Harvard Catalyst Profiles

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Diane Elizabeth Handy, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P50HL055001 (GAVRAS, HARALAMBOS GAVRAS) Feb 1, 1996 - Jul 31, 2006
    Role: Co-Principal Investigator
  2. R29HL048181 (HANDY, DIANE E) Jan 1, 1993 - Dec 31, 1997
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Handy DE, Loscalzo J. The role of glutathione peroxidase-1 in health and disease. Free Radic Biol Med. 2022 08 01; 188:146-161. PMID: 35691509; PMCID: PMC9586416.
    Citations:    Fields:    Translation:Animals
  2. Paci P, Fiscon G, Conte F, Wang RS, Handy DE, Farina L, Loscalzo J. Comprehensive network medicine-based drug repositioning via integration of therapeutic efficacy and side effects. NPJ Syst Biol Appl. 2022 04 20; 8(1):12. PMID: 35443763; PMCID: PMC9021283.
    Citations: 1     Fields:    Translation:Humans
  3. Lee LY, Oldham WM, He H, Wang R, Mulhern R, Handy DE, Loscalzo J. Interferon-? Impairs Human Coronary Artery Endothelial Glucose Metabolism by Tryptophan Catabolism and Activates Fatty Acid Oxidation. Circulation. 2021 11 16; 144(20):1612-1628. PMID: 34636650; PMCID: PMC8595869.
    Citations: 3     Fields:    Translation:HumansCells
  4. Handy DE, Joseph J, Loscalzo J. Selenium, a Micronutrient That Modulates Cardiovascular Health via Redox Enzymology. Nutrients. 2021 Sep 17; 13(9). PMID: 34579115.
    Citations: 4     Fields:    Translation:HumansCells
  5. Joseph J, Giczewska A, Alhanti B, Cheema AK, Handy DE, Mann DL, Loscalzo J, Givertz MM. Associations of methyl donor and methylation inhibitor levels during anti-oxidant therapy in heart failure. J Physiol Biochem. 2021 May; 77(2):295-304. PMID: 33595776; PMCID: PMC8295059.
    Citations:    Fields:    Translation:HumansCells
  6. An X, Ogawa-Wong A, Carmody C, Ambrosio R, Cicatiello AG, Luongo C, Salvatore D, Handy DE, Larsen PR, Wajner SM, Dentice M, Zavacki AM. A Type 2 Deiodinase-Dependent Increase in Vegfa Mediates Myoblast-Endothelial Cell Crosstalk During Skeletal Muscle Regeneration. Thyroid. 2021 01; 31(1):115-127. PMID: 32787533.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  7. Cheng F, Lu W, Liu C, Fang J, Hou Y, Handy DE, Wang R, Zhao Y, Yang Y, Huang J, Hill DE, Vidal M, Eng C, Loscalzo J. A genome-wide positioning systems network algorithm for in silico drug repurposing. Nat Commun. 2019 08 02; 10(1):3476. PMID: 31375661.
    Citations: 64     Fields:    Translation:HumansCells
  8. Wang M, Hu J, Yan L, Yang Y, He M, Wu M, Li Q, Gong W, Yang Y, Wang Y, Handy DE, Lu B, Hao C, Wang Q, Li Y, Hu R, Stanton RC, Zhang Z. High glucose-induced ubiquitination of G6PD leads to the injury of podocytes. FASEB J. 2019 05; 33(5):6296-6310. PMID: 30785802.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  9. Cheng F, Desai RJ, Handy DE, Wang R, Schneeweiss S, Barabási AL, Loscalzo J. Network-based approach to prediction and population-based validation of in silico drug repurposing. Nat Commun. 2018 07 12; 9(1):2691. PMID: 30002366.
    Citations: 149     Fields:    Translation:Humans
  10. Pang P, Abbott M, Abdi M, Fucci QA, Chauhan N, Mistri M, Proctor B, Chin M, Wang B, Yin W, Lu TS, Halim A, Lim K, Handy DE, Loscalzo J, Siedlecki AM. Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function. Nephrol Dial Transplant. 2018 06 01; 33(6):923-934. PMID: 29244159; PMCID: PMC5982720.
    Citations: 10     Fields:    Translation:Animals
  11. Xiao W, Wang RS, Handy DE, Loscalzo J. NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism. Antioxid Redox Signal. 2018 Jan 20; 28(3):251-272. PMID: 28648096; PMCID: PMC5737637.
