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Last Name

profileThomas Livingston Benjamin, Ph.D.

TitleVirginia and D.K. Ludwig Professor of Microbiology and Immunobiology, Emeritus
InstitutionHarvard Medical School
AddressHarvard Medical School, NRB
Benjamin Lab, Room 939i
77 Avenue Louis Pasteur
Boston MA 02115
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R01CA092520     (BENJAMIN, THOMAS LIVINGSTON)Sep 1, 2001 - Jul 31, 2012
Tumor Host Range Mutants of Polyoma and Their Targets
Role: Principal Investigator

R01CA090992     (BENJAMIN, THOMAS LIVINGSTON)Sep 1, 2001 - Aug 31, 2008
Role: Principal Investigator

R01CA082395     (BENJAMIN, THOMAS LIVINGSTON)Nov 30, 1999 - Jul 31, 2012
Cell Entry and Spread by Polyoma Virus
Role: Principal Investigator

P01CA050661     (LIVINGSTON, DAVID MORSE)Jul 1, 1989 - Mar 31, 2014
Papova Virus Transforming Mechanisms
Role: Co-Principal Investigator

R35CA044343     (BENJAMIN, THOMAS L)Sep 1, 1987 - Aug 31, 2001
Role: Principal Investigator
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. You J, O'Hara SD, Velupillai P, Castle S, Levery S, Garcea RL, Benjamin T. Ganglioside and Non-ganglioside Mediated Host Responses to the Mouse Polyomavirus. PLoS Pathog. 2015 Oct; 11(10):e1005175. PMID: 26474471; PMCID: PMC4608836.
  2. Sung CK, Yim H, Andrews E, Benjamin TL. A mouse polyomavirus-encoded microRNA targets the cellular apoptosis pathway through Smad2 inhibition. Virology. 2014 Nov; 468-470:57-62. PMID: 25146733; PMCID: PMC4253860.
  3. Sung CK, Li D, Andrews E, Drapkin R, Benjamin T. Promoter methylation of the SALL2 tumor suppressor gene in ovarian cancers. Mol Oncol. 2013 Jun; 7(3):419-27. PMID: 23273547.
    View in: PubMed
  4. Sung CK, Yim H, Gu H, Li D, Andrews E, Duraisamy S, Li C, Drapkin R, Benjamin T. The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC. PLoS One. 2012; 7(9):e46486. PMID: 23029531; PMCID: PMC3460914.
  5. Chinnapen DJ, Hsieh WT, te Welscher YM, Saslowsky DE, Kaoutzani L, Brandsma E, D'Auria L, Park H, Wagner JS, Drake KR, Kang M, Benjamin T, Ullman MD, Costello CE, Kenworthy AK, Baumgart T, Massol RH, Lencer WI. Lipid sorting by ceramide structure from plasma membrane to ER for the cholera toxin receptor ganglioside GM1. Dev Cell. 2012 Sep 11; 23(3):573-86. PMID: 22975326; PMCID: PMC3443397.
  6. Velupillai P, Sung CK, Andrews E, Moran J, Beier D, Kagan J, Benjamin T. Polymorphisms in toll-like receptor 4 underlie susceptibility to tumor induction by the mouse polyomavirus. J Virol. 2012 Nov; 86(21):11541-7. PMID: 22896604; PMCID: PMC3486304.
  7. Andrews E, Velupillai P, Sung CK, Beier DR, Benjamin T. Production of a natural antibody to the mouse polyoma virus is a multigenic trait. G3 (Bethesda). 2012 Mar; 2(3):353-5. PMID: 22413089; PMCID: PMC3291505.
  8. Yim H, Sung CK, You J, Tian Y, Benjamin T. Nek1 and TAZ interact to maintain normal levels of polycystin 2. J Am Soc Nephrol. 2011 May; 22(5):832-7. PMID: 21474562; PMCID: PMC3269896.
  9. Gu H, Li D, Sung CK, Yim H, Troke P, Benjamin T. DNA-binding and regulatory properties of the transcription factor and putative tumor suppressor p150(Sal2). Biochim Biophys Acta. 2011 Apr-Jun; 1809(4-6):276-83. PMID: 21362508; PMCID: PMC3281423.
  10. Sung CK, Dahl J, Yim H, Rodig S, Benjamin TL. Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150(Sal2). FASEB J. 2011 Apr; 25(4):1275-83. PMID: 21228219; PMCID: PMC3058699.
  11. Yang Y, Jiang B, Huo Y, Primo L, Dahl JS, Benjamin TL, Luo J. Shp2 suppresses PyMT-induced transformation in mouse fibroblasts by inhibiting Stat3 activity. Virology. 2011 Jan 20; 409(2):204-10. PMID: 21056449; PMCID: PMC3008596.
