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Keith Wyatt Miller, Dr.Phil.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM135550 (MILLER, KEITH W) Apr 1, 2020 - Feb 29, 2024
    NIH/NIGMS
    Molecular Pharmacology of the Synaptic and Extrasynaptic GABA(A) Receptors
    Role: Principal Investigator
  2. R01GM069726 (MILLER, KEITH W) Jan 1, 2004 - Dec 31, 2008
    NIH/NIGMS
    General Anesthetic-Protein Interactions:Protein Kinase C
    Role: Principal Investigator
  3. U01AA014812 (MILLER, KEITH W) Sep 30, 2003 - Aug 31, 2008
    NIH/NIAAA
    Photolabeling of alcohol binding sites L1:
    Role: Principal Investigator
  4. P41RR015301 (EALICK, STEVEN E) Jun 15, 2001 - Mar 31, 2013
    NIH/NCRR
    An Undulator Resource for Structural Biology
    Role: Co-Principal Investigator
  5. P01GM058448 (MILLER, KEITH W) Dec 1, 1998 - Sep 29, 2009
    NIH/NIGMS
    General Anesthetic Sites on Ligand Gated Ion Channels
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. McGrath M, Hoyt H, Pence A, Jayakar SS, Zhou X, Forman SA, Cohen JB, Miller KW, Raines DE. Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies. Anesthesiology. 2020 09; 133(3):583-594. PMID: 32541553.
    Citations:    Fields:    Translation:Animals
  2. Herkert J, Borenstein J, Miller K. The Boeing 737 MAX: Lessons for Engineering Ethics. Sci Eng Ethics. 2020 Jul 10. PMID: 32651773.
    Citations:    Fields:    
  3. Jayakar SS, Chiara DC, Zhou X, Wu B, Bruzik KS, Miller KW, Cohen JB. Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABAA) receptors. J Biol Chem. 2020 Aug 14; 295(33):11495-11512. PMID: 32540960.
    Citations: 1     Fields:    
  4. Shalabi AR, Yu Z, Zhou X, Jounaidi Y, Chen H, Dai J, Kent DE, Feng HJ, Forman SA, Cohen JB, Bruzik KS, Miller KW. A potent photoreactive general anesthetic with novel binding site selectivity for GABAA receptors. Eur J Med Chem. 2020 May 15; 194:112261. PMID: 32247113.
    Citations:    Fields:    
  5. Kent DE, Savechenkov PY, Bruzik KS, Miller KW. Binding site location on GABAA receptors determines whether mixtures of intravenous general anaesthetics interact synergistically or additively in vivo. Br J Pharmacol. 2019 12; 176(24):4760-4772. PMID: 31454409.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Jayakar SS, Zhou X, Chiara DC, Jarava-Barrera C, Savechenkov PY, Bruzik KS, Tortosa M, Miller KW, Cohen JB. Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the a1ß3?2 GABAAR Transmembrane Domain. Mol Pharmacol. 2019 06; 95(6):615-628. PMID: 30952799.
    Citations: 3     Fields:    Translation:HumansCells
  7. Masiulis S, Desai R, Uchanski T, Martin IS, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR. Author Correction: GABAA receptor signalling mechanisms revealed by structural pharmacology. Nature. 2019 02; 566(7744):E8. PMID: 30733619.
    Citations:    Fields:    
  8. Laverty D, Desai R, Uchanski T, Masiulis S, Stec WJ, Malinauskas T, Zivanov J, Pardon E, Steyaert J, Miller KW, Aricescu AR. Cryo-EM structure of the human a1ß3?2 GABAA receptor in a lipid bilayer. Nature. 2019 01; 565(7740):516-520. PMID: 30602789.
    Citations: 35     Fields:    Translation:HumansCells
  9. Masiulis S, Desai R, Uchanski T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR. GABAA receptor signalling mechanisms revealed by structural pharmacology. Nature. 2019 01; 565(7740):454-459. PMID: 30602790.
