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profileNutan Sharma, M.D., Ph.D.

TitleAssociate Professor of Neurology
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMassachusetts General Hospital
Neurology Research, Rm 6407
114 16th Street
Charlestown MA 02129
Phone617/726-1728
Fax617/726-4101
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
P01NS087997     (BREAKEFIELD, XANDRA OWENS)Jul 1, 2015 - Jun 30, 2020
NIH/NINDS
Molecular etiology of early onset dystonia
Role: Co-Principal Investigator

K08NS044272     (SHARMA, NUTAN)May 1, 2003 - Feb 28, 2009
NIH/NINDS
Role of DYT1 Mutation in Dystonia
Role: Principal Investigator

P50NS037409     (BREAKEFIELD, XANDRA OWENS)Jan 1, 2000 - Jul 31, 2014
NIH/NINDS
Molecular etiology of early onset torsion dystonia
Role: Co-Principal Investigator

M01RR001066     (SLAVIN, PETER L)Feb 1, 1978 - May 31, 2008
NIH/NCRR
General Clinical Research Center
Role: Co-Principal Investigator

P01-01A1     (SETTE, ALESSANDRO D.)
NIH
T Cell Responses Following DENV Natural Infections and Live-Attenuated Dengue Virus Vaccination
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Stephen CD, Sharma N, Callahan J, Carson AJ, Perez DL. A Case of Functional Dystonia with Associated Functional Neurological Symptoms: Diagnostic and Therapeutic Challenges. Harv Rev Psychiatry. 2017 Jun 23. PMID: 28650853.
    View in: PubMed
  2. de Gusmao CM, Pollak LE, Sharma N. Neuropsychological and psychiatric outcome of GPi-deep brain stimulation in dystonia. Brain Stimul. 2017 Jun 09. PMID: 28647175.
    View in: PubMed
  3. Jones L, Goode L, Davila E, Brown A, McCarthy DM, Sharma N, Bhide PG, Armata IA. Translational effects and coding potential of an upstream open reading frame associated with DOPA Responsive Dystonia. Biochim Biophys Acta. 2017 Jun; 1863(6):1171-1182. PMID: 28366877.
    View in: PubMed
  4. Vaine CA, Shin D, Liu C, Hendriks WT, Dhakal J, Shin K, Sharma N, Bragg DC. X-linked Dystonia-Parkinsonism patient cells exhibit altered signaling via nuclear factor-kappa B. Neurobiol Dis. 2017 Apr; 100:108-118. PMID: 28017799.
    View in: PubMed
  5. Rittiner JE, Caffall ZF, Hernández-Martinez R, Sanderson SM, Pearson JL, Tsukayama KK, Liu AY, Xiao C, Tracy S, Shipman MK, Hickey P, Johnson J, Scott B, Stacy M, Saunders-Pullman R, Bressman S, Simonyan K, Sharma N, Ozelius LJ, Cirulli ET, Calakos N. Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2a Signaling as a Generalizable Mechanism for Dystonia. Neuron. 2016 Dec 21; 92(6):1238-1251. PMID: 27939583.
    View in: PubMed
  6. de Gusmão CM, Fuchs T, Moses A, Multhaupt-Buell T, Song PC, Ozelius LJ, Franco RA, Sharma N. Dystonia-Causing Mutations as a Contribution to the Etiology of Spasmodic Dysphonia. Otolaryngol Head Neck Surg. 2016 Oct; 155(4):624-8. PMID: 27188707.
    View in: PubMed
  7. Waugh JL, Kuster JK, Levenstein JM, Makris N, Multhaupt-Buell TJ, Sudarsky LR, Breiter HC, Sharma N, Blood AJ. Thalamic Volume Is Reduced in Cervical and Laryngeal Dystonias. PLoS One. 2016; 11(5):e0155302. PMID: 27171035; PMCID: PMC4865047.
  8. Dy ME, Chang FC, Jesus SD, Anselm I, Mahant N, Zeilman P, Rodan LH, Foote KD, Tan WH, Eskandar E, Sharma N, Okun MS, Fung VS, Waugh JL. Treatment of ADCY5-Associated Dystonia, Chorea, and Hyperkinetic Disorders With Deep Brain Stimulation: A Multicenter Case Series. J Child Neurol. 2016 Jul; 31(8):1027-35. PMID: 27052971.
