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Martha L. Gray, Ph.D.


Assessment of Repair of Mechanically Loaded, Damaged Cartilage
Summer, 06/17/05 - 08/31/05

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R25GM116705 (GRAY, MARTHA L) Sep 21, 2015 - Jul 31, 2021
    IMPACT Program for Biomedical Researcher Career Development
    Role: Co-Principal Investigator
  2. R01AR049204 (GRAY, MARTHA L) Jul 15, 2003 - Jun 30, 2008
    Correlation of MRI with Cartilage Mechanical Stiffness
    Role: Principal Investigator
  3. U54GM062114 (GILMAN, ALFRED G) Sep 1, 2000 - Aug 31, 2008
    Alliance for Cellular Signaling
    Role: Co-Principal Investigator
  4. R21AR047085 (GRAY, MARTHA L) Sep 1, 2000 - Jul 31, 2003
    Role: Principal Investigator
  5. R29AR041713 (GRAY, MARTHA L) Jul 10, 1992 - May 31, 1998
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Soenksen LR, Kassis T, Conover ST, Marti-Fuster B, Birkenfeld JS, Tucker-Schwartz J, Naseem A, Stavert RR, Kim CC, Senna MM, Avilés-Izquierdo J, Collins JJ, Barzilay R, Gray ML. Using deep learning for dermatologist-level detection of suspicious pigmented skin lesions from wide-field images. Sci Transl Med. 2021 02 17; 13(581). PMID: 33597262.
    Citations: 6     Fields:    Translation:Humans
  2. Burstein D, Mitchell R, Gray ML. Strategically Guiding Research through Careful Consideration of the Path to Impact. Radiology. 2019 01; 290(1):5-7. PMID: 30457476; PMCID: PMC6312430.
    Citations: 1     Fields:    Translation:Humans
  3. Sánchez-Ferro Á, Matarazzo M, Martínez-Martín P, Martínez-Ávila JC, Gómez de la Cámara A, Giancardo L, Arroyo Gallego T, Montero P, Puertas-Martín V, Obeso I, Butterworth I, Mendoza CS, Catalán MJ, Molina JA, Bermejo-Pareja F, Martínez-Castrillo JC, López-Manzanares L, Alonso-Cánovas A, Herreros Rodríguez J, Gray M. Minimal Clinically Important Difference for UPDRS-III in Daily Practice. Mov Disord Clin Pract. 2018 Jul-Aug; 5(4):448-450. PMID: 30838303; PMCID: PMC6336372.
    Citations: 8     
  4. Bourquard A, Pablo-Trinidad A, Butterworth I, Sánchez-Ferro Á, Cerrato C, Humala K, Fabra Urdiola M, Del Rio C, Valles B, Tucker-Schwartz JM, Lee ES, Vakoc BJ, Padera TP, Ledesma-Carbayo MJ, Chen YB, Hochberg EP, Gray ML, Castro-González C. Non-invasive detection of severe neutropenia in chemotherapy patients by optical imaging of nailfold microcirculation. Sci Rep. 2018 03 28; 8(1):5301. PMID: 29593221.
    Citations: 10     Fields:    Translation:HumansCells
  5. Arroyo-Gallego T, Ledesma-Carbayo MJ, Butterworth I, Matarazzo M, Montero-Escribano P, Puertas-Martín V, Gray ML, Giancardo L, Sánchez-Ferro Á. Detecting Motor Impairment in Early Parkinson's Disease via Natural Typing Interaction With Keyboards: Validation of the neuroQWERTY Approach in an Uncontrolled At-Home Setting. J Med Internet Res. 2018 03 26; 20(3):e89. PMID: 29581092; PMCID: PMC5891671.
    Citations: 5     Fields:    Translation:Humans
  6. Burstein D, Gray M, Mosher T, Dardzinski B. Measures of molecular composition and structure in osteoarthritis. Radiol Clin North Am. 2009 Jul; 47(4):675-86. PMID: 19631075.
    Citations: 59     Fields:    Translation:Humans
  7. Jessel RH, Zurakowski D, Zilkens C, Burstein D, Gray ML, Kim YJ. Radiographic and patient factors associated with pre-radiographic osteoarthritis in hip dysplasia. J Bone Joint Surg Am. 2009 May; 91(5):1120-9. PMID: 19411460.
    Citations: 52     Fields:    Translation:Humans
  8. Dugar A, Farley ML, Wang AL, Goldring MB, Goldring SR, Swaim BH, Bierbaum BE, Burstein D, Gray ML. The effect of paraformaldehyde fixation on the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) measurement. J Orthop Res. 2009 Apr; 27(4):536-9. PMID: 18973237; PMCID: PMC3947557.
