Harvard Catalyst Profiles

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Barbara Alsen Degar, M.D.

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Research
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  1. K08DK002623 (DEGAR, BARBARA A) Apr 1, 1999 - Dec 31, 2003
    NIH
    HOMEOBOX GENE EXPRESSED IN HEMATOPOIETIC STEM CELLS
    Role: Principal Investigator
  2. F32DK009716 (DEGAR, BARBARA A) Feb 10, 1998
    NIH
    GENE EXPRESSION IN HEMATOPOIETIC STEM CELLS
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Degar BA, Halyabar O, Hazen MM, Henderson LA. Dr. Degar et al reply. J Rheumatol. 2022 Nov 15. PMID: 36379573.
    Citations:    Fields:    
  2. Paolino J, Berliner N, Degar B. Hemophagocytic lymphohistiocytosis as an etiology of bone marrow failure. Front Oncol. 2022; 12:1016318. PMID: 36387094; PMCID: PMC9647152.
    Citations:    
  3. Rameh V, Voss S, Bedoya MA, Beaulieu D, Zhang D, Degar BA, Tsai A. The added value of skeletal surveys in the initial evaluation of children diagnosed with Langerhans cell histiocytosis in the era of staging 18 F-FDG PET/CT: A retrospective study. Pediatr Blood Cancer. 2023 01; 70(1):e30057. PMID: 36266951.
    Citations:    Fields:    Translation:Humans
  4. Taylor ML, Hoyt KJ, Han J, Benson L, Case S, Chandler MT, Chang MH, Platt C, Cohen EM, Day-Lewis M, Dedeoglu F, Gorman M, Hausmann JS, Janssen E, Lee PY, Lo J, Priebe GP, Lo MS, Meidan E, Nigrovic PA, Roberts JE, Son MBF, Sundel RP, Alfieri M, Yeun JC, Shobiye DM, Degar B, Chang JC, Halyabar O, Hazen MM, Henderson LA. An Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. J Rheumatol. 2022 Sep; 49(9):1042-1051. PMID: 35840156; PMCID: PMC9588491.
    Citations:    Fields:    
  5. Henderson LA, Degar BA. HLH treatment: smarter, not harder. Blood. 2022 06 16; 139(24):3453-3455. PMID: 35708727.
    Citations:    Fields:    Translation:Humans
  6. Aziz-Bose R, Wachter F, Chiarle R, Lindeman NI, Kim AS, Degar BA, Davies K, Pikman Y. Rapid next-generation sequencing aids in diagnosis of transient abnormal myelopoiesis in a phenotypically normal newborn. Blood Adv. 2022 05 10; 6(9):2893-2896. PMID: 35090166; PMCID: PMC9092404.
    Citations:    Fields:    Translation:Humans
  7. Locatelli F, Jordan MB, Allen C, Cesaro S, Rizzari C, Rao A, Degar B, Garrington TP, Sevilla J, Putti MC, Fagioli F, Ahlmann M, Dapena Diaz JL, Henry M, De Benedetti F, Grom A, Lapeyre G, Jacqmin P, Ballabio M, de Min C. Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis. N Engl J Med. 2020 05 07; 382(19):1811-1822. PMID: 32374962.
    Citations: 97     Fields:    Translation:HumansCTClinical Trials
  8. Andriescu EC, Coughlin CC, Cheng CE, Prajapati VH, Huang JT, Schmidt BA, Degar BA, Aplenc R, Pillai V, Yan AC, Liang MG. Pediatric leukemia cutis: A case series. Pediatr Dermatol. 2019 Sep; 36(5):658-663. PMID: 31273836.
    Citations: 4     Fields:    Translation:Humans
  9. Rubnitz JE, Lacayo NJ, Inaba H, Heym K, Ribeiro RC, Taub J, McNeer J, Degar B, Schiff D, Yeoh AE, Coustan-Smith E, Wang L, Triplett B, Raimondi SC, Klco J, Choi J, Pounds S, Pui CH. Clofarabine Can Replace Anthracyclines and Etoposide in Remission Induction Therapy for Childhood Acute Myeloid Leukemia: The AML08 Multicenter, Randomized Phase III Trial. J Clin Oncol. 2019 08 10; 37(23):2072-2081. PMID: 31246522; PMCID: PMC7001777.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  10. Benson LA, Li H, Henderson LA, Solomon IH, Soldatos A, Murphy J, Bielekova B, Kennedy AL, Rivkin MJ, Davies KJ, Hsu AP, Holland SM, Gahl WA, Sundel RP, Lehmann LE, Lee MA, Alexandrescu S, Degar BA, Duncan CN, Gorman MP. Pediatric CNS-isolated hemophagocytic lymphohistiocytosis. Neurol Neuroimmunol Neuroinflamm. 2019 05; 6(3):e560. PMID: 31044148.