    View in: PubMed
  9. Ito N, Hendriks WT, Dhakal J, Vaine CA, Liu C, Shin D, Shin K, Wakabayashi-Ito N, Dy M, Multhaupt-Buell T, Sharma N, Breakefield XO, Bragg DC. Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells. Dis Model Mech. 2016 Apr; 9(4):451-62. PMID: 26769797; PMCID: PMC4852502.
  10. Vaughn LS, Bragg DC, Sharma N, Camargos S, Cardoso F, Patel RC. Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT. J Biol Chem. 2015 Sep 11; 290(37):22543-57. PMID: 26231208; PMCID: PMC4566229 [Available on 09/11/16].
  11. Zhang L, McCarthy DM, Sharma N, Bhide PG. Dopamine receptor and Ga(olf) expression in DYT1 dystonia mouse models during postnatal development. PLoS One. 2015; 10(4):e0123104. PMID: 25860259; PMCID: PMC4393110.
  12. Bragg DC, Sharma N. Update on treatments for dystonia. Curr Neurol Neurosci Rep. 2014 Jun; 14(6):454. PMID: 24744022; PMCID: PMC4477531.
  13. Waugh JL, Sharma N. Clinical neurogenetics: dystonia from phenotype to genotype. Neurol Clin. 2013 Nov; 31(4):969-86. PMID: 24176419.
    View in: PubMed
  14. Petrossian MT, Paul LR, Multhaupt-Buell TJ, Eckhardt C, Hayes MT, Duhaime AC, Eskandar EN, Sharma N. Pallidal deep brain stimulation for dystonia: a case series. J Neurosurg Pediatr. 2013 Dec; 12(6):582-7. PMID: 24093589.
    View in: PubMed
  15. Armata IA, Balaj L, Kuster JK, Zhang X, Tsai S, Armatas AA, Multhaupt-Buell TJ, Soberman R, Breakefield XO, Ichinose H, Sharma N. Dopa-responsive dystonia: functional analysis of single nucleotide substitutions within the 5' untranslated GCH1 region. PLoS One. 2013; 8(10):e76975. PMID: 24124602; PMCID: PMC3790877.
  16. Sharma N. Lysosomal enzyme defects and Parkinson disease. Neurology. 2013 Apr 23; 80(17):1544-5. PMID: 23535496.
    View in: PubMed
  17. Bragg C, Sharma N. EDITORIAL: Advances in Dystonia. Curr Neuropharmacol. 2013 Jan; 11(1):2. PMID: 23814532; PMCID: PMC3580787.
  18. Fuchs T, Saunders-Pullman R, Masuho I, Luciano MS, Raymond D, Factor S, Lang AE, Liang TW, Trosch RM, White S, Ainehsazan E, Hervé D, Sharma N, Ehrlich ME, Martemyanov KA, Bressman SB, Ozelius LJ. Mutations in GNAL cause primary torsion dystonia. Nat Genet. 2013 Jan; 45(1):88-92. PMID: 23222958; PMCID: PMC3530620.
  19. McCarthy DM, Gioioso V, Zhang X, Sharma N, Bhide PG. Neurogenesis and neuronal migration in the forebrain of the TorsinA knockout mouse embryo. Dev Neurosci. 2012; 34(4):366-78. PMID: 23018676; PMCID: PMC3712350.
  20. Blood AJ, Kuster JK, Woodman SC, Kirlic N, Makhlouf ML, Multhaupt-Buell TJ, Makris N, Parent M, Sudarsky LR, Sjalander G, Breiter H, Breiter HC, Sharma N. Evidence for altered basal ganglia-brainstem connections in cervical dystonia. PLoS One. 2012; 7(2):e31654. PMID: 22384048; PMCID: PMC3285161.
  21. Walcott BP, Nahed BV, Kahle KT, Duhaime AC, Sharma N, Eskandar EN. Deep brain stimulation for medically refractory life-threatening status dystonicus in children. J Neurosurg Pediatr. 2012 Jan; 9(1):99-102. PMID: 22208329; PMCID: PMC3734533.
