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Christian Thomas Farrar, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA203873 (FARRAR, CHRISTIAN T) May 15, 2016 - Apr 30, 2021
    NIH/NCI
    A CEST-MRI Reporter Gene for Image Guided Oncolytic Virotherapy
    Role: Principal Investigator
  2. R21CA155862 (FARRAR, CHRISTIAN T) Mar 1, 2011 - Jun 30, 2013
    NIH/NCI
    Novel MRI Vascular Biomarkers for the Detection of Tumor Invasion
    Role: Principal Investigator
  3. K25AG029415 (FARRAR, CHRISTIAN T) Aug 1, 2007 - Jun 30, 2013
    NIH/NIA
    Magnetic Resonance Molecular Imaging Studies of Alzheimer's Disease
    Role: Principal Investigator
  4. F32GM018790 (FARRAR, CHRISTIAN T) Aug 24, 1997
    NIH/NIGMS
    STRUCTURAL CHARACTERIZATION OF BACTERIORHODOPSIN BY DNP/
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Erstad DJ, Sojoodi M, Taylor MS, Jordan VC, Farrar CT, Axtell AL, Rotile NJ, Jones C, Graham-O'Regan KA, Ferreira DS, Michelakos T, Kontos F, Chawla A, Li S, Ghoshal S, Chen YI, Arora G, Humblet V, Deshpande V, Qadan M, Bardeesy N, Ferrone CR, Lanuti M, Tanabe KK, Caravan P, Fuchs BC. Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI. Clin Cancer Res. 2020 Jul 01. PMID: 32611647.
    Citations:    
  2. Zhou IY, Clavijo Jordan V, Rotile NJ, Akam E, Krishnan S, Arora G, Krishnan H, Slattery H, Warner N, Mercaldo N, Farrar CT, Wellen J, Martinez R, Schlerman F, Tanabe KK, Fuchs BC, Caravan P. Advanced MRI of Liver Fibrosis and Treatment Response in a Rat Model of Nonalcoholic Steatohepatitis. Radiology. 2020 Jul; 296(1):67-75. PMID: 32343209.
    Citations:    
  3. Perlman O, Herz K, Zaiss M, Cohen O, Rosen MS, Farrar CT. CEST MR-Fingerprinting: Practical considerations and insights for acquisition schedule design and improved reconstruction. Magn Reson Med. 2020 02; 83(2):462-478. PMID: 31400034.
    Citations:    
  4. Kuruppu D, Bhere D, Farrar CT, Shah K, Brownell AL, Tanabe KK. A model of breast cancer meningeal metastases: characterization with in vivo molecular imaging. Cancer Gene Ther. 2019 05; 26(5-6):145-156. PMID: 30420717.
    Citations:    Fields:    
  5. Erstad DJ, Farrar CT, Ghoshal S, Masia R, Ferreira DS, Chen YI, Choi JK, Wei L, Waghorn PA, Rotile NJ, Tu C, Graham-O'Regan KA, Sojoodi M, Li S, Li Y, Wang G, Corey KE, Or YS, Jiang L, Tanabe KK, Caravan P, Fuchs BC. Molecular magnetic resonance imaging accurately measures the antifibrotic effect of EDP-305, a novel farnesoid X receptor agonist. Hepatol Commun. 2018 Jul; 2(7):821-835. PMID: 30027140.
    Citations:    
  6. Cohen O, Huang S, McMahon MT, Rosen MS, Farrar CT. Rapid and quantitative chemical exchange saturation transfer (CEST) imaging with magnetic resonance fingerprinting (MRF). Magn Reson Med. 2018 12; 80(6):2449-2463. PMID: 29756286.
    Citations:    Fields:    
  7. Farrar CT, Gale EM, Kennan R, Ramsay I, Masia R, Arora G, Looby K, Wei L, Kalpathy-Cramer J, Bunzel MM, Zhang C, Zhu Y, Akiyama TE, Klimas M, Pinto S, Diyabalanage H, Tanabe KK, Humblet V, Fuchs BC, Caravan P. CM-101: Type I Collagen-targeted MR Imaging Probe for Detection of Liver Fibrosis. Radiology. 2018 05; 287(2):581-589. PMID: 29156148.
    Citations: 2     Fields:    Translation:Animals
  8. Dos Santos Ferreira D, Jesus de Oliveira Pinto BL, Kumar V, Cardoso VN, Fernandes SO, Souza CM, Cassali GD, Moore A, Sosnovik DE, Farrar CT, Leite EA, Alves RJ, de Oliveira MC, Guimarães AR, Caravan P. Evaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sensitive liposomal formulation in a bone metastasis tumor model in mice. Nanomedicine. 2017 07; 13(5):1693-1701. PMID: 28343016.
