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Xunwei Wu, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Li F, Yuan CW, Xu S, Zu T, Woappi Y, Lee CAA, Abarzua P, Wells M, Ramsey MR, Frank NY, Wu X, Mandinova A, Frank MH, Lian CG, Murphy GF. Loss of the Epigenetic Mark 5-hmC in Psoriasis: Implications for Epidermal Stem Cell Dysregulation. J Invest Dermatol. 2019 Dec 11. PMID: 31837302.
    Citations:    
  2. Zhang X, Qin J, Xie Z, Liu C, Su Y, Chen Z, Zhou Q, Ma C, Liu G, Paus R, Guo J, Wu X. Y-27632 preserves epidermal integrity in a human skin organ-culture (hSOC) system by regulating AKT and ERK signaling pathways. J Dermatol Sci. 2019 Nov; 96(2):99-109. PMID: 31718896.
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  3. Mi J, Feng Y, Wen J, Su Y, Xu L, Zu T, Liu C, Fisher DE, Wu X. A ROCK inhibitor promotes keratinocyte survival and paracrine secretion, enhancing establishment of primary human melanocytes and melanocyte-keratinocyte co-cultures. Pigment Cell Melanoma Res. 2020 Jan; 33(1):16-29. PMID: 31386789.
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  4. Mi J, Chen S, Xu L, Wen J, Xu X, Wu X. Human Reconstructed Skin in a Mouse Model. Methods Mol Biol. 2019; 1993:227-237. PMID: 31148091.
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  5. Qian H, Leng X, Wen J, Zhou Q, Xu X, Wu X. One-Step Simple Isolation Method to Obtain Both Epidermal and Dermal Stem Cells from Human Skin Specimen. Methods Mol Biol. 2019; 1879:139-148. PMID: 29478135.
    Citations:    
  6. Chang F, Zhang Y, Mi J, Zhou Q, Bai F, Xu X, Fisher DE, Sun Q, Wu X. ROCK inhibitor enhances the growth and migration of BRAF-mutant skin melanoma cells. Cancer Sci. 2018 Nov; 109(11):3428-3437. PMID: 30168234.
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  7. Liu Z, Wen J, Leng X, Zhou Q, Zhou C, Zhao H, Wu X. A Simplified and Efficient Method to Isolate Primary Human Keratinocytes from Adult Skin Tissue. J Vis Exp. 2018 08 25; (138). PMID: 30199027.
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  8. Leng X, Wang P, Chen Z, Li D, Wen J, Zhang X, Qian H, Guo J, Wu X. Dissociated skin cells regenerate hair follicles in a microwound, "The Punch Assay". Exp Dermatol. 2020 Mar; 29(3):349-356. PMID: 30033549.
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  9. Wu X, Tommasi di Vignano A, Zhou Q, Michel-Dziunycz PJ, Bai F, Mi J, Qin J, Zu T, Hofbauer GFL. The ARE-binding protein Tristetraprolin (TTP) is a novel target and mediator of calcineurin tumor suppressing function in the skin. PLoS Genet. 2018 05; 14(5):e1007366. PMID: 29723192.
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  10. Wu X, Fisher DE. Negative Regulation of Skin Pigmentation in Three-Dimensional Reconstructs by Adipose-Derived Mesenchymal Cells. J Invest Dermatol. 2017 12; 137(12):2464-2466. PMID: 29169460.
    Citations:    Fields:    
  11. Wen J, Zu T, Zhou Q, Leng X, Wu X. Y-27632 simplifies the isolation procedure of human primary epidermal cells by selectively blocking focal adhesion of dermal cells. J Tissue Eng Regen Med. 2018 02; 12(2):e1251-e1255. PMID: 28752652.
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  12. Zhang Q, Zu T, Zhou Q, Wen J, Leng X, Wu X. The patch assay reconstitutes mature hair follicles by culture-expanded human cells. Regen Med. 2017 07; 12(5):503-511. PMID: 28749726.
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  13. Wen J, Li X, Leng X, Xu X, Wu X. An advanced mouse model for human skin wound healing. Exp Dermatol. 2017 05; 26(5):433-435. PMID: 27892608.
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  14. Won CH, Park GH, Wu X, Tran TN, Park KY, Park BS, Kim DY, Kwon O, Kim KH. The Basic Mechanism of Hair Growth Stimulation by Adipose-derived Stem Cells and Their Secretory Factors. Curr Stem Cell Res Ther. 2017; 12(7):535-543. PMID: 28875863.