  22. Sengel C, Gavarini S, Sharma N, Ozelius LJ, Bragg DC. Dimerization of the DYT6 dystonia protein, THAP1, requires residues within the coiled-coil domain. J Neurochem. 2011 Sep; 118(6):1087-100. PMID: 21752024; PMCID: PMC3166381.
  23. Sharma N, Armata IA, Multhaupt-Buell TJ, Ozelius LJ, Xin W, Sims KB. Mutation in 5' upstream region of GCHI gene causes familial dopa-responsive dystonia. Mov Disord. 2011 Sep; 26(11):2140-1. PMID: 21674621; PMCID: PMC3175261.
  24. Sharma N, Franco RA. Consideration of genetic contributions to the risk for spasmodic dysphonia. Otolaryngol Head Neck Surg. 2011 Sep; 145(3):369-70. PMID: 21636841.
    View in: PubMed
  25. Karakis I, Cole AJ, Hoch DB, Sharma N. Extrapyramidal epilepsy. Epileptic Disord. 2011 Jun; 13(2):181-4. PMID: 21561840.
    View in: PubMed
  26. Bragg DC, Armata IA, Nery FC, Breakefield XO, Sharma N. Molecular pathways in dystonia. Neurobiol Dis. 2011 May; 42(2):136-47. PMID: 21134457; PMCID: PMC3073693.
  27. Sharma N, Franco RA, Kuster JK, Mitchell AA, Fuchs T, Saunders-Pullman R, Raymond D, Brin MF, Blitzer A, Bressman SB, Ozelius LJ. Genetic evidence for an association of the TOR1A locus with segmental/focal dystonia. Mov Disord. 2010 Oct 15; 25(13):2183-7. PMID: 20669276; PMCID: PMC3095887.
  28. Hewett J, Johanson P, Sharma N, Standaert D, Balcioglu A. Function of dopamine transporter is compromised in DYT1 transgenic animal model in vivo. J Neurochem. 2010 Apr; 113(1):228-35. PMID: 20132487; PMCID: PMC3036947.
  29. Martella G, Tassone A, Sciamanna G, Platania P, Cuomo D, Viscomi MT, Bonsi P, Cacci E, Biagioni S, Usiello A, Bernardi G, Sharma N, Standaert DG, Pisani A. Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine. Brain. 2009 Sep; 132(Pt 9):2336-49. PMID: 19641103; PMCID: PMC2766181.
  30. Sciamanna G, Bonsi P, Tassone A, Cuomo D, Tscherter A, Viscomi MT, Martella G, Sharma N, Bernardi G, Standaert DG, Pisani A. Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia. Neurobiol Dis. 2009 Apr; 34(1):133-45. PMID: 19187797; PMCID: PMC3786200.
  31. Sharma, N. Gene Repression or Imprinting: Rett Syndrome. New Encyclopedia of Neuroscience. 2008.
  32. Sharma, N. Effectiveness of Botulinum Toxin in the Treatment of Movement Disorders. Journal Watch Neurology. 2008.
  33. Nutan Sharma. Parkinson's disease. 2008.
  34. Shields DC, Sharma N, Gale JT, Eskandar EN. Pallidal stimulation for dystonia in pantothenate kinase-associated neurodegeneration. Pediatr Neurol. 2007 Dec; 37(6):442-5. PMID: 18021929.
    View in: PubMed
  35. Nutan Sharma. Structural abnormalities in the cerebellum and sensorimotor circuit in writer's cramp. Journal Watch Neurology. 2007; 9(11):88.
  36. Balcioglu A, Kim MO, Sharma N, Cha JH, Breakefield XO, Standaert DG. Dopamine release is impaired in a mouse model of DYT1 dystonia. J Neurochem. 2007 Aug; 102(3):783-8. PMID: 17550429.
    View in: PubMed
  37. Sharma, N. Patient Preference in Botulinum Toxin for Writer’s Cramp. Journal Watch Neurology. 2007; 9(7):49-56.
  38. Pisani A, Martella G, Tscherter A, Bonsi P, Sharma N, Bernardi G, Standaert DG. Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia. Neurobiol Dis. 2006 Nov; 24(2):318-25. PMID: 16934985.
