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profileCaterina Mainero, M.D.

TitleAssistant Professor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMassachusetts General Hospital
A. A. Martinos Center for Biomedical Imag, Rm 2301
149 13th Street
Charlestown MA 02129
Phone617/724-7746
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01NS078322     (MAINERO, CATERINA)Sep 15, 2013 - Aug 31, 2018
NIH/NINDS
Cortical mechanisms of disease progression in early multiple sclerosis
Role: Principal Investigator

R21NS058293     (MAINERO, CATERINA)Jul 1, 2008 - Jun 30, 2011
NIH/NINDS
In vivo Imaging of Brain Damage in HTLV-I Associated Tropical Spastic Paraparesis
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Granberg T, Fan Q, Treaba CA, Ouellette R, Herranz E, Mangeat G, Louapre C, Cohen-Adad J, Klawiter EC, Sloane JA, Mainero C. In vivo characterization of cortical and white matter neuroaxonal pathology in early multiple sclerosis. Brain. 2017 Nov 01; 140(11):2912-2926. PMID: 29053798.
    View in: PubMed
  2. Paganoni S, Alshikho MJ, Zürcher NR, Cernasov P, Babu S, Loggia ML, Chan J, Chonde DB, Garcia DI, Catana C, Mainero C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Imaging of glia activation in people with primary lateral sclerosis. Neuroimage Clin. 2018; 17:347-353. PMID: 29159046.
    View in: PubMed
  3. Mainero C, Louapre C. Unraveling cortical pathology in multiple sclerosis using the T1-/T2-weighted ratio? Ann Neurol. 2017 Oct; 82(4):516-518. PMID: 28976603.
    View in: PubMed
  4. Louapre C, Govindarajan ST, Giannì C, Madigan N, Sloane JA, Treaba CA, Herranz E, Kinkel RP, Mainero C. Heterogeneous pathological processes account for thalamic degeneration in multiple sclerosis: Insights from 7?T imaging. Mult Scler. 2017 Aug 01; 1352458517726382. PMID: 28803512.
    View in: PubMed
  5. De Santis S, Granberg T, Ouellette R, Treaba CA, Herranz E, Mainero C, Toschi N. Early axonal damage in normal appearing white matter in multiple sclerosis: Novel insights from multi-shell diffusion MRI. Conf Proc IEEE Eng Med Biol Soc. 2017 Jul; 2017:3024-3027. PMID: 29060535.
    View in: PubMed
  6. Koley S, Chakraborty C, Mainero C, Fischl B, Aganj I. A Fast Approach to Automatic Detection of Brain Lesions. Brainlesion (2016). 2016; 10154:52-61. PMID: 29082383.
    View in: PubMed
  7. Herranz E, Hooker JM, Izquierdo-Garcia D, Loggia ML, Mainero C. Reply. Ann Neurol. 2017 Feb; 81(2):324-325. PMID: 28032651.
    View in: PubMed
  8. Sati P, Oh J, Constable RT, Evangelou N, Guttmann CR, Henry RG, Klawiter EC, Mainero C, Massacesi L, McFarland H, Nelson F, Ontaneda D, Rauscher A, Rooney WD, Samaraweera AP, Shinohara RT, Sobel RA, Solomon AJ, Treaba CA, Wuerfel J, Zivadinov R, Sicotte NL, Pelletier D, Reich DS. The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative. Nat Rev Neurol. 2016 12; 12(12):714-722. PMID: 27834394.
    View in: PubMed
  9. Louapre C, Govindarajan ST, Giannì C, Madigan N, Nielsen AS, Sloane JA, Kinkel RP, Mainero C. The association between intra- and juxta-cortical pathology and cognitive impairment in multiple sclerosis by quantitative T2* mapping at 7 T MRI. Neuroimage Clin. 2016; 12:879-886. PMID: 27872810.
