Harvard Catalyst Profiles

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Hak Soo Choi, Ph.D.

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Available: 01/01/00, Expires: 12/31/25

Our mission is to create a novel medical imaging methodology using near-infrared light and advance our understanding of immunology and immunotherapy. Our central focus has been to develop a new imaging technology to dissect the immune response in the context of cancer, allergy, and infectious diseases with the ultimate goal of translating the knowledge into clinical practice. For example, our group successfully established (1) near-infrared imaging technology of immune components including vaccines and exosomes to improve immunotherapy and (2) molecular imaging of cancer signaling to develop a novel targeted cancer therapy. We are also working to establish safe, effective, simple, and affordable immunotherapy for infectious diseases, allergies, autoimmune diseases, and cancer using near-infrared laser technology. 1. Immunotherapy imaging Once a vaccine or immunotherapeutic is injected, it has to reach the right location called “secondary lymphoid tissue” to be effective. However, there is no non-invasive method to describe its behavior in a real-time manner. We are solving this issue to create a reliable monitoring strategy for vaccine or immunotherapeutic imaging using renal clearable zwitterionic near-infrared fluorophores with high target-to-background ratios. Recently, we demonstrated the size-dependent transportation of vaccine from the injection site to the secondary lymphoid tissues using a multispectral near-infrared imaging platform. In this program, we aim to develop a novel technology that can be used to optimize formulation and evaluate the safety of vaccines and immunotherapeutics. 2. Immuno-oncology imaging Pre- and post-operative and intraoperative cancer imaging is critical for the management of cancer patients. However, traditional imaging including CT, MRI, and ultrasound is not good enough to precisely describe the location of small cancers. We are solving this issue by creating a high-sensitive and specific imaging modality. Recently, we established a reliable imaging method with a high signal-to-background ratio using TLR4 antibody conjugated with a renal clearable zwitterionic near-infrared fluorophore. In this project, we were able to image liver cancer in real-time after a single intravenous injection of TLR4-targeted near-infrared fluorophores over 3 days under the NIR fluorescence imaging system. The probe was determined to target tumor-associated macrophages resulting in specific imaging of liver cancer which is enriched with tumor-associated macrophages. This method can be further extended for intraoperative imaging of many types of cancer. 3. Laser adjuvant technology To boost the immune system, we have been traditionally using chemicals and biologicals. However, they may induce adverse effects. We are working to create a novel solution using “laser light”. Recently, we have shown that skin treatment with near-infrared laser light boosts the immune response to vaccines. This “laser adjuvant” has numerous advantages over the historical chemical or biological agents; it is free from cold-chain storage, hypodermic needles, biohazardous sharp waste, irreversible formulation with vaccine antigen, undesirable biodistribution in vital organs or unknown long-term toxicity. In addition, laser technology has been used in the clinic for more than three decades and is therefore technically matured and safe. Since vaccine formulations are given to healthy populations, these characteristics render the “laser adjuvant” significant advantages for clinical use and open a new developmental path for a safe and effective vaccine. 4. Immune-function imaging Real-time assessment of immune cell function is challenging. In order to resolve this issue, we recently developed a new optical platform equipped with two distinct wavelengths of lasers to realize high-throughput single cell live immune cell imaging. Using this technology, we successfully observed mitochondrial retrograde signaling including intracellular calcium and reactive oxygen species (ROS) in a large number of T cells simultaneously. This technology could be further used to study the function of other types of immune cells.

Available: 01/03/23, Expires: 12/31/25

The Bioengineering & Nanomedicine (BENMD) Program has been trying to solve an important clinical problem, “curing cancer”, by applying the first principles of chemistry and engineering. To achieve this goal, we have a multi-disciplinary team of researchers including chemists, engineers, biologists, physicists, and surgeons. This is a very unique environment, where experts from several fields come together and work together to achieve the same goal. The BENMD program is conceptually organized into four areas: 1) targeted chemistry agents development, 2) engineering bioengineered devices, 3) image-guided drug delivery, and 4) immuno-oncology imaging. Although much of our research is multi-modality, including MRI, SPECT, and PET, our primary focus is near-infrared (NIR) fluorescence imaging and its clinical application. NIR light is invisible to the human eye, but is capable of penetrating relatively deeply into living tissue. The field was so new when we started that few imaging systems or contrast agents even existed. Our Imaging Center took a lead in imaging system development, and invented an intraoperative NIR fluorescence imaging system that permits anatomy and function to be visualized simultaneously, in real-time, with high sensitivity, and with no moving parts. This system provides complete image guidance to surgeons during tumor resection, sentinel lymph node mapping, and other surgery in which a tissue target must be detected, assessed, or resected. We have described versions of this imaging system that are optimized for small animal or large animal/human use. Contrast for our imaging system is provided by exogenously introduced NIR fluorophores. Here, too, our BENMD program has taken a lead role in the field. To date we have developed robust methods for synthesizing organic contrast agents based on tetra-sulfonated heptamethine indocyanines, as well as inorganic/organic contrast agents based on quantum dots and organic fluorophores. In each case, we have published detailed methods that have advanced the field. Moreover, to date, our BENMD program has developed specific NIR fluorescent contrast agents for NIR fluorescence angiography, sentinel lymph node mapping, vascular mapping, quantitative assessment of tissue perfusion, and detection of hydroxyapatite calcification. In addition, manuscripts in preparation or review include those describing NIR fluorescent contrast agents for high-sensitivity detection of cellular injury and death, targeted cancer therapy, inflammatory diseases, and real-time image-guided drug delivery to the brain, bone, cartilage, nerve, brown fat, lymphoid tissues, and endocrine glands. Currently, the BENMD Program consists of over 20 staff members of scientists, postdoctoral fellows, graduate students, and technicians. We are combining our advanced chemistry and engineering experience with an advanced understanding of animal/human physiology to develop a new class of contrast agents for image-guided interventions in oncology. Through the rich infrastructure and scientific environment at MGH Radiology, we will try to combine our optical imaging technology with nuclear medicine, which could provide anatomic and functional imaging and treatment of human cancers. To that extent, the BENMD program provides an Optical Core and a Mass Core to the MGH and Harvard research communities for elucidating the mechanism of action of small molecules by converting them to NIR-PET, NIR-SPECT, NIR-CT, and NIR-MR multimodal imaging agents. By developing targeted imaging probes that are able to localize in the cancerous tissue, we will be able to provide healthcare professionals with a new method to both detect and treat these tumors, through radioimaging and/or laparoscopic imaging as well as image-guided surgery.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL143020 (KIM, JONGHAN) Jan 1, 2021 - Aug 31, 2022
    Nanochelation Therapies for Iron Overload Disorders
    Role: Multi-PI/PD
  2. R21CA223270 (CHOI, HAK SOO) Sep 25, 2018 - Aug 31, 2021
    Image-Guided Drug Delivery and Treatment for GIST
    Role: Principal Investigator
  3. R01EB022230 (CHOI, HAK SOO) Sep 16, 2017 - Sep 21, 2021
    Image-Guided Drug Delivery for Pancreatic Neuroendocrine Tumor.
    Role: Principal Investigator
  4. R01EB010022 (FRANGIONI, JOHN V) Aug 1, 2010 - Jul 31, 2015
    Ultra-Low Background NIR Fluorophores for In Vivo Imaging and Image-Guided Surger
    Role: Multi-PI/PD
  5. R01EB011523 (CHOI, HAK SOO) Aug 1, 2010 - Apr 30, 2014
    Image-Guided Surgery of Endocrine Glands and Their Tumors using Near-Infrared Flu
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hou SS, Yang J, Lee JH, Kwon Y, Calvo-Rodriguez M, Bao K, Ahn S, Kashiwagi S, Kumar ATN, Bacskai BJ, Choi HS. Near-infrared fluorescence lifetime imaging of amyloid-ß aggregates and tau fibrils through the intact skull of mice. Nat Biomed Eng. 2023 Feb 06. PMID: 36747008.
    Citations:    Fields:    
  2. Bao K, Tully M, Cardenas K, Wang H, Srinivas S, Rho J, Jeon OH, Dinh J, Yokomizo S, McDonnell R, Yamashita A, Kashiwagi S, Kang H, Kim HK, Choi HS. Ultralow Background Near-Infrared Fluorophores with Dual-Channel Intraoperative Imaging Capability. Adv Healthc Mater. 2023 Jan 14; e2203134. PMID: 36640372.
    Citations:    Fields:    
  3. Choi HS, Lee JH, Kim HK. Targeted intraoperative fluorescence imaging for the visualization of ground-glass nodules in the lung. Transl Lung Cancer Res. 2022 Nov; 11(11):2175-2177. PMID: 36519012; PMCID: PMC9742616.
  4. Dinh J, Yamashita A, Kang H, Gioux S, Choi HS. Optical Tissue Phantoms for Quantitative Evaluation of Surgical Imaging Devices. Adv Photonics Res. 2023 Jan; 4(1). PMID: 36643020; PMCID: PMC9838008.
