Harvard Catalyst Profiles

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Nutan Sharma, M.D., Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS118541 (SHARMA, NUTAN) Jun 15, 2020 - May 30, 2022
    Natural history study of x-linked Dystonia Parkinsonism
    Role: Principal Investigator
  2. P01NS087997 (BREAKEFIELD, XANDRA OWENS) Jul 1, 2015 - Jun 30, 2021
    Molecular etiology of early onset dystonia
    Role: Co-Principal Investigator
  3. K08NS044272 (SHARMA, NUTAN) May 1, 2003 - Feb 28, 2009
    Role of DYT1 Mutation in Dystonia
    Role: Principal Investigator
  4. P50NS037409 (BREAKEFIELD, XANDRA OWENS) Jan 1, 2000 - Mar 31, 2015
    Molecular etiology of early onset torsion dystonia
    Role: Co-Principal Investigator
  5. M01RR001066 (SLAVIN, PETER L) Feb 1, 1978 - May 31, 2008
    General Clinical Research Center
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Alecu JE, Ohmi Y, Bhuiyan RH, Inamori KI, Nitta T, Saffari A, Jumo H, Ziegler M, de Gusmao CM, Sharma N, Ohno S, Manabe N, Yamaguchi Y, Kambe M, Furukawa K, Sahin M, Inokuchi JI, Furakawa K, Ebrahimi-Fakhari D. Functional validation of novel variants in B4GALNT1 associated with early-onset complex hereditary spastic paraplegia with impaired ganglioside synthesis. Am J Med Genet A. 2022 09; 188(9):2590-2598. PMID: 35775650; PMCID: PMC9378512.
    Citations:    Fields:    Translation:Humans
  2. Vaughn LS, Frederick K, Burnett SB, Sharma N, Bragg DC, Camargos S, Cardoso F, Patel RC. DYT-PRKRA Mutation P222L Enhances PACT's Stimulatory Activity on Type I Interferon Induction. Biomolecules. 2022 05 17; 12(5). PMID: 35625640; PMCID: PMC9138762.
    Citations:    Fields:    Translation:HumansCells
  3. Campion LN, Mejia Maza A, Yadav R, Penney EB, Murcar MG, Correia K, Gillis T, Fernandez-Cerado C, Velasco-Andrada MS, Legarda GP, Ganza-Bautista NG, Lagarde JBB, Acuña PJ, Multhaupt-Buell T, Aldykiewicz G, Supnet ML, De Guzman JK, Go C, Sharma N, Munoz EL, Ang MC, Diesta CCE, Bragg DC, Ozelius LJ, Wheeler VC. Correction to: Tissue-specific and repeat length-dependent somatic instability of the X-linked dystonia parkinsonism-associated CCCTCT repeat. Acta Neuropathol Commun. 2022 Apr 25; 10(1):62. PMID: 35468867; PMCID: PMC9040229.
    Citations:    Fields:    
  4. Campion LN, Mejia Maza A, Yadav R, Penney EB, Murcar MG, Correia K, Gillis T, Fernandez-Cerado C, Velasco-Andrada MS, Legarda GP, Ganza-Bautista NG, Lagarde JBB, Acuña PJ, Multhaupt-Buell T, Aldykiewicz G, Supnet ML, De Guzman JK, Go C, Sharma N, Munoz EL, Ang MC, Diesta CCE, Bragg DC, Ozelius LJ, Wheeler VC. Tissue-specific and repeat length-dependent somatic instability of the X-linked dystonia parkinsonism-associated CCCTCT repeat. Acta Neuropathol Commun. 2022 04 08; 10(1):49. PMID: 35395816; PMCID: PMC8994295.
    Citations: 1     Fields:    Translation:HumansCells
  5. Domingo A, Yadav R, Shah S, Hendriks WT, Erdin S, Gao D, O'Keefe K, Currall B, Gusella JF, Sharma N, Ozelius LJ, Ehrlich ME, Talkowski ME, Bragg DC. Dystonia-specific mutations in THAP1 alter transcription of genes associated with neurodevelopment and myelin. Am J Hum Genet. 2021 11 04; 108(11):2145-2158. PMID: 34672987; PMCID: PMC8595948.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Zaninotto AL, de Guzman JK, Stipancic KL, Perry BJ, Supnet ML, Go C, Sharma N, Green JR. Speech and swallowing deficits in X-Linked Dystonia-Parkinsonism. Parkinsonism Relat Disord. 2021 08; 89:105-110. PMID: 34274618.
