Harvard Catalyst Profiles

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Richard Leslie Stevens, Ph.D.

Co-Author

This page shows the publications co-authored by Richard Stevens and K Austen.
Connection Strength

1.861
  1. Stevens RL, Friend DS, McNeil HP, Schiller V, Ghildyal N, Austen KF. Strain-specific and tissue-specific expression of mouse mast cell secretory granule proteases. Proc Natl Acad Sci U S A. 1994 Jan 04; 91(1):128-32.
    View in: PubMed
    Score: 0.160
  2. Stevens RL, Fox CC, Lichtenstein LM, Austen KF. Identification of chondroitin sulfate E proteoglycans and heparin proteoglycans in the secretory granules of human lung mast cells. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2284-7.
    View in: PubMed
    Score: 0.107
  3. Stevens RL, Austen KF. Effect of p-nitrophenyl-beta-D-xyloside on proteoglycan and glycosaminoglycan biosynthesis in rat serosal mast cell cultures. J Biol Chem. 1982 Jan 10; 257(1):253-9.
    View in: PubMed
    Score: 0.070
  4. Stevens RL, Austen KF. Proteoglycans of the mast cell. Kroc Found Ser. 1981; 14:69-88.
    View in: PubMed
    Score: 0.065
  5. Friend DS, Gurish MF, Austen KF, Hunt J, Stevens RL. Senescent jejunal mast cells and eosinophils in the mouse preferentially translocate to the spleen and draining lymph node, respectively, during the recovery phase of helminth infection. J Immunol. 2000 Jul 01; 165(1):344-52.
    View in: PubMed
    Score: 0.063
  6. Friend DS, Ghildyal N, Gurish MF, Hunt J, Hu X, Austen KF, Stevens RL. Reversible expression of tryptases and chymases in the jejunal mast cells of mice infected with Trichinella spiralis. J Immunol. 1998 Jun 01; 160(11):5537-45.
    View in: PubMed
    Score: 0.054
  7. Hunt JE, Friend DS, Gurish MF, Feyfant E, Sali A, Huang C, Ghildyal N, Stechschulte S, Austen KF, Stevens RL. Mouse mast cell protease 9, a novel member of the chromosome 14 family of serine proteases that is selectively expressed in uterine mast cells. J Biol Chem. 1997 Nov 14; 272(46):29158-66.
    View in: PubMed
    Score: 0.052
  8. Friend DS, Ghildyal N, Austen KF, Gurish MF, Matsumoto R, Stevens RL. Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and chymase phenotype. J Cell Biol. 1996 Oct; 135(1):279-90.
    View in: PubMed
    Score: 0.048
  9. Xia Z, Ghildyal N, Austen KF, Stevens RL. Post-transcriptional regulation of chymase expression in mast cells. A cytokine-dependent mechanism for controlling the expression of granule neutral proteases of hematopoietic cells. J Biol Chem. 1996 Apr 12; 271(15):8747-53.
    View in: PubMed
    Score: 0.047
  10. Ghildyal N, Friend DS, Freelund R, Austen KF, McNeil HP, Schiller V, Stevens RL. Lack of expression of the tryptase mouse mast cell protease 7 in mast cells of the C57BL/6J mouse. J Immunol. 1994 Sep 15; 153(6):2624-30.
    View in: PubMed
    Score: 0.042
  11. Eklund KK, Ghildyal N, Austen KF, Friend DS, Schiller V, Stevens RL. Mouse bone marrow-derived mast cells (mBMMC) obtained in vitro from mice that are mast cell-deficient in vivo express the same panel of granule proteases as mBMMC and serosal mast cells from their normal littermates. J Exp Med. 1994 Jul 01; 180(1):67-73.
    View in: PubMed
    Score: 0.041
  12. Bankova LG, Lezcano C, Pejler G, Stevens RL, Murphy GF, Austen KF, Gurish MF. Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions. J Immunol. 2014 Mar 15; 192(6):2812-20.
    View in: PubMed
    Score: 0.040
  13. Eklund KK, Ghildyal N, Austen KF, Stevens RL. Induction by IL-9 and suppression by IL-3 and IL-4 of the levels of chromosome 14-derived transcripts that encode late-expressed mouse mast cell proteases. J Immunol. 1993 Oct 15; 151(8):4266-73.
    View in: PubMed
    Score: 0.039
  14. Ghildyal N, Friend DS, Nicodemus CF, Austen KF, Stevens RL. Reversible expression of mouse mast cell protease 2 mRNA and protein in cultured mast cells exposed to IL-10. J Immunol. 1993 Sep 15; 151(6):3206-14.