  12. Velupillai P, Sung CK, Tian Y, Dahl J, Carroll J, Bronson R, Benjamin T. Polyoma virus-induced osteosarcomas in inbred strains of mice: host determinants of metastasis. PLoS Pathog. 2010 Jan 22; 6(1):e1000733. PMID: 20107604; PMCID: PMC2809769.
  13. Sullivan CS, Sung CK, Pack CD, Grundhoff A, Lukacher AE, Benjamin TL, Ganem D. Murine Polyomavirus encodes a microRNA that cleaves early RNA transcripts but is not essential for experimental infection. Virology. 2009 Apr 25; 387(1):157-67. PMID: 19272626; PMCID: PMC2722155.
  14. Whalen KA, Weber GF, Benjamin TL, Schaffhausen BS. Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for the migration of transformed cells. J Virol. 2008 May; 82(10):4946-54. PMID: 18337582; PMCID: PMC2346735.
  15. Carroll J, Dey D, Kreisman L, Velupillai P, Dahl J, Telford S, Bronson R, Benjamin T. Receptor-binding and oncogenic properties of polyoma viruses isolated from feral mice. PLoS Pathog. 2007 Dec; 3(12):e179. PMID: 18085820; PMCID: PMC2134959.
  16. Tian Y, Kolb R, Hong JH, Carroll J, Li D, You J, Bronson R, Yaffe MB, Zhou J, Benjamin T. TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol Cell Biol. 2007 Sep; 27(18):6383-95. PMID: 17636028; PMCID: PMC2099608.
  17. Dahl J, Chen HI, George M, Benjamin TL. Polyomavirus small T antigen controls viral chromatin modifications through effects on kinetics of virus growth and cell cycle progression. J Virol. 2007 Sep; 81(18):10064-71. PMID: 17626093; PMCID: PMC2045420.
  18. Lilley BN, Gilbert JM, Ploegh HL, Benjamin TL. Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection. J Virol. 2006 Sep; 80(17):8739-44. PMID: 16912321; PMCID: PMC1563856.
  19. Gilbert J, Ou W, Silver J, Benjamin T. Downregulation of protein disulfide isomerase inhibits infection by the mouse polyomavirus. J Virol. 2006 Nov; 80(21):10868-70. PMID: 16928750; PMCID: PMC1641741.
  20. Velupillai P, Garcea RL, Benjamin TL. Polyoma virus-like particles elicit polarized cytokine responses in APCs from tumor-susceptible and -resistant mice. J Immunol. 2006 Jan 15; 176(2):1148-53. PMID: 16394003.
    View in: PubMed
  21. Magnuson B, Rainey EK, Benjamin T, Baryshev M, Mkrtchian S, Tsai B. ERp29 triggers a conformational change in polyomavirus to stimulate membrane binding. Mol Cell. 2005 Oct 28; 20(2):289-300. PMID: 16246730.
    View in: PubMed
  22. Dahl J, You J, Benjamin TL. Induction and utilization of an ATM signaling pathway by polyomavirus. J Virol. 2005 Oct; 79(20):13007-17. PMID: 16189003; PMCID: PMC1235815.
  23. Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science. 2005 Aug 12; 309(5737):1074-8. PMID: 16099986.
    View in: PubMed
  24. Benjamin, T.L. . Chapter on Polyoma Virus. The Mouse in Biomedical Research, Diseases. 2005; Vol. 2:In press.
  25. Gilbert J, Dahl J, Riney C, You J, Cui C, Holmes R, Lencer W, Benjamin T. Ganglioside GD1a restores infectibility to mouse cells lacking functional receptors for polyomavirus. J Virol. 2005 Jan; 79(1):615-8. PMID: 15596855; PMCID: PMC538744.
  26. Gilbert J, Benjamin T. Uptake pathway of polyomavirus via ganglioside GD1a. J Virol. 2004 Nov; 78(22):12259-67. PMID: 15507613; PMCID: PMC525080.
  27. Tian Y, Li D, Dahl J, You J, Benjamin T. Identification of TAZ as a binding partner of the polyomavirus T antigens. J Virol. 2004 Nov; 78(22):12657-64. PMID: 15507652; PMCID: PMC525041.
  28. Li D, Tian Y, Ma Y, Benjamin T. p150(Sal2) is a p53-independent regulator of p21(WAF1/CIP). Mol Cell Biol. 2004 May; 24(9):3885-93. PMID: 15082782; PMCID: PMC387742.
  29. Tsai B, Gilbert JM, Stehle T, Lencer W, Benjamin TL, Rapoport TA. Gangliosides are receptors for murine polyoma virus and SV40. EMBO J. 2003 Sep 01; 22(17):4346-55. PMID: 12941687; PMCID: PMC202381.
  30. Gilbert JM, Goldberg IG, Benjamin TL. Cell penetration and trafficking of polyomavirus. J Virol. 2003 Feb; 77(4):2615-22. PMID: 12552000; PMCID: PMC141103.
