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April Fitzsimmons Eichler, M.D.

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  1. R21CA135605 (EICHLER, APRIL FITZSIMMONS) Jul 16, 2009 - Jun 30, 2011
    NIH
    A phase Ib/II study of AZD2171 and radiation for new brain metastases from NSCLC
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Brastianos PK, Kim AE, Giobbie-Hurder A, Lee EQ, Wang N, Eichler AF, Chukwueke U, Forst DA, Arrillaga-Romany IC, Dietrich J, Corbin Z, Moliterno J, Baehring J, White M, Lou KW, Larson J, de Sauvage MA, Evancic K, Mora J, Nayyar N, Loeffler J, Oh K, Shih HA, Curry WT, Cahill DP, Barker FG, Gerstner ER, Santagata S. Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas. Nat Commun. 2022 03 14; 13(1):1325. PMID: 35289329; PMCID: PMC8921328.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  2. Brastianos PK, Strickland MR, Lee EQ, Wang N, Cohen JV, Chukwueke U, Forst DA, Eichler A, Overmoyer B, Lin NU, Chen WY, Bardia A, Juric D, Dagogo-Jack I, White MD, Dietrich J, Nayyar N, Kim AE, Alvarez-Breckenridge C, Mahar M, Mora JL, Nahed BV, Jones PS, Shih HA, Gerstner ER, Giobbie-Hurder A, Carter SL, Oh K, Cahill DP, Sullivan RJ. Phase II study of ipilimumab and nivolumab in leptomeningeal carcinomatosis. Nat Commun. 2021 10 12; 12(1):5954. PMID: 34642329.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  3. Dietrich J, Versmee L, Drappatz J, Eichler AF, Nayak L, Norden A, Wong E, Pisapia MR, Jones SS, Gordon AB, Chabner BA, Hochberg F, Batchelor TT. Pemetrexed in Recurrent or Progressive Central Nervous System Lymphoma: A Phase I Multicenter Clinical Trial. Oncologist. 2020 09; 25(9):747-e1273. PMID: 32520407; PMCID: PMC7485351.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  4. Blakeley JO, Grossman SA, Chi AS, Mikkelsen T, Rosenfeld MR, Ahluwalia MS, Nabors LB, Eichler A, Ribas IG, Desideri S, Ye X. Phase II Study of Iniparib with Concurrent Chemoradiation in Patients with Newly Diagnosed Glioblastoma. Clin Cancer Res. 2019 01 01; 25(1):73-79. PMID: 30131387; PMCID: PMC6367923.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  5. Andronesi OC, Esmaeili M, Borra RJH, Emblem K, Gerstner ER, Pinho MC, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Ivy SP, Wen PY, Duda DG, Jain R, Rosen BR, Sorensen GA, Batchelor TT. Early changes in glioblastoma metabolism measured by MR spectroscopic imaging during combination of anti-angiogenic cediranib and chemoradiation therapy are associated with survival. NPJ Precis Oncol. 2017; 1. PMID: 29202103; PMCID: PMC5708878.
    Citations: 9     
  6. Tao Y, Eichler A, Holzherr T, Degen CL. Ultrasensitive mechanical detection of magnetic moment using a commercial disk drive write head. Nat Commun. 2016 09 20; 7:12714. PMID: 27647039.
    Citations: 5     Fields:    
  7. Ho AL, Koch MJ, Tanaka S, Eichler AF, Batchelor TT, Tanboon J, Louis DN, Cahill DP, Chi AS, Curry WT. Impact of histopathological transformation and overall survival in patients with progressive anaplastic glioma. J Clin Neurosci. 2016 Sep; 31:99-105. PMID: 27279154.
    Citations: 5     Fields:    Translation:Humans
  8. Chheda MG, Wen PY, Hochberg FH, Chi AS, Drappatz J, Eichler AF, Yang D, Beroukhim R, Norden AD, Gerstner ER, Betensky RA, Batchelor TT. Vandetanib plus sirolimus in adults with recurrent glioblastoma: results of a phase I and dose expansion cohort study. J Neurooncol. 2015 Feb; 121(3):627-34. PMID: 25503302; PMCID: PMC4324090.