    Citations: 11     Fields:    Translation:Humans
  11. Nguyen R, Wu H, Pounds S, Inaba H, Ribeiro RC, Cullins D, Rooney B, Bell T, Lacayo NJ, Heym K, Degar B, Schiff D, Janssen WE, Triplett B, Pui CH, Leung W, Rubnitz JE. A phase II clinical trial of adoptive transfer of haploidentical natural killer cells for consolidation therapy of pediatric acute myeloid leukemia. J Immunother Cancer. 2019 03 20; 7(1):81. PMID: 30894213.
    Citations: 34     Fields:    Translation:HumansCellsCTClinical Trials
  12. Li H, Benson LA, Henderson LA, Solomon IH, Kennedy AL, Soldatos A, Bielekova B, Murphy J, Davies KJ, Lehmann LE, Lee MA, Alexandrescu S, Degar BA, Gorman MP, Duncan CN. Central nervous system-restricted familial hemophagocytic lymphohistiocytosis responds to hematopoietic cell transplantation. Blood Adv. 2019 02 26; 3(4):503-507. PMID: 30760465; PMCID: PMC6391665.
    Citations: 2     Fields:    Translation:Humans
  13. Halyabar O, Chang MH, Schoettler ML, Schwartz MA, Baris EH, Benson LA, Biggs CM, Gorman M, Lehmann L, Lo MS, Nigrovic PA, Platt CD, Priebe GP, Rowe J, Sundel RP, Surana NK, Weinacht KG, Mann A, Yuen JC, Meleedy-Rey P, Starmer A, Banerjee T, Dedeoglu F, Degar BA, Hazen MM, Henderson LA. Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Pediatr Rheumatol Online J. 2019 Feb 14; 17(1):7. PMID: 30764840.
    Citations: 25     Fields:    Translation:Humans
  14. Solomon IH, Li H, Benson LA, Henderson LA, Degar BA, Gorman MP, Duncan CN, Lidov HG, Alexandrescu S. Histopathologic Correlates of Familial Hemophagocytic Lymphohistiocytosis Isolated to the Central Nervous System. J Neuropathol Exp Neurol. 2018 12 01; 77(12):1079-1084. PMID: 30295794; PMCID: PMC6658858.
    Citations: 8     Fields:    Translation:Humans
  15. Koegel AK, Hofmann I, Moffitt K, Degar B, Duncan C, Tubman VN. Acute lymphoblastic leukemia in a patient with MonoMAC syndrome/GATA2 haploinsufficiency. Pediatr Blood Cancer. 2016 10; 63(10):1844-7. PMID: 27232273.
    Citations: 9     Fields:    Translation:Humans
  16. Ginat DT, Vargas SO, Silvera VM, Volk MS, Degar BA, Robson CD. Imaging Features of Juvenile Xanthogranuloma of the Pediatric Head and Neck. AJNR Am J Neuroradiol. 2016 May; 37(5):910-6. PMID: 26744443.
    Citations: 3     Fields:    Translation:Humans
  17. Degar B. Familial Hemophagocytic Lymphohistiocytosis. Hematol Oncol Clin North Am. 2015 Oct; 29(5):903-13. PMID: 26461150.
    Citations: 7     Fields:    Translation:HumansAnimals
  18. Chellapandian D, Shaikh F, van den Bos C, Somers GR, Astigarraga I, Jubran R, Degar B, Carret AS, Mandel K, Belletrutti M, Dix D, Visser J, Abuhadra N, Chang T, Rollins B, Whitlock J, Weitzman S, Abla O. Management and Outcome of Patients With Langerhans Cell Histiocytosis and Single-Bone CNS-Risk Lesions: A Multi-Institutional Retrospective Study. Pediatr Blood Cancer. 2015 Dec; 62(12):2162-6. PMID: 26179251.
    Citations: 2     Fields:    Translation:Humans
  19. Ribeiro KB, Degar B, Antoneli CB, Rollins B, Rodriguez-Galindo C. Ethnicity, race, and socioeconomic status influence incidence of Langerhans cell histiocytosis. Pediatr Blood Cancer. 2015 Jun; 62(6):982-7. PMID: 25586293.