    Citations: 161     Fields:    Translation:HumansAnimalsCells
  12. Zarrabi AJ, Kao D, Nguyen DT, Loscalzo J, Handy DE. Hypoxia-induced suppression of c-Myc by HIF-2a in human pulmonary endothelial cells attenuates TFAM expression. Cell Signal. 2017 10; 38:230-237. PMID: 28709643; PMCID: PMC5568858.
    Citations: 9     Fields:    Translation:HumansCells
  13. Handy DE, Loscalzo J. Responses to reductive stress in the cardiovascular system. Free Radic Biol Med. 2017 08; 109:114-124. PMID: 27940350; PMCID: PMC5462861.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  14. Mirzakhani H, Litonjua AA, McElrath TF, O'Connor G, Lee-Parritz A, Iverson R, Macones G, Strunk RC, Bacharier LB, Zeiger R, Hollis BW, Handy DE, Sharma A, Laranjo N, Carey V, Qiu W, Santolini M, Liu S, Chhabra D, Enquobahrie DA, Williams MA, Loscalzo J, Weiss ST. Early pregnancy vitamin D status and risk of preeclampsia. J Clin Invest. 2016 12 01; 126(12):4702-4715. PMID: 27841759; PMCID: PMC5127689.
    Citations: 49     Fields:    Translation:Humans
  15. Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Köhrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovic M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y. Selenoprotein Gene Nomenclature. J Biol Chem. 2016 Nov 11; 291(46):24036-24040. PMID: 27645994.
    Citations: 84     Fields:    Translation:Humans
  16. Zang T, Pottenplackel LP, Handy DE, Loscalzo J, Dai S, Deth RC, Zhou ZS, Ma J. Comparison of Protein N-Homocysteinylation in Rat Plasma under Elevated Homocysteine Using a Specific Chemical Labeling Method. Molecules. 2016 Sep 08; 21(9). PMID: 27617989.
    Citations: 2     Fields:    Translation:AnimalsCells
  17. Garmaroudi FS, Handy DE, Liu YY, Loscalzo J. Systems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case. PLoS Comput Biol. 2016 Mar; 12(3):e1004822. PMID: 26985825.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  18. Barroso M, Kao D, Blom HJ, Tavares de Almeida I, Castro R, Loscalzo J, Handy DE. S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation. Biochim Biophys Acta. 2016 01; 1862(1):82-92. PMID: 26506125; PMCID: PMC4674364.
    Citations: 28     Fields:    Translation:HumansCells
  19. Loscalzo J, Handy DE. Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series). Pulm Circ. 2014 Jun; 4(2):169-74. PMID: 25006435.
    Citations: 50     
  20. Barroso M, Florindo C, Kalwa H, Silva Z, Turanov AA, Carlson BA, de Almeida IT, Blom HJ, Gladyshev VN, Hatfield DL, Michel T, Castro R, Loscalzo J, Handy DE. Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression. J Biol Chem. 2014 May 30; 289(22):15350-62. PMID: 24719327.
    Citations: 20     Fields:    Translation:HumansCells
  21. Handy DE, Loscalzo J, Leopold JA. Systems analysis of oxidant stress in the vasculature. IUBMB Life. 2013 Nov; 65(11):911-20. PMID: 24265198.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  22. Yin T, Bader AR, Hou TK, Maron BA, Kao DD, Qian R, Kohane DS, Handy DE, Loscalzo J, Zhang YY. SDF-1a in glycan nanoparticles exhibits full activity and reduces pulmonary hypertension in rats. Biomacromolecules. 2013 Nov 11; 14(11):4009-20. PMID: 24059347.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  23. Kao DD, Oldebeken SR, Rai A, Lubos E, Leopold JA, Loscalzo J, Handy DE. Tumor necrosis factor-a-mediated suppression of dual-specificity phosphatase 4: crosstalk between NF?B and MAPK regulates endothelial cell survival. Mol Cell Biochem. 2013 Oct; 382(1-2):153-62. PMID: 23812841.
    Citations: 10     Fields:    Translation:HumansCells
  24. Balderman JA, Lee HY, Mahoney CE, Handy DE, White K, Annis S, Lebeche D, Hajjar RJ, Loscalzo J, Leopold JA. Bone morphogenetic protein-2 decreases microRNA-30b and microRNA-30c to promote vascular smooth muscle cell calcification. J Am Heart Assoc. 2012 Dec; 1(6):e003905. PMID: 23316327.