  5. Katagiri W, Yokomizo S, Ishizuka T, Yamashita K, Kopp T, Roessing M, Sato A, Iwasaki T, Sato H, Fukuda T, Monaco H, Manganiello S, Nomura S, Ng MR, Feil S, Ogawa E, Fukumura D, Atochin DN, Choi HS, Kashiwagi S. Dual near-infrared II laser modulates the cellular redox state of T cells and augments the efficacy of cancer immunotherapy. FASEB J. 2022 10; 36(10):e22521. PMID: 36052742; PMCID: PMC9574655.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Yin X, Cheng Y, Feng Y, Stiles WR, Park SH, Kang H, Choi HS. Phototheranostics for multifunctional treatment of cancer with fluorescence imaging. Adv Drug Deliv Rev. 2022 10; 189:114483. PMID: 35944585; PMCID: PMC9860309.
    Citations: 4     Fields:    Translation:Humans
  7. Kang H, Kang MW, Kashiwagi S, Choi HS. NIR fluorescence imaging and treatment for cancer immunotherapy. J Immunother Cancer. 2022 07; 10(7). PMID: 35858710; PMCID: PMC9305898.
    Citations: 1     Fields:    Translation:Humans
  8. Kim J, Jeong M, Stiles WR, Choi HS. Neuroimaging Modalities in Alzheimer's Disease: Diagnosis and Clinical Features. Int J Mol Sci. 2022 May 28; 23(11). PMID: 35682758; PMCID: PMC9181385.
    Citations: 2     Fields:    Translation:Humans
  9. Yokomizo S, Henary M, Buabeng ER, Fukuda T, Monaco H, Baek Y, Manganiello S, Wang H, Kubota J, Ulumben AD, Lv X, Wang C, Inoue K, Fukushi M, Kang H, Bao K, Kashiwagi S, Choi HS. Topical pH Sensing NIR Fluorophores for Intraoperative Imaging and Surgery of Disseminated Ovarian Cancer. Adv Sci (Weinh). 2022 07; 9(20):e2201416. PMID: 35567348; PMCID: PMC9286000.
    Citations: 3     Fields:    Translation:HumansAnimals
  10. Park SH, Kim RS, Stiles WR, Jo M, Zeng L, Rho S, Baek Y, Kim J, Kim MS, Kang H, Choi HS. Injectable Thermosensitive Hydrogels for a Sustained Release of Iron Nanochelators. Adv Sci (Weinh). 2022 05; 9(15):e2200872. PMID: 35343104; PMCID: PMC9130884.
    Citations: 5     Fields:    Translation:Humans
  11. Fukuda T, Yokomizo S, Casa S, Monaco H, Manganiello S, Wang H, Lv X, Ulumben AD, Yang C, Kang MW, Inoue K, Fukushi M, Sumi T, Wang C, Kang H, Bao K, Henary M, Kashiwagi S, Soo Choi H. Fast and Durable Intraoperative Near-infrared Imaging of Ovarian Cancer Using Ultrabright Squaraine Fluorophores. Angew Chem Int Ed Engl. 2022 04 19; 61(17):e202117330. PMID: 35150468; PMCID: PMC9007913.
    Citations: 3     Fields:    Translation:HumansAnimals
  12. Kang H, Shamim M, Yin X, Adluru E, Fukuda T, Yokomizo S, Chang H, Park SH, Cui Y, Moy AJ, Kashiwagi S, Henary M, Choi HS. Tumor-Associated Immune-Cell-Mediated Tumor-Targeting Mechanism with NIR-II Fluorescence Imaging. Adv Mater. 2022 Feb; 34(8):e2106500. PMID: 34913533; PMCID: PMC8881361.
    Citations: 9     Fields:    Translation:Animals
  13. Choi H, Kang WS, Kim JS, Na CS, Kim S. De Novo Assembly and Species-Specific Marker Development as a Useful Tool for the Identification of Scutellaria L. Species. Curr Issues Mol Biol. 2021 Dec 01; 43(3):2177-2188. PMID: 34940126; PMCID: PMC8929090.
    Citations:    Fields:    Translation:Animals
  14. Wu X, Daniel Ulumben A, Long S, Katagiri W, Wilks MQ, Yuan H, Cortese B, Yang C, Kashiwagi S, Choi HS, Normandin MD, El Fakhri G, Zaman RT. Near-Infrared Fluorescence Imaging of Carotid Plaques in an Atherosclerotic Murine Model. Biomolecules. 2021 11 24; 11(12). PMID: 34944397; PMCID: PMC8698491.
    Citations:    Fields:    Translation:HumansAnimalsCells
  15. Park SH, Ju HJ, Ji YB, Shah M, Min BH, Choi HS, Choi S, Kim MS. Endogenous Stem Cell-Based In Situ Tissue Regeneration Using Electrostatically Interactive Hydrogel with a Newly Discovered Substance P Analog and VEGF-Mimicking Peptide. Small. 2021 10; 17(40):e2103244. PMID: 34480409.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  16. Han HH, Kang H, Kim SJ, Pal R, Kumar ATN, Choi HS, Hahn SK. Fluorescent nanodiamond - hyaluronate conjugates for target-specific molecular imaging. RSC Adv. 2021; 11(37):23073-23081. PMID: 34262698; PMCID: PMC8240508.
    Citations: 1     
  17. Yang C, Wang H, Yokomizo S, Hickey M, Chang H, Kang H, Fukuda T, Song MY, Lee SY, Park JW, Bao K, Choi HS. ZW800-PEG: A Renal Clearable Zwitterionic Near-Infrared Fluorophore for Potential Clinical Translation. Angew Chem Int Ed Engl. 2021 06 14; 60(25):13847-13852. PMID: 33857346.
    Citations: 11     Fields:    Translation:Humans
  18. Kim SH, Kwon JS, Cho JG, Park KG, Lim TH, Kim MS, Choi HS, Park CH, Lee SJ. Non-invasive in vivo monitoring of transplanted stem cells in 3D-bioprinted constructs using near-infrared fluorescent imaging. Bioeng Transl Med. 2021 May; 6(2):e10216. PMID: 34027098.
    Citations: 3     
  19. Lee H, An YH, Kim TK, Ryu J, Park GK, Park MJ, Ko J, Kim H, Choi HS, Hwang NS, Park TH. Enhancement of Wound Healing Efficacy by Increasing the Stability and Skin-Penetrating Property of bFGF Using 30Kc19a-Based Fusion Protein. Adv Biol (Weinh). 2021 01; 5(1):e2000176. PMID: 33724733.
    Citations:    Fields:    Translation:AnimalsCells
  20. Baart VM, Deken MM, Bordo MW, Bhairosingh SS, Salvatori DCF, Hyun H, Henary M, Choi HS, Sier CFM, Kuppen PJK, van Scheltinga AGTT, March TL, Valentijn ARPM, Frangioni JV, Vahrmeijer AL. Small Molecules for Multi-Wavelength Near-Infrared Fluorescent Mapping of Regional and Sentinel Lymph Nodes in Colorectal Cancer Staging. Front Oncol. 2020; 10:586112. PMID: 33392081.
  21. Suh YJ, Lim TH, Choi HS, Kim MS, Lee SJ, Kim SH, Park CH. 3D Printing and NIR Fluorescence Imaging Techniques for the Fabrication of Implants. Materials (Basel). 2020 Oct 28; 13(21). PMID: 33126650.
    Citations: 2     
  22. Pham XH, Hahm E, Kim TH, Kim HM, Lee SH, Lee SC, Kang H, Lee HY, Jeong DH, Choi HS, Jun BH. Enzyme-amplified SERS immunoassay with Ag-Au bimetallic SERS hot spots. Nano Res. 2020; 13:3338-3346. View Publication.
  23. Yadav Y, Owens E, Nomura S, Fukuda T, Baek Y, Kashiwagi S, Choi HS, Henary M. Ultrabright and Serum-Stable Squaraine Dyes. J Med Chem. 2020 09 10; 63(17):9436-9445. PMID: 32787096.
    Citations: 1     Fields:    Translation:AnimalsCells
  24. Kim SH, Park JH, Kwon JS, Cho JG, Park KG, Park CH, Yoo JJ, Atala A, Choi HS, Kim MS, Lee SJ. NIR fluorescence for monitoring in vivo scaffold degradation along with stem cell tracking in bone tissue engineering. Biomaterials. 2020 11; 258:120267. PMID: 32781325.
    Citations: 11     Fields:    Translation:AnimalsCells
  25. Kang WS, Choi H, Jang G, Lee KH, Kim E, Kim KJ, Jeong GY, Kim JS, Na CS, Kim S. Long-Term Exposure to Urban Particulate Matter on the Ocular Surface and the Incidence of Deleterious Changes in the Cornea, Conjunctiva and Retina in Rats. Int J Mol Sci. 2020 Jul 14; 21(14). PMID: 32674521; PMCID: PMC7404123.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  26. Ju HJ, Park M, Park JH, Shin GR, Choi HS, Suh MW, Kim MS. In Vivo Imaging of Click-Crosslinked Hydrogel Depots Following Intratympanic Injection. Materials (Basel). 2020 Jul 09; 13(14). PMID: 32660032; PMCID: PMC7412526.
    Citations: 3     
  27. Ji Y, Jones C, Baek Y, Park GK, Kashiwagi S, Choi HS. Near-infrared fluorescence imaging in immunotherapy. Adv Drug Deliv Rev. 2020 12; 167:121-134. PMID: 32579891.