    Citations: 1     Fields:    Translation:Humans
  7. Briere LC, Walker MA, High FA, Cooper C, Rogers CA, Callahan CJ, Ishimura R, Ichimura Y, Caruso PA, Sharma N, Brokamp E, Koziura ME, Mohammad SS, Dale RC, Riley LG, Phillips JA, Komatsu M, Sweetser DA. A description of novel variants and review of phenotypic spectrum in UBA5-related early epileptic encephalopathy. Cold Spring Harb Mol Case Stud. 2021 06; 7(3). PMID: 33811063.
    Citations:    Fields:    Translation:HumansCells
  8. Laabs BH, Klein C, Pozojevic J, Domingo A, Brüggemann N, Grütz K, Rosales RL, Jamora RD, Saranza G, Diesta CCE, Wittig M, Schaake S, Dulovic-Mahlow M, Quismundo J, Otto P, Acuna P, Go C, Sharma N, Multhaupt-Buell T, Müller U, Hanssen H, Kilpert F, Franke A, Rolfs A, Bauer P, Dobricic V, Lohmann K, Ozelius LJ, Kaiser FJ, König IR, Westenberger A. Identifying genetic modifiers of age-associated penetrance in X-linked dystonia-parkinsonism. Nat Commun. 2021 05 28; 12(1):3216. PMID: 34050153.
    Citations: 5     Fields:    Translation:HumansCells
  9. Simonyan K, Barkmeier-Kraemer J, Blitzer A, Hallett M, Houde JF, Jacobson Kimberley T, Ozelius LJ, Pitman MJ, Richardson RM, Sharma N, Tanner K. Laryngeal Dystonia: Multidisciplinary Update on Terminology, Pathophysiology, and Research Priorities. Neurology. 2021 05 25; 96(21):989-1001. PMID: 33858994; PMCID: PMC8205448.
    Citations: 8     Fields:    Translation:Humans
  10. Shinoda K, Zong D, Callen E, Wu W, Dumitrache LC, Belinky F, Chari R, Wong N, Ishikawa M, Stanlie A, Multhaupt-Buell T, Sharma N, Ozelius L, Ehrlich M, McKinnon PJ, Nussenzweig A. The dystonia gene THAP1 controls DNA double-strand break repair choice. Mol Cell. 2021 06 17; 81(12):2611-2624.e10. PMID: 33857404; PMCID: PMC8985095.
    Citations: 6     Fields:    Translation:AnimalsCells
  11. Dy-Hollins M, Carr S, Scharf J, Sharma N, Stern TA. Hyperkinetic Movements in Children: Differential Diagnosis, Evaluation, and Treatment. Prim Care Companion CNS Disord. 2021 04 01; 23(2). PMID: 34000162.
    Citations:    Fields:    Translation:Humans
  12. Stephen CD, Perez DL, Chibnik LB, Sharma N. Functional dystonia: A case-control study and risk prediction algorithm. Ann Clin Transl Neurol. 2021 04; 8(4):732-748. PMID: 33724724.
    Citations: 4     Fields:    Translation:Humans
  13. Frucht L, Perez DL, Callahan J, MacLean J, Song PC, Sharma N, Stephen CD. Functional Dystonia: Differentiation From Primary Dystonia and Multidisciplinary Treatments. Front Neurol. 2020; 11:605262. PMID: 33613415.
    Citations: 6     
  14. Song SA, Go CL, Acuna PB, De Guzman JKP, Sharma N, Song PC. Progressive Decline in Voice and Voice-Related Quality of Life in X-Linked Dystonia Parkinsonism. J Voice. 2023 Jan; 37(1):134-138. PMID: 33334627.
    Citations:    Fields:    Translation:Humans
  15. Petrozziello T, Dios AM, Mueller KA, Vaine CA, Hendriks WT, Glajch KE, Mills AN, Mangkalaphiban K, Penney EB, Ito N, Fernandez-Cerado C, Legarda GPA, Velasco-Andrada MS, Acuña PJ, Ang MA, Muñoz EL, Diesta CCE, Macalintal-Canlas R, Acuña G, Sharma N, Ozelius LJ, Bragg DC, Sadri-Vakili G. SVA insertion in X-linked Dystonia Parkinsonism alters histone H3 acetylation associated with TAF1 gene. PLoS One. 2020; 15(12):e0243655. PMID: 33315879.