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  15. Wu X, Scott L, Washenik K, Stenn K. Full-thickness skin with mature hair follicles generated from tissue culture expanded human cells. Tissue Eng Part A. 2014 Dec; 20(23-24):3314-21. PMID: 25074625.
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  16. Dziunycz PJ, Lefort K, Wu X, Freiberger SN, Neu J, Djerbi N, Iotzowa-Weiss G, French LE, Dotto GP, Hofbauer GFL. The oncogene ATF3 is potentiated by cyclosporine A and ultraviolet light A. J Invest Dermatol. 2014 Jul; 134(7):1998-2004. PMID: 24509533.
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  17. Marshall BT, Ingraham CA, Wu X, Washenik K. Future horizons in hair restoration. Facial Plast Surg Clin North Am. 2013 Aug; 21(3):521-8. PMID: 24017993.
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  18. Nordberg G, Jin T, Wu X, Lu J, Chen L, Liang Y, Lei L, Hong F, Bergdahl IA, Nordberg M. Kidney dysfunction and cadmium exposure--factors influencing dose-response relationships. J Trace Elem Med Biol. 2012 Jun; 26(2-3):197-200. PMID: 22565016.
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  19. Qi Y, Liu J, Wu X, Brakebusch C, Leitges M, Han Y, Corbett SA, Lowry SF, Graham AM, Li S. Cdc42 controls vascular network assembly through protein kinase C? during embryonic vasculogenesis. Arterioscler Thromb Vasc Biol. 2011 Aug; 31(8):1861-70. PMID: 21659643.
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  20. Wu X, Nguyen BC, Dziunycz P, Chang S, Brooks Y, Lefort K, Hofbauer GF, Dotto GP. Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature. 2010 May 20; 465(7296):368-72. PMID: 20485437.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  21. Pleines I, Eckly A, Elvers M, Hagedorn I, Eliautou S, Bender M, Wu X, Lanza F, Gachet C, Brakebusch C, Nieswandt B. Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. Blood. 2010 Apr 22; 115(16):3364-73. PMID: 20139097.
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  22. Du D, Xu F, Yu L, Zhang C, Lu X, Yuan H, Huang Q, Zhang F, Bao H, Jia L, Wu X, Zhu X, Zhang X, Zhang Z, Chen Z. The tight junction protein, occludin, regulates the directional migration of epithelial cells. Dev Cell. 2010 Jan 19; 18(1):52-63. PMID: 20152177.
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  23. Lefever T, Pedersen E, Basse A, Paus R, Quondamatteo F, Stanley AC, Langbein L, Wu X, Wehland J, Lommel S, Brakebusch C. N-WASP is a novel regulator of hair-follicle cycling that controls antiproliferative TGF{beta} pathways. J Cell Sci. 2010 Jan 01; 123(Pt 1):128-40. PMID: 20016073.
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  24. Kesavan G, Sand FW, Greiner TU, Johansson JK, Kobberup S, Wu X, Brakebusch C, Semb H. Cdc42-mediated tubulogenesis controls cell specification. Cell. 2009 Nov 13; 139(4):791-801. PMID: 19914171.
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  25. Mandinova A, Kolev V, Neel V, Hu B, Stonely W, Lieb J, Wu X, Colli C, Han R, Pazin MJ, Pazin M, Ostano P, Dummer R, Brissette JL, Dotto GP. A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. J Clin Invest. 2009 Oct; 119(10):3127-37. PMID: 19729838.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  26. Nordberg GF, Jin T, Wu X, Lu J, Chen L, Lei L, Hong F, Nordberg M. Prevalence of kidney dysfunction in humans - relationship to cadmium dose, metallothionein, immunological and metabolic factors. Biochimie. 2009 Oct; 91(10):1282-5. PMID: 19563860.
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  27. Fuchs S, Herzog D, Sumara G, Büchmann-Møller S, Civenni G, Wu X, Chrostek-Grashoff A, Suter U, Ricci R, Relvas JB, Brakebusch C, Sommer L. Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1. Cell Stem Cell. 2009 Mar 06; 4(3):236-47. PMID: 19265663.
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  28. Lämmermann T, Renkawitz J, Wu X, Hirsch K, Brakebusch C, Sixt M. Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration. Blood. 2009 Jun 04; 113(23):5703-10. PMID: 19190242.
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  29. Yuan H, Zhang H, Wu X, Zhang Z, Du D, Zhou W, Zhou S, Brakebusch C, Chen Z. Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice. Hepatology. 2009 Jan; 49(1):240-9. PMID: 19085966.
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  30. Du D, Pedersen E, Wang Z, Karlsson R, Chen Z, Wu X, Brakebusch C. Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1. Exp Cell Res. 2009 May 01; 315(8):1480-9. PMID: 19100259.