    Citations: 15     Fields:    Translation:HumansAnimals
  28. Kilian HI, Kang H, Nyayapathi N, Fukuda T, Adluru E, Zhang H, Quinn B, Xia J, Choi HS, Lovell JF. Facile formulation of a long-wavelength cyanine for optical imaging in the second near-infrared window. Biomater Sci. 2020 Aug 07; 8(15):4199-4205. PMID: 32515752.
    Citations: 7     Fields:    Translation:Animals
  29. Jones G, Goswami SK, Kang H, Choi HS, Kim J. Combating iron overload: a case for deferoxamine-based nanochelators. Nanomedicine (Lond). 2020 May 20. PMID: 32429801.
    Citations: 7     Fields:    
  30. Park GK, Lee JH, Soriano E, Choi M, Bao K, Katagiri W, Kim DY, Paik JH, Yun SH, Frangioni JV, Clancy TE, Kashiwagi S, Henary M, Choi HS. Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors. iScience. 2020 Apr 24; 23(4):101006. PMID: 32268281.
    Citations: 3     
  31. Wang P, Liu S, Hu M, Zhang H, Duan D, He J, Hong J, Lv R, Choi HS, Yan X, Liang M. Peroxidase-like nanozymes induce a novel form of cell death and inhibit tumor growth in vivo. Adv Funct Mater. 2020; 30(21):2000647. View Publication.
  32. Choi HS, Kim HK. Multispectral image-guided surgery in patients. Nat Biomed Eng. 2020 03; 4(3):245-246. PMID: 32165731.
    Citations: 12     Fields:    Translation:Humans
  33. Katagiri W, Lee G, Tanushi A, Tsukada K, Choi HS, Kashiwagi S. High-throughput single-cell live imaging of photobiomodulation with multispectral near-infrared lasers in cultured T cells. J Biomed Opt. 2020 03; 25(3):1-18. PMID: 32193907.
    Citations: 6     Fields:    Translation:AnimalsCells
  34. Lee KH, Jeong ES, Jang G, Na JR, Park S, Kang WS, Kim E, Choi H, Kim JS, Kim S. Unripe Rubus coreanus Miquel Extract Containing Ellagic Acid Regulates AMPK, SREBP-2, HMGCR, and INSIG-1 Signaling and Cholesterol Metabolism In Vitro and In Vivo. Nutrients. 2020 Feb 26; 12(3). PMID: 32110925; PMCID: PMC7146129.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  35. Moon H-, Cao Y, Yang J, Lee JH, Choi HS, Jin Y. Correction: Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway. Cell Death Dis. 2020 Feb 12; 11(2):116. PMID: 32051400; PMCID: PMC7015944.
    Citations: 1     Fields:    
  36. Mannan MMN, Kamran MA, Kang S, Choi HS, Jeong MY. A Hybrid Speller Design Using Eye Tracking and SSVEP Brain-Computer Interface. Sensors (Basel). 2020 Feb 07; 20(3). PMID: 32046131.
    Citations: 7     Fields:    Translation:Humans
  37. Kim H, Choi HS, Eom JB, Choi Y. Mini-Platform for Off-On Near-Infrared Fluorescence Imaging Using Peptide-Targeting Ligands. Bioconjug Chem. 2020 03 18; 31(3):721-728. PMID: 31895549.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  38. Usama SM, Park GK, Nomura S, Baek Y, Choi HS, Burgess K. Role of Albumin in Accumulation and Persistence of Tumor-Seeking Cyanine Dyes. Bioconjug Chem. 2020 02 19; 31(2):248-259. PMID: 31909595; PMCID: PMC7174984.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  39. Kang H, Stiles WR, Baek Y, Nomura S, Bao K, Hu S, Park GK, Jo MJ, I H, Coll JL, Rubin BP, Choi HS. Renal Clearable Theranostic Nanoplatforms for Gastrointestinal Stromal Tumors. Adv Mater. 2020 Feb; 32(6):e1905899. PMID: 31854033.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  40. Kang H, Rho S, Stiles WR, Hu S, Baek Y, Hwang DW, Kashiwagi S, Kim MS, Choi HS. Size-Dependent EPR Effect of Polymeric Nanoparticles on Tumor Targeting. Adv Healthc Mater. 2020 01; 9(1):e1901223. PMID: 31794153.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  41. Lee JH, Jung SY, Park GK, Bao K, Hyun H, El Fakhri G, Choi HS. Fluorometric Imaging for Early Diagnosis and Prognosis of Rheumatoid Arthritis. Adv Sci (Weinh). 2020 Jan; 7(1):1902267. PMID: 31921569; PMCID: PMC6947695.
    Citations: 4     Fields:    
  42. Kang H, Han M, Xue J, Baek Y, Chang J, Hu S, Nam H, Jo MJ, El Fakhri G, Hutchens MP, Choi HS, Kim J. Renal clearable nanochelators for iron overload therapy. Nat Commun. 2019 11 13; 10(1):5134. PMID: 31723130.
    Citations: 28     Fields:    Translation:Animals
  43. Moon HG, Kim SJ, Lee MK, Kang H, Choi HS, Harijith A, Ren J, Natarajan V, Christman JW, Ackerman SJ, Park GY. Colony-stimulating factor 1 and its receptor are new potential therapeutic targets for allergic asthma. Allergy. 2020 02; 75(2):357-369. PMID: 31385613.
    Citations: 5     Fields:    Translation:AnimalsCells
  44. Yang C, Park GK, McDonald EJ, Choi HS. Targeted Near-Infrared Fluorescence Imaging for Regenerative Medicine. Tissue Eng Regen Med. 2019 10; 16(5):433-442. PMID: 31624699.
    Citations: 3     Translation:Humans
  45. Hwang DW, Jo MJ, Lee JH, Kang H, Bao K, Hu S, Baek Y, Moon HG, Lee DS, Kashiwagi S, Henary M, Choi HS. Chemical Modulation of Bioengineered Exosomes for Tissue-Specific Biodistribution. Adv Ther (Weinh). 2019 Nov; 2(11). PMID: 32318623; PMCID: PMC7172497.
    Citations: 9     
  46. Pal R, Kang H, Choi HS, Kumar ATN. Fluorescence Lifetime-Based Tumor Contrast Enhancement Using an EGFR Antibody-Labeled Near-Infrared Fluorophore. Clin Cancer Res. 2019 11 15; 25(22):6653-6661. PMID: 31481509; PMCID: PMC6858968.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  47. Ji Y, Wang Z, Bao K, Park GK, Kang H, Hu S, McDonald E, Kim MS, Kashiwagi S, Choi HS. Targeted molecular imaging of TLR4 in hepatocellular carcinoma using zwitterionic near-infrared fluorophores. Quant Imaging Med Surg. 2019 Sep; 9(9):1548-1555. PMID: 31667140; PMCID: PMC6785503.
    Citations: 9     
  48. Das P, Santos S, Park GK, Hoseok I, Choi HS. Real-Time Fluorescence Imaging in Thoracic Surgery. Korean J Thorac Cardiovasc Surg. 2019 Aug; 52(4):205-220. PMID: 31403028; PMCID: PMC6687041.
    Citations: 5     
  49. Park SH, Seo JY, Park JY, Ji YB, Kim K, Choi HS, Choi S, Kim JH, Min BH, Kim MS. An injectable, click-crosslinked, cytomodulin-modified hyaluronic acid hydrogel for cartilage tissue engineering. NPG Asia Mater. 2019; 11:1-16. View Publication.
  50. Katagiri W, Lee JH, Tétrault MA, Kang H, Jeong S, Evans CL, Yokomizo S, Santos S, Jones C, Hu S, Fakhri GE, Tsukada K, Choi HS, Kashiwagi S. Real-Time Imaging of Vaccine Biodistribution Using Zwitterionic NIR Nanoparticles. Adv Healthc Mater. 2019 08; 8(15):e1900035. PMID: 31165556.
    Citations: 5     Fields:    Translation:AnimalsCells
  51. Kim MG, Kang TW, Park JY, Park SH, Ji YB, Ju HJ, Kwon DY, Kim YS, Kim SW, Lee B, Choi HS, Lee HB, Kim JH, Lee BY, Min BH, Kim MS. An injectable cationic hydrogel electrostatically interacted with BMP2 to enhance in vivo osteogenic differentiation of human turbinate mesenchymal stem cells. Mater Sci Eng C Mater Biol Appl. 2019 Oct; 103:109853. PMID: 31349513.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  52. Ahn CB, Kim JH, Park GK, Park KY, Bao K, Lee JW, Choi HS, Son KH. Prognostic imaging of iatrogenic and traumatic ureteral injury by near-infrared fluorescence. Quant Imaging Med Surg. 2019 Jun; 9(6):1056-1065. PMID: 31367559; PMCID: PMC6629557.
    Citations: 3     
  53. Park GK, Kim SH, Kim K, Das P, Kim BG, Kashiwagi S, Choi HS, Hwang NS. Dual-Channel Fluorescence Imaging of Hydrogel Degradation and Tissue Regeneration in the Brain. Theranostics. 2019; 9(15):4255-4264. PMID: 31285760.