    View in: PubMed
  39. Blood AJ, Tuch DS, Makris N, Makhlouf ML, Sudarsky LR, Sharma N. White matter abnormalities in dystonia normalize after botulinum toxin treatment. Neuroreport. 2006 Aug 21; 17(12):1251-5. PMID: 16951564; PMCID: PMC3039124.
  40. Sharma N, Baxter MG, Petravicz J, Bragg DC, Schienda A, Standaert DG, Breakefield XO. Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation. J Neurosci. 2005 Jun 01; 25(22):5351-5. PMID: 15930383.
    View in: PubMed
  41. Jinnah HA, Hess EJ, Ledoux MS, Sharma N, Baxter MG, Delong MR. Rodent models for dystonia research: characteristics, evaluation, and utility. Mov Disord. 2005 Mar; 20(3):283-92. PMID: 15641011.
    View in: PubMed
  42. Sharma N, Richman E. Parkinson's disease and the Family. 2005.
  43. Nutan Sharma,N, Bragg, DC, Peteravicz, J, Standaert, DG, Breakefield, XO. DYT1 Transgenic Mouse. Animal Models of Movement Disorders. 2005.
  44. Sharma N. Botulinum Toxin A Reduces Drooling in Neurodegenerative Diseases. Journal Watch Neurology. 2004.
  45. Sharma N. Dopa-Responsive Dystonia Manifesting as Markedly Different Phenotypes in Monozygotic Twins. Journal Watch Neurology. 2004.
  46. Cole D, Sharma N. Progressive Supranuclear Palsy. Office Practice of Neurology. Samuels MA, Feske S. 2003.
  47. McLean PJ, Kawamata H, Shariff S, Hewett J, Sharma N, Ueda K, Breakefield XO, Hyman BT. TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation. J Neurochem. 2002 Nov; 83(4):846-54. PMID: 12421356.
    View in: PubMed
  48. Sharma N, Standaert DG. Inherited movement disorders. Neurol Clin. 2002 Aug; 20(3):759-78, vii. PMID: 12432829.
    View in: PubMed
  49. Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik KS. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol. 2002 May; 160(5):1655-67. PMID: 12000718; PMCID: PMC1850875.
  50. Bhushan V, Pall V, Le T, Nguyen H, Sharma N. Blackwell's Underground Clinical Vignettes, Neurology. 2002.
  51. Sharma N, Schwarzschild M. Movement Disorders in Pregnancy. Neurological Therapeutics: Principles and Practice. Noseworthy JH, Samuels MA. 2002.
  52. Kanthasamy AG, Sharma N, Kirby ML, Schwaraschild M. Neuroprotective Strategies in Parkinson's Disease. Neuroprotection. Marwah J, Lo EH. 2002; 603-640.
  53. Sharma N. Parkinson's. Essentials of Outpatient Rehabilitation. Frontera WR, Silver J. 2002.
  54. Sharma N, McLean PJ, Kawamata H, Irizarry MC, Hyman BT. Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies. Acta Neuropathol. 2001 Oct; 102(4):329-34. PMID: 11603807.
    View in: PubMed
  55. Sharma N, Hewett J, Ozelius LJ, Ramesh V, McLean PJ, Breakefield XO, Hyman BT. A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study. Am J Pathol. 2001 Jul; 159(1):339-44. PMID: 11438481; PMCID: PMC1850427.
  56. Kawamata H, McLean PJ, Sharma N, Hyman BT. Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations. J Neurochem. 2001 May; 77(3):929-34. PMID: 11331421.
    View in: PubMed
  57. Sharma N, Nguyen H, Amin C, Le T, Bhushan V. Neurology Classic Clinical Cases for USMLE Step 2 and Clerkship Review. 2000.
  58. Sharma N. Neurology. First Aid for the USMLE Step 2, Le T, Amin C, Bhusan V, Berkeley R, Levine R, Ruiz D. 1999.
  59. Sharma N, D'Arcangelo G, Kleinlaus A, Halegoua S, Trimmer JS. Nerve growth factor regulates the abundance and distribution of K+ channels in PC12 cells. J Cell Biol. 1993 Dec; 123(6 Pt 2):1835-43. PMID: 8276901; PMCID: PMC2290858.
  60. Sharma N. Characterization of Kv2.1 in PC12 cells. 1993.
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