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  31. Wu X, Liang Y, Jin T, Ye T, Kong Q, Wang Z, Lei L, Bergdahl IA, Nordberg GF. Renal effects evolution in a Chinese population after reduction of cadmium exposure in rice. Environ Res. 2008 Oct; 108(2):233-8. PMID: 18692183.
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  32. van Hengel J, D'Hooge P, Hooghe B, Wu X, Libbrecht L, De Vos R, Quondamatteo F, Klempt M, Brakebusch C, van Roy F. Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver. Gastroenterology. 2008 Mar; 134(3):781-92. PMID: 18325391.
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  33. Garvalov BK, Flynn KC, Neukirchen D, Meyn L, Teusch N, Wu X, Brakebusch C, Bamburg JR, Bradke F. Cdc42 regulates cofilin during the establishment of neuronal polarity. J Neurosci. 2007 Nov 28; 27(48):13117-29. PMID: 18045906.
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  34. Wu X, Li S, Chrostek-Grashoff A, Czuchra A, Meyer H, Yurchenco PD, Brakebusch C. Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development. Dev Dyn. 2007 Oct; 236(10):2767-78. PMID: 17849438.
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  35. Bosse T, Ehinger J, Czuchra A, Benesch S, Steffen A, Wu X, Schloen K, Niemann HH, Scita G, Stradal TE, Brakebusch C, Rottner K. Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways. Mol Cell Biol. 2007 Oct; 27(19):6615-28. PMID: 17682062.
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  36. Benninger Y, Thurnherr T, Pereira JA, Krause S, Wu X, Chrostek-Grashoff A, Herzog D, Nave KA, Franklin RJ, Meijer D, Brakebusch C, Suter U, Relvas JB. Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development. J Cell Biol. 2007 Jun 18; 177(6):1051-61. PMID: 17576798.
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  37. Thurnherr T, Benninger Y, Wu X, Chrostek A, Krause SM, Nave KA, Franklin RJ, Brakebusch C, Suter U, Relvas JB. Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS. J Neurosci. 2006 Oct 04; 26(40):10110-9. PMID: 17021167.
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  38. Wu X, Quondamatteo F, Brakebusch C. Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin. Matrix Biol. 2006 Oct; 25(8):466-74. PMID: 17049825.
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  39. Chrostek A, Wu X, Quondamatteo F, Hu R, Sanecka A, Niemann C, Langbein L, Haase I, Brakebusch C. Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis. Mol Cell Biol. 2006 Sep; 26(18):6957-70. PMID: 16943436.
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  40. Cappello S, Attardo A, Wu X, Iwasato T, Itohara S, Wilsch-Bräuninger M, Eilken HM, Rieger MA, Schroeder TT, Huttner WB, Brakebusch C, Götz M. The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci. 2006 Sep; 9(9):1099-107. PMID: 16892058.
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  41. Wu X, Quondamatteo F, Lefever T, Czuchra A, Meyer H, Chrostek A, Paus R, Langbein L, Brakebusch C. Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev. 2006 Mar 01; 20(5):571-85. PMID: 16510873.
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  42. Czuchra A, Wu X, Meyer H, van Hengel J, Schroeder T, Geffers R, Rottner K, Brakebusch C. Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells. Mol Biol Cell. 2005 Oct; 16(10):4473-84. PMID: 16014609.
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  43. Jin T, Wu X, Tang Y, Nordberg M, Bernard A, Ye T, Kong Q, Lundström NG, Nordberg GF. Environmental epidemiological study and estimation of benchmark dose for renal dysfunction in a cadmium-polluted area in China. Biometals. 2004 Oct; 17(5):525-30. PMID: 15688857.
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  44. Jin T, Kong Q, Ye T, Wu X, Nordberg GF. Renal dysfunction of cadmium-exposed workers residing in a cadmium-polluted environment. Biometals. 2004 Oct; 17(5):513-8. PMID: 15688855.
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  45. Wu X, Su S, Zhai R, Chen K, Jin T, Huang B, Zhou Y, Ge X, Wei G, Liao R. Lack of reversal effect of EDTA treatment on cadmium induced renal dysfunction: a fourteen-year follow-up. Biometals. 2004 Aug; 17(4):435-41. PMID: 15259364.
    Citations: 3     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
  46. Buchet JP, Heilier JF, Bernard A, Lison D, Jin T, Wu X, Kong Q, Nordberg G. Urinary protein excretion in humans exposed to arsenic and cadmium. Int Arch Occup Environ Health. 2003 Mar; 76(2):111-20. PMID: 12733083.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.