    Citations: 16     Fields:    Translation:Humans
  20. Sheu J, Saavedra AP, Degar BA, Duncan CN, Fawaz R, Tan JK, Schmidt BA, Kim HB, Huang JT. Bone marrow engraftment and associated dermatologic sequelae in a three-yr-old after liver transplantation. Pediatr Transplant. 2015 Mar; 19(2):E41-6. PMID: 25516432.
    Citations:    Fields:    Translation:HumansCells
  21. Karol SE, Coustan-Smith E, Cao X, Shurtleff SA, Raimondi SC, Choi JK, Ribeiro RC, Dahl GV, Bowman WP, Taub JW, Degar B, Leung W, Downing JR, Pui CH, Rubnitz JE, Campana D, Inaba H. Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy. Br J Haematol. 2015 Jan; 168(1):94-101. PMID: 25164427.
    Citations: 10     Fields:    Translation:Humans
  22. Walsh KE, Roblin DW, Weingart SN, Houlahan KE, Degar B, Billett A, Keuker C, Biggins C, Li J, Wasilewski K, Mazor KM. Medication errors in the home: a multisite study of children with cancer. Pediatrics. 2013 May; 131(5):e1405-14. PMID: 23629608; PMCID: PMC4074655.
    Citations: 23     Fields:    Translation:Humans
  23. Bates SV, Lakshmanan A, Green AL, Terry J, Badalian-Very G, Rollins BJ, Fleck P, Aslam M, Degar BA. BRAF V600E-Positive Multisite Langerhans Cell Histiocytosis in a Preterm Neonate. AJP Rep. 2013 Oct; 3(2):63-6. PMID: 24147236.
    Citations: 4     
  24. Inaba H, Coustan-Smith E, Cao X, Pounds SB, Shurtleff SA, Wang KY, Raimondi SC, Onciu M, Jacobsen J, Ribeiro RC, Dahl GV, Bowman WP, Taub JW, Degar B, Leung W, Downing JR, Pui CH, Rubnitz JE, Campana D. Comparative analysis of different approaches to measure treatment response in acute myeloid leukemia. J Clin Oncol. 2012 Oct 10; 30(29):3625-32. PMID: 22965955.
    Citations: 70     Fields:    Translation:Humans
  25. Badalian-Very G, Vergilio JA, Degar BA, Rodriguez-Galindo C, Rollins BJ. Recent advances in the understanding of Langerhans cell histiocytosis. Br J Haematol. 2012 Jan; 156(2):163-72. PMID: 22017623.
    Citations: 26     Fields:    Translation:HumansAnimals
  26. Lindamood KE, Fleck P, Narla A, Vergilio JA, Degar BA, Baldwin M, Wintermark P. Neonatal enteroviral sepsis/meningoencephalitis and hemophagocytic lymphohistiocytosis: diagnostic challenges. Am J Perinatol. 2011 May; 28(5):337-46. PMID: 21089006.
    Citations: 5     Fields:    Translation:Humans
  27. Badalian-Very G, Vergilio JA, Degar BA, MacConaill LE, Brandner B, Calicchio ML, Kuo FC, Ligon AH, Stevenson KE, Kehoe SM, Garraway LA, Hahn WC, Meyerson M, Fleming MD, Rollins BJ. Recurrent BRAF mutations in Langerhans cell histiocytosis. Blood. 2010 Sep 16; 116(11):1919-23. PMID: 20519626; PMCID: PMC3173987.
    Citations: 307     Fields:    Translation:Humans
  28. Rubnitz JE, Inaba H, Dahl G, Ribeiro RC, Bowman WP, Taub J, Pounds S, Razzouk BI, Lacayo NJ, Cao X, Meshinchi S, Degar B, Airewele G, Raimondi SC, Onciu M, Coustan-Smith E, Downing JR, Leung W, Pui CH, Campana D. Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial. Lancet Oncol. 2010 Jun; 11(6):543-52. PMID: 20451454.
    Citations: 192     Fields:    Translation:Humans
  29. Degar BA, Rollins BJ. Langerhans cell histiocytosis: malignancy or inflammatory disorder doing a great job of imitating one? Dis Model Mech. 2009 Sep-Oct; 2(9-10):436-9. PMID: 19726802.
    Citations: 11     Fields:    Translation:HumansAnimals
  30. Rodig SJ, Payne EG, Degar BA, Rollins B, Feldman AL, Jaffe ES, Androkites A, Silverman LB, Longtine JA, Kutok JL, Fleming MD, Aster JC. Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1. Am J Hematol. 2008 Feb; 83(2):116-21. PMID: 17874453.