    Citations:    Fields:    Translation:Animals
  9. Wang P, Ross A, Yoo B, Yang J, Farrar C, Ran C, Pantazopoulos P, Medarova Z, Moore A. Magnetic resonance imaging of intra-pancreatic ductal nanoparticle delivery to islet cells. Diabetes Metab Res Rev. 2017 07; 33(5). PMID: 28032446.
    Citations:    Fields:    Translation:Animals
  10. Wei H, Bruns OT, Kaul MG, Hansen EC, Barch M, Wisniowska A, Chen O, Chen Y, Li N, Okada S, Cordero JM, Heine M, Farrar CT, Montana DM, Adam G, Ittrich H, Jasanoff A, Nielsen P, Bawendi MG. Exceedingly small iron oxide nanoparticles as positive MRI contrast agents. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2325-2330. PMID: 28193901.
    Citations: 11     Fields:    Translation:HumansAnimals
  11. Zhu B, Wei L, Rotile N, Day H, Rietz T, Farrar CT, Lauwers GY, Tanabe KK, Rosen B, Fuchs BC, Caravan P. Combined magnetic resonance elastography and collagen molecular magnetic resonance imaging accurately stage liver fibrosis in a rat model. Hepatology. 2017 03; 65(3):1015-1025. PMID: 28039886.
    Citations: 7     Fields:    Translation:Animals
  12. Gale EM, Jones CM, Ramsay I, Farrar CT, Caravan P. A Janus Chelator Enables Biochemically Responsive MRI Contrast with Exceptional Dynamic Range. J Am Chem Soc. 2016 12 14; 138(49):15861-15864. PMID: 27960350.
    Citations: 1     Fields:    Translation:HumansCells
  13. Wang P, Yoo B, Sherman S, Mukherjee P, Ross A, Pantazopoulos P, Petkova V, Farrar C, Medarova Z, Moore A. Predictive imaging of chemotherapeutic response in a transgenic mouse model of pancreatic cancer. Int J Cancer. 2016 08 01; 139(3):712-8. PMID: 26996122.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  14. Peterson TE, Kirkpatrick ND, Huang Y, Farrar CT, Marijt KA, Kloepper J, Datta M, Amoozgar Z, Seano G, Jung K, Kamoun WS, Vardam T, Snuderl M, Goveia J, Chatterjee S, Batista A, Muzikansky A, Leow CC, Xu L, Batchelor TT, Duda DG, Fukumura D, Jain RK. Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4470-5. PMID: 27044097.
    Citations: 33     Fields:    Translation:AnimalsCells
  15. Farrar CT, DePeralta DK, Day H, Rietz TA, Wei L, Lauwers GY, Keil B, Subramaniam A, Sinskey AJ, Tanabe KK, Fuchs BC, Caravan P. 3D molecular MR imaging of liver fibrosis and response to rapamycin therapy in a bile duct ligation rat model. J Hepatol. 2015 Sep; 63(3):689-96. PMID: 26022693.
    Citations: 10     Fields:    Translation:Animals
  16. Farrar CT, Buhrman JS, Liu G, Kleijn A, Lamfers ML, McMahon MT, Gilad AA, Fulci G. Establishing the Lysine-rich Protein CEST Reporter Gene as a CEST MR Imaging Detector for Oncolytic Virotherapy. Radiology. 2015 Jun; 275(3):746-54. PMID: 25686366.
    Citations: 13     Fields:    Translation:AnimalsCells
  17. Chen O, Riedemann L, Etoc F, Herrmann H, Coppey M, Barch M, Farrar CT, Zhao J, Bruns OT, Wei H, Guo P, Cui J, Jensen R, Chen Y, Harris DK, Cordero JM, Wang Z, Jasanoff A, Fukumura D, Reimer R, Dahan M, Jain RK, Bawendi MG. Magneto-fluorescent core-shell supernanoparticles. Nat Commun. 2014 Oct 09; 5:5093. PMID: 25298155.
    Citations: 9     Fields:    
  18. Emblem KE, Farrar CT, Gerstner ER, Batchelor TT, Borra RJ, Rosen BR, Sorensen AG, Jain RK. Vessel caliber--a potential MRI biomarker of tumour response in clinical trials. Nat Rev Clin Oncol. 2014 Oct; 11(10):566-84. PMID: 25113840.
    Citations: 18     Fields:    Translation:Humans
  19. Farrar CT, William CM, Hudry E, Hashimoto T, Hyman BT. RNA aptamer probes as optical imaging agents for the detection of amyloid plaques. PLoS One. 2014; 9(2):e89901. PMID: 24587111.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  20. Emblem KE, Mouridsen K, Bjornerud A, Farrar CT, Jennings D, Borra RJ, Wen PY, Ivy P, Batchelor TT, Rosen BR, Jain RK, Sorensen AG. Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy. Nat Med. 2013 Sep; 19(9):1178-83. PMID: 23955713.