    Citations: 65     Fields:    Translation:HumansCells
  25. Zhang Z, Yang Z, Zhu B, Hu J, Liew CW, Zhang Y, Leopold JA, Handy DE, Loscalzo J, Stanton RC. Increasing glucose 6-phosphate dehydrogenase activity restores redox balance in vascular endothelial cells exposed to high glucose. PLoS One. 2012; 7(11):e49128. PMID: 23185302.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  26. Metes-Kosik N, Luptak I, Dibello PM, Handy DE, Tang SS, Zhi H, Qin F, Jacobsen DW, Loscalzo J, Joseph J. Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. Mol Nutr Food Res. 2012 Dec; 56(12):1812-24. PMID: 23097236.
    Citations: 24     Fields:    Translation:AnimalsCells
  27. Maron BA, Zhang YY, White K, Chan SY, Handy DE, Mahoney CE, Loscalzo J, Leopold JA. Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension. Circulation. 2012 Aug 21; 126(8):963-74. PMID: 22787113; PMCID: PMC3534848.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  28. Handy DE, Loscalzo J. Redox regulation of mitochondrial function. Antioxid Redox Signal. 2012 Jun 01; 16(11):1323-67. PMID: 22146081.
    Citations: 170     Fields:    Translation:HumansAnimalsCells
  29. Wang X, Cui L, Joseph J, Jiang B, Pimental D, Handy DE, Liao R, Loscalzo J. Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress. J Mol Cell Cardiol. 2012 Mar; 52(3):753-60. PMID: 22227328.
    Citations: 36     Fields:    Translation:AnimalsCells
  30. Malinouski M, Kehr S, Finney L, Vogt S, Carlson BA, Seravalli J, Jin R, Handy DE, Park TJ, Loscalzo J, Hatfield DL, Gladyshev VN. High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3. Antioxid Redox Signal. 2012 Feb 01; 16(3):185-92. PMID: 21854231.
    Citations: 15     Fields:    Translation:Animals
  31. Liberman M, Johnson RC, Handy DE, Loscalzo J, Leopold JA. Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification. Biochem Biophys Res Commun. 2011 Sep 30; 413(3):436-41. PMID: 21907184; PMCID: PMC3197703.
    Citations: 49     Fields:    Translation:HumansCells
  32. Lubos E, Kelly NJ, Oldebeken SR, Leopold JA, Zhang YY, Loscalzo J, Handy DE. Glutathione peroxidase-1 deficiency augments proinflammatory cytokine-induced redox signaling and human endothelial cell activation. J Biol Chem. 2011 Oct 14; 286(41):35407-35417. PMID: 21852236.
    Citations: 31     Fields:    Translation:HumansCells
  33. Zhang J, Handy DE, Wang Y, Bouchard G, Selhub J, Loscalzo J, Carey MC. Hyperhomocysteinemia from trimethylation of hepatic phosphatidylethanolamine during cholesterol cholelithogenesis in inbred mice. Hepatology. 2011 Aug; 54(2):697-706. PMID: 21567442.
    Citations: 2     Fields:    Translation:AnimalsCells
  34. Handy DE, Castro R, Loscalzo J. Epigenetic modifications: basic mechanisms and role in cardiovascular disease. Circulation. 2011 May 17; 123(19):2145-56. PMID: 21576679; PMCID: PMC3107542.
    Citations: 243     Fields:    Translation:HumansCells
  35. Jin RC, Mahoney CE, Coleman Anderson L, Ottaviano F, Croce K, Leopold JA, Zhang YY, Tang SS, Handy DE, Loscalzo J. Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo. Circulation. 2011 May 10; 123(18):1963-73. PMID: 21518981; PMCID: PMC3107543.
    Citations: 47     Fields:    Translation:AnimalsCells
  36. Lubos E, Loscalzo J, Handy DE. Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2011 Oct 01; 15(7):1957-97. PMID: 21087145.
    Citations: 314     Fields:    Translation:HumansAnimalsCells
  37. Labunskyy VM, Lee BC, Handy DE, Loscalzo J, Hatfield DL, Gladyshev VN. Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice. Antioxid Redox Signal. 2011 Jun 15; 14(12):2327-36. PMID: 21194350.