    Citations: 2     Fields:    Translation:HumansAnimals
  9. Gray ML, Pearle AD. Advanced imaging and computer-assisted surgery of the knee and hip. Introduction. J Bone Joint Surg Am. 2009 Feb; 91 Suppl 1:1-2. PMID: 19182011.
    Citations: 1     Fields:    Translation:Humans
  10. Gray ML. Toward imaging biomarkers for glycosaminoglycans. J Bone Joint Surg Am. 2009 Feb; 91 Suppl 1:44-9. PMID: 19182023; PMCID: PMC2663352.
    Citations: 6     Fields:    Translation:Humans
  11. Stubbs AJ, Gray ML, Pearle AD. Section I: Setting the stage. J Bone Joint Surg Am. 2009 Feb; 91 Suppl 1:3. PMID: 19182012.
    Citations:    Fields:    Translation:Humans
  12. Augst A, Marolt D, Freed LE, Vepari C, Meinel L, Farley M, Fajardo R, Patel N, Gray M, Kaplan DL, Vunjak-Novakovic G. Effects of chondrogenic and osteogenic regulatory factors on composite constructs grown using human mesenchymal stem cells, silk scaffolds and bioreactors. J R Soc Interface. 2008 Aug 06; 5(25):929-39. PMID: 18230586.
    Citations: 18     Fields:    Translation:HumansCells
  13. Goodwin JL, Farley ML, Swaim B, Goldring SR, Goldring MB, Bierbaum BE, Gray ML. Dual proline labeling protocol for individual "baseline" and "response" biosynthesis measurements in human articular cartilage. Osteoarthritis Cartilage. 2008 Oct; 16(10):1263-6. PMID: 18396421.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  14. Gray ML, Burstein D, Kim YJ, Maroudas A. 2007 Elizabeth Winston Lanier Award Winner. Magnetic resonance imaging of cartilage glycosaminoglycan: basic principles, imaging technique, and clinical applications. J Orthop Res. 2008 Mar; 26(3):281-91. PMID: 17876836.
    Citations: 38     Fields:    Translation:Humans
  15. Williams A, Mikulis B, Krishnan N, Gray M, McKenzie C, Burstein D. Suitability of T(1Gd) as the dGEMRIC index at 1.5T and 3.0T. Magn Reson Med. 2007 Oct; 58(4):830-4. PMID: 17899599.
    Citations: 22     Fields:    Translation:Humans
  16. Baldassarri M, Goodwin JS, Farley ML, Bierbaum BE, Goldring SR, Goldring MB, Burstein D, Gray ML. Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction. J Orthop Res. 2007 Jul; 25(7):904-12. PMID: 17427215.
    Citations: 13     Fields:    Translation:Humans
  17. Freed LE, Guilak F, Guo XE, Gray ML, Tranquillo R, Holmes JW, Radisic M, Sefton MV, Kaplan D, Vunjak-Novakovic G. Advanced tools for tissue engineering: scaffolds, bioreactors, and signaling. Tissue Eng. 2006 Dec; 12(12):3285-305. PMID: 17518670.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  18. Deng X, Farley M, Nieminen MT, Gray M, Burstein D. Diffusion tensor imaging of native and degenerated human articular cartilage. Magn Reson Imaging. 2007 Feb; 25(2):168-71. PMID: 17275610.
    Citations: 25     Fields:    Translation:Humans
  19. Burstein D, Gray ML. Is MRI fulfilling its promise for molecular imaging of cartilage in arthritis? Osteoarthritis Cartilage. 2006 Nov; 14(11):1087-90. PMID: 16901724.
    Citations: 47     Fields:    Translation:Humans
  20. Marolt D, Augst A, Freed LE, Vepari C, Fajardo R, Patel N, Gray M, Farley M, Kaplan D, Vunjak-Novakovic G. Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors. Biomaterials. 2006 Dec; 27(36):6138-49. PMID: 16895736.
    Citations: 41     Fields:    Translation:HumansCells
  21. Samosky JT, Burstein D, Eric Grimson W, Howe R, Martin S, Gray ML. Spatially-localized correlation of dGEMRIC-measured GAG distribution and mechanical stiffness in the human tibial plateau. J Orthop Res. 2005 Jan; 23(1):93-101. PMID: 15607880.
    Citations: 38     Fields:    Translation:Humans
  22. Gray ML, Burstein D. Molecular (and functional) imaging of articular cartilage. J Musculoskelet Neuronal Interact. 2004 Dec; 4(4):365-8. PMID: 15758262.
    Citations: 10     Fields:    Translation:Humans
  23. Gray ML, Eckstein F, Peterfy C, Dahlberg L, Kim YJ, Sorensen AG. Toward imaging biomarkers for osteoarthritis. Clin Orthop Relat Res. 2004 Oct; (427 Suppl):S175-81. PMID: 15480063.