  31. Velupillai P, Carroll JP, Benjamin TL. Susceptibility to polyomavirus-induced tumors in inbred mice: role of innate immune responses. J Virol. 2002 Oct; 76(19):9657-63. PMID: 12208944; PMCID: PMC136524.
  32. Dey D, Dahl J, Cho S, Benjamin TL. Induction and bypass of p53 during productive infection by polyomavirus. J Virol. 2002 Sep; 76(18):9526-32. PMID: 12186934; PMCID: PMC136430.
  33. Li D, Dower K, Ma Y, Tian Y, Benjamin TL. A tumor host range selection procedure identifies p150(sal2) as a target of polyoma virus large T antigen. Proc Natl Acad Sci U S A. 2001 Dec 04; 98(25):14619-24. PMID: 11734654; PMCID: PMC64731.
  34. Benjamin TL. Polyoma virus: old findings and new challenges. Virology. 2001 Oct 25; 289(2):167-73. PMID: 11689038.
    View in: PubMed
  35. Cho S, Tian Y, Benjamin TL. Binding of p300/CBP co-activators by polyoma large T antigen. J Biol Chem. 2001 Sep 07; 276(36):33533-9. PMID: 11438528.
    View in: PubMed
  36. Gilbert JM, Benjamin TL. Early steps of polyomavirus entry into cells. J Virol. 2000 Sep; 74(18):8582-8. PMID: 10954560; PMCID: PMC116371.
  37. Dey DC, Bronson RP, Dahl J, Carroll JP, Benjamin TL. Accelerated development of polyoma tumors and embryonic lethality: different effects of p53 loss on related mouse backgrounds. Cell Growth Differ. 2000 May; 11(5):231-7. PMID: 10845423.
    View in: PubMed
  38. Velupillai P, Yoshizawa I, Dey DC, Nahill SR, Carroll JP, Bronson RT, Benjamin TL. Wild-derived inbred mice have a novel basis of susceptibility to polyomavirus-induced tumors. J Virol. 1999 Dec; 73(12):10079-85. PMID: 10559322; PMCID: PMC113059.
  39. Bauer PH, Cui C, Liu WR, Stehle T, Harrison SC, DeCaprio JA, Benjamin TL. Discrimination between sialic acid-containing receptors and pseudoreceptors regulates polyomavirus spread in the mouse. J Virol. 1999 Jul; 73(7):5826-32. PMID: 10364334; PMCID: PMC112643.
  40. Carroll JP, Fung JS, Bronson RT, Razvi E, Benjamin TL. Radiation-resistant and radiation-sensitive forms of host resistance to polyomavirus. J Virol. 1999 Feb; 73(2):1213-8. PMID: 9882323; PMCID: PMC103942.
  41. Dahl J, Jurczak A, Cheng LA, Baker DC, Benjamin TL. Evidence of a role for phosphatidylinositol 3-kinase activation in the blocking of apoptosis by polyomavirus middle T antigen. J Virol. 1998 Apr; 72(4):3221-6. PMID: 9525648; PMCID: PMC109788.
  42. Duman JG, Li N, Verleye D, Goetz FW, Wu DW, Andorfer CA, Benjamin T, Parmelee DC. Molecular characterization and sequencing of antifreeze proteins from larvae of the beetle Dendroides canadensis. J Comp Physiol B. 1998 Apr; 168(3):225-32. PMID: 9591363.
    View in: PubMed
  43. Culleré X, Rose P, Thathamangalam U, Chatterjee A, Mullane KP, Pallas DC, Benjamin TL, Roberts TM, Schaffhausen BS. Serine 257 phosphorylation regulates association of polyomavirus middle T antigen with 14-3-3 proteins. J Virol. 1998 Jan; 72(1):558-63. PMID: 9420259; PMCID: PMC109408.
  44. Bronson R, Dawe C, Carroll J, Benjamin T. Tumor induction by a transformation-defective polyoma virus mutant blocked in signaling through Shc. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):7954-8. PMID: 9223294; PMCID: PMC21536.
  45. Chen MH, Benjamin T. Roles of N-glycans with alpha2,6 as well as alpha2,3 linked sialic acid in infection by polyoma virus. Virology. 1997 Jul 07; 233(2):440-2. PMID: 9217067.
    View in: PubMed
  46. Bauer PH, Benjamin TL. A novel 39-kilodalton membrane protein binds GTP in polyomavirus-transformed cells. J Virol. 1997 May; 71(5):4128-32. PMID: 9094695; PMCID: PMC191570.
  47. Wirth PJ, Luo LD, Hoang T, Benjamin T. Two-dimensional polyacrylamide gel electrophoresis of cancer-associated proteins. Recent Results Cancer Res. 1997; 143:145-60. PMID: 8912417.
    View in: PubMed
  48. Dahl J, Freund R, Blenis J, Benjamin TL. Studies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinase. Mol Cell Biol. 1996 Jun; 16(6):2728-35. PMID: 8649380; PMCID: PMC231263.
