hu S, Baek Y, Hwang DW, Kashiwagi S, Kim MS, Choi HS. Size-Dependent EPR Effect of Polymeric Nanoparticles on Tumor Targeting. Adv Healthc Mater. 2020 01; 9(1):e1901223. PMID: 31794153.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  23. Lee JH, Jung SY, Park GK, Bao K, Hyun H, El Fakhri G, Choi HS. Fluorometric Imaging for Early Diagnosis and Prognosis of Rheumatoid Arthritis. Adv Sci (Weinh). 2020 Jan; 7(1):1902267. PMID: 31921569.
    Citations:    
  24. Kang H, Han M, Xue J, Baek Y, Chang J, Hu S, Nam H, Jo MJ, El Fakhri G, Hutchens MP, Choi HS, Kim J. Renal clearable nanochelators for iron overload therapy. Nat Commun. 2019 11 13; 10(1):5134. PMID: 31723130.
    Citations: 9     Fields:    Translation:Animals
  25. Moon HG, Kim SJ, Lee MK, Kang H, Choi HS, Harijith A, Ren J, Natarajan V, Christman JW, Ackerman SJ, Park GY. Colony-stimulating factor 1 and its receptor are new potential therapeutic targets for allergic asthma. Allergy. 2020 02; 75(2):357-369. PMID: 31385613.
    Citations: 2     Fields:    Translation:AnimalsCells
  26. Yang C, Park GK, McDonald EJ, Choi HS. Targeted Near-Infrared Fluorescence Imaging for Regenerative Medicine. Tissue Eng Regen Med. 2019 10; 16(5):433-442. PMID: 31624699.
    Citations: 2     Translation:Humans
  27. Hwang DW, Jo MJ, Lee JH, Kang H, Bao K, Hu S, Baek Y, Moon HG, Lee DS, Kashiwagi S, Henary M, Choi HS. Chemical Modulation of Bioengineered Exosomes for Tissue-Specific Biodistribution. Adv Ther (Weinh). 2019 Nov; 2(11). PMID: 32318623.
    Citations: 2     
  28. Pal R, Kang H, Choi HS, Kumar ATN. Fluorescence Lifetime-Based Tumor Contrast Enhancement Using an EGFR Antibody-Labeled Near-Infrared Fluorophore. Clin Cancer Res. 2019 11 15; 25(22):6653-6661. PMID: 31481509.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  29. Ji Y, Wang Z, Bao K, Park GK, Kang H, Hu S, McDonald E, Kim MS, Kashiwagi S, Choi HS. Targeted molecular imaging of TLR4 in hepatocellular carcinoma using zwitterionic near-infrared fluorophores. Quant Imaging Med Surg. 2019 Sep; 9(9):1548-1555. PMID: 31667140.
    Citations: 2     
  30. Das P, Santos S, Park GK, Hoseok I, Choi HS. Real-Time Fluorescence Imaging in Thoracic Surgery. Korean J Thorac Cardiovasc Surg. 2019 Aug; 52(4):205-220. PMID: 31403028.
    Citations: 1     
  31. Park SH, Seo JY, Park JY, Ji YB, Kim K, Choi HS, Choi S, Kim JH, Min BH, Kim MS. An injectable, click-crosslinked, cytomodulin-modified hyaluronic acid hydrogel for cartilage tissue engineering. NPG Asia Mater. 2019; 11:1-16. View Publication.
  32. Katagiri W, Lee JH, Tétrault MA, Kang H, Jeong S, Evans CL, Yokomizo S, Santos S, Jones C, Hu S, Fakhri GE, Tsukada K, Choi HS, Kashiwagi S. Real-Time Imaging of Vaccine Biodistribution Using Zwitterionic NIR Nanoparticles. Adv Healthc Mater. 2019 08; 8(15):e1900035. PMID: 31165556.
    Citations: 1     Fields:    Translation:AnimalsCells
  33. Kim MG, Kang TW, Park JY, Park SH, Ji YB, Ju HJ, Kwon DY, Kim YS, Kim SW, Lee B, Choi HS, Lee HB, Kim JH, Lee BY, Min BH, Kim MS. An injectable cationic hydrogel electrostatically interacted with BMP2 to enhance in vivo osteogenic differentiation of human turbinate mesenchymal stem cells. Mater Sci Eng C Mater Biol Appl. 2019 Oct; 103:109853. PMID: 31349513.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  34. Ahn CB, Kim JH, Park GK, Park KY, Bao K, Lee JW, Choi HS, Son KH. Prognostic imaging of iatrogenic and traumatic ureteral injury by near-infrared fluorescence. Quant Imaging Med Surg. 2019 Jun; 9(6):1056-1065. PMID: 31367559.
    Citations: 1     
  35. Park GK, Kim SH, Kim K, Das P, Kim BG, Kashiwagi S, Choi HS, Hwang NS. Dual-Channel Fluorescence Imaging of Hydrogel Degradation and Tissue Regeneration in the Brain. Theranostics. 2019; 9(15):4255-4264. PMID: 31285760.
    Citations: 5     Fields:    Translation:Animals
  36. Thavornpradit S, Usama SM, Park GK, Shrestha JP, Nomura S, Baek Y, Choi HS, Burgess K. QuatCy: A Heptamethine Cyanine Modification With Improved Characteristics. Theranostics. 2019; 9(10):2856-2867. PMID: 31244928.
    Citations: 6     Fields:    Translation:AnimalsCells
  37. Park GK, Lee JH, Levitz A, El Fakhri G, Hwang NS, Henary M, Choi HS. Lysosome-Targeted Bioprobes for Sequential Cell Tracking from Macroscopic to Microscopic Scales. . 2019 Apr; 31(14):e1806216. PMID: 30740778.
    Citations: 5     Translation:HumansAnimalsCells
  38. Kim H, Cho MH, Choi HS, Lee BI, Choi Y. Zwitterionic near-infrared fluorophore-conjugated epidermal growth factor for fast, real-time, and target-cell-specific cancer imaging. Theranostics. 2019; 9(4):1085-1095. PMID: 30867817.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  39. Fu Z, Lin Q, Hu B, Zhang Y, Chen W, Zhu J, Zhao Y, Choi HS, Shi H, Cheng D. P2X7 PET Radioligand 18F-PTTP for Differentiation of Lung Tumor from Inflammation. J Nucl Med. 2019 07; 60(7):930-936. PMID: 30655332.