    Citations: 4     Fields:    Translation:HumansCells
  31. Hazen MM, Woodward AL, Hofmann I, Degar BA, Grom A, Filipovich AH, Binstadt BA. Mutations of the hemophagocytic lymphohistiocytosis-associated gene UNC13D in a patient with systemic juvenile idiopathic arthritis. Arthritis Rheum. 2008 Feb; 58(2):567-70. PMID: 18240215.
    Citations: 31     Fields:    Translation:HumansCells
  32. Degar, BA; Fleming, MD; Rollins, BJ. The Histiocytoses. Hematology of Infancy and Childhood (Orkin SH et al., eds.). 2008.
  33. Mullen, EA; Degar, BA. Oncology (Section Editor). Comprehensive Pediatric Hospital Medicine (Zaoutis and Chiang, eds.). 2007.
  34. Degar, BA; Isakoff, M . Childhood Cancer. Comprehensive Pediatric Hospital Medicine (Zaoutis and Chiang, eds.). 2007.
  35. Hait E, Liang M, Degar B, Glickman J, Fox VL. Gastrointestinal tract involvement in Langerhans cell histiocytosis: case report and literature review. Pediatrics. 2006 Nov; 118(5):e1593-9. PMID: 17030599.
    Citations: 9     Fields:    Translation:Humans
  36. Zhang HZ, Degar BA, Rogoulina S, Resor C, Booth CJ, Sinning J, Gage PJ, Forget BG. Hematopoiesis following disruption of the Pitx2 homeodomain gene. Exp Hematol. 2006 Feb; 34(2):167-78. PMID: 16459185.
    Citations: 5     Fields:    Translation:AnimalsCells
  37. Wang S, Degar BA, Zieske A, Shafi NQ, Rose MG. Hemophagocytosis exacerbated by G-CSF/GM-CSF treatment in a patient with myelodysplasia. Am J Hematol. 2004 Dec; 77(4):391-6. PMID: 15551287.
    Citations: 14     Fields:    Translation:Humans
  38. Rose MG, Degar BA, Berliner N. Molecular diagnostics of malignant disorders. Clin Adv Hematol Oncol. 2004 Oct; 2(10):650-60. PMID: 16163252.
    Citations:    Fields:    Translation:Humans
  39. Rose, MG; Degar, BA; Berliner, N. Molecular Diagnostics of Malignant Disorders. Clin Advances in Hematology/Oncology. 2004; 2(10):650-660.
  40. K Stegmaier, B Degar. Molecular Basis of Hematology. 2004.
  41. Degar, BA; Berliner, N . Introduction to the Lymphoproliferative Disorders. Oxford Textbook of Medicine, E.J. Benz (ed). 2003.
  42. N Berliner, B Degar. Molecular Basis of Hematology. 2003.
  43. Degar BA, Baskaran N, Hulspas R, Quesenberry PJ, Weissman SM, Forget BG. The homeodomain gene Pitx2 is expressed in primitive hematopoietic stem/progenitor cells but not in their differentiated progeny. Exp Hematol. 2001 Jul; 29(7):894-902. PMID: 11438212.
    Citations: 7     Fields:    Translation:AnimalsCells
  44. Forget, BG ; Degar, BA; Arcasoy, MO. Familial Polycythemia Due to Truncations of the Erythropoietin Receptor. Transactions of the American Clinical and Climatological Association. 2000; 11:38-45.
  45. Degar BA, Harrington RD, Rappeport JM, Woolfrey AE. 13-cis-retinoic acid-induced eosinophilia following autologous bone marrow transplantation for neuroblastoma. Med Pediatr Oncol. 1999 Apr; 32(4):308-10. PMID: 10102029.
    Citations: 1     Fields:    Translation:Humans
  46. Arcasoy MO, Degar BA, Harris KW, Forget BG. Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene. Blood. 1997 Jun 15; 89(12):4628-35. PMID: 9192789.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  47. Silber R, Degar B, Costin D, Newcomb EW, Mani M, Rosenberg CR, Morse L, Drygas JC, Canellakis ZN, Potmesil M. Chemosensitivity of lymphocytes from patients with B-cell chronic lymphocytic leukemia to chlorambucil, fludarabine, and camptothecin analogs. Blood. 1994 Nov 15; 84(10):3440-6. PMID: 7949099.
    Citations: 11     Fields:    Translation:HumansCellsCTClinical Trials
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.