    View in: PubMed
  10. Koudriavtseva T, Mainero C. Neuroinflammation, neurodegeneration and regeneration in multiple sclerosis: intercorrelated manifestations of the immune response. Neural Regen Res. 2016 Nov; 11(11):1727-1730. PMID: 28123401.
    View in: PubMed
  11. Herranz E, Giannì C, Louapre C, Treaba CA, Govindarajan ST, Ouellette R, Loggia ML, Sloane JA, Madigan N, Izquierdo-Garcia D, Ward N, Mangeat G, Granberg T, Klawiter EC, Catana C, Hooker JM, Taylor N, Ionete C, Kinkel RP, Mainero C. Neuroinflammatory component of gray matter pathology in multiple sclerosis. Ann Neurol. 2016 Nov; 80(5):776-790. PMID: 27686563.
    View in: PubMed
  12. Mainero C, Granberg T. Visualization of cortical MS lesions with MRI need not be further improved - NO. Mult Scler. 2017 01; 23(1):17-19. PMID: 27566449.
    View in: PubMed
  13. Tobyne SM, Boratyn D, Johnson JA, Greve DN, Mainero C, Klawiter EC. A surface-based technique for mapping homotopic interhemispheric connectivity: Development, characterization, and clinical application. Hum Brain Mapp. 2016 Aug; 37(8):2849-68. PMID: 27219660; PMCID: PMC4945467 [Available on 08/01/17].
  14. Koudriavtseva T, Mainero C. Brain Atrophy as a Measure of Neuroprotective Drug Effects in Multiple Sclerosis: Influence of Inflammation. Front Hum Neurosci. 2016; 10:226. PMID: 27242489; PMCID: PMC4865512.
  15. Truini A, Tinelli E, Gerardi MC, Calistri V, Iannuccelli C, La Cesa S, Tarsitani L, Mainero C, Sarzi-Puttini P, Cruccu G, Caramia F, Di Franco M. Abnormal resting state functional connectivity of the periaqueductal grey in patients with fibromyalgia. Clin Exp Rheumatol. 2016 Mar-Apr; 34(2 Suppl 96):S129-33. PMID: 27157397.
    View in: PubMed
  16. Louapre C, Govindarajan ST, Giannì C, Langkammer C, Sloane JA, Kinkel RP, Mainero C. Beyond focal cortical lesions in MS: An in vivo quantitative and spatial imaging study at 7T. Neurology. 2015 Nov 10; 85(19):1702-9. PMID: 26468411; PMCID: PMC4653110 [Available on 11/10/16].
  17. Louapre C, Govindarajan ST, Giannì C, Cohen-Adad J, Gregory MD, Nielsen AS, Madigan N, Sloane JA, Kinkel RP, Mainero C. Is the Relationship between Cortical and White Matter Pathologic Changes in Multiple Sclerosis Spatially Specific? A Multimodal 7-T and 3-T MR Imaging Study with Surface and Tract-based Analysis. Radiology. 2016 Feb; 278(2):524-35. PMID: 26334679; PMCID: PMC4734161 [Available on 02/01/17].
  18. Koudriavtseva T, Plantone D, Renna R, Mandoj C, Giannarelli D, Mainero C. Interferon-ß therapy and risk of thrombocytopenia in multiple sclerosis patients. Neurol Sci. 2015 Dec; 36(12):2263-8. PMID: 26209931.
    View in: PubMed
  19. Sloane JA, Mainero C, Kinkel RP. No Evidence of Disease Activity in Multiple Sclerosis. JAMA Neurol. 2015 Jul; 72(7):835-6. PMID: 26167901.
    View in: PubMed
  20. Mangeat G, Govindarajan ST, Mainero C, Cohen-Adad J. Multivariate combination of magnetization transfer, T2* and B0 orientation to study the myelo-architecture of the in vivo human cortex. Neuroimage. 2015 Oct 01; 119:89-102. PMID: 26095090; PMCID: PMC4564318 [Available on 10/01/16].