    Citations: 16     Fields:    Translation:HumansCTClinical Trials
  9. Panageas KS, Reiner AS, Iwamoto FM, Cloughesy TF, Aldape KD, Rivera AL, Eichler AF, Louis DN, Paleologos NA, Fisher BJ, Ashby LS, Cairncross JG, Urgoiti GB, Wen PY, Ligon KL, Schiff D, Robins HI, Rocque BG, Chamberlain MC, Mason WP, Weaver SA, Green RM, Kamar FG, Abrey LE, DeAngelis LM, Jhanwar SC, Rosenblum MK, Lassman AB. Recursive partitioning analysis of prognostic variables in newly diagnosed anaplastic oligodendroglial tumors. Neuro Oncol. 2014 Nov; 16(11):1541-6. PMID: 24997140.
    Citations: 7     Fields:    Translation:HumansCells
  10. Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen B, Loeffler JS, Wen PY, Sorensen AG, Jain RK. Increased perfusion due to vascular normalization improves oxygenation and survival in glioblastoma patients treated with cediranib with or without chemoradiation. Neuro Oncol. 2014 Jul; 16 Suppl 3:iii12. PMID: 25165209.
    Citations:    
  11. Peereboom DM, Murphy C, Ahluwalia MS, Conlin A, Eichler A, Van Poznak C, Baar J, Elson P, Seidman AD. Phase II trial of patupilone in patients with brain metastases from breast cancer. Neuro Oncol. 2014 Apr; 16(4):579-83. PMID: 24470546.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  12. Lin NU, Freedman RA, Ramakrishna N, Younger J, Storniolo AM, Bellon JR, Come SE, Gelman RS, Harris GJ, Henderson MA, Macdonald SM, Mahadevan A, Eisenberg E, Ligibel JA, Mayer EL, Moy B, Eichler AF, Winer EP. A phase I study of lapatinib with whole brain radiotherapy in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer brain metastases. Breast Cancer Res Treat. 2013 Nov; 142(2):405-14. PMID: 24197661.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  13. Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen BR, Loeffler JS, Wen PY, Sorensen AG, Jain RK. Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19059-64. PMID: 24190997.
    Citations: 178     Fields:    Translation:HumansCTClinical Trials
  14. Lu-Emerson C, Snuderl M, Kirkpatrick ND, Goveia J, Davidson C, Huang Y, Riedemann L, Taylor J, Ivy P, Duda DG, Ancukiewicz M, Plotkin SR, Chi AS, Gerstner ER, Eichler AF, Dietrich J, Stemmer-Rachamimov AO, Batchelor TT, Jain RK. Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma. Neuro Oncol. 2013 Aug; 15(8):1079-87. PMID: 23828240.
    Citations: 110     Fields:    Translation:HumansCells
  15. Drappatz J, Brenner A, Wong ET, Eichler A, Schiff D, Groves MD, Mikkelsen T, Rosenfeld S, Sarantopoulos J, Meyers CA, Fielding RM, Elian K, Wang X, Lawrence B, Shing M, Kelsey S, Castaigne JP, Wen PY. Phase I study of GRN1005 in recurrent malignant glioma. Clin Cancer Res. 2013 Mar 15; 19(6):1567-76. PMID: 23349317.
    Citations: 48     Fields:    Translation:HumansCTClinical Trials
  16. Eichler A, Moser J, Dykman MI, Bachtold A. Symmetry breaking in a mechanical resonator made from a carbon nanotube. Nat Commun. 2013; 4:2843. PMID: 24270088.
    Citations: 4     Fields:    
  17. Volandes AE, Paasche-Orlow MK, Mitchell SL, El-Jawahri A, Davis AD, Barry MJ, Hartshorn KL, Jackson VA, Gillick MR, Walker-Corkery ES, Chang Y, López L, Kemeny M, Bulone L, Mann E, Misra S, Peachey M, Abbo ED, Eichler AF, Epstein AS, Noy A, Levin TT, Temel JS. Randomized controlled trial of a video decision support tool for cardiopulmonary resuscitation decision making in advanced cancer. J Clin Oncol. 2013 Jan 20; 31(3):380-6. PMID: 23233708.