    Citations: 2     Fields:    Translation:AnimalsCells
  40. Miranda D, Huang H, Kang H, Zhan Y, Wang D, Zhou Y, Geng J, Kilian HI, Stiles W, Razi A, Ortega J, Xia J, Choi HS, Lovell JF. Highly-Soluble Cyanine J-aggregates Entrapped by Liposomes for In Vivo Optical Imaging around 930 nm. Theranostics. 2019; 9(2):381-390. PMID: 30809281.
    Citations: 4     Fields:    Translation:Animals
  41. Sajedi S, Sabet H, Choi HS. Intraoperative biophotonic imaging systems for image-guided interventions. Nanophotonics. 2019 Jan; 8(1):99-116. PMID: 31187017.
    Citations: 8     
  42. Yeo SJ, Kang H, Dao TD, Cuc BT, Nguyen ATV, Tien TTT, Hang NLK, Phuong HVM, Thanh LT, Mai LQ, Rah Y, Yu K, Shin HJ, Chong CK, Choi HS, Park H. Development of a smartphone-based rapid dual fluorescent diagnostic system for the simultaneous detection of influenza A and H5 subtype in avian influenza A-infected patients. Theranostics. 2018; 8(22):6132-6148. PMID: 30613288.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  43. Kang H, Hu S, Cho MH, Hong SH, Choi Y, Choi HS. Theranostic Nanosystems for Targeted Cancer Therapy. Nano Today. 2018 Dec; 23:59-72. PMID: 31186672.
    Citations: 17     
  44. Son J, Yi G, Yoo J, Park C, Koo H, Choi HS. Light-responsive nanomedicine for biophotonic imaging and targeted therapy. Adv Drug Deliv Rev. 2019 01 01; 138:133-147. PMID: 30321619.
    Citations: 14     Fields:    Translation:HumansAnimals
  45. Liang M, Tan H, Zhou J, Wang T, Duan D, Fan K, He J, Cheng D, Shi H, Choi HS, Yan X. Bioengineered H-Ferritin Nanocages for Quantitative Imaging of Vulnerable Plaques in Atherosclerosis. ACS Nano. 2018 09 25; 12(9):9300-9308. PMID: 30165015.
    Citations: 5     Fields:    Translation:HumansAnimals
  46. Moon HG, Kim SJ, Jeong JJ, Han SS, Jarjour NN, Lee H, Abboud-Werner SL, Chung S, Choi HS, Natarajan V, Ackerman SJ, Christman JW, Park GY. Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization. Immunity. 2018 08 21; 49(2):275-287.e5. PMID: 30054206.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  47. Lee JW, Park JY, Park SH, Kim MJ, Song BR, Yun HW, Kang TW, Choi HS, Kim YJ, Min BH, Kim MS. Cross-linked electrospun cartilage acellular matrix/poly(caprolactone-co-lactide-co-glycolide) nanofiber as an antiadhesive barrier. Acta Biomater. 2018 07 01; 74:192-206. PMID: 29793074.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  48. Hu S, Kang H, Baek Y, El Fakhri G, Kuang A, Choi HS. Real-Time Imaging of Brain Tumor for Image-Guided Surgery. Adv Healthc Mater. 2018 08; 7(16):e1800066. PMID: 29719137.
    Citations: 14     Fields:    Translation:HumansAnimals
  49. Seo Y, Jeong S, Lee J, Choi HS, Kim J, Lee H. Innovations in biomedical nanoengineering: nanowell array biosensor. Nano Converg. 2018; 5(1):9. PMID: 29670832.
    Citations: 5     
  50. Hu Y, Liu G, Zhang H, Li Y, Gray BD, Pak KY, Choi HS, Cheng D, Shi H. A Comparison of [99mTc]Duramycin and [99mTc]Annexin V in SPECT/CT Imaging Atherosclerotic Plaques. Mol Imaging Biol. 2018 04; 20(2):249-259. PMID: 28785938.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  51. Wada H, Hyun H, Bao K, Lee JH, El Fakhri G, Choi Y, Choi HS. Multivalent Mannose-Decorated NIR Nanoprobes for Targeting Pan Lymph Nodes. Chem Eng J. 2018 May 15; 340:51-57. PMID: 29962899.
    Citations: 3     
  52. Kim KS, Kim YS, Bao K, Wada H, Choi HS, Hahn SK. Bioimaging of botulinum toxin and hyaluronate hydrogels using zwitterionic near-infrared fluorophores. Biomater Res. 2017; 21:15. PMID: 29046820.
    Citations: 3     
  53. Tran BNN, Angelo JP, Lee JH, Ruan QZ, Laurence RG, Choi HS, Lee BT, Singhal D. A novel pilot animal model for the surgical prevention of lymphedema: the power of optical imaging. J Surg Res. 2018 01; 221:285-292. PMID: 29229140.
    Citations: 1     Fields:    Translation:Animals
  54. Lee G, Lee J, Kim J, Choi HS, Kim J, Lee S, Lee H. Single Microfluidic Electrochemical Sensor System for Simultaneous Multi-Pulmonary Hypertension Biomarker Analyses. Sci Rep. 2017 08 08; 7(1):7545. PMID: 28790334.
    Citations: 5     Fields:    Translation:Humans
  55. Valdes PA, Angelo JP, Choi HS, Gioux S. qF-SSOP: real-time optical property corrected fluorescence imaging. Biomed Opt Express. 2017 Aug 01; 8(8):3597-3605. PMID: 28856038.
    Citations: 15     
  56. Lee J, Shin S, Desalvo A, Lee G, Lee JY, Polini A, Chae S, Jeong H, Kim J, Choi H, Lee H. Nonmediated, Label-Free Based Detection of Cardiovascular Biomarker in a Biological Sample. Adv Healthc Mater. 2017 Sep; 6(17). PMID: 28636127.
    Citations:    Fields:    Translation:Humans
  57. Park GK, Kim GS, Hwang NS, Choi HS. Optical spectroscopic imaging for cell therapy and tissue engineering. Appl Spectrosc Rev. 2018; 53(2-4):360-375. PMID: 29563664.