    Citations: 69     Fields:    Translation:HumansAnimals
  38. Michas G, Liberman M, Becker KC, Handy DE, Loscalzo J, Leopold JA. Reciprocal regulation of 11ß-hydroxysteroid dehydrogenase 1 and glucocorticoid receptor expression by dexamethasone inhibits human coronary artery smooth muscle cell proliferation in vitro. Mol Cell Biochem. 2011 Jan; 346(1-2):69-79. PMID: 20922465.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  39. Lubos E, Mahoney CE, Leopold JA, Zhang YY, Loscalzo J, Handy DE. Glutathione peroxidase-1 modulates lipopolysaccharide-induced adhesion molecule expression in endothelial cells by altering CD14 expression. FASEB J. 2010 Jul; 24(7):2525-32. PMID: 20219985; PMCID: PMC2887263.
    Citations: 16     Fields:    Translation:HumansCells
  40. Zhang Z, Liew CW, Handy DE, Zhang Y, Leopold JA, Hu J, Guo L, Kulkarni RN, Loscalzo J, Stanton RC. High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis. FASEB J. 2010 May; 24(5):1497-505. PMID: 20032314.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  41. Xu Y, Zhang Z, Hu J, Stillman IE, Leopold JA, Handy DE, Loscalzo J, Stanton RC. Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria. FASEB J. 2010 Feb; 24(2):609-16. PMID: 19805580.
    Citations: 30     Fields:    Translation:AnimalsCells
  42. Lim CC, Bryan NS, Jain M, Garcia-Saura MF, Fernandez BO, Sawyer DB, Handy DE, Loscalzo J, Feelisch M, Liao R. Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms. Am J Physiol Heart Circ Physiol. 2009 Dec; 297(6):H2144-53. PMID: 19801492.
    Citations: 15     Fields:    Translation:AnimalsCells
  43. Jahangir E, Vita JA, Handy D, Holbrook M, Palmisano J, Beal R, Loscalzo J, Eberhardt RT. The effect of L-arginine and creatine on vascular function and homocysteine metabolism. Vasc Med. 2009 Aug; 14(3):239-48. PMID: 19651674.
    Citations: 21     Fields:    Translation:Humans
  44. Joseph J, Handy DE, Loscalzo J. Quo vadis: whither homocysteine research? Cardiovasc Toxicol. 2009 Jun; 9(2):53-63. PMID: 19484390.
    Citations: 21     Fields:    Translation:HumansAnimals
  45. Handy DE, Lubos E, Yang Y, Galbraith JD, Kelly N, Zhang YY, Leopold JA, Loscalzo J. Glutathione peroxidase-1 regulates mitochondrial function to modulate redox-dependent cellular responses. J Biol Chem. 2009 May 01; 284(18):11913-21. PMID: 19254950.
    Citations: 68     Fields:    Translation:HumansCells
  46. Ottaviano FG, Tang SS, Handy DE, Loscalzo J. Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells. Mol Cell Biochem. 2009 Jul; 327(1-2):111-26. PMID: 19219623.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  47. Maron BA, Zhang YY, Handy DE, Beuve A, Tang SS, Loscalzo J, Leopold JA. Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells. J Biol Chem. 2009 Mar 20; 284(12):7665-72. PMID: 19141618.
    Citations: 45     Fields:    Translation:AnimalsCells
  48. Schnabel R, Lubos E, Messow CM, Sinning CR, Zeller T, Wild PS, Peetz D, Handy DE, Munzel T, Loscalzo J, Lackner KJ, Blankenberg S. Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease The SElenium Therapy in Coronary Artery disease Patients (SETCAP) Study. Am Heart J. 2008 Dec; 156(6):1201.e1-11. PMID: 19033020; PMCID: PMC3624729.
    Citations: 17     Fields:    Translation:HumansCellsCTClinical Trials
  49. Lubos E, Handy DE, Loscalzo J. Role of oxidative stress and nitric oxide in atherothrombosis. Front Biosci. 2008 May 01; 13:5323-44. PMID: 18508590.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  50. Ottaviano FG, Handy DE, Loscalzo J. Redox regulation in the extracellular environment. Circ J. 2008 Jan; 72(1):1-16. PMID: 18159092.
    Citations: 39     Fields:    Translation:Cells
  51. Voetsch B, Jin RC, Bierl C, Deus-Silva L, Camargo EC, Annichino-Bizacchi JM, Handy DE, Loscalzo J. Role of promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene as a risk factor for cerebral venous thrombosis. Stroke. 2008 Feb; 39(2):303-7. PMID: 18096833.