    Citations: 4     Fields:    Translation:HumansCells
  16. Cif L, Demailly D, Lin JP, Barwick KE, Sa M, Abela L, Malhotra S, Chong WK, Steel D, Sanchis-Juan A, Ngoh A, Trump N, Meyer E, Vasques X, Rankin J, Allain MW, Applegate CD, Attaripour Isfahani S, Baleine J, Balint B, Bassetti JA, Baple EL, Bhatia KP, Blanchet C, Burglen L, Cambonie G, Seng EC, Bastaraud SC, Cyprien F, Coubes C, d'Hardemare V, Doja A, Dorison N, Doummar D, Dy-Hollins ME, Farrelly E, Fitzpatrick DR, Fearon C, Fieg EL, Fogel BL, Forman EB, Fox RG, Gahl WA, Galosi S, Gonzalez V, Graves TD, Gregory A, Hallett M, Hasegawa H, Hayflick SJ, Hamosh A, Hully M, Jansen S, Jeong SY, Krier JB, Krystal S, Kumar KR, Laurencin C, Lee H, Lesca G, François LL, Lynch T, Mahant N, Martinez-Agosto JA, Milesi C, Mills KA, Mondain M, Morales-Briceno H, Ostergaard JR, Pal S, Pallais JC, Pavillard F, Perrigault PF, Petersen AK, Polo G, Poulen G, Rinne T, Roujeau T, Rogers C, Roubertie A, Sahagian M, Schaefer E, Selim L, Selway R, Sharma N, Signer R, Soldatos AG, Stevenson DA, Stewart F, Tchan M, Verma IC, de Vries BBA, Wilson JL, Wong DA, Zaitoun R, Zhen D, Znaczko A, Dale RC, de Gusmão CM, Friedman J, Fung VSC, King MD, Mohammad SS, Rohena L, Waugh JL, Toro C, Raymond FL, Topf M, Coubes P, Gorman KM, Kurian MA. KMT2B-related disorders: expansion of the phenotypic spectrum and long-term efficacy of deep brain stimulation. Brain. 2020 12 05; 143(11):3242-3261. PMID: 33150406; PMCID: PMC7719027.
    Citations: 21     Fields:    Translation:Humans
  17. Perez DL, Hunt A, Sharma N, Flaherty A, Caplan D, Schmahmann JD. Cautionary notes on diagnosing functional neurologic disorder as a neurologist-in-training. Neurol Clin Pract. 2020 Dec; 10(6):484-487. PMID: 33520411.
    Citations: 3     
  18. Supnet ML, Acuna P, Carr SJ, Kristoper de Guzman J, Al Qahtani X, Multhaupt-Buell T, Francoeur T, Aldykiewicz GE, Alluri PR, Campion L, Paul L, Ozelius L, Penney EB, Stephen CD, Dy-Hollins M, Sharma N. Isolated Cervical Dystonia: Management and Barriers to Care. Front Neurol. 2020; 11:591418. PMID: 33329340.
    Citations: 1     
  19. Burnett SB, Vaughn LS, Sharma N, Kulkarni R, Patel RC. Dystonia 16 (DYT16) mutations in PACT cause dysregulated PKR activation and eIF2a signaling leading to a compromised stress response. Neurobiol Dis. 2020 12; 146:105135. PMID: 33049316.
    Citations: 7     Fields:    Translation:HumansCells
  20. Al Ali J, Vaine CA, Shah S, Campion L, Hakoum A, Supnet ML, Acuña P, Aldykiewicz G, Multhaupt-Buell T, Ganza NGM, Lagarde JBB, De Guzman JK, Go C, Currall B, Trombetta B, Webb PK, Talkowski M, Arnold SE, Cheah PS, Ito N, Sharma N, Bragg DC, Ozelius L, Breakefield XO. TAF1 Transcripts and Neurofilament Light Chain as Biomarkers for X-linked Dystonia-Parkinsonism. Mov Disord. 2021 01; 36(1):206-215. PMID: 32975318; PMCID: PMC7891430.
    Citations: 6     Fields:    Translation:HumansCells
  21. Sharma N. Editorial: Advances in rare movement disorders. Curr Opin Neurol. 2020 08; 33(4):498-499. PMID: 32657891.
    Citations: 1     Fields:    
  22. Petrozziello T, Mills AN, Vaine CA, Penney EB, Fernandez-Cerado C, Legarda GPA, Velasco-Andrada MS, Acuña PJ, Ang MA, Muñoz EL, Diesta CCE, Macalintal-Canlas R, Acuña-Sunshine G, Ozelius LJ, Sharma N, Bragg DC, Sadri-Vakili G. Neuroinflammation and histone H3 citrullination are increased in X-linked Dystonia Parkinsonism post-mortem prefrontal cortex. Neurobiol Dis. 2020 10; 144:105032. PMID: 32739252.