    Citations: 59     Fields:    Translation:Humans
  18. Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, Tannous BA, Eichler AF, Fukumura D, Engelman JA, Jain RK. Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):E3119-27. PMID: 23071298.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  19. Panageas KS, Iwamoto FM, Cloughesy TF, Aldape KD, Rivera AL, Eichler AF, Louis DN, Paleologos NA, Fisher BJ, Ashby LS, Cairncross JG, Roldán Urgoiti GB, Wen PY, Ligon KL, Schiff D, Robins HI, Rocque BG, Chamberlain MC, Mason WP, Weaver SA, Green RM, Kamar FG, Abrey LE, Deangelis LM, Jhanwar SC, Rosenblum MK, Lassman AB. Initial treatment patterns over time for anaplastic oligodendroglial tumors. Neuro Oncol. 2012 Jun; 14(6):761-7. PMID: 22661585.
    Citations: 22     Fields:    Translation:HumansCells
  20. Lu-Emerson C, Eichler AF. Brain metastases. Continuum (Minneap Minn). 2012 Apr; 18(2):295-311. PMID: 22810128.
    Citations: 28     Fields:    Translation:Humans
  21. Lassman AB, Iwamoto FM, Cloughesy TF, Aldape KD, Rivera AL, Eichler AF, Louis DN, Paleologos NA, Fisher BJ, Ashby LS, Cairncross JG, Roldán GB, Wen PY, Ligon KL, Schiff D, Robins HI, Rocque BG, Chamberlain MC, Mason WP, Weaver SA, Green RM, Kamar FG, Abrey LE, DeAngelis LM, Jhanwar SC, Rosenblum MK, Panageas KS. International retrospective study of over 1000 adults with anaplastic oligodendroglial tumors. Neuro Oncol. 2011 Jun; 13(6):649-59. PMID: 21636710.
    Citations: 66     Fields:    Translation:HumansCells
  22. Eichler AF, Chung E, Kodack DP, Loeffler JS, Fukumura D, Jain RK. The biology of brain metastases-translation to new therapies. Nat Rev Clin Oncol. 2011 Jun; 8(6):344-56. PMID: 21487419.
    Citations: 206     Fields:    Translation:HumansAnimals
  23. Gerstner ER, Eichler AF, Plotkin SR, Drappatz J, Doyle CL, Xu L, Duda DG, Wen PY, Jain RK, Batchelor TT. Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide. J Neurooncol. 2011 Jun; 103(2):325-32. PMID: 20821342.
    Citations: 43     Fields:    Translation:HumansCTClinical Trials
  24. Eichler AF, Kahle KT, Wang DL, Joshi VA, Willers H, Engelman JA, Lynch TJ, Sequist LV. EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer. Neuro Oncol. 2010 Nov; 12(11):1193-9. PMID: 20627894.
    Citations: 132     Fields:    Translation:Humans
  25. Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, Eichler AF, Drappatz J, Hochberg FH, Benner T, Louis DN, Cohen KS, Chea H, Exarhopoulos A, Loeffler JS, Moses MA, Ivy P, Sorensen AG, Wen PY, Jain RK. Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol. 2010 Jun 10; 28(17):2817-23. PMID: 20458050.
    Citations: 230     Fields:    Translation:HumansCTClinical Trials
  26. El-Jawahri A, Podgurski LM, Eichler AF, Plotkin SR, Temel JS, Mitchell SL, Chang Y, Barry MJ, Volandes AE. Use of video to facilitate end-of-life discussions with patients with cancer: a randomized controlled trial. J Clin Oncol. 2010 Jan 10; 28(2):305-10. PMID: 19949010.
    Citations: 92     Fields:    Translation:Humans
  27. Costello DJ, Eichler AF, Eichler FS. Leukodystrophies: classification, diagnosis, and treatment. Neurologist. 2009 Nov; 15(6):319-28. PMID: 19901710.
    Citations: 34     Fields:    Translation:HumansCells
  28. Snuderl M, Eichler AF, Ligon KL, Vu QU, Silver M, Betensky RA, Ligon AH, Wen PY, Louis DN, Iafrate AJ. Polysomy for chromosomes 1 and 19 predicts earlier recurrence in anaplastic oligodendrogliomas with concurrent 1p/19q loss. Clin Cancer Res. 2009 Oct 15; 15(20):6430-7. PMID: 19808867.