    Citations: 21     Fields:    Translation:HumansCells
  52. Lubos E, Loscalzo J, Handy DE. Homocysteine and glutathione peroxidase-1. Antioxid Redox Signal. 2007 Nov; 9(11):1923-40. PMID: 17822368.
    Citations: 16     Fields:    Translation:HumansAnimals
  53. Leopold JA, Dam A, Maron BA, Scribner AW, Liao R, Handy DE, Stanton RC, Pitt B, Loscalzo J. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat Med. 2007 Feb; 13(2):189-97. PMID: 17273168; PMCID: PMC3648863.
    Citations: 128     Fields:    Translation:HumansCells
  54. Voetsch B, Jin RC, Bierl C, Benke KS, Kenet G, Simioni P, Ottaviano F, Damasceno BP, Annichino-Bizacchi JM, Handy DE, Loscalzo J. Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. Stroke. 2007 Jan; 38(1):41-9. PMID: 17122425.
    Citations: 48     Fields:    Translation:HumansCells
  55. Handy DE, Loscalzo J. Nitric oxide and posttranslational modification of the vascular proteome: S-nitrosation of reactive thiols. Arterioscler Thromb Vasc Biol. 2006 Jun; 26(6):1207-14. PMID: 16543494.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  56. Matsui R, Xu S, Maitland KA, Mastroianni R, Leopold JA, Handy DE, Loscalzo J, Cohen RA. Glucose-6-phosphate dehydrogenase deficiency decreases vascular superoxide and atherosclerotic lesions in apolipoprotein E(-/-) mice. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):910-6. PMID: 16439706.
    Citations: 26     Fields:    Translation:AnimalsCells
  57. Handy DE. . Hyperhomocysteinemia: the protein C pathway to thrombosis [editorial]. Blood. 2006; 108(7):2137-8.
  58. Galasso G, Schiekofer S, Sato K, Shibata R, Handy DE, Ouchi N, Leopold JA, Loscalzo J, Walsh K. Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction. Circ Res. 2006 Feb 03; 98(2):254-61. PMID: 16373599; PMCID: PMC1472658.
    Citations: 61     Fields:    Translation:AnimalsCells
  59. Handy DE, Hang G, Scolaro J, Metes N, Razaq N, Yang Y, Loscalzo J. Aminoglycosides decrease glutathione peroxidase-1 activity by interfering with selenocysteine incorporation. J Biol Chem. 2006 Feb 10; 281(6):3382-8. PMID: 16354666.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  60. Kamath AF, Chauhan AK, Kisucka J, Dole VS, Loscalzo J, Handy DE, Wagner DD. Elevated levels of homocysteine compromise blood-brain barrier integrity in mice. Blood. 2006 Jan 15; 107(2):591-3. PMID: 16189268; PMCID: PMC1895614.
    Citations: 82     Fields:    Translation:AnimalsCells
  61. Matsui R, Xu S, Maitland KA, Hayes A, Leopold JA, Handy DE, Loscalzo J, Cohen RA. Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II. Circulation. 2005 Jul 12; 112(2):257-63. PMID: 15998684.
    Citations: 34     Fields:    Translation:AnimalsCells
  62. Zhang Y, Handy DE, Loscalzo J. Adenosine-dependent induction of glutathione peroxidase 1 in human primary endothelial cells and protection against oxidative stress. Circ Res. 2005 Apr 29; 96(8):831-7. PMID: 15802613.
    Citations: 21     Fields:    Translation:HumansCells
  63. Handy DE, Zhang Y, Loscalzo J. Homocysteine down-regulates cellular glutathione peroxidase (GPx1) by decreasing translation. J Biol Chem. 2005 Apr 22; 280(16):15518-25. PMID: 15734734.
    Citations: 51     Fields:    Translation:AnimalsCells
  64. Handy DE, Gavras H. Hypertension and atherogenesis. In: Loscalzo J, editor. Molecular mechanisms of atherosclerosis. United Kingdom: Taylor & Francis; 2005. p. 195-207. Hypertension and atherogenesis. In: Loscalzo J, editor. Molecular mechanisms of atherosclerosis. 2005; 195-207.
  65. Handy DE, Loscalzo J. . Homocysteine and atherogenesis. In: Loscalzo J, editor. Molecular mechanisms of atherosclerosis. 2005; 221-36.