  49. Young AT, Dahl J, Hausdorff SF, Bauer PH, Birnbaum MJ, Benjamin TL. Phosphatidylinositol 3-kinase binding to polyoma virus middle tumor antigen mediates elevation of glucose transport by increasing translocation of the GLUT1 transporter. Proc Natl Acad Sci U S A. 1995 Dec 05; 92(25):11613-7. PMID: 8524814; PMCID: PMC40452.
  50. Bauer PH, Bronson RT, Fung SC, Freund R, Stehle T, Harrison SC, Benjamin TL. Genetic and structural analysis of a virulence determinant in polyomavirus VP1. J Virol. 1995 Dec; 69(12):7925-31. PMID: 7494305; PMCID: PMC189737.
  51. Lukacher AE, Ma Y, Carroll JP, Abromson-Leeman SR, Laning JC, Dorf ME, Benjamin TL. Susceptibility to tumors induced by polyoma virus is conferred by an endogenous mouse mammary tumor virus superantigen. J Exp Med. 1995 May 01; 181(5):1683-92. PMID: 7722447; PMCID: PMC2191990.
  52. Freund R, Bauer PH, Crissman HA, Bradbury EM, Benjamin TL. Host range and cell cycle activation properties of polyomavirus large T-antigen mutants defective in pRB binding. J Virol. 1994 Nov; 68(11):7227-34. PMID: 7933105; PMCID: PMC237162.
  53. Stehle T, Yan Y, Benjamin TL, Harrison SC. Structure of murine polyomavirus complexed with an oligosaccharide receptor fragment. Nature. 1994 May 12; 369(6476):160-3. PMID: 8177322.
    View in: PubMed
  54. Johnson SC, Dahl J, Shih TL, Schedler DJ, Anderson L, Benjamin TL, Baker DC. Synthesis and evaluation of 3-modified 1D-myo-inositols as inhibitors and substrates of phosphatidylinositol synthase and inhibitors of myo-inositol uptake by cells. J Med Chem. 1993 Nov 12; 36(23):3628-35. PMID: 8246231.
    View in: PubMed
  55. Wirth PJ, Luo LD, Benjamin T, Hoang TN, Olson AD, Parmelee DC. The rat liver epithelial (RLE) cell nuclear protein database. Electrophoresis. 1993 Nov; 14(11):1199-215. PMID: 7508859.
    View in: PubMed
  56. Lukacher AE, Freund R, Carroll JP, Bronson RT, Benjamin TL. Pyvs: a dominantly acting gene in C3H/BiDa mice conferring susceptibility to tumor induction by polyoma virus. Virology. 1993 Sep; 196(1):241-8. PMID: 8395116.
    View in: PubMed
  57. Sahli R, Freund R, Dubensky T, Garcea R, Bronson R, Benjamin T. Defect in entry and altered pathogenicity of a polyoma virus mutant blocked in VP2 myristylation. Virology. 1993 Jan; 192(1):142-53. PMID: 8390748.
    View in: PubMed
  58. Freund R, Dawe CJ, Carroll JP, Benjamin TL. Changes in frequency, morphology, and behavior of tumors induced in mice by a polyoma virus mutant with a specifically altered oncogene. Am J Pathol. 1992 Dec; 141(6):1409-25. PMID: 1334636; PMCID: PMC1886769.
  59. Freund R, Dubensky T, Bronson R, Sotnikov A, Carroll J, Benjamin T. Polyoma tumorigenesis in mice: evidence for dominant resistance and dominant susceptibility genes of the host. Virology. 1992 Dec; 191(2):724-31. PMID: 1333121.
    View in: PubMed
  60. Freund R, Sotnikov A, Bronson RT, Benjamin TL. Polyoma virus middle T is essential for virus replication and persistence as well as for tumor induction in mice. Virology. 1992 Dec; 191(2):716-23. PMID: 1333120.
    View in: PubMed
  61. Dahl J, Thathamangalam U, Freund R, Benjamin TL. Functional asymmetry of the regions juxtaposed to the membrane-binding sequence of polyomavirus middle T antigen. Mol Cell Biol. 1992 Nov; 12(11):5050-8. PMID: 1406680; PMCID: PMC360438.
  62. Freund R, Bronson RT, Benjamin TL. Separation of immortalization from tumor induction with polyoma large T mutants that fail to bind the retinoblastoma gene product. Oncogene. 1992 Oct; 7(10):1979-87. PMID: 1328987.
    View in: PubMed
  63. Sanjuan N, Zijlstra M, Carroll J, Jaenisch R, Benjamin T. Infection by polyomavirus of murine cells deficient in class I major histocompatibility complex expression. J Virol. 1992 Jul; 66(7):4587-90. PMID: 1318421; PMCID: PMC241273.
  64. Talmage DA, Freund R, Dubensky T, Salcedo M, Gariglio P, Rangel LM, Dawe CJ, Benjamin TL. Heterogeneity in state and expression of viral DNA in polyoma virus-induced tumors of the mouse. Virology. 1992 Apr; 187(2):734-47. PMID: 1312275.