    Citations: 10     Fields:    Translation:HumansCells
  23. Tsuboi T, Cif L, Coubes P, Ostrem JL, Romero DA, Miyagi Y, Lozano AM, De Vloo P, Haq I, Meng F, Sharma N, Ozelius LJ, Wagle Shukla A, Cauraugh JH, Foote KD, Okun MS. Secondary Worsening Following DYT1 Dystonia Deep Brain Stimulation: A Multi-country Cohort. Front Hum Neurosci. 2020; 14:242. PMID: 32670041; PMCID: PMC7330126.
    Citations: 3     
  24. Sharma N. Advances in rare movement disorders. Curr Opin Neurol. 2020 Jun 08. PMID: 32520806.
    Citations:    Fields:    
  25. Cruz L, György B, Cheah PS, Kleinstiver BP, Eimer WA, Garcia SP, Sharma N, Ozelius LJ, Bragg DC, Joung JK, Norberto de Souza O, Macedo Timmers LFS, Breakefield XO. Mutant Allele-Specific CRISPR Disruption in DYT1 Dystonia Fibroblasts Restores Cell Function. Mol Ther Nucleic Acids. 2020 Sep 04; 21:1-12. PMID: 32502938.
    Citations: 3     
  26. Stephen CD, Go CL, Acuna P, Sharma N. Phasic Knee Bending Dystonic and Parkinsonian Gait: A Characteristic Finding in X-Linked Dystonia Parkinsonism. Mov Disord Clin Pract. 2020 May; 7(4):448-452. PMID: 32373662; PMCID: PMC7197325.
    Citations: 2     
  27. Lungu C, Ozelius L, Standaert D, Hallett M, Sieber BA, Swanson-Fisher C, Berman BD, Calakos N, Moore JC, Perlmutter JS, Pirio Richardson SE, Saunders-Pullman R, Scheinfeldt L, Sharma N, Sillitoe R, Simonyan K, Starr PA, Taylor A, Vitek J. Defining research priorities in dystonia. Neurology. 2020 03 24; 94(12):526-537. PMID: 32098856; PMCID: PMC7274927.
    Citations: 11     Fields:    Translation:HumansAnimals
  28. Bragg DC, Sharma N, Ozelius LJ. X-Linked Dystonia-Parkinsonism: recent advances. Curr Opin Neurol. 2019 08; 32(4):604-609. PMID: 31116117; PMCID: PMC7243267.
    Citations: 8     Fields:    Translation:HumansCells
  29. Blood AJ, Kuster JK, Waugh JL, Levenstein JM, Multhaupt-Buell TJ, Sudarsky LR, Breiter HC, Sharma N. White Matter Changes in Cervical Dystonia Relate to Clinical Effectiveness of Botulinum Toxin Treatment. Front Neurol. 2019; 10:265. PMID: 31019484.
    Citations: 6     
  30. Song PC, Le H, Acuna P, De Guzman JKP, Sharma N, Francouer TN, Dy ME, Go CL. Voice and swallowing dysfunction in X-linked dystonia parkinsonism. Laryngoscope. 2020 01; 130(1):171-177. PMID: 30889292.
    Citations: 5     Fields:    Translation:Humans
  31. Sharma N. Neuropathology of Dystonia. Tremor Other Hyperkinet Mov (N Y). 2019; 9:569. PMID: 30886764.
    Citations: 6     Fields:    Translation:Humans
  32. Wissel BD, Dwivedi AK, Merola A, Chin D, Jacob C, Duker AP, Vaughan JE, Lovera L, LaFaver K, Levy A, Lang AE, Morgante F, Nirenberg MJ, Stephen C, Sharma N, Romagnolo A, Lopiano L, Balint B, Yu XX, Bhatia KP, Espay AJ. Functional neurological disorders in Parkinson disease. J Neurol Neurosurg Psychiatry. 2018 06; 89(6):566-571. PMID: 29549192.
    Citations: 26     Fields:    Translation:Humans
  33. Aneichyk T, Hendriks WT, Yadav R, Shin D, Gao D, Vaine CA, Collins RL, Domingo A, Currall B, Stortchevoi A, Multhaupt-Buell T, Penney EB, Cruz L, Dhakal J, Brand H, Hanscom C, Antolik C, Dy M, Ragavendran A, Underwood J, Cantsilieris S, Munson KM, Eichler EE, Acuña P, Go C, Jamora RDG, Rosales RL, Church DM, Williams SR, Garcia S, Klein C, Müller U, Wilhelmsen KC, Timmers HTM, Sapir Y, Wainger BJ, Henderson D, Ito N, Weisenfeld N, Jaffe D, Sharma N, Breakefield XO, Ozelius LJ, Bragg DC, Talkowski ME. Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly. Cell. 2018 02 22; 172(5):897-909.e21. PMID: 29474918; PMCID: PMC5831509.