    Citations: 38     Fields:    Translation:HumansCells
  29. Eichler AF, Lamont EB. Utility of administrative claims data for the study of brain metastases: a validation study. J Neurooncol. 2009 Dec; 95(3):427-431. PMID: 19562256.
    Citations: 34     Fields:    Translation:Humans
  30. Batchelor TT, Eichler AF, Plotkin SR, Drappatz J, Wen P, Sorensen AG, Gerstner ER. Phase I trial of vatalanib (PTK787) in combination with standard radiation and temozolomide in patients with newly diagnosed glioblastoma. American Society of Clinical Oncology Annual Meeting, Orlando, FL. 2009.
  31. Chi AS, Gerstner ER, Eichler AF, Chea HK, Drappatz J, Wen PY, Ivy SP, Loeffler JS, Sorensen AG, Jain RK, Batchelor TT. Phase Ib study of cediranib in combination with daily temozolomide and radiation in patients with newly diagnosed glioblastoma. American Society of Clinical Oncology Annual Meeting, Orlando, FL. 2009.
  32. Chi AS, Gerstner ER, Eichler AF, Chea HK, Drappatz J, Wen PY, Ivy SP, Loeffler JS, Sorensen AG, Jain RK, Batchelor TT. Phase Ib study of cediranib in combination with daily temozolomide and radiation in patients with newly diagnosed glioblastoma. J Clin Oncol. 2009 May 20; 27(15_suppl):e13010. PMID: 27962847.
    Citations:    
  33. Batchelor T, Eichler AF, Plotkin SR, Drappatz J, Wen P, Sorensen AG, Gerstner E. Phase I trial of vatalanib (PTK787) in combination with standard radiation and temozolomide in patients with newly diagnosed glioblastoma. J Clin Oncol. 2009 May 20; 27(15_suppl):2035. PMID: 27964624.
    Citations:    
  34. Eichler AF. Neuro-Oncology Book Review: Cancer Neurology in Clinical Practice. Lancet Neurology. 2009; 18(1):36.
  35. Eichler AF, Plotkin SR. Brain metastases. Curr Treat Options Neurol. 2008 Jul; 10(4):308-14. PMID: 18579017.
    Citations: 7     
  36. Eichler AF, Kuter I, Ryan P, Schapira L, Younger J, Henson JW. Survival in patients with brain metastases from breast cancer: the importance of HER-2 status. Cancer. 2008 Jun; 112(11):2359-67. PMID: 18361426.
    Citations: 67     Fields:    Translation:HumansCTClinical Trials
  37. Eichler AF, Lamont EB. Measuring the occurence and timing of brain metastsaes using administrative ICD-9 codes. Society of Neuro-Oncology 13th Annual Meeting, Las Vegas, NV. 2008.
  38. Eichler A, Kuter I, Ryan P, Schapira L, Younger J, Henson J. HER2 Status Predicts Survival After Diagnosis of Brain Metastasis in Breast Cancer. Society of Neuro-Oncology 12th Annual Meeting, Dallas, TX. 2007.
  39. Eichler AF, Loeffler JS. Multidisciplinary management of brain metastases. Oncologist. 2007 Jul; 12(7):884-98. PMID: 17673619.
    Citations: 128     Fields:    Translation:Humans
  40. Eichler AF, Batchelor TT, Henson JW. Diffusion and perfusion imaging in subacute neurotoxicity following high-dose intravenous methotrexate. Neuro Oncol. 2007 Jul; 9(3):373-7. PMID: 17522329; PMCID: PMC1907407.
    Citations: 8     Fields:    Translation:Humans
  41. Fitzsimmons AL, Batchelor TT. Primary and Metastatic Brain Tumors. Handbook of Cancer Chemotherapy, RT Skeel, ed. 2007; (in press).
  42. Fitzsimmons AL, Wen PY. Tumors of the Spinal Cord. Neurology and Clinical Neuroscience, Anthony H. V. Schapira, ed. 2007; 1341-1352.