    Citations: 12     Fields:    Translation:Animals
  54. Thavornpradit S, Usama SM, Park GK, Shrestha JP, Nomura S, Baek Y, Choi HS, Burgess K. QuatCy: A Heptamethine Cyanine Modification With Improved Characteristics. Theranostics. 2019; 9(10):2856-2867. PMID: 31244928.
    Citations: 15     Fields:    Translation:AnimalsCells
  55. Park GK, Lee JH, Levitz A, El Fakhri G, Hwang NS, Henary M, Choi HS. Lysosome-Targeted Bioprobes for Sequential Cell Tracking from Macroscopic to Microscopic Scales. Adv Mater. 2019 Apr; 31(14):e1806216. PMID: 30740778; PMCID: PMC6574216.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  56. Kim H, Cho MH, Choi HS, Lee BI, Choi Y. Zwitterionic near-infrared fluorophore-conjugated epidermal growth factor for fast, real-time, and target-cell-specific cancer imaging. Theranostics. 2019; 9(4):1085-1095. PMID: 30867817; PMCID: PMC6401407.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  57. Fu Z, Lin Q, Hu B, Zhang Y, Chen W, Zhu J, Zhao Y, Choi HS, Shi H, Cheng D. P2X7 PET Radioligand 18F-PTTP for Differentiation of Lung Tumor from Inflammation. J Nucl Med. 2019 07; 60(7):930-936. PMID: 30655332; PMCID: PMC6604685.
    Citations: 8     Fields:    Translation:AnimalsCells
  58. Miranda D, Huang H, Kang H, Zhan Y, Wang D, Zhou Y, Geng J, Kilian HI, Stiles W, Razi A, Ortega J, Xia J, Choi HS, Lovell JF. Highly-Soluble Cyanine J-aggregates Entrapped by Liposomes for In Vivo Optical Imaging around 930 nm. Theranostics. 2019; 9(2):381-390. PMID: 30809281; PMCID: PMC6376187.
    Citations: 11     Fields:    Translation:Animals
  59. Sajedi S, Sabet H, Choi HS. Intraoperative biophotonic imaging systems for image-guided interventions. Nanophotonics. 2019 Jan; 8(1):99-116. PMID: 31187017; PMCID: PMC6559750.
    Citations: 16     
  60. Yeo SJ, Kang H, Dao TD, Cuc BT, Nguyen ATV, Tien TTT, Hang NLK, Phuong HVM, Thanh LT, Mai LQ, Rah Y, Yu K, Shin HJ, Chong CK, Choi HS, Park H. Development of a smartphone-based rapid dual fluorescent diagnostic system for the simultaneous detection of influenza A and H5 subtype in avian influenza A-infected patients. Theranostics. 2018; 8(22):6132-6148. PMID: 30613288; PMCID: PMC6299699.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  61. Kang H, Hu S, Cho MH, Hong SH, Choi Y, Choi HS. Theranostic Nanosystems for Targeted Cancer Therapy. Nano Today. 2018 Dec; 23:59-72. PMID: 31186672; PMCID: PMC6559746.
    Citations: 26     
  62. Son J, Yi G, Yoo J, Park C, Koo H, Choi HS. Light-responsive nanomedicine for biophotonic imaging and targeted therapy. Adv Drug Deliv Rev. 2019 01 01; 138:133-147. PMID: 30321619; PMCID: PMC6547138.
    Citations: 35     Fields:    Translation:HumansAnimals
  63. Liang M, Tan H, Zhou J, Wang T, Duan D, Fan K, He J, Cheng D, Shi H, Choi HS, Yan X. Bioengineered H-Ferritin Nanocages for Quantitative Imaging of Vulnerable Plaques in Atherosclerosis. ACS Nano. 2018 09 25; 12(9):9300-9308. PMID: 30165015.
    Citations: 10     Fields:    Translation:HumansAnimals
  64. Moon HG, Kim SJ, Jeong JJ, Han SS, Jarjour NN, Lee H, Abboud-Werner SL, Chung S, Choi HS, Natarajan V, Ackerman SJ, Christman JW, Park GY. Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization. Immunity. 2018 08 21; 49(2):275-287.e5. PMID: 30054206.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  65. Kim J, Kang H, Choi H, Jo A, Oh DR, Kim Y, Im S, Lee SG, Jeong KI, Ryu GC, Choi C. Aqueous Extract of Perilla frutescens var. acuta Relaxes the Ciliary Smooth Muscle by Increasing NO/cGMP Content In Vitro and In Vivo. Molecules. 2018 Jul 19; 23(7). PMID: 30029520.
    Citations: 1     Fields:    Translation:Animals
  66. Lee JW, Park JY, Park SH, Kim MJ, Song BR, Yun HW, Kang TW, Choi HS, Kim YJ, Min BH, Kim MS. Cross-linked electrospun cartilage acellular matrix/poly(caprolactone-co-lactide-co-glycolide) nanofiber as an antiadhesive barrier. Acta Biomater. 2018 07 01; 74:192-206. PMID: 29793074.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  67. Hu S, Kang H, Baek Y, El Fakhri G, Kuang A, Choi HS. Real-Time Imaging of Brain Tumor for Image-Guided Surgery. Adv Healthc Mater. 2018 08; 7(16):e1800066. PMID: 29719137.
    Citations: 25     Fields:    Translation:HumansAnimals
  68. Seo Y, Jeong S, Lee J, Choi HS, Kim J, Lee H. Innovations in biomedical nanoengineering: nanowell array biosensor. Nano Converg. 2018; 5(1):9. PMID: 29670832; PMCID: PMC5897454.
    Citations: 9     
  69. Hu Y, Liu G, Zhang H, Li Y, Gray BD, Pak KY, Choi HS, Cheng D, Shi H. A Comparison of [99mTc]Duramycin and [99mTc]Annexin V in SPECT/CT Imaging Atherosclerotic Plaques. Mol Imaging Biol. 2018 04; 20(2):249-259. PMID: 28785938.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  70. Kim J, Kim H, Choi H, Jo A, Kang H, Yun H, Im S, Choi C. Anti-Inflammatory Effects of a Stauntonia hexaphylla Fruit Extract in Lipopolysaccharide-Activated RAW-264.7 Macrophages and Rats by Carrageenan-Induced Hind Paw Swelling. Nutrients. 2018 Jan 22; 10(1). PMID: 29361789.
    Citations: 15     Fields:    Translation:AnimalsCells
  71. Wada H, Hyun H, Bao K, Lee JH, El Fakhri G, Choi Y, Choi HS. Multivalent Mannose-Decorated NIR Nanoprobes for Targeting Pan Lymph Nodes. Chem Eng J. 2018 May 15; 340:51-57. PMID: 29962899; PMCID: PMC6022841.
    Citations: 10     
  72. Kim KS, Kim YS, Bao K, Wada H, Choi HS, Hahn SK. Bioimaging of botulinum toxin and hyaluronate hydrogels using zwitterionic near-infrared fluorophores. Biomater Res. 2017; 21:15. PMID: 29046820; PMCID: PMC5633902.
    Citations: 6     
  73. Tran BNN, Angelo JP, Lee JH, Ruan QZ, Laurence RG, Choi HS, Lee BT, Singhal D. A novel pilot animal model for the surgical prevention of lymphedema: the power of optical imaging. J Surg Res. 2018 01; 221:285-292. PMID: 29229140.
    Citations: 2     Fields:    Translation:Animals
  74. Lee G, Lee J, Kim J, Choi HS, Kim J, Lee S, Lee H. Single Microfluidic Electrochemical Sensor System for Simultaneous Multi-Pulmonary Hypertension Biomarker Analyses. Sci Rep. 2017 08 08; 7(1):7545. PMID: 28790334.
    Citations: 7     Fields:    Translation:Humans
  75. Valdes PA, Angelo JP, Choi HS, Gioux S. qF-SSOP: real-time optical property corrected fluorescence imaging. Biomed Opt Express. 2017 Aug 01; 8(8):3597-3605. PMID: 28856038; PMCID: PMC5560828.
    Citations: 24     
  76. Lee J, Shin S, Desalvo A, Lee G, Lee JY, Polini A, Chae S, Jeong H, Kim J, Choi H, Lee H. Nonmediated, Label-Free Based Detection of Cardiovascular Biomarker in a Biological Sample. Adv Healthc Mater. 2017 Sep; 6(17). PMID: 28636127.
    Citations: 1     Fields:    Translation:Humans
  77. Park GK, Kim GS, Hwang NS, Choi HS. Optical spectroscopic imaging for cell therapy and tissue engineering. Appl Spectrosc Rev. 2018; 53(2-4):360-375. PMID: 29563664; PMCID: PMC5858719.
    Citations: 12     
  78. Kim TH, O’Brien C, Choi HS, Jeong MY. Fluorescence molecular imaging systems for intraoperative image-guided surgery. Appl Spectrosc Rev. 2017; 58:349-359. View Publication.
  79. Kim H, Choi HS, Kim SK, Lee BI, Choi Y. Antigen-responsive molecular sensor enables real-time tumor-specific imaging. Theranostics. 2017; 7(4):952-961. PMID: 28382167.