    Citations: 9     
  58. Kim TH, O’Brien C, Choi HS, Jeong MY. Fluorescence molecular imaging systems for intraoperative image-guided surgery. Appl Spectrosc Rev. 2017; 58:349-359. View Publication.
  59. Kim H, Choi HS, Kim SK, Lee BI, Choi Y. Antigen-responsive molecular sensor enables real-time tumor-specific imaging. Theranostics. 2017; 7(4):952-961. PMID: 28382167.
    Citations: 3     Fields:    Translation:HumansCells
  60. Bao K, Lee JH, Kang H, Park GK, El Fakhri G, Choi HS. PSMA-targeted contrast agents for intraoperative imaging of prostate cancer. Chem Commun (Camb). 2017 Feb 04; 53(10):1611-1614. PMID: 28085163.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  61. Ikeda M, Wakasaki R, Schenning KJ, Swide T, Lee JH, Miller MB, Choi HS, Anderson S, Hutchens MP. Determination of renal function and injury using near-infrared fluorimetry in experimental cardiorenal syndrome. Am J Physiol Renal Physiol. 2017 04 01; 312(4):F629-F639. PMID: 28077373.
    Citations: 7     Fields:    Translation:Animals
  62. Wada H, Hyun H, Kang H, Gravier J, Henary M, Bordo MW, Choi HS, Frangioni JV. Intraoperative Near-Infrared Fluorescence Imaging of Thymus in Preclinical Models. Ann Thorac Surg. 2017 Apr; 103(4):1132-1141. PMID: 27964920.
    Citations: 2     Fields:    Translation:Animals
  63. Koo H, Lee JH, Bao K, Wu Y, El Fakhri G, Henary M, Yun SH, Choi HS. Site-Specific In Vivo Bioorthogonal Ligation via Chemical Modulation. Adv Healthc Mater. 2016 10; 5(19):2510-2516. PMID: 27568818.
    Citations: 6     Fields:    Translation:AnimalsCells
  64. Owens EA, Henary M, El Fakhri G, Choi HS. Tissue-Specific Near-Infrared Fluorescence Imaging. Acc Chem Res. 2016 09 20; 49(9):1731-40. PMID: 27564418.
    Citations: 43     Fields:    Translation:Humans
  65. Ashitate Y, Levitz A, Park MH, Hyun H, Venugopal V, Park G, El Fakhri G, Henary M, Gioux S, Frangioni JV, Choi HS. Endocrine-specific NIR fluorophores for adrenal gland targeting. Chem Commun (Camb). 2016 Aug 11; 52(67):10305-8. PMID: 27476533.
    Citations: 7     Fields:    Translation:Humans
  66. Kang H, Gravier J, Bao K, Wada H, Lee JH, Baek Y, El Fakhri G, Gioux S, Rubin BP, Coll JL, Choi HS. Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery. . 2016 Oct; 28(37):8162-8168. PMID: 27414255.
    Citations: 27     
  67. Jee JE, Lim J, Ong YS, Oon J, Gao L, Choi HS, Lee SS. An efficient strategy to enhance binding affinity and specificity of a known isozyme inhibitor. Org Biomol Chem. 2016 Jul 12; 14(28):6833-9. PMID: 27339902.
    Citations: 2     Fields:    Translation:HumansCells
  68. Owens EA, Hyun H, Dost TL, Lee JH, Park G, Pham DH, Park MH, Choi HS, Henary M. Near-Infrared Illumination of Native Tissues for Image-Guided Surgery. J Med Chem. 2016 06 09; 59(11):5311-23. PMID: 27100476.
    Citations: 17     Fields:    Translation:AnimalsCells
  69. Choi J, Cho SU, Kim DI, Lee HG, Choi HS, Jeong MY. A study on characteristics analysis of multichannel filter module for near-infrared fluorescence imaging. J Microelectron Packag Soc. 2016; 23(1):29-34. View Publication.
  70. Choi HS, Kim S, Lee D, Kim CS, Jeong MY. Synchronized tracking of brain cognitive processing using EEG and vision signals. Appl Spectrosc Rev. 2016; 51(7):592-602. View Publication.
  71. Zhao Y, Liang M, Li X, Fan K, Xiao J, Li Y, Shi H, Wang F, Choi HS, Cheng D, Yan X. Bioengineered Magnetoferritin Nanoprobes for Single-Dose Nuclear-Magnetic Resonance Tumor Imaging. ACS Nano. 2016 04 26; 10(4):4184-91. PMID: 26959856.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  72. Hyun H, Henary M, Gao T, Narayana L, Owens EA, Lee JH, Park G, Wada H, Ashitate Y, Frangioni JV, Choi HS. 700-nm Zwitterionic Near-Infrared Fluorophores for Dual-Channel Image-Guided Surgery. Mol Imaging Biol. 2016 Feb; 18(1):52-61. PMID: 26084246.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  73. Yeo SJ, Choi K, Cuc BT, Hong NN, Bao DT, Ngoc NM, Le MQ, Hang Nle K, Thach NC, Mallik SK, Kim HS, Chong CK, Choi HS, Sung HW, Yu K, Park H. Smartphone-Based Fluorescent Diagnostic System for Highly Pathogenic H5N1 Viruses. Theranostics. 2016; 6(2):231-42. PMID: 26877781.
    Citations: 24     Fields:    Translation:HumansCells
  74. Kang H, Mintri S, Menon AV, Lee HY, Choi HS, Kim J. Pharmacokinetics, pharmacodynamics and toxicology of theranostic nanoparticles. Nanoscale. 2015 Dec 07; 7(45):18848-62. PMID: 26528835.
    Citations: 26     Fields:    Translation:HumansAnimals
  75. Kim KS, Hyun H, Yang JA, Lee MY, Kim H, Yun SH, Choi HS, Hahn SK. Bioimaging of Hyaluronate-Interferon a Conjugates Using a Non-Interfering Zwitterionic Fluorophore. Biomacromolecules. 2015 Sep 14; 16(9):3054-61. PMID: 26258264.