    Citations: 38     Fields:    Translation:HumansCells
  10. Wu B, Jayakar SS, Zhou X, Titterton K, Chiara DC, Szabo AL, Savechenkov PY, Kent DE, Cohen JB, Forman SA, Miller KW, Bruzik KS. Inhibitable photolabeling by neurosteroid diazirine analog in the ß3-Subunit of human hetereopentameric type A GABA receptors. Eur J Med Chem. 2019 Jan 15; 162:810-824. PMID: 30544077.
    Citations: 3     Fields:    Translation:HumansCells
  11. McGrath M, Yu Z, Jayakar SS, Ma C, Tolia M, Zhou X, Miller KW, Cohen JB, Raines DE. Etomidate and Etomidate Analog Binding and Positive Modulation of ?-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect. Anesthesiology. 2018 11; 129(5):959-969. PMID: 30052529.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Woll KA, Zhou X, Bhanu NV, Garcia BA, Covarrubias M, Miller KW, Eckenhoff RG. Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors. FASEB J. 2018 08; 32(8):4172-4189. PMID: 29505303.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  13. Zhou X, Desai R, Zhang Y, Stec WJ, Miller KW, Jounaidi Y. High-level production and purification in a functional state of an extrasynaptic gamma-aminobutyric acid type A receptor containing a4ß3d subunits. PLoS One. 2018; 13(1):e0191583. PMID: 29352320.
    Citations:    Fields:    Translation:HumansCells
  14. Borenstein J, Herkert JR, Miller KW. Self-Driving Cars and Engineering Ethics: The Need for a System Level Analysis. Sci Eng Ethics. 2019 04; 25(2):383-398. PMID: 29134429.
    Citations: 1     Fields:    Translation:Humans
  15. Ma C, Pejo E, McGrath M, Jayakar SS, Zhou X, Miller KW, Cohen JB, Raines DE. Competitive Antagonism of Anesthetic Action at the ?-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy. Anesthesiology. 2017 11; 127(5):824-837. PMID: 28857763.
    Citations: 1     Fields:    Translation:AnimalsCells
  16. Jounaidi Y, Cotten JF, Miller KW, Forman SA. Tethering IL2 to Its Receptor IL2Rß Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells. Cancer Res. 2017 11 01; 77(21):5938-5951. PMID: 28916655.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  17. Nagasaka Y, Wepler M, Thoonen R, Sips PY, Allen K, Graw JA, Yao V, Burns SM, Muenster S, Brouckaert P, Miller K, Solt K, Buys ES, Ichinose F, Zapol WM. Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha. BMC Anesthesiol. 2017 06 14; 17(1):76. PMID: 28615047.
    Citations: 1     Fields:    Translation:Animals
  18. Savechenkov PY, Chiara DC, Desai R, Stern AT, Zhou X, Ziemba AM, Szabo AL, Zhang Y, Cohen JB, Forman SA, Miller KW, Bruzik KS. Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands. Eur J Med Chem. 2017 Aug 18; 136:334-347. PMID: 28505538.
    Citations: 3     Fields:    Translation:HumansCells
  19. Cheung CC, D'Arrigo C, Dietel M, Francis GD, Fulton R, Gilks CB, Hall JA, Hornick JL, Ibrahim M, Marchetti A, Miller K, van Krieken JH, Nielsen S, Swanson PE, Taylor CR, Vyberg M, Zhou X, Torlakovic EE. Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine: Part 4: Tissue Tools for Quality Assurance in Immunohistochemistry. Appl Immunohistochem Mol Morphol. 2017 04; 25(4):227-230. PMID: 27941560.
    Citations: 4     Fields:    Translation:Humans
  20. Torlakovic EE, Cheung CC, D'Arrigo C, Dietel M, Francis GD, Gilks CB, Hall JA, Hornick JL, Ibrahim M, Marchetti A, Miller K, van Krieken JH, Nielsen S, Swanson PE, Vyberg M, Zhou X, Taylor CR. Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine. Part 3: Technical Validation of Immunohistochemistry (IHC) Assays in Clinical IHC Laboratories. Appl Immunohistochem Mol Morphol. 2017 03; 25(3):151-159. PMID: 28187030.