    Citations: 62     Fields:    Translation:HumansCTClinical Trials
  21. Huang S, Kim JK, Atochin DN, Farrar CT, Huang PL, Suh JY, Kwon SJ, Shim WH, Cho H, Cho G, Kim YR. Cerebral blood volume affects blood-brain barrier integrity in an acute transient stroke model. J Cereb Blood Flow Metab. 2013 Jun; 33(6):898-905. PMID: 23462571.
    Citations: 2     Fields:    Translation:Animals
  22. Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell. 2013 Feb 28; 152(5):1065-76. PMID: 23452854.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  23. Hingtgen S, Figueiredo JL, Farrar C, Duebgen M, Martinez-Quintanilla J, Bhere D, Shah K. Real-time multi-modality imaging of glioblastoma tumor resection and recurrence. J Neurooncol. 2013 Jan; 111(2):153-61. PMID: 23242736.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  24. Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, Tannous BA, Eichler AF, Fukumura D, Engelman JA, Jain RK. Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):E3119-27. PMID: 23071298.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  25. Huang S, Farrar CT, Dai G, Kwon SJ, Bogdanov AA, Rosen BR, Kim YR. Dynamic monitoring of blood-brain barrier integrity using water exchange index (WEI) during mannitol and CO2 challenges in mouse brain. NMR Biomed. 2013 Apr; 26(4):376-85. PMID: 23055278.
    Citations: 2     Fields:    Translation:Animals
  26. Uppal R, Medarova Z, Farrar CT, Dai G, Moore A, Caravan P. Molecular imaging of fibrin in a breast cancer xenograft mouse model. Invest Radiol. 2012 Oct; 47(10):553-8. PMID: 22960948.
    Citations: 8     Fields:    Translation:Animals
  27. Bajaj VS, Farrar CT, Hornstein MK, Mastovsky I, Vieregg J, Bryant J, Eléna B, Kreischer KE, Temkin RJ, Griffin RG. Dynamic nuclear polarization at 9T using a novel 250 GHz gyrotron microwave source. 2003. J Magn Reson. 2011 Dec; 213(2):404-9. PMID: 22152358.
    Citations: 2     Fields:    
  28. Koffie RM, Farrar CT, Saidi LJ, William CM, Hyman BT, Spires-Jones TL. Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18837-42. PMID: 22065785.
    Citations: 41     Fields:    Translation:Animals
  29. Farrar CT, Kamoun WS, Ley CD, Kim YR, Catana C, Kwon SJ, Rosen BR, Jain RK, Sorensen AG. Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model. PLoS One. 2011 Mar 03; 6(3):e17228. PMID: 21390238.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  30. Chae SS, Kamoun WS, Farrar CT, Kirkpatrick ND, Niemeyer E, de Graaf AM, Sorensen AG, Munn LL, Jain RK, Fukumura D. Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas. Clin Cancer Res. 2010 Jul 15; 16(14):3618-27. PMID: 20501615.
    Citations: 37     Fields:    Translation:HumansAnimals
  31. Farrar CT, Kamoun WS, Ley CD, Kim YR, Kwon SJ, Dai G, Rosen BR, di Tomaso E, Jain RK, Sorensen AG. In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model. Neuro Oncol. 2010 Apr; 12(4):341-50. PMID: 20308312.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  32. Blackwell ML, Farrar CT, Fischl B, Rosen BR. Target-specific contrast agents for magnetic resonance microscopy. Neuroimage. 2009 Jun; 46(2):382-93. PMID: 19385012.
    Citations: 6     Fields:    Translation:HumansCells
  33. Kamoun WS, Ley CD, Farrar CT, Duyverman AM, Lahdenranta J, Lacorre DA, Batchelor TT, di Tomaso E, Duda DG, Munn LL, Fukumura D, Sorensen AG, Jain RK. Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice. J Clin Oncol. 2009 May 20; 27(15):2542-52. PMID: 19332720.
    Citations: 115     Fields:    Translation:HumansAnimals
  34. Caravan P, Farrar CT, Frullano L, Uppal R. Influence of molecular parameters and increasing magnetic field strength on relaxivity of gadolinium- and manganese-based T1 contrast agents. Contrast Media Mol Imaging. 2009 Mar-Apr; 4(2):89-100. PMID: 19177472.
    Citations: 88     Fields:    
  35. Farrar CT, Dai G, Novikov M, Rosenzweig A, Weissleder R, Rosen BR, Sosnovik DE. Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging. NMR Biomed. 2008 Jun; 21(5):453-63. PMID: 17918777.