    Citations: 8     Fields:    Translation:HumansCells
  76. Wang J, Choi HS, Wáng YX. Exponential growth of publications on carbon nanodots by Chinese authors. J Thorac Dis. 2015 Jul; 7(7):E201-5. PMID: 26380753.
    Citations: 3     
  77. Hyun H, Owens EA, Wada H, Levitz A, Park G, Park MH, Frangioni JV, Henary M, Choi HS. Cartilage-Specific Near-Infrared Fluorophores for Biomedical Imaging. Angew Chem Int Ed Engl. 2015 Jul 20; 54(30):8648-52. PMID: 26095685.
    Citations: 31     Fields:    Translation:Animals
  78. Wada H, Hyun H, Vargas C, Genega EM, Gravier J, Gioux S, Frangioni JV, Choi HS. Sentinel Lymph Node Mapping of Liver. Ann Surg Oncol. 2015 Dec; 22 Suppl 3:S1147-55. PMID: 25968620.
    Citations: 10     Fields:    Translation:Animals
  79. Owens EA, Hyun H, Tawney JG, Choi HS, Henary M. Correlating molecular character of NIR imaging agents with tissue-specific uptake. J Med Chem. 2015 May 28; 58(10):4348-56. PMID: 25923454.
    Citations: 20     Fields:    Translation:Animals
  80. Bordo MW, Oketokoun R, Cross CJ, Bao K, Lee JH, Feygin I, Chang AB, Frangioni JV, Choi HS. High-Throughput Sorting and Placement of One-Bead-One-Compound (OBOC) Libraries from Bulk to Single Wells in Organic Solvent. ACS Comb Sci. 2015 May 11; 17(5):303-9. PMID: 25879633.
    Citations:    Fields:    
  81. Njiojob CN, Owens EA, Narayana L, Hyun H, Choi HS, Henary M. Tailored near-infrared contrast agents for image guided surgery. J Med Chem. 2015 Mar 26; 58(6):2845-54. PMID: 25711712.
    Citations: 19     Fields:    Translation:Animals
  82. Bao K, Nasr KA, Hyun H, Lee JH, Gravier J, Gibbs SL, Choi HS. Charge and hydrophobicity effects of NIR fluorophores on bone-specific imaging. Theranostics. 2015; 5(6):609-17. PMID: 25825600.
    Citations: 13     Fields:    Translation:Animals
  83. Owens EA, Lee S, Choi J, Henary M, Choi HS. NIR fluorescent small molecules for intraoperative imaging. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 Nov-Dec; 7(6):828-38. PMID: 25645081.
    Citations: 27     Fields:    Translation:HumansAnimals
  84. Hyun H, Park MH, Owens EA, Wada H, Henary M, Handgraaf HJ, Vahrmeijer AL, Frangioni JV, Choi HS. Structure-inherent targeting of near-infrared fluorophores for parathyroid and thyroid gland imaging. Nat Med. 2015 Feb; 21(2):192-7. PMID: 25559343.
    Citations: 53     Fields:    Translation:Animals
  85. Kim S, Jung UT, Kim SK, Lee JH, Choi HS, Kim CS, Jeong MY. Nanostructured multifunctional surface with antireflective and antimicrobial characteristics. ACS Appl Mater Interfaces. 2015 Jan 14; 7(1):326-31. PMID: 25560094.
    Citations: 14     Fields:    Translation:Cells
  86. Wada H, Hyun H, Vargas C, Gravier J, Park G, Gioux S, Frangioni JV, Henary M, Choi HS. Pancreas-targeted NIR fluorophores for dual-channel image-guided abdominal surgery. Theranostics. 2015; 5(1):1-11. PMID: 25553094.
    Citations: 16     Fields:    Translation:Animals
  87. Lee JH, Bao K, Frangioni JV, Choi HS. Screening of Small Molecule Microarrays for Ligands Targeted to the Extracellular Epitopes of Living Cells. Microarrays (Basel). 2015; 4(1):53-63. PMID: 26435848.
    Citations: 2     
  88. Yang AW, Cho SU, Jeong MY, Choi HS. NIR fluorescence imaging systems with optical packaging technology. J Microelectron Packag Soc. 2014; 21(4):25-31. View Publication.
  89. Jee JE, Lim J, Hyun H, Oon J, Ong YS, Massif C, Chang YT, Choi HS, Lee SS. Investigating fluorescent dyes in fluorescence-assisted screenings. Chem Commun (Camb). 2014 Dec 14; 50(96):15220-3. PMID: 25340456.
    Citations: 1     Fields:    Translation:HumansCells
  90. Inoue K, Gibbs SL, Liu F, Lee JH, Xie Y, Ashitate Y, Fujii H, Frangioni JV, Choi HS. Microscopic validation of macroscopic in vivo images enabled by same-slide optical and nuclear fusion. J Nucl Med. 2014 Nov; 55(11):1899-904. PMID: 25324521.
    Citations: 1     Fields:    Translation:HumansAnimals
  91. Salim MM, Owens EA, Gao T, Lee JH, Hyun H, Choi HS, Henary M. Hydroxylated near-infrared BODIPY fluorophores as intracellular pH sensors. Analyst. 2014 Oct 07; 139(19):4862-73. PMID: 25105177.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  92. Chung JE, Tan S, Gao SJ, Yongvongsoontorn N, Kim SH, Lee JH, Choi HS, Yano H, Zhuo L, Kurisawa M, Ying JY. Self-assembled micellar nanocomplexes comprising green tea catechin derivatives and protein drugs for cancer therapy. Nat Nanotechnol. 2014 Nov; 9(11):907-912. PMID: 25282044.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  93. Yeo SJ, Huong DT, Hong NN, Li CY, Choi K, Yu K, Choi DY, Chong CK, Choi HS, Mallik SK, Kim HS, Sung HW, Park H. Rapid and quantitative detection of zoonotic influenza A virus infection utilizing coumarin-derived dendrimer-based fluorescent immunochromatographic strip test (FICT). Theranostics. 2014; 4(12):1239-49. PMID: 25285172.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  94. Hyun H, Wada H, Bao K, Gravier J, Yadav Y, Laramie M, Henary M, Frangioni JV, Choi HS. Phosphonated near-infrared fluorophores for biomedical imaging of bone. Angew Chem Int Ed Engl. 2014 Sep 26; 53(40):10668-72. PMID: 25139079.