    Citations: 6     Fields:    Translation:HumansCells
  80. Bao K, Lee JH, Kang H, Park GK, El Fakhri G, Choi HS. PSMA-targeted contrast agents for intraoperative imaging of prostate cancer. Chem Commun (Camb). 2017 Feb 04; 53(10):1611-1614. PMID: 28085163; PMCID: PMC5728657.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  81. Ikeda M, Wakasaki R, Schenning KJ, Swide T, Lee JH, Miller MB, Choi HS, Anderson S, Hutchens MP. Determination of renal function and injury using near-infrared fluorimetry in experimental cardiorenal syndrome. Am J Physiol Renal Physiol. 2017 04 01; 312(4):F629-F639. PMID: 28077373; PMCID: PMC5407071.
    Citations: 13     Fields:    Translation:Animals
  82. Wada H, Hyun H, Kang H, Gravier J, Henary M, Bordo MW, Choi HS, Frangioni JV. Intraoperative Near-Infrared Fluorescence Imaging of Thymus in Preclinical Models. Ann Thorac Surg. 2017 Apr; 103(4):1132-1141. PMID: 27964920; PMCID: PMC5376245.
    Citations: 3     Fields:    Translation:Animals
  83. Koo H, Lee JH, Bao K, Wu Y, El Fakhri G, Henary M, Yun SH, Choi HS. Site-Specific In Vivo Bioorthogonal Ligation via Chemical Modulation. Adv Healthc Mater. 2016 10; 5(19):2510-2516. PMID: 27568818.
    Citations: 6     Fields:    Translation:AnimalsCells
  84. Owens EA, Henary M, El Fakhri G, Choi HS. Tissue-Specific Near-Infrared Fluorescence Imaging. Acc Chem Res. 2016 09 20; 49(9):1731-40. PMID: 27564418; PMCID: PMC5776714.
    Citations: 83     Fields:    Translation:Humans
  85. Ashitate Y, Levitz A, Park MH, Hyun H, Venugopal V, Park G, El Fakhri G, Henary M, Gioux S, Frangioni JV, Choi HS. Endocrine-specific NIR fluorophores for adrenal gland targeting. Chem Commun (Camb). 2016 Aug 11; 52(67):10305-8. PMID: 27476533; PMCID: PMC4982771.
    Citations: 9     Fields:    Translation:Humans
  86. Kang H, Gravier J, Bao K, Wada H, Lee JH, Baek Y, El Fakhri G, Gioux S, Rubin BP, Coll JL, Choi HS. Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery. Adv Mater. 2016 Oct; 28(37):8162-8168. PMID: 27414255; PMCID: PMC5155334.
    Citations: 43     Fields:    
  87. Jee JE, Lim J, Ong YS, Oon J, Gao L, Choi HS, Lee SS. An efficient strategy to enhance binding affinity and specificity of a known isozyme inhibitor. Org Biomol Chem. 2016 Jul 12; 14(28):6833-9. PMID: 27339902; PMCID: PMC4942345.
    Citations: 3     Fields:    Translation:HumansCells
  88. Owens EA, Hyun H, Dost TL, Lee JH, Park G, Pham DH, Park MH, Choi HS, Henary M. Near-Infrared Illumination of Native Tissues for Image-Guided Surgery. J Med Chem. 2016 06 09; 59(11):5311-23. PMID: 27100476; PMCID: PMC5733074.
    Citations: 25     Fields:    Translation:AnimalsCells
  89. Choi J, Cho SU, Kim DI, Lee HG, Choi HS, Jeong MY. A study on characteristics analysis of multichannel filter module for near-infrared fluorescence imaging. J Microelectron Packag Soc. 2016; 23(1):29-34. View Publication.
  90. Choi HS, Kim S, Lee D, Kim CS, Jeong MY. Synchronized tracking of brain cognitive processing using EEG and vision signals. Appl Spectrosc Rev. 2016; 51(7):592-602. View Publication.
  91. Zhao Y, Liang M, Li X, Fan K, Xiao J, Li Y, Shi H, Wang F, Choi HS, Cheng D, Yan X. Bioengineered Magnetoferritin Nanoprobes for Single-Dose Nuclear-Magnetic Resonance Tumor Imaging. ACS Nano. 2016 04 26; 10(4):4184-91. PMID: 26959856.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  92. Hyun H, Henary M, Gao T, Narayana L, Owens EA, Lee JH, Park G, Wada H, Ashitate Y, Frangioni JV, Choi HS. 700-nm Zwitterionic Near-Infrared Fluorophores for Dual-Channel Image-Guided Surgery. Mol Imaging Biol. 2016 Feb; 18(1):52-61. PMID: 26084246.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  93. Yeo SJ, Choi K, Cuc BT, Hong NN, Bao DT, Ngoc NM, Le MQ, Hang Nle K, Thach NC, Mallik SK, Kim HS, Chong CK, Choi HS, Sung HW, Yu K, Park H. Smartphone-Based Fluorescent Diagnostic System for Highly Pathogenic H5N1 Viruses. Theranostics. 2016; 6(2):231-42. PMID: 26877781.
    Citations: 36     Fields:    Translation:HumansCells
  94. Moon HG, Cao Y, Yang J, Lee JH, Choi HS, Jin Y. Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway. Cell Death Dis. 2015 Dec 10; 6:e2016. PMID: 26658190.
    Citations: 74     Fields:    Translation:AnimalsCells
  95. Kang H, Mintri S, Menon AV, Lee HY, Choi HS, Kim J. Pharmacokinetics, pharmacodynamics and toxicology of theranostic nanoparticles. Nanoscale. 2015 Dec 07; 7(45):18848-62. PMID: 26528835.
    Citations: 38     Fields:    Translation:HumansAnimals
  96. Kim KS, Hyun H, Yang JA, Lee MY, Kim H, Yun SH, Choi HS, Hahn SK. Bioimaging of Hyaluronate-Interferon a Conjugates Using a Non-Interfering Zwitterionic Fluorophore. Biomacromolecules. 2015 Sep 14; 16(9):3054-61. PMID: 26258264.
    Citations: 12     Fields:    Translation:HumansCells
  97. Wang J, Choi HS, Wáng YX. Exponential growth of publications on carbon nanodots by Chinese authors. J Thorac Dis. 2015 Jul; 7(7):E201-5. PMID: 26380753; PMCID: PMC4522500.
    Citations: 3     
  98. Hyun H, Owens EA, Wada H, Levitz A, Park G, Park MH, Frangioni JV, Henary M, Choi HS. Cartilage-Specific Near-Infrared Fluorophores for Biomedical Imaging. Angew Chem Int Ed Engl. 2015 Jul 20; 54(30):8648-52. PMID: 26095685; PMCID: PMC4504790.
    Citations: 39     Fields:    Translation:Animals
  99. Wada H, Hyun H, Vargas C, Genega EM, Gravier J, Gioux S, Frangioni JV, Choi HS. Sentinel Lymph Node Mapping of Liver. Ann Surg Oncol. 2015 Dec; 22 Suppl 3:S1147-55. PMID: 25968620; PMCID: PMC4644113.
    Citations: 10     Fields:    Translation:Animals
  100. Owens EA, Hyun H, Tawney JG, Choi HS, Henary M. Correlating molecular character of NIR imaging agents with tissue-specific uptake. J Med Chem. 2015 May 28; 58(10):4348-56. PMID: 25923454; PMCID: PMC4603651.
    Citations: 23     Fields:    Translation:Animals
  101. Bordo MW, Oketokoun R, Cross CJ, Bao K, Lee JH, Feygin I, Chang AB, Frangioni JV, Choi HS. High-Throughput Sorting and Placement of One-Bead-One-Compound (OBOC) Libraries from Bulk to Single Wells in Organic Solvent. ACS Comb Sci. 2015 May 11; 17(5):303-9. PMID: 25879633.
    Citations: 1     Fields:    
  102. Njiojob CN, Owens EA, Narayana L, Hyun H, Choi HS, Henary M. Tailored near-infrared contrast agents for image guided surgery. J Med Chem. 2015 Mar 26; 58(6):2845-54. PMID: 25711712; PMCID: PMC4388048.
    Citations: 31     Fields:    Translation:Animals
  103. Bao K, Nasr KA, Hyun H, Lee JH, Gravier J, Gibbs SL, Choi HS. Charge and hydrophobicity effects of NIR fluorophores on bone-specific imaging. Theranostics. 2015; 5(6):609-17. PMID: 25825600.
    Citations: 25     Fields:    Translation:Animals
  104. Owens EA, Lee S, Choi J, Henary M, Choi HS. NIR fluorescent small molecules for intraoperative imaging. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 Nov-Dec; 7(6):828-38. PMID: 25645081.
    Citations: 39     Fields:    Translation:HumansAnimals
  105. Kim S, Jung UT, Kim SK, Lee JH, Choi HS, Kim CS, Jeong MY. Nanostructured multifunctional surface with antireflective and antimicrobial characteristics. ACS Appl Mater Interfaces. 2015 Jan 14; 7(1):326-31. PMID: 25560094.
    Citations: 23     Fields:    Translation:Cells
  106. Hyun H, Park MH, Owens EA, Wada H, Henary M, Handgraaf HJ, Vahrmeijer AL, Frangioni JV, Choi HS. Structure-inherent targeting of near-infrared fluorophores for parathyroid and thyroid gland imaging. Nat Med. 2015 Feb; 21(2):192-7. PMID: 25559343; PMCID: PMC4319985.