    Citations: 28     Fields:    Translation:Humans
  24. Menezes NM, Gray ML, Hartke JR, Burstein D. T2 and T1rho MRI in articular cartilage systems. Magn Reson Med. 2004 Mar; 51(3):503-9. PMID: 15004791.
    Citations: 132     Fields:    Translation:HumansAnimals
  25. Seidel JO, Pei M, Gray ML, Langer R, Freed LE, Vunjak-Novakovic G. Long-term culture of tissue engineered cartilage in a perfused chamber with mechanical stimulation. Biorheology. 2004; 41(3-4):445-58. PMID: 15299276.
    Citations: 28     Fields:    Translation:AnimalsCells
  26. Kim YJ, Jaramillo D, Millis MB, Gray ML, Burstein D. Assessment of early osteoarthritis in hip dysplasia with delayed gadolinium-enhanced magnetic resonance imaging of cartilage. J Bone Joint Surg Am. 2003 Oct; 85(10):1987-92. PMID: 14563809.
    Citations: 89     Fields:    Translation:Humans
  27. Gold GE, McCauley TR, Gray ML, Disler DG. What's new in cartilage? Radiographics. 2003 Sep-Oct; 23(5):1227-42. PMID: 14518449.
    Citations: 25     Fields:    Translation:Humans
  28. Greenberg JE, Delgutte B, Gray ML. Hands-on learning in biomedical signal processing. IEEE Eng Med Biol Mag. 2003 Jul-Aug; 22(4):71-9. PMID: 14515696.
    Citations:    Fields:    
  29. Williams A, Oppenheimer RA, Gray ML, Burstein D. Differential recovery of glycosaminoglycan after IL-1-induced degradation of bovine articular cartilage depends on degree of degradation. Arthritis Res Ther. 2003; 5(2):R97-105. PMID: 12718753; PMCID: PMC165027.
    Citations: 10     Fields:    Translation:Animals
  30. Burstein D, Gray M. New MRI techniques for imaging cartilage. J Bone Joint Surg Am. 2003; 85-A Suppl 2:70-7. PMID: 12721347.
    Citations: 32     Fields:    Translation:Humans
  31. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12; 420(6916):703-6. PMID: 12478301.
    Citations: 38     Fields:    Translation:HumansCells
  32. Gillis A, Gray M, Burstein D. Relaxivity and diffusion of gadolinium agents in cartilage. Magn Reson Med. 2002 Dec; 48(6):1068-71. PMID: 12465119.
    Citations: 27     Fields:    Translation:Animals
  33. Voldman J, Gray ML, Toner M, Schmidt MA. A microfabrication-based dynamic array cytometer. Anal Chem. 2002 Aug 15; 74(16):3984-90. PMID: 12199564.
    Citations: 43     Fields:    Translation:HumansCells
  34. Gray ML, Bonventre JV. Training PhD researchers to translate science to clinical medicine: closing the gap from the other side. Nat Med. 2002 May; 8(5):433-6. PMID: 11984576.
    Citations: 5     Fields:    Translation:Humans
  35. Gray ML, Burstein D, Xia Y. Biochemical (and functional) imaging of articular cartilage. Semin Musculoskelet Radiol. 2001 Dec; 5(4):329-43. PMID: 11745049.
    Citations: 29     Fields:    Translation:Humans
  36. Gillis A, Bashir A, McKeon B, Scheller A, Gray ML, Burstein D. Magnetic resonance imaging of relative glycosaminoglycan distribution in patients with autologous chondrocyte transplants. Invest Radiol. 2001 Dec; 36(12):743-8. PMID: 11753146.
    Citations: 31     Fields:    Translation:Humans
  37. Voldman J, Braff RA, Toner M, Gray ML, Schmidt MA. Holding forces of single-particle dielectrophoretic traps. Biophys J. 2001 Jan; 80(1):531-41. PMID: 11159423; PMCID: PMC1301254.
    Citations: 26     Fields:    
  38. Burstein D, Velyvis J, Scott KT, Stock KW, Kim YJ, Jaramillo D, Boutin RD, Gray ML. Protocol issues for delayed Gd(DTPA)(2-)-enhanced MRI (dGEMRIC) for clinical evaluation of articular cartilage. Magn Reson Med. 2001 Jan; 45(1):36-41. PMID: 11146483.
    Citations: 134     Fields:    Translation:Humans
  39. Burstein D, Bashir A, Gray ML. MRI techniques in early stages of cartilage disease. Invest Radiol. 2000 Oct; 35(10):622-38. PMID: 11041156.