    Citations: 31     Fields:    Translation:Animals
  95. Park MH, Hyun H, Ashitate Y, Wada H, Park G, Lee JH, Njiojob C, Henary M, Frangioni JV, Choi HS. Prototype nerve-specific near-infrared fluorophores. Theranostics. 2014; 4(8):823-33. PMID: 24955143.
    Citations: 35     Fields:    Translation:Animals
  96. Ashitate Y, Hyun H, Kim SH, Lee JH, Henary M, Frangioni JV, Choi HS. Simultaneous mapping of pan and sentinel lymph nodes for real-time image-guided surgery. Theranostics. 2014; 4(7):693-700. PMID: 24883119.
    Citations: 19     Fields:    Translation:Animals
  97. Verbeek FP, van der Vorst JR, Tummers QR, Boonstra MC, de Rooij KE, Löwik CW, Valentijn AR, van de Velde CJ, Choi HS, Frangioni JV, Vahrmeijer AL. Near-infrared fluorescence imaging of both colorectal cancer and ureters using a low-dose integrin targeted probe. Ann Surg Oncol. 2014 Dec; 21 Suppl 4:S528-37. PMID: 24515567.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  98. Choi HS. Nanoparticle assembly: building blocks for tumour delivery. Nat Nanotechnol. 2014 Feb; 9(2):93-4. PMID: 24463360.
    Citations: 5     Fields:    Translation:Animals
  99. Hyun H, Owens EA, Narayana L, Wada H, Gravier J, Bao K, Frangioni JV, Choi HS, Henary M. Central C-C Bonding Increases Optical and Chemical Stability of NIR Fluorophores. RSC Adv. 2014 Jan 01; 4(102):58762-58768. PMID: 25530846.
    Citations: 19     
  100. Lee D, Bae S, Ke Q, Lee J, Song B, Karumanchi SA, Khang G, Choi HS, Kang PM. Hydrogen peroxide-responsive copolyoxalate nanoparticles for detection and therapy of ischemia-reperfusion injury. J Control Release. 2013 Dec 28; 172(3):1102-10. PMID: 24096013.
    Citations: 19     Fields:    Translation:AnimalsCells
  101. Huang X, Zhang F, Zhu L, Choi KY, Guo N, Guo J, Tackett K, Anilkumar P, Liu G, Quan Q, Choi HS, Niu G, Sun YP, Lee S, Chen X. Effect of injection routes on the biodistribution, clearance, and tumor uptake of carbon dots. ACS Nano. 2013 Jul 23; 7(7):5684-93. PMID: 23731122.
    Citations: 35     Fields:    Translation:Animals
  102. Lee JH, Park S, Hyun H, Bordo MW, Oketokoun R, Nasr KA, Frangioni JV, Choi HS. High-throughput screening of small molecule ligands targeted to live bacteria surface. Anal Chem. 2013 Apr 02; 85(7):3508-14. PMID: 23461528.
    Citations: 4     Fields:    Translation:HumansCells
  103. Ashitate Y, Lee BT, Laurence RG, Lunsford E, Hutteman M, Oketokoun R, Choi HS, Frangioni JV. Intraoperative prediction of postoperative flap outcome using the near-infrared fluorophore methylene blue. Ann Plast Surg. 2013 Mar; 70(3):360-5. PMID: 22395044.
    Citations: 5     Fields:    Translation:Animals
  104. Kim SH, Lee JH, Hyun H, Ashitate Y, Park G, Robichaud K, Lunsford E, Lee SJ, Khang G, Choi HS. Near-infrared fluorescence imaging for noninvasive trafficking of scaffold degradation. Sci Rep. 2013; 3:1198. PMID: 23386968.
    Citations: 21     Fields:    Translation:Animals
  105. Ashitate Y, Lee BT, Ngo LH, Laurence RG, Hutteman M, Oketokoun R, Lunsford E, Soo Choi H, Frangioni JV. Quantitative assessment of nipple perfusion with near-infrared fluorescence imaging. Ann Plast Surg. 2013 Feb; 70(2):149-53. PMID: 21862913.
    Citations: 5     Fields:    Translation:Animals
  106. Owens EA, Hyun H, Kim SH, Lee JH, Park G, Ashitate Y, Choi J, Hong GH, Alyabyev S, Lee SJ, Khang G, Henary M, Choi HS. Highly charged cyanine fluorophores for trafficking scaffold degradation. Biomed Mater. 2013 Feb; 8(1):014109. PMID: 23353870.
    Citations: 12     Fields:    Translation:Animals
  107. Kim SH, Park G, Hyun H, Lee JH, Ashitate Y, Choi J, Hong GH, Owens EA, Henary M, Choi HS. Near-infrared lipophilic fluorophores for tracing tissue growth. Biomed Mater. 2013 Feb; 8(1):014110. PMID: 23353894.
    Citations: 19     Fields:    Translation:AnimalsCells
  108. Choi HS, Gibbs SL, Lee JH, Kim SH, Ashitate Y, Liu F, Hyun H, Park G, Xie Y, Bae S, Henary M, Frangioni JV. Targeted zwitterionic near-infrared fluorophores for improved optical imaging. Nat Biotechnol. 2013 Feb; 31(2):148-53. PMID: 23292608.
    Citations: 151     Fields:    Translation:HumansAnimalsCells
  109. Huang X, Zhang F, Wang H, Niu G, Choi KY, Swierczewska M, Zhang G, Gao H, Wang Z, Zhu L, Choi HS, Lee S, Chen X. Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery. Biomaterials. 2013 Feb; 34(7):1772-80. PMID: 23228423.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  110. Lee JH, Park G, Hong GH, Choi J, Choi HS. Design considerations for targeted optical contrast agents. Quant Imaging Med Surg. 2012 Dec; 2(4):266-73. PMID: 23289086.
    Citations: 31     
  111. Hyun H, Bordo MW, Nasr K, Feith D, Lee JH, Kim SH, Ashitate Y, Moffitt LA, Rosenberg M, Henary M, Choi HS, Frangioni JV. cGMP-Compatible preparative scale synthesis of near-infrared fluorophores. Contrast Media Mol Imaging. 2012 Nov-Dec; 7(6):516-24. PMID: 22991318.