    Citations: 68     Fields:    Translation:Animals
  107. Wada H, Hyun H, Vargas C, Gravier J, Park G, Gioux S, Frangioni JV, Henary M, Choi HS. Pancreas-targeted NIR fluorophores for dual-channel image-guided abdominal surgery. Theranostics. 2015; 5(1):1-11. PMID: 25553094.
    Citations: 20     Fields:    Translation:Animals
  108. Lee JH, Bao K, Frangioni JV, Choi HS. Screening of Small Molecule Microarrays for Ligands Targeted to the Extracellular Epitopes of Living Cells. Microarrays (Basel). 2015; 4(1):53-63. PMID: 26435848; PMCID: PMC4589137.
    Citations: 2     
  109. Yang AW, Cho SU, Jeong MY, Choi HS. NIR fluorescence imaging systems with optical packaging technology. J Microelectron Packag Soc. 2014; 21(4):25-31. View Publication.
  110. Jee JE, Lim J, Hyun H, Oon J, Ong YS, Massif C, Chang YT, Choi HS, Lee SS. Investigating fluorescent dyes in fluorescence-assisted screenings. Chem Commun (Camb). 2014 Dec 14; 50(96):15220-3. PMID: 25340456.
    Citations: 2     Fields:    Translation:HumansCells
  111. Inoue K, Gibbs SL, Liu F, Lee JH, Xie Y, Ashitate Y, Fujii H, Frangioni JV, Choi HS. Microscopic validation of macroscopic in vivo images enabled by same-slide optical and nuclear fusion. J Nucl Med. 2014 Nov; 55(11):1899-904. PMID: 25324521.
    Citations: 1     Fields:    Translation:HumansAnimals
  112. Salim MM, Owens EA, Gao T, Lee JH, Hyun H, Choi HS, Henary M. Hydroxylated near-infrared BODIPY fluorophores as intracellular pH sensors. Analyst. 2014 Oct 07; 139(19):4862-73. PMID: 25105177.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  113. Chung JE, Tan S, Gao SJ, Yongvongsoontorn N, Kim SH, Lee JH, Choi HS, Yano H, Zhuo L, Kurisawa M, Ying JY. Self-assembled micellar nanocomplexes comprising green tea catechin derivatives and protein drugs for cancer therapy. Nat Nanotechnol. 2014 Nov; 9(11):907-912. PMID: 25282044.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  114. Yeo SJ, Huong DT, Hong NN, Li CY, Choi K, Yu K, Choi DY, Chong CK, Choi HS, Mallik SK, Kim HS, Sung HW, Park H. Rapid and quantitative detection of zoonotic influenza A virus infection utilizing coumarin-derived dendrimer-based fluorescent immunochromatographic strip test (FICT). Theranostics. 2014; 4(12):1239-49. PMID: 25285172.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  115. Hyun H, Wada H, Bao K, Gravier J, Yadav Y, Laramie M, Henary M, Frangioni JV, Choi HS. Phosphonated near-infrared fluorophores for biomedical imaging of bone. Angew Chem Int Ed Engl. 2014 Sep 26; 53(40):10668-72. PMID: 25139079.
    Citations: 43     Fields:    Translation:Animals
  116. Park MH, Hyun H, Ashitate Y, Wada H, Park G, Lee JH, Njiojob C, Henary M, Frangioni JV, Choi HS. Prototype nerve-specific near-infrared fluorophores. Theranostics. 2014; 4(8):823-33. PMID: 24955143.
    Citations: 45     Fields:    Translation:Animals
  117. Ashitate Y, Hyun H, Kim SH, Lee JH, Henary M, Frangioni JV, Choi HS. Simultaneous mapping of pan and sentinel lymph nodes for real-time image-guided surgery. Theranostics. 2014; 4(7):693-700. PMID: 24883119.
    Citations: 20     Fields:    Translation:Animals
  118. Verbeek FP, van der Vorst JR, Tummers QR, Boonstra MC, de Rooij KE, Löwik CW, Valentijn AR, van de Velde CJ, Choi HS, Frangioni JV, Vahrmeijer AL. Near-infrared fluorescence imaging of both colorectal cancer and ureters using a low-dose integrin targeted probe. Ann Surg Oncol. 2014 Dec; 21 Suppl 4:S528-37. PMID: 24515567.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  119. Choi HS. Nanoparticle assembly: building blocks for tumour delivery. Nat Nanotechnol. 2014 Feb; 9(2):93-4. PMID: 24463360.
    Citations: 7     Fields:    Translation:Animals
  120. Hyun H, Owens EA, Narayana L, Wada H, Gravier J, Bao K, Frangioni JV, Choi HS, Henary M. Central C-C Bonding Increases Optical and Chemical Stability of NIR Fluorophores. RSC Adv. 2014 Jan 01; 4(102):58762-58768. PMID: 25530846; PMCID: PMC4267294.
    Citations: 25     
  121. Lee D, Bae S, Ke Q, Lee J, Song B, Karumanchi SA, Khang G, Choi HS, Kang PM. Hydrogen peroxide-responsive copolyoxalate nanoparticles for detection and therapy of ischemia-reperfusion injury. J Control Release. 2013 Dec 28; 172(3):1102-10. PMID: 24096013.
    Citations: 26     Fields:    Translation:AnimalsCells
  122. Huang X, Zhang F, Zhu L, Choi KY, Guo N, Guo J, Tackett K, Anilkumar P, Liu G, Quan Q, Choi HS, Niu G, Sun YP, Lee S, Chen X. Effect of injection routes on the biodistribution, clearance, and tumor uptake of carbon dots. ACS Nano. 2013 Jul 23; 7(7):5684-93. PMID: 23731122.
    Citations: 47     Fields:    Translation:Animals
  123. Lee JH, Park S, Hyun H, Bordo MW, Oketokoun R, Nasr KA, Frangioni JV, Choi HS. High-throughput screening of small molecule ligands targeted to live bacteria surface. Anal Chem. 2013 Apr 02; 85(7):3508-14. PMID: 23461528.
    Citations: 4     Fields:    Translation:HumansCells
  124. Ashitate Y, Lee BT, Laurence RG, Lunsford E, Hutteman M, Oketokoun R, Choi HS, Frangioni JV. Intraoperative prediction of postoperative flap outcome using the near-infrared fluorophore methylene blue. Ann Plast Surg. 2013 Mar; 70(3):360-5. PMID: 22395044.
    Citations: 5     Fields:    Translation:Animals
  125. Kim SH, Lee JH, Hyun H, Ashitate Y, Park G, Robichaud K, Lunsford E, Lee SJ, Khang G, Choi HS. Near-infrared fluorescence imaging for noninvasive trafficking of scaffold degradation. Sci Rep. 2013; 3:1198. PMID: 23386968.
    Citations: 25     Fields:    Translation:Animals
  126. Ashitate Y, Lee BT, Ngo LH, Laurence RG, Hutteman M, Oketokoun R, Lunsford E, Soo Choi H, Frangioni JV. Quantitative assessment of nipple perfusion with near-infrared fluorescence imaging. Ann Plast Surg. 2013 Feb; 70(2):149-53. PMID: 21862913.
    Citations: 5     Fields:    Translation:Animals
  127. Owens EA, Hyun H, Kim SH, Lee JH, Park G, Ashitate Y, Choi J, Hong GH, Alyabyev S, Lee SJ, Khang G, Henary M, Choi HS. Highly charged cyanine fluorophores for trafficking scaffold degradation. Biomed Mater. 2013 Feb; 8(1):014109. PMID: 23353870.
    Citations: 14     Fields:    Translation:Animals
  128. Kim SH, Park G, Hyun H, Lee JH, Ashitate Y, Choi J, Hong GH, Owens EA, Henary M, Choi HS. Near-infrared lipophilic fluorophores for tracing tissue growth. Biomed Mater. 2013 Feb; 8(1):014110. PMID: 23353894.
    Citations: 25     Fields:    Translation:AnimalsCells
  129. Choi HS, Gibbs SL, Lee JH, Kim SH, Ashitate Y, Liu F, Hyun H, Park G, Xie Y, Bae S, Henary M, Frangioni JV. Targeted zwitterionic near-infrared fluorophores for improved optical imaging. Nat Biotechnol. 2013 Feb; 31(2):148-53. PMID: 23292608.
    Citations: 196     Fields:    Translation:HumansAnimalsCells
  130. Huang X, Zhang F, Wang H, Niu G, Choi KY, Swierczewska M, Zhang G, Gao H, Wang Z, Zhu L, Choi HS, Lee S, Chen X. Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery. Biomaterials. 2013 Feb; 34(7):1772-80. PMID: 23228423.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  131. Lee JH, Park G, Hong GH, Choi J, Choi HS. Design considerations for targeted optical contrast agents. Quant Imaging Med Surg. 2012 Dec; 2(4):266-73. PMID: 23289086.
    Citations: 38     
  132. Hyun H, Bordo MW, Nasr K, Feith D, Lee JH, Kim SH, Ashitate Y, Moffitt LA, Rosenberg M, Henary M, Choi HS, Frangioni JV. cGMP-Compatible preparative scale synthesis of near-infrared fluorophores. Contrast Media Mol Imaging. 2012 Nov-Dec; 7(6):516-24. PMID: 22991318.