    View in: PubMed
  65. Liddington RC, Yan Y, Moulai J, Sahli R, Benjamin TL, Harrison SC. Structure of simian virus 40 at 3.8-A resolution. Nature. 1991 Nov 28; 354(6351):278-84. PMID: 1659663.
    View in: PubMed
  66. Freund R, Garcea RL, Sahli R, Benjamin TL. A single-amino-acid substitution in polyomavirus VP1 correlates with plaque size and hemagglutination behavior. J Virol. 1991 Jan; 65(1):350-5. PMID: 1845896; PMCID: PMC240524.
  67. Talmage DA, Riney C, Benjamin TL. Regulation of pp60c-src expression in rat and mouse fibroblasts by an inducible antisense gene: effects on serum regulation of growth and polyoma virus middle T function. Cell Growth Differ. 1991 Jan; 2(1):51-8. PMID: 1706618.
    View in: PubMed
  68. Dubensky TW, Freund R, Dawe CJ, Benjamin TL. Polyomavirus replication in mice: influences of VP1 type and route of inoculation. J Virol. 1991 Jan; 65(1):342-9. PMID: 1845895; PMCID: PMC240523.
  69. Freund R, Calderone A, Dawe CJ, Benjamin TL. Polyomavirus tumor induction in mice: effects of polymorphisms of VP1 and large T antigen. J Virol. 1991 Jan; 65(1):335-41. PMID: 1845894; PMCID: PMC240522.
  70. Dawe CJ, Freund R, Abromson-Leeman SR, Dubensky TW, Carroll J, Dorf ME, Benjamin TL. T-cell lymphomas emerging as epineoplasms in mice bearing transplanted polyoma virus-induced salivary gland tumors. Cancer Res. 1990 Sep 01; 50(17 Suppl):5643S-5648S. PMID: 2167161.
    View in: PubMed
  71. Gorga FR, Riney CE, Benjamin TL. Inositol trisphosphate levels in cells expressing wild-type and mutant polyomavirus middle T antigens: evidence for activation of phospholipase C via activation of pp60c-src. J Virol. 1990 Jan; 64(1):105-12. PMID: 2152807; PMCID: PMC249057.
  72. Benjamin, T. and P.K. Vogt. Chapter 14 - Cell transformation by viruses. Virology (ed. B.N. Fields, D.M. Knipe et al.). 1990; 317-367.
  73. Talmage DA, Freund R, Young AT, Dahl J, Dawe CJ, Benjamin TL. Phosphorylation of middle T by pp60c-src: a switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis. Cell. 1989 Oct 06; 59(1):55-65. PMID: 2551507.
    View in: PubMed
  74. Lips DL, Majerus PW, Gorga FR, Young AT, Benjamin TL. Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II. J Biol Chem. 1989 May 25; 264(15):8759-63. PMID: 2542286.
    View in: PubMed
  75. Garcea RL, Talmage DA, Harmatz A, Freund R, Benjamin TL. Separation of host range from transformation functions of the hr-t gene of polyomavirus. Virology. 1989 Feb; 168(2):312-9. PMID: 2536985.
    View in: PubMed
  76. Freund, R., T.W. Dubensky, S.A. Talmage, C.J. Dawe and T.L. Benjamin. Molecular aspects of pathogenesis in the polyoma virus-mouse system. Concepts on Viral Pathogenesis III (ed. A.L. Notkins and M.B. A. Oldstone). 1989; 50-57.
  77. Freund R, Dawe CJ, Benjamin TL. The middle T proteins of high and low tumor strains of polyomavirus function equivalently in tumor induction. Virology. 1988 Dec; 167(2):657-9. PMID: 2849243.
    View in: PubMed
  78. Freund R, Dawe CJ, Benjamin TL. Duplication of noncoding sequences in polyomavirus specifically augments the development of thymic tumors in mice. J Virol. 1988 Oct; 62(10):3896-9. PMID: 2843686; PMCID: PMC253541.
  79. Talmage DA, Blenis J, Benjamin TL. Polyomavirus middle T antigen induces ribosomal protein S6 phosphorylation through pp60c-src-dependent and -independent pathways. Mol Cell Biol. 1988 Jun; 8(6):2309-15. PMID: 2457149; PMCID: PMC363428.
  80. Freund R, Mandel G, Carmichael GG, Barncastle JP, Dawe CJ, Benjamin TL. Polyomavirus tumor induction in mice: influences of viral coding and noncoding sequences on tumor profiles. J Virol. 1987 Jul; 61(7):2232-9. PMID: 3035223; PMCID: PMC283687.
  81. Dawe CJ, Freund R, Mandel G, Ballmer-Hofer K, Talmage DA, Benjamin TL. Variations in polyoma virus genotype in relation to tumor induction in mice. Characterization of wild type strains with widely differing tumor profiles. Am J Pathol. 1987 May; 127(2):243-61. PMID: 2437801; PMCID: PMC1899751.