    View in: PubMed
    Score: 0.039
  15. Gurish MF, Nadeau JH, Johnson KR, McNeil HP, Grattan KM, Austen KF, Stevens RL. A closely linked complex of mouse mast cell-specific chymase genes on chromosome 14. J Biol Chem. 1993 May 25; 268(15):11372-9.
    View in: PubMed
    Score: 0.038
  16. McNeil HP, Reynolds DS, Schiller V, Ghildyal N, Gurley DS, Austen KF, Stevens RL. Isolation, characterization, and transcription of the gene encoding mouse mast cell protease 7. Proc Natl Acad Sci U S A. 1992 Dec 01; 89(23):11174-8.
    View in: PubMed
    Score: 0.037
  17. McNeil HP, Frenkel DP, Austen KF, Friend DS, Stevens RL. Translation and granule localization of mouse mast cell protease-5. Immunodetection with specific antipeptide Ig. J Immunol. 1992 Oct 01; 149(7):2466-72.
    View in: PubMed
    Score: 0.037
  18. Ghildyal N, McNeil HP, Stechschulte S, Austen KF, Silberstein D, Gurish MF, Somerville LL, Stevens RL. IL-10 induces transcription of the gene for mouse mast cell protease-1, a serine protease preferentially expressed in mucosal mast cells of Trichinella spiralis-infected mice. J Immunol. 1992 Sep 15; 149(6):2123-9.
    View in: PubMed
    Score: 0.036
  19. Ghildyal N, McNeil HP, Gurish MF, Austen KF, Stevens RL. Transcriptional regulation of the mucosal mast cell-specific protease gene, MMCP-2, by interleukin 10 and interleukin 3. J Biol Chem. 1992 Apr 25; 267(12):8473-7.
    View in: PubMed
    Score: 0.035
  20. Gurish MF, Ghildyal N, McNeil HP, Austen KF, Gillis S, Stevens RL. Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand. J Exp Med. 1992 Apr 01; 175(4):1003-12.
    View in: PubMed
    Score: 0.035
  21. Avraham S, Avraham H, Austen KF, Stevens RL. Negative and positive cis-acting elements in the promoter of the mouse gene that encodes the serine/glycine-rich peptide core of secretory granule proteoglycans. J Biol Chem. 1992 Jan 05; 267(1):610-7.
    View in: PubMed
    Score: 0.035
  22. McNeil HP, Austen KF, Somerville LL, Gurish MF, Stevens RL. Molecular cloning of the mouse mast cell protease-5 gene. A novel secretory granule protease expressed early in the differentiation of serosal mast cells. J Biol Chem. 1991 Oct 25; 266(30):20316-22.
    View in: PubMed
    Score: 0.034
  23. Serafin WE, Guidry UA, Dayton ET, Kamada MM, Stevens RL, Austen KF. Identification of aminopeptidase activity in the secretory granules of mouse mast cells. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):5984-8.
    View in: PubMed
    Score: 0.034
  24. Gurish MF, Ghildyal N, Arm J, Austen KF, Avraham S, Reynolds D, Stevens RL. Cytokine mRNA are preferentially increased relative to secretory granule protein mRNA in mouse bone marrow-derived mast cells that have undergone IgE-mediated activation and degranulation. J Immunol. 1991 Mar 01; 146(5):1527-33.
    View in: PubMed
    Score: 0.033
  25. Younan G, Suber F, Xing W, Shi T, Kunori Y, Abrink M, Pejler G, Schlenner SM, Rodewald HR, Moore FD, Stevens RL, Adachi R, Austen KF, Gurish MF. The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5. J Immunol. 2010 Dec 15; 185(12):7681-90.
    View in: PubMed
    Score: 0.032
  26. Caulfield JP, Hein A, Rothenberg ME, Owen WF, Soberman RJ, Stevens RL, Austen KF. A morphometric study of normodense and hypodense human eosinophils that are derived in vivo and in vitro. Am J Pathol. 1990 Jul; 137(1):27-41.
    View in: PubMed
    Score: 0.031
  27. Nicodemus CF, Avraham S, Austen KF, Purdy S, Jablonski J, Stevens RL. Characterization of the human gene that encodes the peptide core of secretory granule proteoglycans in promyelocytic leukemia HL-60 cells and analysis of the translated product. J Biol Chem. 1990 Apr 05; 265(10):5889-96.
    View in: PubMed
    Score: 0.031
  28. Serafin WE, Reynolds DS, Rogelj S, Lane WS, Conder GA, Johnson SS, Austen KF, Stevens RL. Identification and molecular cloning of a novel mouse mucosal mast cell serine protease. J Biol Chem. 1990 Jan 05; 265(1):423-9.