    Citations: 35     Fields:    Translation:Animals
  133. Zhu L, Guo N, Li Q, Ma Y, Jacboson O, Lee S, Choi HS, Mansfield JR, Niu G, Chen X. Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe. Theranostics. 2012; 2(8):746-56. PMID: 22916074.
    Citations: 16     Fields:    
  134. Ashitate Y, Vooght CS, Hutteman M, Oketokoun R, Choi HS, Frangioni JV. Simultaneous assessment of luminal integrity and vascular perfusion of the gastrointestinal tract using dual-channel near-infrared fluorescence. Mol Imaging. 2012 Jul-Aug; 11(4):301-8. PMID: 22954146.
    Citations: 11     Fields:    Translation:Animals
  135. Liu F, Lunsford EP, Tong J, Ashitate Y, Gibbs SL, Yu J, Choi HS, Henske EP, Frangioni JV. Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex. PLoS One. 2012; 7(6):e38589. PMID: 22719903.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  136. Ashitate Y, Kim SH, Tanaka E, Henary M, Choi HS, Frangioni JV, Flaumenhaft R. Two-wavelength near-infrared fluorescence for the quantitation of drug antiplatelet effects in large animal model systems. J Vasc Surg. 2012 Jul; 56(1):171-80. PMID: 22503225.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  137. Huang X, Zhang F, Lee S, Swierczewska M, Kiesewetter DO, Lang L, Zhang G, Zhu L, Gao H, Choi HS, Niu G, Chen X. Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes. Biomaterials. 2012 Jun; 33(17):4370-8. PMID: 22425023.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  138. Lee JH, Hyun H, Cross CJ, Henary M, Nasr KA, Oketokoun R, Choi HS, Frangioni JV. Rapid and Facile Microwave-Assisted Surface Chemistry for Functionalized Microarray Slides. Adv Funct Mater. 2012 Feb 22; 22(4):872-878. PMID: 23467787.
    Citations: 4     
  139. Kim KH, Lee EN, Park JK, Lee JR, Kim JH, Choi HJ, Kim BS, Lee HW, Lee KS, Yoon S. Curcumin attenuates TNF-a-induced expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and proinflammatory cytokines in human endometriotic stromal cells. Phytother Res. 2012 Jul; 26(7):1037-47. PMID: 22183741.
    Citations: 28     Fields:    Translation:HumansCells
  140. Ashitate Y, Stockdale A, Choi HS, Laurence RG, Frangioni JV. Real-time simultaneous near-infrared fluorescence imaging of bile duct and arterial anatomy. J Surg Res. 2012 Jul; 176(1):7-13. PMID: 21816414.
    Citations: 38     Fields:    Translation:Animals
  141. Lee JH, Choi HS, Nasr KA, Ha M, Kim Y, Frangioni JV. High-throughput small molecule identification using MALDI-TOF and a nanolayered substrate. Anal Chem. 2011 Jul 01; 83(13):5283-9. PMID: 21651231.
    Citations: 7     Fields:    Translation:Cells
  142. Choi HS, Nasr K, Alyabyev S, Feith D, Lee JH, Kim SH, Ashitate Y, Hyun H, Patonay G, Strekowski L, Henary M, Frangioni JV. Synthesis and in vivo fate of zwitterionic near-infrared fluorophores. Angew Chem Int Ed Engl. 2011 Jul 04; 50(28):6258-63. PMID: 21656624.
    Citations: 152     Fields:    Translation:Animals
  143. Ashitate Y, Tanaka E, Stockdale A, Choi HS, Frangioni JV. Near-infrared fluorescence imaging of thoracic duct anatomy and function in open surgery and video-assisted thoracic surgery. J Thorac Cardiovasc Surg. 2011 Jul; 142(1):31-8.e1-2. PMID: 21477818; PMCID: PMC3118972.
    Citations: 22     Fields:    Translation:Animals
  144. Mieog JS, Troyan SL, Hutteman M, Donohoe KJ, van der Vorst JR, Stockdale A, Liefers GJ, Choi HS, Gibbs-Strauss SL, Putter H, Gioux S, Kuppen PJ, Ashitate Y, Löwik CW, Smit VT, Oketokoun R, Ngo LH, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer. Ann Surg Oncol. 2011 Sep; 18(9):2483-91. PMID: 21360250.
    Citations: 109     Fields:    Translation:HumansAnimals
  145. Choi HS, Frangioni JV. Nanoparticles for biomedical imaging: fundamentals of clinical translation. Mol Imaging. 2010 Dec; 9(6):291-310. PMID: 21084027; PMCID: PMC3017480.
    Citations: 125     Fields:    Translation:Humans
  146. Hutteman M, Choi HS, Mieog JS, van der Vorst JR, Ashitate Y, Kuppen PJ, van Groningen MC, Löwik CW, Smit VT, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Clinical translation of ex vivo sentinel lymph node mapping for colorectal cancer using invisible near-infrared fluorescence light. Ann Surg Oncol. 2011 Apr; 18(4):1006-14. PMID: 21080086.
    Citations: 33     Fields:    Translation:HumansAnimals
  147. Choi HS, Ashitate Y, Lee JH, Kim SH, Matsui A, Insin N, Bawendi MG, Semmler-Behnke M, Frangioni JV, Tsuda A. Rapid translocation of nanoparticles from the lung airspaces to the body. Nat Biotechnol. 2010 Dec; 28(12):1300-3. PMID: 21057497.
    Citations: 209     Fields:    Translation:Animals
  148. Gioux S, Choi HS, Frangioni JV. Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation. Mol Imaging. 2010 Oct; 9(5):237-55. PMID: 20868625.
    Citations: 228     Fields:    Translation:Humans
  149. Gioux S, Lomnes SJ, Choi HS, Frangioni JV. Low-frequency wide-field fluorescence lifetime imaging using a high-power near-infrared light-emitting diode light source. J Biomed Opt. 2010 Mar-Apr; 15(2):026005. PMID: 20459250.
    Citations: 7     Fields:    
  150. Matsui A, Tanaka E, Choi HS, Winer JH, Kianzad V, Gioux S, Laurence RG, Frangioni JV. Real-time intra-operative near-infrared fluorescence identification of the extrahepatic bile ducts using clinically available contrast agents. Surgery. 2010 Jul; 148(1):87-95. PMID: 20117813; PMCID: PMC2886157.
    Citations: 57     Fields:    Translation:Animals
  151. Matsui A, Tanaka E, Choi HS, Kianzad V, Gioux S, Lomnes SJ, Frangioni JV. Real-time, near-infrared, fluorescence-guided identification of the ureters using methylene blue. Surgery. 2010 Jul; 148(1):78-86. PMID: 20117811; PMCID: PMC2886170.
    Citations: 56     Fields:    Translation:Animals
  152. Winer JH, Choi HS, Gibbs-Strauss SL, Ashitate Y, Colson YL, Frangioni JV. Intraoperative localization of insulinoma and normal pancreas using invisible near-infrared fluorescent light. Ann Surg Oncol. 2010 Apr; 17(4):1094-100. PMID: 20033320.
    Citations: 38     Fields:    Translation:Animals
  153. Choi HS, Liu W, Liu F, Nasr K, Misra P, Bawendi MG, Frangioni JV. Design considerations for tumour-targeted nanoparticles. Nat Nanotechnol. 2010 Jan; 5(1):42-7. PMID: 19893516.
    Citations: 250     Fields:    Translation:HumansAnimalsCells
  154. Choi HS, Ipe BI, Misra P, Lee JH, Bawendi MG, Frangioni JV. Tissue- and organ-selective biodistribution of NIR fluorescent quantum dots. Nano Lett. 2009 Jun; 9(6):2354-9. PMID: 19422261.
    Citations: 94     Fields:    Translation:Animals
  155. Yuan TL, Choi HS, Matsui A, Benes C, Lifshits E, Luo J, Frangioni JV, Cantley LC. Class 1A PI3K regulates vessel integrity during development and tumorigenesis. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9739-44. PMID: 18621722.
    Citations: 37     Fields:    Translation:Animals
  156. Tanaka E, Choi HS, Humblet V, Ohnishi S, Laurence RG, Frangioni JV. Real-time intraoperative assessment of the extrahepatic bile ducts in rats and pigs using invisible near-infrared fluorescent light. Surgery. 2008 Jul; 144(1):39-48. PMID: 18571583; PMCID: PMC2453786.
    Citations: 32     Fields:    Translation:Animals
  157. Gioux S, Kianzad V, Ciocan R, Choi HS, Nelson C, Thumm J, Filkins RJ, Lomnes SJ, Frangioni JV. A low-cost, linear, DC - 35 MHz, high-power LED driver for continuous wave (CW) and fluorescence lifetime imaging (FLIM). Proc SPIE Int Soc Opt Eng. 2008; 6848:684807. PMID: 19655029.
    Citations: 4     
  158. Liu W, Choi HS, Zimmer JP, Tanaka E, Frangioni JV, Bawendi M. Compact cysteine-coated CdSe(ZnCdS) quantum dots for in vivo applications. J Am Chem Soc. 2007 Nov 28; 129(47):14530-1. PMID: 17983223.