  82. Dawe CJ, Freund R, Barncastle JP, Dubensky TW, Mandel G, Benjamin TL. Necrotizing arterial lesions in mice-bearing tumors induced by polyoma virus. J Exp Pathol. 1987; 3(2):177-201. PMID: 2826731.
    View in: PubMed
  83. Ballmer-Hofer K, Mandel G, Faller DV, Roberts TM, Benjamin TL. Expression of influenza hemagglutinin-polyoma T-antigen fusion proteins in a rat embryo fibroblast cell line. Virus Res. 1987 Jan; 6(4):345-61. PMID: 3031893.
    View in: PubMed
  84. Matthews JT, Benjamin TL. 12-O-tetradecanoylphorbol-13-acetate stimulates phosphorylation of the 58,000-Mr form of polyomavirus middle T antigen in vivo: implications for a possible role of protein kinase C in middle T function. J Virol. 1986 May; 58(2):239-46. PMID: 2422391; PMCID: PMC252906.
  85. Wirth PJ, Benjamin T, Schwartz DM, Thorgeirsson SS. Sequential analysis of chemically induced hepatoma development in rats by two dimensional electrophoresis. Cancer Res. 1986 Jan; 46(1):400-13. PMID: 3940206.
    View in: PubMed
  86. Ballmer-Hofer K, Benjamin TL. Phosphorylation of polyoma middle T antigen and cellular proteins in purified plasma membranes of polyoma virus-infected cells. EMBO J. 1985 Sep; 4(9):2321-7. PMID: 2416563; PMCID: PMC554504.
  87. Raptis L, Lamfrom H, Benjamin TL. Regulation of cellular phenotype and expression of polyomavirus middle T antigen in rat fibroblasts. Mol Cell Biol. 1985 Sep; 5(9):2476-86. PMID: 2426583; PMCID: PMC366975.
  88. Schaffhausen BS, Liang TJ, Carmichael GG, Benjamin TL. Residual transforming activity of PY1178T, a mutant lacking the principal in vitro tyrosine phosphorylation site, is not affected by removal of the secondary tyrosine phosphorylation site at residue 322. Virology. 1985 Jun; 143(2):671-5. PMID: 2998034.
    View in: PubMed
  89. Garcea RL, Ballmer-Hofer K, Benjamin TL. Virion assembly defect of polyomavirus hr-t mutants: underphosphorylation of major capsid protein VP1 before viral DNA encapsidation. J Virol. 1985 May; 54(2):311-6. PMID: 2985800; PMCID: PMC254799.
  90. Schaffhausen B, Benjamin TL, Lodge J, Kaplan D, Roberts TM. Expression of polyoma early gene products in E. coli. Nucleic Acids Res. 1985 Jan 25; 13(2):501-19. PMID: 2987799; PMCID: PMC341011.
  91. Liang TJ, Carmichael GG, Benjamin TL. A polyoma mutant that encodes small T antigen but not middle T antigen demonstrates uncoupling of cell surface and cytoskeletal changes associated with cell transformation. Mol Cell Biol. 1984 Dec; 4(12):2774-83. PMID: 6098822; PMCID: PMC369288.
  92. Carmichael G, Schaffhausen BS, Mandel G, Liang TJ, Benjamin TL. Transformation by polyoma virus is drastically reduced by substitution of phenylalanine for tyrosine at residue 315 of middle-sized tumor antigen. Proc Natl Acad Sci U S A. 1984 Feb; 81(3):679-83. PMID: 6322163; PMCID: PMC344898.
  93. Benjamin, T.L. The polyoma hr-t gene - an "oncogene" with a purpose. Cancer Cells 2/Oncogenes and Viral Genes (ed. G.F.Vande Woude, A.J. Levine, W.C. Topp, J.D. Watson). 1984; 117-122.
  94. Fluck MM, Shaikh R, Benjamin TL. An analysis of transformed clones obtained by coinfections with hr-t and ts-a mutants of polyoma virus. Virology. 1983 Oct 15; 130(1):29-43. PMID: 6314651.
    View in: PubMed
  95. Garcea RL, Benjamin TL. Isolation and characterization of polyoma nucleoprotein complexes. Virology. 1983 Oct 15; 130(1):65-75. PMID: 6314652.
    View in: PubMed
  96. Garcea RL, Benjamin TL. Host range transforming gene of polyoma virus plays a role in virus assembly. Proc Natl Acad Sci U S A. 1983 Jun; 80(12):3613-7. PMID: 6304724; PMCID: PMC394100.
  97. Roberts TM, Schaffhausen B, Benjamin TL, Bikel I, Lodge J, Kaplan D. Expression of SV40 and polyoma T antigens in E. coli. Gene Amplif Anal. 1983; 3:135-46. PMID: 6400699.