    Citations: 24     Fields:    Translation:Animals
  112. Zhu L, Guo N, Li Q, Ma Y, Jacboson O, Lee S, Choi HS, Mansfield JR, Niu G, Chen X. Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe. Theranostics. 2012; 2(8):746-56. PMID: 22916074.
    Citations: 15     Fields:    
  113. Ashitate Y, Vooght CS, Hutteman M, Oketokoun R, Choi HS, Frangioni JV. Simultaneous assessment of luminal integrity and vascular perfusion of the gastrointestinal tract using dual-channel near-infrared fluorescence. Mol Imaging. 2012 Jul-Aug; 11(4):301-8. PMID: 22954146.
    Citations: 9     Fields:    Translation:Animals
  114. Liu F, Lunsford EP, Tong J, Ashitate Y, Gibbs SL, Yu J, Choi HS, Henske EP, Frangioni JV. Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex. PLoS One. 2012; 7(6):e38589. PMID: 22719903.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  115. Ashitate Y, Kim SH, Tanaka E, Henary M, Choi HS, Frangioni JV, Flaumenhaft R. Two-wavelength near-infrared fluorescence for the quantitation of drug antiplatelet effects in large animal model systems. J Vasc Surg. 2012 Jul; 56(1):171-80. PMID: 22503225.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  116. Huang X, Zhang F, Lee S, Swierczewska M, Kiesewetter DO, Lang L, Zhang G, Zhu L, Gao H, Choi HS, Niu G, Chen X. Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes. Biomaterials. 2012 Jun; 33(17):4370-8. PMID: 22425023.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  117. Lee JH, Hyun H, Cross CJ, Henary M, Nasr KA, Oketokoun R, Choi HS, Frangioni JV. Rapid and Facile Microwave-Assisted Surface Chemistry for Functionalized Microarray Slides. Adv Funct Mater. 2012 Feb 22; 22(4):872-878. PMID: 23467787.
    Citations: 4     
  118. Kim KH, Lee EN, Park JK, Lee JR, Kim JH, Choi HJ, Kim BS, Lee HW, Lee KS, Yoon S. Curcumin attenuates TNF-a-induced expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and proinflammatory cytokines in human endometriotic stromal cells. Phytother Res. 2012 Jul; 26(7):1037-47. PMID: 22183741.
    Citations: 13     Fields:    Translation:HumansCells
  119. Ashitate Y, Stockdale A, Choi HS, Laurence RG, Frangioni JV. Real-time simultaneous near-infrared fluorescence imaging of bile duct and arterial anatomy. J Surg Res. 2012 Jul; 176(1):7-13. PMID: 21816414.
    Citations: 36     Fields:    Translation:Animals
  120. Lee JH, Choi HS, Nasr KA, Ha M, Kim Y, Frangioni JV. High-throughput small molecule identification using MALDI-TOF and a nanolayered substrate. Anal Chem. 2011 Jul 01; 83(13):5283-9. PMID: 21651231.
    Citations: 7     Fields:    Translation:Cells
  121. Choi HS, Nasr K, Alyabyev S, Feith D, Lee JH, Kim SH, Ashitate Y, Hyun H, Patonay G, Strekowski L, Henary M, Frangioni JV. Synthesis and in vivo fate of zwitterionic near-infrared fluorophores. Angew Chem Int Ed Engl. 2011 Jul 04; 50(28):6258-63. PMID: 21656624.
    Citations: 117     Fields:    Translation:Animals
  122. Ashitate Y, Tanaka E, Stockdale A, Choi HS, Frangioni JV. Near-infrared fluorescence imaging of thoracic duct anatomy and function in open surgery and video-assisted thoracic surgery. J Thorac Cardiovasc Surg. 2011 Jul; 142(1):31-8.e1-2. PMID: 21477818.
    Citations: 21     Fields:    Translation:Animals
  123. Mieog JS, Troyan SL, Hutteman M, Donohoe KJ, van der Vorst JR, Stockdale A, Liefers GJ, Choi HS, Gibbs-Strauss SL, Putter H, Gioux S, Kuppen PJ, Ashitate Y, Löwik CW, Smit VT, Oketokoun R, Ngo LH, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer. Ann Surg Oncol. 2011 Sep; 18(9):2483-91. PMID: 21360250.
    Citations: 101     Fields:    Translation:HumansAnimals
  124. Choi HS, Frangioni JV. Nanoparticles for biomedical imaging: fundamentals of clinical translation. Mol Imaging. 2010 Dec; 9(6):291-310. PMID: 21084027.
    Citations: 101     Fields:    Translation:Humans
  125. Hutteman M, Choi HS, Mieog JS, van der Vorst JR, Ashitate Y, Kuppen PJ, van Groningen MC, Löwik CW, Smit VT, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Clinical translation of ex vivo sentinel lymph node mapping for colorectal cancer using invisible near-infrared fluorescence light. Ann Surg Oncol. 2011 Apr; 18(4):1006-14. PMID: 21080086.
    Citations: 29     Fields:    Translation:HumansAnimals
  126. Choi HS, Ashitate Y, Lee JH, Kim SH, Matsui A, Insin N, Bawendi MG, Semmler-Behnke M, Frangioni JV, Tsuda A. Rapid translocation of nanoparticles from the lung airspaces to the body. Nat Biotechnol. 2010 Dec; 28(12):1300-3. PMID: 21057497.
    Citations: 180     Fields:    Translation:Animals
  127. Gioux S, Choi HS, Frangioni JV. Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation. Mol Imaging. 2010 Oct; 9(5):237-55. PMID: 20868625.
    Citations: 193     Fields:    Translation:Humans
  128. Gioux S, Lomnes SJ, Choi HS, Frangioni JV. Low-frequency wide-field fluorescence lifetime imaging using a high-power near-infrared light-emitting diode light source. J Biomed Opt. 2010 Mar-Apr; 15(2):026005. PMID: 20459250.