    View in: PubMed
    Score: 0.030
  29. Avraham S, Austen KF, Nicodemus CF, Gartner MC, Stevens RL. Cloning and characterization of the mouse gene that encodes the peptide core of secretory granule proteoglycans and expression of this gene in transfected rat-1 fibroblasts. J Biol Chem. 1989 Oct 05; 264(28):16719-26.
    View in: PubMed
    Score: 0.030
  30. Owen WF, Rothenberg ME, Petersen J, Weller PF, Silberstein D, Sheffer AL, Stevens RL, Soberman RJ, Austen KF. Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome. J Exp Med. 1989 Jul 01; 170(1):343-8.
    View in: PubMed
    Score: 0.029
  31. Dayton ET, Caulfield JP, Hein A, Austen KF, Stevens RL. Regulation of the growth rate of mouse fibroblasts by IL-3-activated mouse bone marrow-derived mast cells. J Immunol. 1989 Jun 15; 142(12):4307-13.
    View in: PubMed
    Score: 0.029
  32. Kamada MM, Michon J, Ritz J, Holldack J, Serafin WE, Austen KF, MacDermott RP, Stevens RL. Identification of carboxypeptidase and tryptic esterase activities that are complexed to proteoglycans in the secretory granules of human cloned natural killer cells. J Immunol. 1989 Jan 15; 142(2):609-15.
    View in: PubMed
    Score: 0.028
  33. Rothenberg ME, Pomerantz JL, Owen WF, Avraham S, Soberman RJ, Austen KF, Stevens RL. Characterization of a human eosinophil proteoglycan, and augmentation of its biosynthesis and size by interleukin 3, interleukin 5, and granulocyte/macrophage colony stimulating factor. J Biol Chem. 1988 Sep 25; 263(27):13901-8.
    View in: PubMed
    Score: 0.028
  34. Reynolds DS, Serafin WE, Faller DV, Wall DA, Abbas AK, Dvorak AM, Austen KF, Stevens RL. Immortalization of murine connective tissue-type mast cells at multiple stages of their differentiation by coculture of splenocytes with fibroblasts that produce Kirsten sarcoma virus. J Biol Chem. 1988 Sep 05; 263(25):12783-91.
    View in: PubMed
    Score: 0.028
  35. Rothenberg ME, Owen WF, Silberstein DS, Woods J, Soberman RJ, Austen KF, Stevens RL. Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3. J Clin Invest. 1988 Jun; 81(6):1986-92.
    View in: PubMed
    Score: 0.027
  36. Stevens RL, Avraham S, Gartner MC, Bruns GA, Austen KF, Weis JH. Isolation and characterization of a cDNA that encodes the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL-60 cells. J Biol Chem. 1988 May 25; 263(15):7287-91.
    View in: PubMed
    Score: 0.027
  37. Katz HR, Dayton ET, Levi-Schaffer F, Benson AC, Austen KF, Stevens RL. Coculture of mouse IL-3-dependent mast cells with 3T3 fibroblasts stimulates synthesis of globopentaosylceramide (Forssman glycolipid) by fibroblasts and surface expression on both populations. J Immunol. 1988 May 01; 140(9):3090-7.
    View in: PubMed
    Score: 0.027
  38. Heavey DJ, Ernst PB, Stevens RL, Befus AD, Bienenstock J, Austen KF. Generation of leukotriene C4, leukotriene B4, and prostaglandin D2 by immunologically activated rat intestinal mucosa mast cells. J Immunol. 1988 Mar 15; 140(6):1953-7.
    View in: PubMed
    Score: 0.027
  39. Dayton ET, Pharr P, Ogawa M, Serafin WE, Austen KF, Levi-Schaffer F, Stevens RL. 3T3 fibroblasts induce cloned interleukin 3-dependent mouse mast cells to resemble connective tissue mast cells in granular constituency. Proc Natl Acad Sci U S A. 1988 Jan; 85(2):569-72.
    View in: PubMed
    Score: 0.026
  40. Serafin WE, Dayton ET, Gravallese PM, Austen KF, Stevens RL. Carboxypeptidase A in mouse mast cells. Identification, characterization, and use as a differentiation marker. J Immunol. 1987 Dec 01; 139(11):3771-6.
    View in: PubMed
    Score: 0.026
  41. Levi-Schaffer F, Dayton ET, Austen KF, Hein A, Caulfield JP, Gravallese PM, Liu FT, Stevens RL. Mouse bone marrow-derived mast cells cocultured with fibroblasts. Morphology and stimulation-induced release of histamine, leukotriene B4, leukotriene C4, and prostaglandin D2. J Immunol. 1987 Nov 15; 139(10):3431-41.
