Harvard Catalyst Profiles

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Thomas F. Deuel, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA084400 (DEUEL, THOMAS F) Dec 20, 1999 - Nov 30, 2004
    NIH/NCI
    PLEIOTROPHIN-- AN ANGIOGENIC SWITCH IN TUMOR PROGRESSION
    Role: Principal Investigator
  2. R01DK053557 (DEUEL, THOMAS F) May 1, 1998 - Feb 28, 2005
    NIH/NIDDK
    PLEIOTROPHIN SIGNALING MECHANISMS
    Role: Principal Investigator
  3. P01CA049712 (LEY, TIMOTHY J) Dec 10, 1997 - Nov 30, 1999
    NIH/NCI
    GENE REGULATION IN NORMAL AND TRANSFORMED CELLS
    Role: Co-Principal Investigator
  4. P50HL056993 (CANTLEY, LEWIS C) Apr 23, 1997 - Mar 31, 2002
    NIH/NHLBI
    SCOR IN MOLECULAR MEDICINE AND ATHEROSCLEROSIS
    Role: Co-Principal Investigator
  5. R01CA066029 (DEUEL, THOMAS F) Jun 10, 1995 - Mar 31, 2006
    NIH/NCI
    ROLE OF PLEIOTROPHIN IN BREAST CANCER
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Herradon G, Ezquerra L, Nguyen T, Vogt TF, Bronson R, Silos-Santiago I, Deuel TF. Pleiotrophin is an important regulator of the renin-angiotensin system in mouse aorta. Biochem Biophys Res Commun. 2004 Nov 19; 324(3):1041-7. PMID: 15485659.
    Citations: 5     Fields:    Translation:AnimalsCells
  2. Ezquerra L, Herradón G, Nguyen T, Vogt TF, Bronson R, Silos-Santiago I, Deuel TF. Pleiotrophin is a major regulator of the catecholamine biosynthesis pathway in mouse aorta. Biochem Biophys Res Commun. 2004 Oct 15; 323(2):512-7. PMID: 15369781.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. Deuel TF, Zhang N, Yeh HJ, Silos-Santiago I, Wang ZY. Pleiotrophin: a cytokine with diverse functions and a novel signaling pathway. Arch Biochem Biophys. 2002 Jan 15; 397(2):162-71. PMID: 11795867.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  4. Yu J, Deuel TF, Kim HR. Platelet-derived growth factor (PDGF) receptor-alpha activates c-Jun NH2-terminal kinase-1 and antagonizes PDGF receptor-beta -induced phenotypic transformation. J Biol Chem. 2000 Jun 23; 275(25):19076-82. PMID: 10777515.
    Citations: 17     Fields:    Translation:AnimalsCells
  5. Meng K, Rodriguez-Peña A, Dimitrov T, Chen W, Yamin M, Noda M, Deuel TF. Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. Proc Natl Acad Sci U S A. 2000 Mar 14; 97(6):2603-8. PMID: 10706604.
    Citations: 117     Fields:    Translation:HumansCells
  6. Zhang N, Yeh HJ, Zhong R, Li YS, Deuel TF. A dominant-negative pleiotrophin mutant introduced by homologous recombination leads to germ-cell apoptosis in male mice. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):6734-8. PMID: 10359781.
    Citations: 5     Fields:    Translation:HumansAnimals
  7. Zhang N, Zhong R, Deuel TF. Domain structure of pleiotrophin required for transformation. J Biol Chem. 1999 May 07; 274(19):12959-62. PMID: 10224041.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  8. Liu JJ, Wang ZY, Deuel TF, Xu YH. Imbalanced expression of functionally different WT1 isoforms may contribute to sporadic unilateral Wilms' tumor. Biochem Biophys Res Commun. 1999 Jan 08; 254(1):197-9. PMID: 9920757.
    Citations:    Fields:    Translation:HumansCells
  9. Deuel TF, Guan LS, Wang ZY. Wilms' tumor gene product WT1 arrests macrophage differentiation of HL-60 cells through its zinc-finger domain. Biochem Biophys Res Commun. 1999 Jan 08; 254(1):192-6. PMID: 9920756.
    Citations: 5     Fields:    Translation:HumansCells
  10. Zhang N, Deuel TF. Pleiotrophin and midkine, a family of mitogenic and angiogenic heparin-binding growth and differentiation factors. Curr Opin Hematol. 1999 Jan; 6(1):44-50. PMID: 9915553.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  11. Yeh HJ, He YY, Xu J, Hsu CY, Deuel TF. Upregulation of pleiotrophin gene expression in developing microvasculature, macrophages, and astrocytes after acute ischemic brain injury. J Neurosci. 1998 May 15; 18(10):3699-707. PMID: 9570800.
    Citations: 31     Fields:    Translation:AnimalsCells
  12. Zhang N, Zhong R, Wang ZY, Deuel TF. Human breast cancer growth inhibited in vivo by a dominant negative pleiotrophin mutant. J Biol Chem. 1997 Jul 04; 272(27):16733-6. PMID: 9201975.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  13. Nobuyoshi M, Lin XH, Takimoto Y, Deuel TF, Wang ZY. Transcription regulation of the PDGF A-chain gene by first intron elements. Biochem Biophys Res Commun. 1997 Jan 23; 230(3):569-72. PMID: 9015363.
    Citations: 4     Fields:    Translation:HumansCells
  14. Wang ZY, Qiu QQ, Seufert W, Taguchi T, Testa JR, Whitmore SA, Callen DF, Welsh D, Shenk T, Deuel TF. Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9. J Biol Chem. 1996 Oct 04; 271(40):24811-6. PMID: 8798754.
    Citations: 9     Fields:    Translation:HumansCells
  15. Mitchell CA, Jefferson AB, Bejeck BE, Brugge JS, Deuel TF, Majerus PW. Thrombin-stimulated immunoprecipitation of phosphatidylinositol 3-kinase from human platelets. Proc Natl Acad Sci U S A. 1990 Dec; 87(23):9396-400. PMID: 2174561.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.