    Citations: 7     Fields:    
  129. Matsui A, Tanaka E, Choi HS, Winer JH, Kianzad V, Gioux S, Laurence RG, Frangioni JV. Real-time intra-operative near-infrared fluorescence identification of the extrahepatic bile ducts using clinically available contrast agents. Surgery. 2010 Jul; 148(1):87-95. PMID: 20117813.
    Citations: 49     Fields:    Translation:Animals
  130. Matsui A, Tanaka E, Choi HS, Kianzad V, Gioux S, Lomnes SJ, Frangioni JV. Real-time, near-infrared, fluorescence-guided identification of the ureters using methylene blue. Surgery. 2010 Jul; 148(1):78-86. PMID: 20117811.
    Citations: 43     Fields:    Translation:Animals
  131. Winer JH, Choi HS, Gibbs-Strauss SL, Ashitate Y, Colson YL, Frangioni JV. Intraoperative localization of insulinoma and normal pancreas using invisible near-infrared fluorescent light. Ann Surg Oncol. 2010 Apr; 17(4):1094-100. PMID: 20033320.
    Citations: 33     Fields:    Translation:Animals
  132. Choi HS, Liu W, Liu F, Nasr K, Misra P, Bawendi MG, Frangioni JV. Design considerations for tumour-targeted nanoparticles. Nat Nanotechnol. 2010 Jan; 5(1):42-7. PMID: 19893516.
    Citations: 215     Fields:    Translation:HumansAnimalsCells
  133. Choi HS, Ipe BI, Misra P, Lee JH, Bawendi MG, Frangioni JV. Tissue- and organ-selective biodistribution of NIR fluorescent quantum dots. . 2009 Jun; 9(6):2354-9. PMID: 19422261.
    Citations: 85     Translation:Animals
  134. Yuan TL, Choi HS, Matsui A, Benes C, Lifshits E, Luo J, Frangioni JV, Cantley LC. Class 1A PI3K regulates vessel integrity during development and tumorigenesis. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9739-44. PMID: 18621722.
    Citations: 36     Fields:    Translation:Animals
  135. Tanaka E, Choi HS, Humblet V, Ohnishi S, Laurence RG, Frangioni JV. Real-time intraoperative assessment of the extrahepatic bile ducts in rats and pigs using invisible near-infrared fluorescent light. Surgery. 2008 Jul; 144(1):39-48. PMID: 18571583.
    Citations: 32     Fields:    Translation:Animals
  136. Gioux S, Kianzad V, Ciocan R, Choi HS, Nelson C, Thumm J, Filkins RJ, Lomnes SJ, Frangioni JV. A low-cost, linear, DC - 35 MHz, high-power LED driver for continuous wave (CW) and fluorescence lifetime imaging (FLIM). Proc SPIE Int Soc Opt Eng. 2008; 6848:684807. PMID: 19655029.
    Citations: 4     
  137. Liu W, Choi HS, Zimmer JP, Tanaka E, Frangioni JV, Bawendi M. Compact cysteine-coated CdSe(ZnCdS) quantum dots for in vivo applications. J Am Chem Soc. 2007 Nov 28; 129(47):14530-1. PMID: 17983223.
    Citations: 65     Fields:    Translation:AnimalsCells
  138. Choi HS, Liu W, Misra P, Tanaka E, Zimmer JP, Itty Ipe B, Bawendi MG, Frangioni JV. Renal clearance of quantum dots. Nat Biotechnol. 2007 Oct; 25(10):1165-70. PMID: 17891134.
    Citations: 876     Fields:    Translation:Animals
  139. Tanaka E, Ohnishi S, Laurence RG, Choi HS, Humblet V, Frangioni JV. Real-time intraoperative ureteral guidance using invisible near-infrared fluorescence. J Urol. 2007 Nov; 178(5):2197-202. PMID: 17870110.
    Citations: 35     Fields:    Translation:Animals
  140. Joung YK, Choi HS, Ooya T, Yui N. 1H NMR titration study of stimuli-responsive supramolecular assemblies: inclusion complexes between PEG–b-PEI copolymer-grafted dextran and naphthalene-appended gamma-cyclodextrin via double-strand inclusion. J Incl Phenom Macro Chem. 2007; 57:323-328. View Publication.
  141. Tanaka E, Choi HS, Fujii H, Bawendi MG, Frangioni JV. Image-guided oncologic surgery using invisible light: completed pre-clinical development for sentinel lymph node mapping. Ann Surg Oncol. 2006 Dec; 13(12):1671-81. PMID: 17009138.
    Citations: 115     Fields:    Translation:Animals
  142. Loethen S, Ooya T, Choi HS, Yui N, Thompson DH. Synthesis, characterization, and pH-triggered dethreading of alpha-cyclodextrin-poly(ethylene glycol) polyrotaxanes bearing cleavable endcaps. Biomacromolecules. 2006 Sep; 7(9):2501-6. PMID: 16961310.
    Citations: 7     Fields:    Translation:Cells
  143. Choi HS, Takahashi A, Ooya T, Yui N. Molecular-recognition and binding properties of cyclodextrin-conjugated polyrotaxanes. Chemphyschem. 2006 Aug 11; 7(8):1668-70. PMID: 16807959.
    Citations: 1     Fields:    Translation:Cells
  144. Choi HS, Hirasawa A, Ooya T, Kajihara D, Hohsaka T, Yui N. pH-sensitive locomotion of cyclodextrins in a block-selective mobile polyrotaxane. Chemphyschem. 2006 Aug 11; 7(8):1671-3. PMID: 16832804.
    Citations: 1     Fields:    
  145. Ooya T, Inoue D, Choi HS, Kobayashi Y, Loethen S, Thompson DH, Ko YH, Kim K, Yui N. pH-responsive movement of cucurbit[7]uril in a diblock polypseudorotaxane containing dimethyl beta-cyclodextrin and cucurbit[7]uril. Org Lett. 2006 Jul 20; 8(15):3159-62. PMID: 16836355.
    Citations: 3     Fields:    Translation:Cells
  146. Choi HS, Ooya T, Yui N. One-pot synthesis of a polyrotaxane via selective threading of a PEI-b-PEG-b-PEI copolymer. Macromol Biosci. 2006 Jun 16; 6(6):420-4. PMID: 16761273.
