Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

William Taylor Kimberly, Ph.D., M.D.


This page shows the publications co-authored by William Kimberly and Dennis Selkoe.
Connection Strength

  1. Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation. J Neurosci. 2005 Jun 08; 25(23):5533-43.
    View in: PubMed
    Score: 0.324
  2. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6382-7.
    View in: PubMed
    Score: 0.280
  3. Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation. J Biol Chem. 2002 Sep 20; 277(38):35113-7.
    View in: PubMed
    Score: 0.265
  4. The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem. 2001 Oct 26; 276(43):40288-92.
    View in: PubMed
    Score: 0.250
  5. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. J Biol Chem. 2000 Feb 04; 275(5):3173-8.
    View in: PubMed
    Score: 0.224
  6. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. J Biol Chem. 2003 Sep 26; 278(39):37213-22.
    View in: PubMed
    Score: 0.071
  7. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s). Biochemistry. 2003 Jan 14; 42(1):137-44.
    View in: PubMed
    Score: 0.069
  8. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):9299-304.
    View in: PubMed
    Score: 0.058
  9. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. 1999 Apr 08; 398(6727):513-7.
    View in: PubMed
    Score: 0.053
  10. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Biochemistry. 1998 Nov 24; 37(47):16465-71.
    View in: PubMed
    Score: 0.051
  11. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2720-5.
    View in: PubMed
    Score: 0.016
  12. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nat Cell Biol. 2000 Jul; 2(7):428-34.
    View in: PubMed
    Score: 0.014
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.