    Citations: 75     Fields:    Translation:HumansCells
  34. Bragg DC, Mangkalaphiban K, Vaine CA, Kulkarni NJ, Shin D, Yadav R, Dhakal J, Ton ML, Cheng A, Russo CT, Ang M, Acuña P, Go C, Franceour TN, Multhaupt-Buell T, Ito N, Müller U, Hendriks WT, Breakefield XO, Sharma N, Ozelius LJ. Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1. Proc Natl Acad Sci U S A. 2017 12 19; 114(51):E11020-E11028. PMID: 29229810; PMCID: PMC5754783.
    Citations: 54     Fields:    Translation:HumansCells
  35. Peall KJ, Ng J, Dy ME, Sharma N, Pope S, Heales S, Friedman JR, Kurian MA. Low CSF 5-HIAA in Myoclonus Dystonia. Mov Disord. 2017 11; 32(11):1647-1649. PMID: 28949039; PMCID: PMC5796435.
    Citations: 1     Fields:    Translation:Humans
  36. Stephen CD, Sharma N, Callahan J, Carson AJ, Perez DL. A Case of Functional Dystonia with Associated Functional Neurological Symptoms: Diagnostic and Therapeutic Challenges. Harv Rev Psychiatry. 2017 Sep/Oct; 25(5):241-251. PMID: 28650853.
    Citations: 4     Fields:    Translation:Humans
  37. de Gusmao CM, Pollak LE, Sharma N. Neuropsychological and psychiatric outcome of GPi-deep brain stimulation in dystonia. Brain Stimul. 2017 Sep - Oct; 10(5):994-996. PMID: 28647175.
    Citations: 4     Fields:    Translation:Humans
  38. Dy ME, Waugh JL, Sharma N, O'Leary H, Kapur K, D'Gama AM, Sahin M, Urion DK, Kaufmann WE. Defining Hand Stereotypies in Rett Syndrome: A Movement Disorders Perspective. Pediatr Neurol. 2017 Oct; 75:91-95. PMID: 28838622; PMCID: PMC5624791.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  39. Jones L, Goode L, Davila E, Brown A, McCarthy DM, Sharma N, Bhide PG, Armata IA. Translational effects and coding potential of an upstream open reading frame associated with DOPA Responsive Dystonia. Biochim Biophys Acta Mol Basis Dis. 2017 06; 1863(6):1171-1182. PMID: 28366877; PMCID: PMC6766408.
    Citations: 1     Fields:    Translation:HumansCells
  40. Vaine CA, Shin D, Liu C, Hendriks WT, Dhakal J, Shin K, Sharma N, Bragg DC. X-linked Dystonia-Parkinsonism patient cells exhibit altered signaling via nuclear factor-kappa B. Neurobiol Dis. 2017 Apr; 100:108-118. PMID: 28017799; PMCID: PMC5316362.
    Citations: 4     Fields:    Translation:HumansCells
  41. Rittiner JE, Caffall ZF, Hernández-Martinez R, Sanderson SM, Pearson JL, Tsukayama KK, Liu AY, Xiao C, Tracy S, Shipman MK, Hickey P, Johnson J, Scott B, Stacy M, Saunders-Pullman R, Bressman S, Simonyan K, Sharma N, Ozelius LJ, Cirulli ET, Calakos N. Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2a Signaling as a Generalizable Mechanism for Dystonia. Neuron. 2016 Dec 21; 92(6):1238-1251. PMID: 27939583.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  42. de Gusmão CM, Fuchs T, Moses A, Multhaupt-Buell T, Song PC, Ozelius LJ, Franco RA, Sharma N. Dystonia-Causing Mutations as a Contribution to the Etiology of Spasmodic Dysphonia. Otolaryngol Head Neck Surg. 2016 10; 155(4):624-8. PMID: 27188707.
    Citations: 5     Fields:    Translation:Humans
  43. Waugh JL, Kuster JK, Levenstein JM, Makris N, Multhaupt-Buell TJ, Sudarsky LR, Breiter HC, Sharma N, Blood AJ. Thalamic Volume Is Reduced in Cervical and Laryngeal Dystonias. PLoS One. 2016; 11(5):e0155302. PMID: 27171035.
    Citations: 15     Fields:    Translation:Humans
  44. Dy ME, Chang FC, Jesus SD, Anselm I, Mahant N, Zeilman P, Rodan LH, Foote KD, Tan WH, Eskandar E, Sharma N, Okun MS, Fung VS, Waugh JL. Treatment of ADCY5-Associated Dystonia, Chorea, and Hyperkinetic Disorders With Deep Brain Stimulation: A Multicenter Case Series. J Child Neurol. 2016 07; 31(8):1027-35. PMID: 27052971.