  21. Mainero C, Louapre C. Meningeal inflammation in multiple sclerosis: The key to the origin of cortical lesions? Neurology. 2015 Jul 07; 85(1):12-3. PMID: 25888561.
    View in: PubMed
  22. Koudriavtseva T, Renna R, Plantone D, Mainero C. Demyelinating and thrombotic diseases of the central nervous system: common pathogenic and triggering factors. Front Neurol. 2015; 6:63. PMID: 25852641; PMCID: PMC4371702.
  23. Langkammer C, Bredies K, Poser BA, Barth M, Reishofer G, Fan AP, Bilgic B, Fazekas F, Mainero C, Ropele S. Fast quantitative susceptibility mapping using 3D EPI and total generalized variation. Neuroimage. 2015 May 01; 111:622-30. PMID: 25731991.
    View in: PubMed
  24. Mainero C, Louapre C, Govindarajan ST, Giannì C, Nielsen AS, Cohen-Adad J, Sloane J, Kinkel RP. A gradient in cortical pathology in multiple sclerosis by in vivo quantitative 7 T imaging. Brain. 2015 Apr; 138(Pt 4):932-45. PMID: 25681411; PMCID: PMC4677339.
  25. Koudriavtseva T, Sbardella E, Mainero C. Brain perfusion and vasoreactivity in multiple sclerosis. AJNR Am J Neuroradiol. 2015 Apr; 36(4):E27-8. PMID: 25593205.
    View in: PubMed
  26. Polidori MC, Calistri V, Mainero C, Tinelli E, Aceti A, Pontico M, Tardioli S, Santini M, Fiorelli M, Panico MA, Speziale F, Caramia MD, Schulz RJ, Caramia F. Differential Influence of Carotid Stenosis and White Matter Disease on Motor and Cognitive Activation. Curr Alzheimer Res. 2015; 12(6):585-91. PMID: 26238813.
    View in: PubMed
  27. Govindarajan ST, Cohen-Adad J, Sormani MP, Fan AP, Louapre C, Mainero C. Reproducibility of T2 * mapping in the human cerebral cortex in vivo at 7 tesla MRI. J Magn Reson Imaging. 2015 Aug; 42(2):290-6. PMID: 25407671; PMCID: PMC4437971.
  28. Fan AP, Govindarajan ST, Kinkel RP, Madigan NK, Nielsen AS, Benner T, Tinelli E, Rosen BR, Adalsteinsson E, Mainero C. Quantitative oxygen extraction fraction from 7-Tesla MRI phase: reproducibility and application in multiple sclerosis. J Cereb Blood Flow Metab. 2015 Jan; 35(1):131-9. PMID: 25352043; PMCID: PMC4294406.
  29. Mainero C, Louapre C. Migraine and inhibitory system - I can't hold it! Curr Pain Headache Rep. 2014 Jul; 18(7):426. PMID: 24824993.
    View in: PubMed
  30. Nielsen AS, Kinkel RP, Madigan N, Tinelli E, Benner T, Mainero C. Contribution of cortical lesion subtypes at 7T MRI to physical and cognitive performance in MS. Neurology. 2013 Aug 13; 81(7):641-9. PMID: 23864311; PMCID: PMC3775688.
  31. Filippi M, Evangelou N, Kangarlu A, Inglese M, Mainero C, Horsfield MA, Rocca MA. Ultra-high-field MR imaging in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2014 Jan; 85(1):60-6. PMID: 23813636.
    View in: PubMed
  32. Hadjikhani N, Ward N, Boshyan J, Napadow V, Maeda Y, Truini A, Caramia F, Tinelli E, Mainero C. The missing link: enhanced functional connectivity between amygdala and visceroceptive cortex in migraine. Cephalalgia. 2013 Nov; 33(15):1264-8. PMID: 23720503; PMCID: PMC3797870.
  33. Puccioni-Sohler M, Gasparetto E, Cabral-Castro MJ, Slatter C, Vidal CM, Cortes RD, Rosen BR, Mainero C. HAM/TSP: association between white matter lesions on magnetic resonance imaging, clinical and cerebrospinal fluid findings. Arq Neuropsiquiatr. 2012 Apr; 70(4):246-51. PMID: 22510735.
    View in: PubMed
  34. Cohen-Adad J, Polimeni JR, Helmer KG, Benner T, McNab JA, Wald LL, Rosen BR, Mainero C. T2* mapping and B0 orientation-dependence at 7 T reveal cyto- and myeloarchitecture organization of the human cortex. Neuroimage. 2012 Apr 02; 60(2):1006-14. PMID: 22270354; PMCID: PMC3442114.
  35. Mainero C, Boshyan J, Hadjikhani N. Altered functional magnetic resonance imaging resting-state connectivity in periaqueductal gray networks in migraine. Ann Neurol. 2011 Nov; 70(5):838-45. PMID: 22162064; PMCID: PMC3243965.
  36. Nielsen AS, Kinkel RP, Tinelli E, Benner T, Cohen-Adad J, Mainero C. Focal cortical lesion detection in multiple sclerosis: 3 Tesla DIR versus 7 Tesla FLASH-T2. J Magn Reson Imaging. 2012 Mar; 35(3):537-42. PMID: 22045554; PMCID: PMC4198329.
  37. Cohen-Adad J, Benner T, Greve D, Kinkel RP, Radding A, Fischl B, Rosen BR, Mainero C. In vivo evidence of disseminated subpial T2* signal changes in multiple sclerosis at 7 T: a surface-based analysis. Neuroimage. 2011 Jul 01; 57(1):55-62. PMID: 21511042; PMCID: PMC3823384.
  38. Caramia F, Mainero C, Gragnani F, Tinelli E, Fiorelli M, Ceschin V, Pantano P, Bucci E, Barra V, Bozzao L, Antonini G. Functional MRI changes in the central motor system in myotonic dystrophy type 1. Magn Reson Imaging. 2010 Feb; 28(2):226-34. PMID: 19695817.
    View in: PubMed
  39. Mainero C, Benner T, Radding A, van der Kouwe A, Jensen R, Rosen BR, Kinkel RP. In vivo imaging of cortical pathology in multiple sclerosis using ultra-high field MRI. Neurology. 2009 Sep 22; 73(12):941-8. PMID: 19641168; PMCID: PMC2754332.
  40. Caramia F, Francia A, Mainero C, Tinelli E, Palmieri MG, Colonnese C, Bozzao L, Caramia MD. Neurophysiological and functional MRI evidence of reorganization of cortical motor areas in cerebral arteriovenous malformation. Magn Reson Imaging. 2009 Dec; 27(10):1360-9. PMID: 19608370.
    View in: PubMed
  41. Lenzi D, Conte A, Mainero C, Frasca V, Fubelli F, Totaro P, Caramia F, Inghilleri M, Pozzilli C, Pantano P. Effect of corpus callosum damage on ipsilateral motor activation in patients with multiple sclerosis: a functional and anatomical study. Hum Brain Mapp. 2007 Jul; 28(7):636-44. PMID: 17080438.
    View in: PubMed
  42. Mainero C, Zhang WT, Kumar A, Rosen BR, Sorensen AG. Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI. Neuroimage. 2007 Apr 15; 35(3):1201-10. PMID: 17336547; PMCID: PMC2921774.
  43. Mainero C, Pantano P, Caramia F, Pozzilli C. Brain reorganization during attention and memory tasks in multiple sclerosis: insights from functional MRI studies. J Neurol Sci. 2006 Jun 15; 245(1-2):93-8. PMID: 16626753.
    View in: PubMed
  44. Zhang WT, Mainero C, Kumar A, Wiggins CJ, Benner T, Purdon PL, Bolar DS, Kwong KK, Sorensen AG. Strategies for improving the detection of fMRI activation in trigeminal pathways with cardiac gating. Neuroimage. 2006 Jul 15; 31(4):1506-12. PMID: 16624588.
    View in: PubMed
  45. Pantano P, Mainero C, Caramia F. Functional brain reorganization in multiple sclerosis: evidence from fMRI studies. J Neuroimaging. 2006 Apr; 16(2):104-14. PMID: 16629730.
    View in: PubMed
  46. Ristori G, Cannoni S, Stazi MA, Vanacore N, Cotichini R, Alfò M, Pugliatti M, Sotgiu S, Solaro C, Bomprezzi R, Di Giovanni S, Figà Talamanca L, Nisticò L, Fagnani C, Neale MC, Cascino I, Giorgi G, Battaglia MA, Buttinelli C, Tosi R, Salvetti M for the Italian Study Group on Multiple Sclerosis in Twins* (*member of the investigative team cited in the appendix of the manuscript). . Multiple sclerosis in twins from continental Italy and Sardinia: a nationwide study. Ann Neurology. 2006; 1(59):27-34.
  47. Pantano P, Mainero C, Lenzi D, Caramia F, Iannetti GD, Piattella MC, Pestalozza I, Di Legge S, Bozzao L, Pozzilli C. A longitudinal fMRI study on motor activity in patients with multiple sclerosis. Brain. 2005 Sep; 128(Pt 9):2146-53. PMID: 15901646.
    View in: PubMed
  48. Tomassini V, Onesti E, Mainero C, Giugni E, Paolillo A, Salvetti M, Nicoletti F, Pozzilli C. Sex hormones modulate brain damage in multiple sclerosis: MRI evidence. J Neurol Neurosurg Psychiatry. 2005 Feb; 76(2):272-5. PMID: 15654051; PMCID: PMC1739476.
  49. Antonini G, Mainero C, Romano A, Giubilei F, Ceschin V, Gragnani F, Morino S, Fiorelli M, Soscia F, Di Pasquale A, Caramia F. Cerebral atrophy in myotonic dystrophy: a voxel based morphometric study. J Neurol Neurosurg Psychiatry. 2004 Nov; 75(11):1611-3. PMID: 15489397; PMCID: PMC1738796.
  50. Calistri V, Lenzi D, Gilio F, Di Bonaventura C, Inghilleri M, Mainero C, Pantano P. Anatomical functional changes in a patient presenting a complex malformation of cortical development. J Neuroimaging. 2004 Oct; 14(4):380-4. PMID: 15358963.
    View in: PubMed
  51. Pozzilli C, Palmisano L, Mainero C, Tomassini V, Marinelli F, Ristori G, Gasperini C, Fabiani M, Battaglia MA. Relationship between emotional distress in caregivers and health status in persons with multiple sclerosis. Mult Scler. 2004 Aug; 10(4):442-6. PMID: 15327043.
    View in: PubMed
  52. Mainero C, Inghilleri M, Pantano P, Conte A, Lenzi D, Frasca V, Bozzao L, Pozzilli C. Enhanced brain motor activity in patients with MS after a single dose of 3,4-diaminopyridine. Neurology. 2004 Jun 08; 62(11):2044-50. PMID: 15184612.
    View in: PubMed
  53. Mainero C, Caramia F, Pozzilli C, Pisani A, Pestalozza I, Borriello G, Bozzao L, Pantano P. fMRI evidence of brain reorganization during attention and memory tasks in multiple sclerosis. Neuroimage. 2004 Mar; 21(3):858-67. PMID: 15006652.
    View in: PubMed
  54. Pantano P, Mainero C, Iannetti GD, Caramia F, Di Legge S, Piattella MC, Pozzilli C, Bozzao L, Lenzi GL. Contribution of corticospinal tract damage to cortical motor reorganization after a single clinical attack of multiple sclerosis. Neuroimage. 2002 Dec; 17(4):1837-43. PMID: 12498757.
    View in: PubMed
  55. Paolillo A, Pozzilli C, Giugni E, Tomassini V, Gasperini C, Fiorelli M, Mainero C, Horsfield M, Galgani S, Bastianello S, Buttinelli C. A 6-year clinical and MRI follow-up study of patients with relapsing-remitting multiple sclerosis treated with Interferon-beta. Eur J Neurol. 2002 Nov; 9(6):645-55. PMID: 12453081.
    View in: PubMed
  56. Pantano P, Iannetti GD, Caramia F, Mainero C, Di Legge S, Bozzao L, Pozzilli C, Lenzi GL. Cortical motor reorganization after a single clinical attack of multiple sclerosis. Brain. 2002 Jul; 125(Pt 7):1607-15. PMID: 12077009.
    View in: PubMed
  57. Gasperini C, Paolillo A, Giugni E, Galgani S, Bagnato F, Mainero C, Onesti E, Bastianello S, Pozzilli C. MRI brain volume changes in relapsing-remitting multiple sclerosis patients treated with interferon beta-1a. Mult Scler. 2002 Apr; 8(2):119-23. PMID: 11990868.
    View in: PubMed
  58. Pozzilli C, Antonini G, Bagnato F, Mainero C, Tomassini V, Onesti E, Fantozzi R, Galgani S, Pasqualetti P, Millefiorini E, Spadaro M, Dahlke F, Gasperini C. Monthly corticosteroids decrease neutralizing antibodies to IFNbeta1 b: a randomized trial in multiple sclerosis. J Neurol. 2002 Jan; 249(1):50-6. PMID: 11954868.
    View in: PubMed
  59. Mainero C, De Stefano N, Iannucci G, Sormani MP, Guidi L, Federico A, Bartolozzi ML, Comi G, Filippi M. Correlates of MS disability assessed in vivo using aggregates of MR quantities. Neurology. 2001 May 22; 56(10):1331-4. PMID: 11376183.
    View in: PubMed
  60. Ciccarelli O, Bagnato F, Mainero C, Salvetti M, Paolillo A, Gasperini C, Bastianello S, Pozzilli C. Antinuclear antibodies and response to IFNbeta-1a therapy in relapsing-remitting multiple sclerosis. Mult Scler. 2000 Jun; 6(3):137-9. PMID: 10871823.
    View in: PubMed
  61. Paolillo A, Pozzilli C, Gasperini C, Giugni E, Mainero C, Giuliani S, Tomassini V, Millefiorini E, Bastianello S. Brain atrophy in relapsing-remitting multiple sclerosis: relationship with 'black holes', disease duration and clinical disability. J Neurol Sci. 2000 Mar 15; 174(2):85-91. PMID: 10727693.
    View in: PubMed
  62. Pozzilli C, Falaschi P, Mainero C, Martocchia A, D'Urso R, Proietti A, Frontoni M, Bastianello S, Filippi M. MRI in multiple sclerosis during the menstrual cycle: relationship with sex hormone patterns. Neurology. 1999 Aug 11; 53(3):622-4. PMID: 10449131.
    View in: PubMed
  63. Ciccarelli O, Giugni E, Paolillo A, Mainero C, Gasperini C, Bastianello S, Pozzilli C. Magnetic resonance outcome of new enhancing lesions in patients with relapsing-remitting multiple sclerosis. Eur J Neurol. 1999 Jul; 6(4):455-9. PMID: 10362899.
    View in: PubMed
  64. Mainero C, Faroni J, Gasperini C, Filippi M, Giugni E, Ciccarelli O, Rovaris M, Bastianello S, Comi G, Pozzilli C. Fatigue and magnetic resonance imaging activity in multiple sclerosis. J Neurol. 1999 Jun; 246(6):454-8. PMID: 10431770.
    View in: PubMed
  65. Pontieri FE, Mainero C, La Riccia M, Passarelli F, Orzi F. Functional correlates of repeated administration of cocaine and apomorphine in the rat. Eur J Pharmacol. 1995 Sep 15; 284(1-2):205-9. PMID: 8549628.
    View in: PubMed
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