    Citations: 27     Fields:    Translation:AnimalsCells
  36. Sun PZ, Farrar CT, Sorensen AG. Correction for artifacts induced by B(0) and B(1) field inhomogeneities in pH-sensitive chemical exchange saturation transfer (CEST) imaging. Magn Reson Med. 2007 Dec; 58(6):1207-15. PMID: 17969015.
    Citations: 53     Fields:    
  37. Liu CH, Huang S, Cui J, Kim YR, Farrar CT, Moskowitz MA, Rosen BR, Liu PK. MR contrast probes that trace gene transcripts for cerebral ischemia in live animals. FASEB J. 2007 Sep; 21(11):3004-15. PMID: 17478745.
    Citations: 16     Fields:    Translation:AnimalsCells
  38. Medarova Z, Pham W, Farrar C, Petkova V, Moore A. In vivo imaging of siRNA delivery and silencing in tumors. Nat Med. 2007 Mar; 13(3):372-7. PMID: 17322898.
    Citations: 161     Fields:    Translation:HumansAnimalsCells
  39. Fleischman A, Johnsen S, Systrom DM, Hrovat M, Farrar CT, Frontera W, Fitch K, Thomas BJ, Torriani M, Côté HC, Grinspoon SK. Effects of a nucleoside reverse transcriptase inhibitor, stavudine, on glucose disposal and mitochondrial function in muscle of healthy adults. Am J Physiol Endocrinol Metab. 2007 Jun; 292(6):E1666-73. PMID: 17284576.
    Citations: 51     Fields:    Translation:HumansCells
  40. Farrar CT, Wedeen VJ, Ackerman JL. Cylindrical meanderline radiofrequency coil for intravascular magnetic resonance studies of atherosclerotic plaque. Magn Reson Med. 2005 Jan; 53(1):226-30. PMID: 15690524.
    Citations: 4     Fields:    Translation:Humans
  41. Bajaj VS, Farrar CT, Hornstein MK, Mastovsky I, Vieregg J, Bryant J, Eléna B, Kreischer KE, Temkin RJ, Griffin RG. Dynamic nuclear polarization at 9T using a novel 250GHz gyrotron microwave source. J Magn Reson. 2003 Feb; 160(2):85-90. PMID: 12615147.
    Citations: 38     Fields:    Translation:HumansCells
  42. Farrar CT, Ma J, Singel DJ, Halkides CJ. Structural changes induced in p21Ras upon GAP-334 complexation as probed by ESEEM spectroscopy and molecular-dynamics simulation. Structure. 2000 Dec 15; 8(12):1279-87. PMID: 11188692.
    Citations: 3     Fields:    Translation:HumansCells
  43. Farrar CT, Hall DA, Gerfen GJ, Rosay M, Ardenkjaer-Larsen JH, Griffin RG. High-frequency dynamic nuclear polarization in the nuclear rotating frame. J Magn Reson. 2000 May; 144(1):134-41. PMID: 10783283.
    Citations: 12     Fields:    Translation:Cells
  44. Bennati M, Farrar CT, Bryant JA, Inati SJ, Weis V, Gerfen GJ, Riggs-Gelasco P, Stubbe J, Griffin RG. Pulsed electron-nuclear double resonance (ENDOR) at 140 GHz. J Magn Reson. 1999 Jun; 138(2):232-43. PMID: 10341127.
    Citations: 19     Fields:    Translation:Cells
  45. Halkides CJ, Farrar CT, Singel DJ. The effects of cryoprotection on the structure and activity of p21 ras: implications for electron spin-echo envelope modulation spectroscopy. J Magn Reson. 1998 Sep; 134(1):142-53. PMID: 9740740.
    Citations: 3     Fields:    Translation:Cells
  46. Farrar CT, Halkides CJ, Singel DJ. The frozen solution structure of p21 ras determined by ESEEM spectroscopy reveals weak coordination of Thr35 to the active site metal ion. Structure. 1997 Aug 15; 5(8):1055-66. PMID: 9309221.
    Citations: 3     Fields:    Translation:Cells
  47. Halkides CJ, Bellew BF, Gerfen GJ, Farrar CT, Carter PH, Ruo B, Evans DA, Griffin RG, Singel DJ. High frequency (139.5 GHz) electron paramagnetic resonance spectroscopy of the GTP form of p21 ras with selective 17O labeling of threonine. Biochemistry. 1996 Sep 17; 35(37):12194-2200. PMID: 8810927.
    Citations: 3     Fields:    Translation:Cells
  48. Halkides CJ, Farrar CT, Larsen RG, Redfield AG, Singel DJ. Characterization of the active site of p21 ras by electron spin-echo envelope modulation spectroscopy with selective labeling: comparisons between GDP and GTP forms. Biochemistry. 1994 Apr 05; 33(13):4019-35. PMID: 8142406.
    Citations: 4     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.