    Citations: 18     Fields:    Translation:Humans
  45. de Gusmao CM, Dy M, Sharma N. Beyond Dystonia-Parkinsonism: Chorea and Ataxia with ATP1A3 Mutations. Mov Disord Clin Pract. 2016 Jul-Aug; 3(4):402-404. PMID: 30363590.
    Citations: 6     
  46. Ito N, Hendriks WT, Dhakal J, Vaine CA, Liu C, Shin D, Shin K, Wakabayashi-Ito N, Dy M, Multhaupt-Buell T, Sharma N, Breakefield XO, Bragg DC. Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells. Dis Model Mech. 2016 Apr; 9(4):451-62. PMID: 26769797.
    Citations: 18     Fields:    Translation:HumansCells
  47. Vaughn LS, Bragg DC, Sharma N, Camargos S, Cardoso F, Patel RC. Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT. J Biol Chem. 2015 Sep 11; 290(37):22543-57. PMID: 26231208.
    Citations: 21     Fields:    Translation:HumansCells
  48. Zhang L, McCarthy DM, Sharma N, Bhide PG. Dopamine receptor and Ga(olf) expression in DYT1 dystonia mouse models during postnatal development. PLoS One. 2015; 10(4):e0123104. PMID: 25860259.
    Citations: 10     Fields:    Translation:HumansAnimals
  49. Bragg DC, Sharma N. Update on treatments for dystonia. Curr Neurol Neurosci Rep. 2014 Jun; 14(6):454. PMID: 24744022.
    Citations: 2     Fields:    Translation:Humans
  50. Waugh JL, Sharma N. Clinical neurogenetics: dystonia from phenotype to genotype. Neurol Clin. 2013 Nov; 31(4):969-86. PMID: 24176419.
    Citations:    Fields:    Translation:Humans
  51. Petrossian MT, Paul LR, Multhaupt-Buell TJ, Eckhardt C, Hayes MT, Duhaime AC, Eskandar EN, Sharma N. Pallidal deep brain stimulation for dystonia: a case series. J Neurosurg Pediatr. 2013 Dec; 12(6):582-7. PMID: 24093589.
    Citations: 5     Fields:    Translation:Humans
  52. Armata IA, Balaj L, Kuster JK, Zhang X, Tsai S, Armatas AA, Multhaupt-Buell TJ, Soberman R, Breakefield XO, Ichinose H, Sharma N. Dopa-responsive dystonia: functional analysis of single nucleotide substitutions within the 5' untranslated GCH1 region. PLoS One. 2013; 8(10):e76975. PMID: 24124602.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  53. Sharma N. Lysosomal enzyme defects and Parkinson disease. Neurology. 2013 Apr 23; 80(17):1544-5. PMID: 23535496.
    Citations: 2     Fields:    Translation:Humans
  54. Bragg C, Sharma N. EDITORIAL: Advances in Dystonia. Curr Neuropharmacol. 2013 Jan; 11(1):2. PMID: 23814532.
    Citations:    Fields:    
  55. Fuchs T, Saunders-Pullman R, Masuho I, Luciano MS, Raymond D, Factor S, Lang AE, Liang TW, Trosch RM, White S, Ainehsazan E, Hervé D, Sharma N, Ehrlich ME, Martemyanov KA, Bressman SB, Ozelius LJ. Mutations in GNAL cause primary torsion dystonia. Nat Genet. 2013 Jan; 45(1):88-92. PMID: 23222958.
    Citations: 105     Fields:    Translation:HumansCells
  56. McCarthy DM, Gioioso V, Zhang X, Sharma N, Bhide PG. Neurogenesis and neuronal migration in the forebrain of the TorsinA knockout mouse embryo. Dev Neurosci. 2012; 34(4):366-78. PMID: 23018676.
    Citations: 7     Fields:    Translation:AnimalsCells
  57. Blood AJ, Kuster JK, Woodman SC, Kirlic N, Makhlouf ML, Multhaupt-Buell TJ, Makris N, Parent M, Sudarsky LR, Sjalander G, Breiter H, Breiter HC, Sharma N. Evidence for altered basal ganglia-brainstem connections in cervical dystonia. PLoS One. 2012; 7(2):e31654. PMID: 22384048.