  66. Handy DE, Scolaro J, Chen J, Huang P, Loscalzo J. L-arginine increases plasma homocysteine in apoE-/-/iNOS-/- double knockout mice. Cell Mol Biol (Noisy-le-grand). 2004 Dec; 50(8):903-9. PMID: 15704254.
    Citations: 3     Fields:    Translation:AnimalsCells
  67. Bierl C, Voetsch B, Jin RC, Handy DE, Loscalzo J. Determinants of human plasma glutathione peroxidase (GPx-3) expression. J Biol Chem. 2004 Jun 25; 279(26):26839-45. PMID: 15096516.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  68. Jain M, Cui L, Brenner DA, Wang B, Handy DE, Leopold JA, Loscalzo J, Apstein CS, Liao R. Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase. Circulation. 2004 Feb 24; 109(7):898-903. PMID: 14757696.
    Citations: 47     Fields:    Translation:AnimalsCells
  69. Chotani MA, Mitra S, Su BY, Flavahan S, Eid AH, Clark KR, Montague CR, Paris H, Handy DE, Flavahan NA. Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2004 Jan; 286(1):H59-67. PMID: 12946937.
    Citations: 27     Fields:    Translation:HumansCells
  70. Handy DE, Loscalzo J. Homocysteine and atherothrombosis: diagnosis and treatment. Curr Atheroscler Rep. 2003 Jul; 5(4):276-83. PMID: 12793968.
    Citations: 3     Fields:    Translation:Humans
  71. Jain M, Brenner DA, Cui L, Lim CC, Wang B, Pimentel DR, Koh S, Sawyer DB, Leopold JA, Handy DE, Loscalzo J, Apstein CS, Liao R. Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circ Res. 2003 Jul 25; 93(2):e9-16. PMID: 12829617.
    Citations: 57     Fields:    Translation:AnimalsCells
  72. Duka I, Gavras I, Johns C, Handy DE, Gavras H. Role of the postsynaptic alpha(2)-adrenergic receptor subtypes in catecholamine-induced vasoconstriction. Gen Pharmacol. 2000 Feb; 34(2):101-6. PMID: 10974417.
    Citations: 13     Fields:    Translation:Animals
  73. Makaritsis KP, Johns C, Gavras I, Altman JD, Handy DE, Bresnahan MR, Gavras H. Sympathoinhibitory function of the alpha(2A)-adrenergic receptor subtype. Hypertension. 1999 Sep; 34(3):403-7. PMID: 10489385.
    Citations: 14     Fields:    Translation:Animals
  74. Baldwin CT, Schwartz F, Baima J, Burzstyn M, DeStefano AL, Gavras I, Handy DE, Joost O, Martel T, Manolis A, Nicolaou M, Bresnahan M, Farrer L, Gavras H. Identification of a polymorphic glutamic acid stretch in the alpha2B-adrenergic receptor and lack of linkage with essential hypertension. Am J Hypertens. 1999 Sep; 12(9 Pt 1):853-7. PMID: 10509541.
    Citations: 5     Fields:    Translation:Humans
  75. Makaritsis KP, Handy DE, Johns C, Kobilka B, Gavras I, Gavras H. Role of the alpha2B-adrenergic receptor in the development of salt-induced hypertension. Hypertension. 1999 Jan; 33(1):14-7. PMID: 9931075.
    Citations: 14     Fields:    Translation:AnimalsCells
  76. DeStefano AL, Baldwin CT, Burzstyn M, Gavras I, Handy DE, Joost O, Martel T, Nicolaou M, Schwartz F, Streeten DH, Farrer LA, Gavras H. Autosomal dominant orthostatic hypotensive disorder maps to chromosome 18q. Am J Hum Genet. 1998 Nov; 63(5):1425-30. PMID: 9792870; PMCID: PMC1377553.
    Citations: 5     Fields:    Translation:HumansCells
  77. Handy DE, Johns C, Bresnahan MR, Tavares A, Bursztyn M, Gavras H. Expression of alpha2-adrenergic receptors in normal and atherosclerotic rabbit aorta. Hypertension. 1998 Aug; 32(2):311-7. PMID: 9719060.
    Citations: 5     Fields:    Translation:AnimalsCells
  78. Johns C, Gavras I, Handy DE, Salomao A, Gavras H. Models of experimental hypertension in mice. Hypertension. 1996 Dec; 28(6):1064-9. PMID: 8952597.