    View in: PubMed
  98. Benjamin TL. The hr-t gene of polyoma virus. Biochim Biophys Acta. 1982 Dec 21; 695(2):69-95. PMID: 6305416.
    View in: PubMed
  99. Schaffhausen B, Benjamin TL, Pike L, Casnellie J, Krebs E. Antibody to the nonapeptide Glu-Glu-Glu-Glu-Tyr-Met-Pro-Met-Glu is specific for polyoma middle T antigen and inhibits in vitro kinase activity. J Biol Chem. 1982 Nov 10; 257(21):12467-70. PMID: 6290466.
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  100. Schaffhausen BS, Dorai H, Arakere G, Benjamin TL. Polyoma virus middle T antigen: relationship to cell membranes and apparent lack of ATP-binding activity. Mol Cell Biol. 1982 Oct; 2(10):1187-98. PMID: 6184609; PMCID: PMC369917.
  101. Carmichael GG, Schaffhausen BS, Dorsky DI, Oliver DB, Benjamin TL. Carboxy terminus of polyoma middle-sized tumor antigen is required for attachment to membranes, associated protein kinase activities, and cell transformation. Proc Natl Acad Sci U S A. 1982 Jun; 79(11):3579-83. PMID: 6179082; PMCID: PMC346465.
  102. Feunteun J, Benjamin TL. Isolation of transformation-defective host-range mutants of polyoma virus on normal mouse cells. Virology. 1982 Jun; 119(2):310-6. PMID: 6281975.
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  103. Greene MI, Perry LL, Kinney-Thomas E, Benjamin TL. Specific thymus-derived (T) cell recognition of papova virus-transformed cells. J Immunol. 1982 Feb; 128(2):732-6. PMID: 6172505.
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  104. Benjamin, T.L. Biological and biochemical studies of polyoma virus transformation. Expression of Differentiated Function in Cancer Cells (ed. R. Revoltella). 1982; 353-359.
  105. Schaffhausen B, Benjamin TL. Comparison of phosphorylation of two polyoma virus middle T antigens in vivo and in vitro. J Virol. 1981 Oct; 40(1):184-96. PMID: 6169848; PMCID: PMC256608.
  106. Carmichael GG, Benjamin TL. Identification of DNA sequence changes leading to loss of transforming ability in polyoma virus. J Biol Chem. 1980 Jan 10; 255(1):230-5. PMID: 6243123.
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  107. Benjamin, T.L., Schaffhausen, B.S., and Carmichael, G.G. The polyoma virus hr-t gene products. Animal Virus Genetics (ed. Fields, Jaenish, Fox). 1980; 18:309-316.
  108. Benjamin TL, Carmichael GG, Schaffhausen BS. The hr-t gene of polyoma virus. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 1,:263-70. PMID: 6253140.
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  109. Fluck, M.M. and Benjamin, T.L. Complementation studies with transformation defective mutants of polyoma virus. Animal Virus Genetics (ed. Fields, Jaenish, Fox). 1980.
  110. Schaffhausen BS, Benjamin TL. Phosphorylation of polyoma T antigens. Cell. 1979 Dec; 18(4):935-46. PMID: 229974.
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  111. Fluck MM, Benjamin TL. Comparisons of two early gene functions essential for transformation in polyoma virus and SV-40. Virology. 1979 Jul 15; 96(1):205-28. PMID: 223300.
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  112. Goldman E, Hattori J, Benjamin T. Cellular and C-type viral factors in infections by polyoma virus hr-t mutants. Virology. 1979 Jun; 95(2):373-84. PMID: 223287.
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  113. Hattori J, Carmichael GG, Benjamin TL. DNA sequence alterations in Hr-t deletion mutants of polyoma virus. Cell. 1979 Mar; 16(3):505-13. PMID: 222464.
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  114. Benjamin TL, Schaffhausen BS, Silver JE. Polyoma T (tumor) antigen species in abortively and stably transformed cells. J Supramol Struct. 1979; 12(1):127-37. PMID: 232526.
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  115. Silver J, Schaffhausen B, Benjamin T. Tumor antigens induced by nontransforming mutants of polyoma virus. Cell. 1978 Oct; 15(2):485-96. PMID: 214241.
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  116. Schlegel R, Benjamin TL. Cellular alterations dependent upon the polyoma virus Hr-t function: separation of mitogenic from transforming capacities. Cell. 1978 Jul; 14(3):587-99. PMID: 210955.
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  117. Schaffhausen BS, Silver JE, Benjamin TL. Tumor antigen(s) in cell productively infected by wild-type polyoma virus and mutant NG-18. Proc Natl Acad Sci U S A. 1978 Jan; 75(1):79-83. PMID: 203944; PMCID: PMC411187.
  118. Fluck MM, Staneloni RJ, Benjamin TL. Hr-t and ts-a: two early gene functions of polyoma virus. Virology. 1977 Apr; 77(2):610-24. PMID: 193256.