    Citations: 2     Fields:    
  147. Ooya T, Choi HS, Yamashita A, Yui N, Sugaya Y, Kano A, Maruyama A, Akita H, Ito R, Kogure K, Harashima H. Biocleavable polyrotaxane-plasmid DNA polyplex for enhanced gene delivery. J Am Chem Soc. 2006 Mar 29; 128(12):3852-3. PMID: 16551060.
    Citations: 35     Fields:    Translation:Cells
  148. Yamashita A, Choi HS, Ooya T, Yui N, Akita H, Kogure K, Harashima H. Improved cell viability of linear polyethylenimine through gamma-cyclodextrin inclusion for effective gene delivery. Chembiochem. 2006 Feb; 7(2):297-302. PMID: 16408311.
    Citations: 1     Fields:    Translation:AnimalsCells
  149. Choi HS, Yui N. Design of rapidly assembling supramolecular systems responsive to synchronized stimuli based on cyclodextrin-conjugated poly(epsilon-lysine). Prog Polym Sci. 2006; 31(2):121-144. View Publication.
  150. Choi HS, Yamashita A, Ooya T, Yui N, Akita H, Kogure K, Ito R, Harashima H. Sunflower-shaped cyclodextrin-conjugated poly(epsilon-lysine) polyplex as a controlled intracellular trafficking device. Chembiochem. 2005 Nov; 6(11):1986-90. PMID: 16222730.
    Citations: 6     Fields:    Translation:AnimalsCells
  151. Choi HS, Lee SC, Yamamoto K, Yui N. Block-selective movement of a-cyclodextrins in polyrotaxanes of PEI-b-PEG-b-PEI copolymer. Macromolecules. 2005; 38(23):9878-9881. View Publication.
  152. Choi HS, Yamamoto K, Ooya T, Yui N. Synthesis of poly(epsilon-lysine)-grafted dextrans and their pH- and thermosensitive hydrogelation with cyclodextrins. Chemphyschem. 2005 Jun 13; 6(6):1081-6. PMID: 15937894.
    Citations: 2     Fields:    
  153. Choi HS, Ooya T, Huh KM, Yui N. pH-triggered changes in assembling properties of beta-cyclodextrin-conjugated poly(epsilon-lysine) complexes. Biomacromolecules. 2005 May-Jun; 6(3):1200-4. PMID: 15877334.
    Citations: 1     Fields:    
  154. Choi HS, Takahashi A, Ooya T, Yui N. Structural Role of Guest Molecules in Rapid and Sensitive Supramolecular Assembling System Based on ß-Cyclodextrin-Conjugated Poly(e-lysine). Macromolecules. 2004; 37(26):10036-10041. View Publication.
  155. Choi HS, Ooya T, Sasaki S, Yui N, Kurisawa M, Uyama H, Kobayashi S. Spontaneous change of physical state from hydrogels to crystalline precipitates during poly-pseudorotaxane formation. Chemphyschem. 2004 Sep 20; 5(9):1431-4. PMID: 15499862.
    Citations: 1     Fields:    
  156. Lee SC, Choi HS, Ooya T, Yui N. Block-Selective Polypseudorotaxane Formation in PEI-b-PEG-b-PEI Copolymers via pH Variation. Macromolecules. 2004; 37(20):7464-7468. View Publication.
  157. Choi HS, Huh KM, Ooya T, Yui N. pH-Triggered assembling system using cooperative binding between cyclodextrin-conjugated poly(epsilon-lysine)s and anionic guest in aqueous media. J Phys Chem B. 2004; 108(23):7646-7650. View Publication.
  158. Choi HS, Ooya T, Sasaki S, Yui N, Ohya Y, Nakai T, Ouchi T. Preparation and characterization of polypseudorotaxanes based on biodegradable poly(L-lactide)/poly(ethylene glycol) triblock copolymers. Macromolecules. 2003; 36(25):9313-9318. View Publication.
  159. Choi HS, Ooya T, Sasaki S, Yui N. Control of rapid phase transition induced by supramolecular complexation of beta-cyclodextrin-conjugated poly(epsilon-lysine) with a specific guest. Macromolecules. 2003; 36(14):5342–5347. View Publication.
  160. Choi HS, Huh KM, Ooya T, Yui N. pH- and thermosensitive supramolecular assembling system: rapidly responsive properties of beta-cyclodextrin-conjugated poly(epsilon-lysine). J Am Chem Soc. 2003 May 28; 125(21):6350-1. PMID: 12785758.
    Citations: 5     Fields:    
  161. Choi HS, Kontani K, Huh KM, Sasaki S, Ooya T, Lee WK, Yui N. Rapid induction of thermoreversible hydrogel formation based on a poly(propylene glycol)-grafted dextran inclusion complex. Macromol Biosci. 2002; 2(6):298-303. View Publication.
  162. Khang G, Seo S-A, Choi HS, Rhee JM, Lee HB. Evaluation of in vitro release profiles of fentanyl-loaded PLGA oligomer microspheres. Macromol Res. 2002; 10(5):246-252. View Publication.
  163. Seo SA, Choi HS, Khang G, Rhee JM, Lee HB. A local delivery system for fentanyl based on biodegradable poly(L-lactide-co-glycolide) oligomer. Int J Pharm. 2002 Jun 04; 239(1-2):93-101. PMID: 12052694.
    Citations: 2     Fields:    
  164. Choi HS, Seo SA, Khang G, Rhee JM, Lee HB. Preparation and characterization of fentanyl-loaded PLGA microspheres: in vitro release profiles. Int J Pharm. 2002 Mar 02; 234(1-2):195-203. PMID: 11839450.
    Citations: 7     Fields:    
  165. Choi HS, Shin HC, Khang G, Rhee JM, Lee HB. Quantitative analysis of fentanyl in rat plasma by gas chromatography with nitrogen-phosphorus detection. J Chromatogr B Biomed Sci Appl. 2001 Dec 05; 765(1):63-9. PMID: 11817311.
    Citations:    Fields:    Translation:Animals
  166. Choi HS, Kim SW, Yun D-I, Khang G, Rhee JM, Lee HB. Preparation of biodegradable PHBV devices containing gentamicin sulfate. Polym. 2001; 25(3):334-342. View Publication.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.