    Citations: 9     Fields:    
  21. Torlakovic EE, Cheung CC, D'Arrigo C, Dietel M, Francis GD, Gilks CB, Hall JA, Hornick JL, Ibrahim M, Marchetti A, Miller K, van Krieken JH, Nielsen S, Swanson PE, Vyberg M, Zhou X, Taylor CR. Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine - Part 2: Immunohistochemistry Test Performance Characteristics. Appl Immunohistochem Mol Morphol. 2017 02; 25(2):79-85. PMID: 28182587.
    Citations: 7     Fields:    Translation:Humans
  22. Cheung CC, D'Arrigo C, Dietel M, Francis GD, Gilks CB, Hall JA, Hornick JL, Ibrahim M, Marchetti A, Miller K, van Krieken JH, Nielsen S, Swanson PE, Taylor CR, Vyberg M, Zhou X, Torlakovic EE. Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine: Part 1: Fit-for-Purpose Approach to Classification of Clinical Immunohistochemistry Biomarkers. Appl Immunohistochem Mol Morphol. 2017 01; 25(1):4-11. PMID: 27922482.
    Citations: 4     Fields:    Translation:Humans
  23. Chiara DC, Jounaidi Y, Zhou X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB. General Anesthetic Binding Sites in Human a4ß3d ?-Aminobutyric Acid Type A Receptors (GABAARs). J Biol Chem. 2016 Dec 16; 291(51):26529-26539. PMID: 27821594.
    Citations: 5     Fields:    Translation:HumansCells
  24. Roth SH, Miller KW, Orser BA, Urban BW. Unlocking the Mechanisms of Anesthesia. Anesth Analg. 2016 11; 123(5):1070-1071. PMID: 27454067.
    Citations:    Fields:    Translation:HumansAnimals
  25. Amlong CA, Perkins MG, Houle TT, Miller KW, Pearce RA. Contrasting Effects of the ?-Aminobutyric Acid Type A Receptor ß3 Subunit N265M Mutation on Loss of Righting Reflexes Induced by Etomidate and the Novel Anesthetic Barbiturate R-mTFD-MPAB. Anesth Analg. 2016 11; 123(5):1241-1246. PMID: 27331778.
    Citations: 5     Fields:    Translation:AnimalsCells
  26. Forman SA, Miller KW. Mapping General Anesthetic Sites in Heteromeric ?-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes. Anesth Analg. 2016 11; 123(5):1263-1273. PMID: 27167687.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  27. Miller KW, Wolf MJ, Grodzinsky F. This "Ethical Trap" Is for Roboticists, Not Robots: On the Issue of Artificial Agent Ethical Decision-Making. Sci Eng Ethics. 2017 04; 23(2):389-401. PMID: 27116039.
    Citations:    Fields:    Translation:Humans
  28. Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KW. Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the a1 ß3 ?2L GABAA receptor account for their in vivo effects. J Physiol. 2015 Nov 15; 593(22):4943-61. PMID: 26378885.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  29. Jayakar SS, Zhou X, Savechenkov PY, Chiara DC, Desai R, Bruzik KS, Miller KW, Cohen JB. Positive and Negative Allosteric Modulation of an a1ß3?2 ?-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the ?+-ß- Interface. J Biol Chem. 2015 Sep 18; 290(38):23432-46. PMID: 26229099.
    Citations: 11     Fields:    Translation:HumansCells
  30. Zhang X, Miller KW. Dodecyl maltopyranoside enabled purification of active human GABA type A receptors for deep and direct proteomic sequencing. Mol Cell Proteomics. 2015 Mar; 14(3):724-38. PMID: 25473089.
    Citations: 5     Fields:    Translation:HumansCells
  31. Forman SA, Miller KW, Talmor D, Hickey P, Strichartz G, Wiener-Kronish J. Research at the Harvard Anesthesia Departments. Anesthesiology. 2014 Dec; 121(6):1141-3. PMID: 25299744.
    Citations:    Fields:    Translation:Humans
  32. