Harvard Catalyst Profiles

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M. Amin Arnaout, M.D.

Co-Author

This page shows the publications co-authored by M. Arnaout and Johannes van Agthoven.
Connection Strength

2.213
  1. Van Agthoven JF, Shams H, Cochran FV, Alonso JL, Kintzing JR, Garakani K, Adair BD, Xiong JP, Mofrad MRK, Cochran JR, Arnaout MA. Structural Basis of the Differential Binding of Engineered Knottins to Integrins aVß3 and a5ß1. Structure. 2019 09 03; 27(9):1443-1451.e6.
    View in: PubMed
    Score: 0.938
  2. Van Agthoven JF, Xiong JP, Alonso JL, Rui X, Adair BD, Goodman SL, Arnaout MA. Structural basis for pure antagonism of integrin aVß3 by a high-affinity form of fibronectin. Nat Struct Mol Biol. 2014 Apr; 21(4):383-8.
    View in: PubMed
    Score: 0.648
  3. Adair BD, Alonso JL, van Agthoven J, Hayes V, Ahn HS, Yu IS, Lin SW, Xiong JP, Poncz M, Arnaout MA. Structure-guided design of pure orthosteric inhibitors of aIIbß3 that prevent thrombosis but preserve hemostasis. Nat Commun. 2020 01 21; 11(1):398.
    View in: PubMed
    Score: 0.243
  4. Rui X, Mehrbod M, Van Agthoven JF, Anand S, Xiong JP, Mofrad MR, Arnaout MA. The a-subunit regulates stability of the metal ion at the ligand-associated metal ion-binding site in ß3 integrins. J Biol Chem. 2014 Aug 15; 289(33):23256-63.
    View in: PubMed
    Score: 0.165
  5. Mahalingam B, Van Agthoven JF, Xiong JP, Alonso JL, Adair BD, Rui X, Anand S, Mehrbod M, Mofrad MR, Burger C, Goodman SL, Arnaout MA. Atomic basis for the species-specific inhibition of aV integrins by monoclonal antibody 17E6 is revealed by the crystal structure of aVß3 ectodomain-17E6 Fab complex. J Biol Chem. 2014 May 16; 289(20):13801-9.
    View in: PubMed
    Score: 0.162
  6. Li J, Fukase Y, Shang Y, Zou W, Muñoz-Félix JM, Buitrago L, van Agthoven J, Zhang Y, Hara R, Tanaka Y, Okamoto R, Yasui T, Nakahata T, Imaeda T, Aso K, Zhou Y, Locuson C, Nesic D, Duggan M, Takagi J, Vaughan RD, Walz T, Hodivala-Dilke K, Teitelbaum SL, Arnaout MA, Filizola M, Foley MA, Coller BS. Novel Pure aVß3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations. ACS Pharmacol Transl Sci. 2019 Dec 13; 2(6):387-401.
    View in: PubMed
    Score: 0.059
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.