    View in: PubMed
    Score: 0.026
  42. MacDermott RP, Schmidt RE, Caulfield JP, Hein A, Bartley GT, Ritz J, Schlossman SF, Austen KF, Stevens RL. Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis. J Exp Med. 1985 Dec 01; 162(6):1771-87.
    View in: PubMed
    Score: 0.023
  43. Abonia JP, Friend DS, Austen WG, Moore FD, Carroll MC, Chan R, Afnan J, Humbles A, Gerard C, Knight P, Kanaoka Y, Yasuda S, Morokawa N, Austen KF, Stevens RL, Gurish MF. Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle. J Immunol. 2005 Jun 01; 174(11):7285-91.
    View in: PubMed
    Score: 0.022
  44. DuBuske L, Austen KF, Czop J, Stevens RL. Granule-associated serine neutral proteases of the mouse bone marrow-derived mast cell that degrade fibronectin: their increase after sodium butyrate treatment of the cells. J Immunol. 1984 Sep; 133(3):1535-41.
    View in: PubMed
    Score: 0.021
  45. Ghildyal N, Friend DS, Stevens RL, Austen KF, Huang C, Penrose JF, Sali A, Gurish MF. Fate of two mast cell tryptases in V3 mastocytosis and normal BALB/c mice undergoing passive systemic anaphylaxis: prolonged retention of exocytosed mMCP-6 in connective tissues, and rapid accumulation of enzymatically active mMCP-7 in the blood. J Exp Med. 1996 Sep 01; 184(3):1061-73.
    View in: PubMed
    Score: 0.012
  46. Hunt JE, Stevens RL, Austen KF, Zhang J, Xia Z, Ghildyal N. Natural disruption of the mouse mast cell protease 7 gene in the C57BL/6 mouse. J Biol Chem. 1996 Feb 02; 271(5):2851-5.
    View in: PubMed
    Score: 0.012
  47. Gurish MF, Pear WS, Stevens RL, Scott ML, Sokol K, Ghildyal N, Webster MJ, Hu X, Austen KF, Baltimore D, et al. Tissue-regulated differentiation and maturation of a v-abl-immortalized mast cell-committed progenitor. Immunity. 1995 Aug; 3(2):175-86.
    View in: PubMed
    Score: 0.011
  48. Zon LI, Gurish MF, Stevens RL, Mather C, Reynolds DS, Austen KF, Orkin SH. GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 05; 266(34):22948-53.
    View in: PubMed
    Score: 0.009
  49. Reynolds DS, Stevens RL, Lane WS, Carr MH, Austen KF, Serafin WE. Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases. Proc Natl Acad Sci U S A. 1990 Apr; 87(8):3230-4.
    View in: PubMed
    Score: 0.008
  50. Reynolds DS, Gurley DS, Stevens RL, Sugarbaker DJ, Austen KF, Serafin WE. Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9480-4.
    View in: PubMed
    Score: 0.008
  51. Reynolds DS, Stevens RL, Gurley DS, Lane WS, Austen KF, Serafin WE. Isolation and molecular cloning of mast cell carboxypeptidase A. A novel member of the carboxypeptidase gene family. J Biol Chem. 1989 Nov 25; 264(33):20094-9.
    View in: PubMed
    Score: 0.007
  52. Rothenberg ME, Petersen J, Stevens RL, Silberstein DS, McKenzie DT, Austen KF, Owen WF. IL-5-dependent conversion of normodense human eosinophils to the hypodense phenotype uses 3T3 fibroblasts for enhanced viability, accelerated hypodensity, and sustained antibody-dependent cytotoxicity. J Immunol. 1989 Oct 01; 143(7):2311-6.
    View in: PubMed
    Score: 0.007
  53. Avraham S, Stevens RL, Nicodemus CF, Gartner MC, Austen KF, Weis JH. Molecular cloning of a cDNA that encodes the peptide core of a mouse mast cell secretory granule proteoglycan and comparison with the analogous rat and human cDNA. Proc Natl Acad Sci U S A. 1989 May; 86(10):3763-7.
    View in: PubMed
    Score: 0.007
  54. Avraham S, Stevens RL, Gartner MC, Austen KF, Lalley PA, Weis JH. Isolation of a cDNA that encodes the peptide core of the secretory granule proteoglycan of rat basophilic leukemia-1 cells and assessment of its homology to the human analogue. J Biol Chem. 1988 May 25; 263(15):7292-6.
    View in: PubMed
    Score: 0.007
  55. Schmidt RE, MacDermott RP, Bartley G, Bertovich M, Amato DA, Austen KF, Schlossman SF, Stevens RL, Ritz J. Specific release of proteoglycans from human natural killer cells during target lysis. Nature. 1985 Nov 21-27; 318(6043):289-91.
    View in: PubMed
    Score: 0.006
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.