    Citations: 71     Fields:    Translation:AnimalsCells
  159. Choi HS, Liu W, Misra P, Tanaka E, Zimmer JP, Itty Ipe B, Bawendi MG, Frangioni JV. Renal clearance of quantum dots. Nat Biotechnol. 2007 Oct; 25(10):1165-70. PMID: 17891134; PMCID: PMC2702539.
    Citations: 1053     Fields:    Translation:Animals
  160. Tanaka E, Ohnishi S, Laurence RG, Choi HS, Humblet V, Frangioni JV. Real-time intraoperative ureteral guidance using invisible near-infrared fluorescence. J Urol. 2007 Nov; 178(5):2197-202. PMID: 17870110; PMCID: PMC2505174.
    Citations: 39     Fields:    Translation:Animals
  161. Joung YK, Choi HS, Ooya T, Yui N. 1H NMR titration study of stimuli-responsive supramolecular assemblies: inclusion complexes between PEG–b-PEI copolymer-grafted dextran and naphthalene-appended gamma-cyclodextrin via double-strand inclusion. J Incl Phenom Macro Chem. 2007; 57:323-328. View Publication.
  162. Tanaka E, Choi HS, Fujii H, Bawendi MG, Frangioni JV. Image-guided oncologic surgery using invisible light: completed pre-clinical development for sentinel lymph node mapping. Ann Surg Oncol. 2006 Dec; 13(12):1671-81. PMID: 17009138; PMCID: PMC2474791.
    Citations: 120     Fields:    Translation:Animals
  163. Loethen S, Ooya T, Choi HS, Yui N, Thompson DH. Synthesis, characterization, and pH-triggered dethreading of alpha-cyclodextrin-poly(ethylene glycol) polyrotaxanes bearing cleavable endcaps. Biomacromolecules. 2006 Sep; 7(9):2501-6. PMID: 16961310.
    Citations: 10     Fields:    Translation:Cells
  164. Choi HS, Takahashi A, Ooya T, Yui N. Molecular-recognition and binding properties of cyclodextrin-conjugated polyrotaxanes. Chemphyschem. 2006 Aug 11; 7(8):1668-70. PMID: 16807959.
    Citations: 1     Fields:    Translation:Cells
  165. Choi HS, Hirasawa A, Ooya T, Kajihara D, Hohsaka T, Yui N. pH-sensitive locomotion of cyclodextrins in a block-selective mobile polyrotaxane. Chemphyschem. 2006 Aug 11; 7(8):1671-3. PMID: 16832804.
    Citations: 1     Fields:    
  166. Ooya T, Inoue D, Choi HS, Kobayashi Y, Loethen S, Thompson DH, Ko YH, Kim K, Yui N. pH-responsive movement of cucurbit[7]uril in a diblock polypseudorotaxane containing dimethyl beta-cyclodextrin and cucurbit[7]uril. Org Lett. 2006 Jul 20; 8(15):3159-62. PMID: 16836355.
    Citations: 3     Fields:    Translation:Cells
  167. Choi HS, Ooya T, Yui N. One-pot synthesis of a polyrotaxane via selective threading of a PEI-b-PEG-b-PEI copolymer. Macromol Biosci. 2006 Jun 16; 6(6):420-4. PMID: 16761273.
    Citations: 2     Fields:    
  168. Ooya T, Choi HS, Yamashita A, Yui N, Sugaya Y, Kano A, Maruyama A, Akita H, Ito R, Kogure K, Harashima H. Biocleavable polyrotaxane-plasmid DNA polyplex for enhanced gene delivery. J Am Chem Soc. 2006 Mar 29; 128(12):3852-3. PMID: 16551060.
    Citations: 37     Fields:    Translation:Cells
  169. Choi HS, Yui N. Design of rapidly assembling supramolecular systems responsive to synchronized stimuli based on cyclodextrin-conjugated poly(epsilon-lysine). Prog Polym Sci. 2006; 31(2):121-144. View Publication.
  170. Yamashita A, Choi HS, Ooya T, Yui N, Akita H, Kogure K, Harashima H. Improved cell viability of linear polyethylenimine through gamma-cyclodextrin inclusion for effective gene delivery. Chembiochem. 2006 Feb; 7(2):297-302. PMID: 16408311.
    Citations: 2     Fields:    Translation:AnimalsCells
  171. Choi HS, Yamashita A, Ooya T, Yui N, Akita H, Kogure K, Ito R, Harashima H. Sunflower-shaped cyclodextrin-conjugated poly(epsilon-lysine) polyplex as a controlled intracellular trafficking device. Chembiochem. 2005 Nov; 6(11):1986-90. PMID: 16222730.
    Citations: 7     Fields:    Translation:AnimalsCells
  172. Choi HS, Lee SC, Yamamoto K, Yui N. Block-selective movement of a-cyclodextrins in polyrotaxanes of PEI-b-PEG-b-PEI copolymer. Macromolecules. 2005; 38(23):9878-9881. View Publication.
  173. Choi HS, Yamamoto K, Ooya T, Yui N. Synthesis of poly(epsilon-lysine)-grafted dextrans and their pH- and thermosensitive hydrogelation with cyclodextrins. Chemphyschem. 2005 Jun 13; 6(6):1081-6. PMID: 15937894.
    Citations: 3     Fields:    
  174. Choi HS, Ooya T, Huh KM, Yui N. pH-triggered changes in assembling properties of beta-cyclodextrin-conjugated poly(epsilon-lysine) complexes. Biomacromolecules. 2005 May-Jun; 6(3):1200-4. PMID: 15877334.
    Citations: 1     Fields:    
  175. Choi HS, Takahashi A, Ooya T, Yui N. Structural Role of Guest Molecules in Rapid and Sensitive Supramolecular Assembling System Based on ß-Cyclodextrin-Conjugated Poly(e-lysine). Macromolecules. 2004; 37(26):10036-10041. View Publication.
  176. Choi HS, Ooya T, Sasaki S, Yui N, Kurisawa M, Uyama H, Kobayashi S. Spontaneous change of physical state from hydrogels to crystalline precipitates during poly-pseudorotaxane formation. Chemphyschem. 2004 Sep 20; 5(9):1431-4. PMID: 15499862.
    Citations: 1     Fields:    
  177. Lee SC, Choi HS, Ooya T, Yui N. Block-Selective Polypseudorotaxane Formation in PEI-b-PEG-b-PEI Copolymers via pH Variation. Macromolecules. 2004; 37(20):7464-7468. View Publication.
  178. Choi HS, Huh KM, Ooya T, Yui N. pH-Triggered assembling system using cooperative binding between cyclodextrin-conjugated poly(epsilon-lysine)s and anionic guest in aqueous media. J Phys Chem B. 2004; 108(23):7646-7650. View Publication.
  179. Choi HS, Ooya T, Sasaki S, Yui N, Ohya Y, Nakai T, Ouchi T. Preparation and characterization of polypseudorotaxanes based on biodegradable poly(L-lactide)/poly(ethylene glycol) triblock copolymers. Macromolecules. 2003; 36(25):9313-9318. View Publication.
  180. Choi HS, Ooya T, Sasaki S, Yui N. Control of rapid phase transition induced by supramolecular complexation of beta-cyclodextrin-conjugated poly(epsilon-lysine) with a specific guest. Macromolecules. 2003; 36(14):5342–5347. View Publication.
  181. Choi HS, Huh KM, Ooya T, Yui N. pH- and thermosensitive supramolecular assembling system: rapidly responsive properties of beta-cyclodextrin-conjugated poly(epsilon-lysine). J Am Chem Soc. 2003 May 28; 125(21):6350-1. PMID: 12785758.
    Citations: 6     Fields:    
  182. Choi HS, Kontani K, Huh KM, Sasaki S, Ooya T, Lee WK, Yui N. Rapid induction of thermoreversible hydrogel formation based on a poly(propylene glycol)-grafted dextran inclusion complex. Macromol Biosci. 2002; 2(6):298-303. View Publication.
  183. Khang G, Seo S-A, Choi HS, Rhee JM, Lee HB. Evaluation of in vitro release profiles of fentanyl-loaded PLGA oligomer microspheres. Macromol Res. 2002; 10(5):246-252. View Publication.
  184. Seo SA, Choi HS, Khang G, Rhee JM, Lee HB. A local delivery system for fentanyl based on biodegradable poly(L-lactide-co-glycolide) oligomer. Int J Pharm. 2002 Jun 04; 239(1-2):93-101. PMID: 12052694.
    Citations: 2     Fields:    
  185. Choi HS, Seo SA, Khang G, Rhee JM, Lee HB. Preparation and characterization of fentanyl-loaded PLGA microspheres: in vitro release profiles. Int J Pharm. 2002 Mar 02; 234(1-2):195-203. PMID: 11839450.
    Citations: 8     Fields:    
  186. Choi HS, Shin HC, Khang G, Rhee JM, Lee HB. Quantitative analysis of fentanyl in rat plasma by gas chromatography with nitrogen-phosphorus detection. J Chromatogr B Biomed Sci Appl. 2001 Dec 05; 765(1):63-9. PMID: 11817311.
    Citations:    Fields:    Translation:Animals
  187. Choi HS, Kim SW, Yun D-I, Khang G, Rhee JM, Lee HB. Preparation of biodegradable PHBV devices containing gentamicin sulfate. Polym. 2001; 25(3):334-342. View Publication.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.