    Citations: 58     Fields:    Translation:HumansAnimals
  40. Bashir A, Gray ML, Hartke J, Burstein D. Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI. Magn Reson Med. 1999 May; 41(5):857-65. PMID: 10332865.
    Citations: 151     Fields:    Translation:HumansAnimals
  41. Allen RG, Burstein D, Gray ML. Monitoring glycosaminoglycan replenishment in cartilage explants with gadolinium-enhanced magnetic resonance imaging. J Orthop Res. 1999 May; 17(3):430-6. PMID: 10376734.
    Citations: 12     Fields:    Translation:Animals
  42. Voldman J, Gray ML, Schmidt MA. Microfabrication in biology and medicine. Annu Rev Biomed Eng. 1999; 1:401-25. PMID: 11701495.
    Citations: 54     Fields:    Translation:HumansAnimals
  43. Meazzini MC, Toma CD, Schaffer JL, Gray ML, Gerstenfeld LC. Osteoblast cytoskeletal modulation in response to mechanical strain in vitro. J Orthop Res. 1998 Mar; 16(2):170-80. PMID: 9621891.
    Citations: 10     Fields:    Translation:AnimalsCells
  44. Bashir A, Gray ML, Boutin RD, Burstein D. Glycosaminoglycan in articular cartilage: in vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging. Radiology. 1997 Nov; 205(2):551-8. PMID: 9356644.
    Citations: 104     Fields:    Translation:Humans
  45. Bashir A, Gray ML, Burstein D. Gd-DTPA2- as a measure of cartilage degradation. Magn Reson Med. 1996 Nov; 36(5):665-73. PMID: 8916016.
    Citations: 145     Fields:    Translation:HumansAnimals
  46. Gray ML, Burstein D, Lesperance LM, Gehrke L. Magnetization transfer in cartilage and its constituent macromolecules. Magn Reson Med. 1995 Sep; 34(3):319-25. PMID: 7500869.
    Citations: 36     Fields:    Translation:Animals
  47. Boustany NN, Gray ML, Black AC, Hunziker EB. Correlation between synthetic activity and glycosaminoglycan concentration in epiphyseal cartilage raises questions about the regulatory role of interstitial pH. J Orthop Res. 1995 Sep; 13(5):733-9. PMID: 7472752.
    Citations: 3     Fields:    Translation:AnimalsCells
  48. Boustany NN, Gray ML, Black AC, Hunziker EB. Time-dependent changes in the response of cartilage to static compression suggest interstitial pH is not the only signaling mechanism. J Orthop Res. 1995 Sep; 13(5):740-50. PMID: 7472753.
    Citations: 1     Fields:    Translation:AnimalsCells
  49. Garcia AM, Gray ML. Dimensional growth and extracellular matrix accumulation by neonatal rat mandibular condyles in long-term culture. J Orthop Res. 1995 Mar; 13(2):208-19. PMID: 7722758.
    Citations: 4     Fields:    Translation:AnimalsCells
  50. Donahue KM, Burstein D, Manning WJ, Gray ML. Studies of Gd-DTPA relaxivity and proton exchange rates in tissue. Magn Reson Med. 1994 Jul; 32(1):66-76. PMID: 8084239.
    Citations: 62     Fields:    Translation:HumansAnimals
  51. García AM, Black AC, Gray ML. Effects of physicochemical factors on the growth of mandibular condyles in vitro. Calcif Tissue Int. 1994 Jun; 54(6):499-504. PMID: 8082055.
    Citations:    Fields:    Translation:AnimalsCells
  52. Burstein D, Gray ML, Hartman AL, Gipe R, Foy BD. Diffusion of small solutes in cartilage as measured by nuclear magnetic resonance (NMR) spectroscopy and imaging. J Orthop Res. 1993 Jul; 11(4):465-78. PMID: 8340820.
    Citations: 67     Fields:    Translation:AnimalsCells
  53. Lesperance LM, Gray ML, Burstein D. Determination of fixed charge density in cartilage using nuclear magnetic resonance. J Orthop Res. 1992 Jan; 10(1):1-13. PMID: 1309384.
    Citations: 56     Fields:    Translation:Animals
  54. Gray ML, Pizzanelli AM, Lee RC, Grodzinsky AJ, Swann DA. Kinetics of the chondrocyte biosynthetic response to compressive load and release. Biochim Biophys Acta. 1989 Jun 27; 991(3):415-25. PMID: 2730919.
    Citations: 9     Fields:    Translation:AnimalsCells
  55. Gray ML, Pizzanelli AM, Grodzinsky AJ, Lee RC. Mechanical and physiochemical determinants of the chondrocyte biosynthetic response. J Orthop Res. 1988; 6(6):777-92. PMID: 3171760.
    Citations: 53     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.