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  119. Staneloni RJ, Fluck MM, Benjamin TL. Host range selection of transformation-defective hr-t mutants of polyoma virus. Virology. 1977 Apr; 77(2):598-609. PMID: 193255.
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  120. Benjamin, T.L. Hr-t mutants of polyoma virus. Genetic Manipulation as It Affects the Cancer Problem (ed. J. Schultz and Z. Brada). 1977; (14):73-85.
  121. Benjamin TL. Tumor viruses and cellular gene expression. Cancer Res. 1976 Nov; 36(11 Pt. 2):4289-90. PMID: 184933.
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  122. Feunteun J, Sompayrac L, Fluck M, Benjamin T. Localization of gene functions in polyoma virus DNA. Proc Natl Acad Sci U S A. 1976 Nov; 73(11):4169-73. PMID: 186787; PMCID: PMC431371.
  123. Schaffhausen BS, Benjamin TL. Deficiency in histone acetylation in nontransforming host range mutants of polyoma virus. Proc Natl Acad Sci U S A. 1976 Apr; 73(4):1092-6. PMID: 177973; PMCID: PMC430206.
  124. Ukena TE, Goldman E, Benjamin TL, Karnovsky MJ. Lack of correlation between agglutinability, the surface distribution of con A and post-confluence inhibition of cell division in ten cell lines. Cell. 1976 Feb; 7(2):213-22. PMID: 954079.
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  125. Benjamin, T.L. Transformation-defective mutants of polyoma virus. Onco-Developmental Gene Expression (ed. Fishman, W.H. and Stewart, S.). 1976; 85-87.
  126. Goldman E, Benjamin TL. Analysis of host range of nontransforming polyoma virus mutants. Virology. 1975 Aug; 66(2):372-84. PMID: 168683.
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  127. Glinsukon T, Benjamin T, Grantham PH, Weisburger EK, Roller PP. Enzymic N-acetylation of 2,4-toluenediamine by liver cytosols from various species. Xenobiotica. 1975 Aug; 5(8):475-83. PMID: 241157.
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  128. Ward JM, Weisburger JH, Yamamoto RS, Benjamin T, Brown CA, Weisburger EK. Long-term effect of benzene in C57BL/6N mice. Arch Environ Health. 1975 Jan; 30(1):22-5. PMID: 1053658.
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  129. Benjamin TL, Goldman E. Indirect complementation of a nontransforming mutant of polyoma virus. Cold Spring Harb Symp Quant Biol. 1975; 39 Pt 1:41-4. PMID: 169086.
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  130. Ward JM, Weisburger EK, Benjamin T, Moss RA. Shift of organotropy of azoxy compounds--replacement of methyl with an octyl group. J Natl Cancer Inst. 1974 Oct; 53(4):1181-5. PMID: 4473557.
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  131. Benjamin TL. Methods of cell transformation by tumor viruses. Methods Cell Biol. 1974; 8(0):367-437. PMID: 4366071.
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  132. Benjamin, T.L. Methods and techniques of cell transformation. Methods in Cell Biology (ed. D. Prescott). 1973; VIII:367-437.
  133. Benjamin TL. Physiological and genetic studies of polyoma virus. Curr Top Microbiol Immunol. 1972; 59:107-33. PMID: 4347941.
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  134. Benjamin TL, Burger MM. Absence of a cell membrane alteration function in non-transforming mutants of polyoma virus. Proc Natl Acad Sci U S A. 1970 Oct; 67(2):929-34. PMID: 4332911; PMCID: PMC283294.
  135. Benjamin TL. Host range mutants of polyoma virus. Proc Natl Acad Sci U S A. 1970 Sep; 67(1):394-9. PMID: 4318787; PMCID: PMC283217.
  136. Benjamin, T.L. Isolation and characterization of non-transforming mutants of polyoma virus. Biology of Oncogenic Viruses. 1970; 300-305.
  137. Benjamin TL. Absence of homology between polyoma or SV40 viral DNA and mitochondrial DNA from virus-induced tumors. Virology. 1968 Dec; 36(4):685-7. PMID: 4302007.
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  138. Benjamin, T.L. Radiobiological and biochemical investigaions of polyoma virus-cell interactions. Sub viral Carcinogenesis 1st International Symposium on Tumor Viruses, Nagoya, Japan. 1967; 62-81.
  139. Benjamin TL. Virus-specific RNA in cells productively infected or transformed by polyoma virus. J Mol Biol. 1966 Apr; 16(2):359-73. PMID: 4288987.
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  140. Benjamin TL. Relative target sizes for the inactivation of the transforming and reproductive abilities of polyoma virus. Proc Natl Acad Sci U S A. 1965 Jul; 54(1):121-4. PMID: 4285420; PMCID: PMC285807.
  141. BENJAMIN TL, YOST HT. The mechanism of uncoupling of oxidative phosphorylation in rat spleen and liver mitochondria after whole-body irradiation. Radiat Res. 1960 Jun; 12:613-25. PMID: 13798910.
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