    Citations: 40     Fields:    Translation:Animals
  79. Handy DE, Gavras H. Evidence for cell-specific regulation of transcription of the rat alpha2A-adrenergic receptor gene. Hypertension. 1996 Apr; 27(4):1018-24. PMID: 8613257.
    Citations: 1     Fields:    Translation:AnimalsCells
  80. Tavares A, Handy DE, Bogdanova NN, Rosene DL, Gavras H. Localization of alpha 2A- and alpha 2B-adrenergic receptor subtypes in brain. Hypertension. 1996 Mar; 27(3 Pt 1):449-55. PMID: 8698452.
    Citations: 11     Fields:    Translation:Animals
  81. Handy DE, Zanella MT, Kanemaru A, Tavares A, Flordellis C, Gavras H. A negative regulatory element in the promoter region of the rat alpha 2A-adrenergic receptor gene overlaps an SP1 consensus binding site. Biochem J. 1995 Oct 15; 311 ( Pt 2):541-7. PMID: 7487893; PMCID: PMC1136033.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  82. Flordellis CS, Berguerand M, Gouache P, Barbu V, Gavras H, Handy DE, Béréziat G, Masliah J. Alpha 2 adrenergic receptor subtypes expressed in Chinese hamster ovary cells activate differentially mitogen-activated protein kinase by a p21ras independent pathway. J Biol Chem. 1995 Feb 24; 270(8):3491-4. PMID: 7876081.
    Citations: 5     Fields:    Translation:AnimalsCells
  83. Marine JB, Shirakata Y, Wadsworth SA, Hooley JJ, Handy DE, Coligan JE. Role of the Q10 class I regulatory element region 1 in controlling tissue-specific expression in vivo. J Immunol. 1993 Aug 15; 151(4):1989-97. PMID: 8345192.
    Citations: 2     Fields:    Translation:AnimalsCells
  84. Handy DE, Flordellis CS, Bogdanova NN, Bresnahan MR, Gavras H. Diverse tissue expression of rat alpha 2-adrenergic receptor genes. Hypertension. 1993 Jun; 21(6 Pt 1):861-5. PMID: 7684725.
    Citations: 8     Fields:    Translation:AnimalsCells
  85. Handy DE, Gavras H. Promoter region of the human alpha 2A adrenergic receptor gene. J Biol Chem. 1992 Nov 25; 267(33):24017-22. PMID: 1385431.
    Citations: 5     Fields:    Translation:HumansCells
  86. Castellano M, Handy DE, Beschi M, Wang YX, Agabiti-Rosei E, Gavras H. Gene expression of catecholaminergic receptors in the central nervous system of hypertensive rats. J Hypertens Suppl. 1991 Dec; 9(6):S54-5. PMID: 1819011.
    Citations:    Fields:    Translation:Animals
  87. Flordellis CS, Handy DE, Bresnahan MR, Zannis VI, Gavras H. Cloning and expression of a rat brain alpha 2B-adrenergic receptor. Proc Natl Acad Sci U S A. 1991 Feb 01; 88(3):1019-23. PMID: 1704126; PMCID: PMC50946.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  88. Handy DE, Burke PA, Ozato K, Coligan JE. Site-specific mutagenesis of the class I regulatory element the Q10 gene allows expression in non-liver tissues. J Immunol. 1989 Feb 01; 142(3):1015-21. PMID: 2913151.
    Citations: 5     Fields:    Translation:AnimalsCells
  89. Handy DE, McCluskey J, Lew AM, Coligan JE, Margulies DH. Signals controlling alternative splicing of major histocompatibility complex H-2 class I pre-mRNA. Immunogenetics. 1988; 28(2):81-90. PMID: 3397132.
    Citations: 6     Fields:    Translation:AnimalsCells
  90. Handy DE, Larsen SH, Karn RC, Hodes ME. Identification of a human salivary amylase gene. Partial sequence of genomic DNA suggests a mode of regulation different from that of mouse, Amy1. Mol Biol Med. 1987 Jun; 4(3):145-55. PMID: 2442579.
    Citations: 4     Fields:    Translation:HumansCells
  91. Mattson DH, Handy DE, Bradley DA, Coligan JE, Cowan EP, Biddison WE. DNA sequences of the genes that encode the CTL-defined HLA-A2 variants M7 and DK1. Immunogenetics. 1987; 26(3):190-2. PMID: 3497874.
    Citations: 14     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.