    Citations: 36     Fields:    Translation:HumansCells
  58. Walcott BP, Nahed BV, Kahle KT, Duhaime AC, Sharma N, Eskandar EN. Deep brain stimulation for medically refractory life-threatening status dystonicus in children. J Neurosurg Pediatr. 2012 Jan; 9(1):99-102. PMID: 22208329.
    Citations: 6     Fields:    Translation:Humans
  59. Sengel C, Gavarini S, Sharma N, Ozelius LJ, Bragg DC. Dimerization of the DYT6 dystonia protein, THAP1, requires residues within the coiled-coil domain. J Neurochem. 2011 Sep; 118(6):1087-100. PMID: 21752024.
    Citations: 18     Fields:    Translation:HumansCells
  60. Sharma N, Armata IA, Multhaupt-Buell TJ, Ozelius LJ, Xin W, Sims KB. Mutation in 5' upstream region of GCHI gene causes familial dopa-responsive dystonia. Mov Disord. 2011 Sep; 26(11):2140-1. PMID: 21674621.
    Citations: 3     Fields:    Translation:Humans
  61. Sharma N, Franco RA. Consideration of genetic contributions to the risk for spasmodic dysphonia. Otolaryngol Head Neck Surg. 2011 Sep; 145(3):369-70. PMID: 21636841.
    Citations: 2     Fields:    Translation:Humans
  62. Karakis I, Cole AJ, Hoch DB, Sharma N. Extrapyramidal epilepsy. Epileptic Disord. 2011 Jun; 13(2):181-4. PMID: 21561840.
    Citations:    Fields:    Translation:Humans
  63. Bragg DC, Armata IA, Nery FC, Breakefield XO, Sharma N. Molecular pathways in dystonia. Neurobiol Dis. 2011 May; 42(2):136-47. PMID: 21134457.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  64. Sharma N, Franco RA, Kuster JK, Mitchell AA, Fuchs T, Saunders-Pullman R, Raymond D, Brin MF, Blitzer A, Bressman SB, Ozelius LJ. Genetic evidence for an association of the TOR1A locus with segmental/focal dystonia. Mov Disord. 2010 Oct 15; 25(13):2183-7. PMID: 20669276.
    Citations: 8     Fields:    Translation:Humans
  65. Hewett J, Johanson P, Sharma N, Standaert D, Balcioglu A. Function of dopamine transporter is compromised in DYT1 transgenic animal model in vivo. J Neurochem. 2010 Apr; 113(1):228-35. PMID: 20132487.
    Citations: 26     Fields:    Translation:HumansAnimals
  66. Martella G, Tassone A, Sciamanna G, Platania P, Cuomo D, Viscomi MT, Bonsi P, Cacci E, Biagioni S, Usiello A, Bernardi G, Sharma N, Standaert DG, Pisani A. Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine. Brain. 2009 Sep; 132(Pt 9):2336-49. PMID: 19641103; PMCID: PMC2766181.
    Citations: 94     Fields:    Translation:AnimalsCells
  67. Sciamanna G, Bonsi P, Tassone A, Cuomo D, Tscherter A, Viscomi MT, Martella G, Sharma N, Bernardi G, Standaert DG, Pisani A. Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia. Neurobiol Dis. 2009 Apr; 34(1):133-45. PMID: 19187797.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  68. Sharma, N. Gene Repression or Imprinting: Rett Syndrome. New Encyclopedia of Neuroscience. 2008.
  69. Sharma, N. Effectiveness of Botulinum Toxin in the Treatment of Movement Disorders. Journal Watch Neurology. 2008.
  70. Nutan Sharma. Parkinson's disease. 2008.
  71. Shields DC, Sharma N, Gale JT, Eskandar EN. Pallidal stimulation for dystonia in pantothenate kinase-associated neurodegeneration. Pediatr Neurol. 2007 Dec; 37(6):442-5. PMID: 18021929.
    Citations: 9     Fields:    Translation:Humans
  72. Nutan Sharma. Structural abnormalities in the cerebellum and sensorimotor circuit in writer's cramp. Journal Watch Neurology. 2007; 9(11):88.
  73. Balcioglu A, Kim MO, Sharma N, Cha JH, Breakefield XO, Standaert DG. Dopamine release is impaired in a mouse model of DYT1 dystonia. J Neurochem. 2007 Aug; 102(3):783-8. PMID: 17550429.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  74. Sharma, N. Patient Preference in Botulinum Toxin for Writer’s Cramp. Journal Watch Neurology. 2007; 9(7):49-56.