  43. Eichler AF, Plotkin SR. Metastatic Brain Tumors. Harrison's Manual of Oncology, BA Chabner, TJ Lynch, DL Longo, eds. 2007; (in press).
  44. Fitzsimmons AL, Batchelor T, O'Neill AM, Henson JW. Secondary acute myelogenous leukemia in three patients treated with temozolomide for glial neoplasm. Society of Neuro-Oncology 11th Annual Meeting, Orlando, FL. 2006; 8(4):391-500.
  45. Eichler AF, Batchelor TT. Primary central nervous system lymphoma: presentation, diagnosis and staging. Neurosurg Focus. 2006 Nov 15; 21(5):E15. PMID: 17134117.
    Citations: 22     Fields:    Translation:Humans
  46. Fitzsimmons A, Upchurch K, Batchelor T. Clinical features and diagnosis of primary central nervous system lymphoma. Hematol Oncol Clin North Am. 2005 Aug; 19(4):689-703, vii. PMID: 16083830.
    Citations: 10     Fields:    Translation:Humans
  47. Smith EE, Fitzsimmons AL, Nogueira RG, Singhal AB. Spontaneous hyperacute postischemic hemorrhage leading to death. J Neuroimaging. 2004 Oct; 14(4):361-4. PMID: 15358958.
    Citations: 3     Fields:    Translation:Humans
  48. Fitzsimmons AL, Hochberg FH. Cognitive dysfunction in primary CNS lymphoma survivors. Journal Watch Neurology. 2004; 6(9):70.
  49. Webber SA, Bentlejeweski C, Boyle GH, Law Y, Bowman P, Miller SA, Gribar S, Fitzsimmons A, McCurry K, Murali S, Griffith B, Zeevi A. Indirect alloresponses are more pronounced in non-rejecting lung than heart allografts. J Heart Lung Transplant. 2001; 20(2):165-166.
  50. Zhong XY, Kaul S, Lin YS, Eichler A, Bastert G. Sensitive detection of micrometastases in bone marrow from patients with breast cancer using immunomagnetic isolation of tumor cells in combination with reverse transcriptase/polymerase chain reaction for cytokeratin-19. J Cancer Res Clin Oncol. 2000 Apr; 126(4):212-8. PMID: 10782894.
    Citations: 4     Fields:    Translation:HumansCells
  51. Zhong XY, Kaul S, Eichler A, Bastert G. Evaluating GA733-2 mRNA as a marker for the detection of micrometastatic breast cancer in peripheral blood and bone marrow. Arch Gynecol Obstet. 1999 Nov; 263(1-2):2-6. PMID: 10728619.
    Citations: 8     Fields:    Translation:HumansCells
  52. Webber SA, Dickman P, Fitzsimmons A, Michaels M, Fricker J, Wollman M, Law Y, Miller S, Jaffe R, Boyle G. Late Onset Lymphoproliferative Disorders in Pediatric Thoracic Transplantation. Americal Heart Association. 1999.
  53. Webber SA, Rowe D, Boyle G, Michaels M, Fitzsimmons A, Law Y, Miller S, Green M, Kurland G, Bentlejeweski C, Zeevi A, Qu L . Natural History of Epstein-Barr Virus Load in Pediatric Thoracic Recipients with Post-transplant Lymphoproliferative Disorders and Other Primary EBV Infections. American Society of Transplantation. 1999.
  54. Webber SA, Bentlejeweski C, Fitzsimmons A, Boyle G, McCurry K, Murali S, Pham S, Kurland G, Griffith B, Zeevi A . Indirect Allorecognition in Quiescent Pediatric and Adult Thoracic Allografts. American Society of Transplantation. 1999.
  55. Webber SA, Fitzsimmons A, Qu L, Boyle G, Law Y, Miller S, Michaels M, Green M, Kurland G, Pigula F, Griffith B, Zeevi A, Rowe D . Evaluation of Circulating Epstein-Barr Viral Load in Pediatric Thoracic Recipients: Implications for Diagnosis of Post-transplant Lymphoproliferative Disorder. International Society for Heart and Lung Transplantation. 1999.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.