  75. Pisani A, Martella G, Tscherter A, Bonsi P, Sharma N, Bernardi G, Standaert DG. Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia. Neurobiol Dis. 2006 Nov; 24(2):318-25. PMID: 16934985.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  76. Blood AJ, Tuch DS, Makris N, Makhlouf ML, Sudarsky LR, Sharma N. White matter abnormalities in dystonia normalize after botulinum toxin treatment. Neuroreport. 2006 Aug 21; 17(12):1251-5. PMID: 16951564.
    Citations: 32     Fields:    Translation:HumansCTClinical Trials
  77. Sharma N, Baxter MG, Petravicz J, Bragg DC, Schienda A, Standaert DG, Breakefield XO. Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation. J Neurosci. 2005 Jun 01; 25(22):5351-5. PMID: 15930383; PMCID: PMC6725000.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  78. Jinnah HA, Hess EJ, Ledoux MS, Sharma N, Baxter MG, Delong MR. Rodent models for dystonia research: characteristics, evaluation, and utility. Mov Disord. 2005 Mar; 20(3):283-92. PMID: 15641011.
    Citations: 34     Fields:    Translation:Animals
  79. Sharma N, Richman E. Parkinson's disease and the Family. 2005.
  80. Nutan Sharma,N, Bragg, DC, Peteravicz, J, Standaert, DG, Breakefield, XO. DYT1 Transgenic Mouse. Animal Models of Movement Disorders. 2005.
  81. Sharma N. Dopa-Responsive Dystonia Manifesting as Markedly Different Phenotypes in Monozygotic Twins. Journal Watch Neurology. 2004.
  82. Sharma N. Botulinum Toxin A Reduces Drooling in Neurodegenerative Diseases. Journal Watch Neurology. 2004.
  83. Cole D, Sharma N. Progressive Supranuclear Palsy. Office Practice of Neurology. Samuels MA, Feske S. 2003.
  84. McLean PJ, Kawamata H, Shariff S, Hewett J, Sharma N, Ueda K, Breakefield XO, Hyman BT. TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation. J Neurochem. 2002 Nov; 83(4):846-54. PMID: 12421356.
    Citations: 127     Fields:    Translation:HumansCells
  85. Sharma N, Standaert DG. Inherited movement disorders. Neurol Clin. 2002 Aug; 20(3):759-78, vii. PMID: 12432829.
    Citations: 1     Fields:    Translation:HumansCells
  86. Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik KS. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol. 2002 May; 160(5):1655-67. PMID: 12000718; PMCID: PMC1850875.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  87. Bhushan V, Pall V, Le T, Nguyen H, Sharma N. Blackwell's Underground Clinical Vignettes, Neurology. 2002.
  88. Sharma N. Parkinson's. Essentials of Outpatient Rehabilitation. Frontera WR, Silver J. 2002.
  89. Sharma N, Schwarzschild M. Movement Disorders in Pregnancy. Neurological Therapeutics: Principles and Practice. Noseworthy JH, Samuels MA. 2002.
  90. Kanthasamy AG, Sharma N, Kirby ML, Schwaraschild M. Neuroprotective Strategies in Parkinson's Disease. Neuroprotection. Marwah J, Lo EH. 2002; 603-640.
  91. Sharma N, McLean PJ, Kawamata H, Irizarry MC, Hyman BT. Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies. Acta Neuropathol. 2001 Oct; 102(4):329-34. PMID: 11603807.
    Citations: 9     Fields:    Translation:HumansCells
  92. Sharma N, Hewett J, Ozelius LJ, Ramesh V, McLean PJ, Breakefield XO, Hyman BT. A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study. Am J Pathol. 2001 Jul; 159(1):339-44. PMID: 11438481; PMCID: PMC1850427.
    Citations: 27     Fields:    Translation:HumansCells
  93. Kawamata H, McLean PJ, Sharma N, Hyman BT. Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations. J Neurochem. 2001 May; 77(3):929-34. PMID: 11331421.
    Citations: 15     Fields:    Translation:HumansCells
  94. Sharma N, Nguyen H, Amin C, Le T, Bhushan V. Neurology Classic Clinical Cases for USMLE Step 2 and Clerkship Review. 2000.
  95. Sharma N. Neurology. First Aid for the USMLE Step 2, Le T, Amin C, Bhusan V, Berkeley R, Levine R, Ruiz D. 1999.
  96. Sharma N, D'Arcangelo G, Kleinlaus A, Halegoua S, Trimmer JS. Nerve growth factor regulates the abundance and distribution of K+ channels in PC12 cells. J Cell Biol. 1993 Dec; 123(6 Pt 2):1835-43. PMID: 8276901; PMCID: PMC2290858.
    Citations: 21     Fields:    Translation:AnimalsCells
  97. Sharma N. Characterization of Kv2.1 in PC12 cells. 1993.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.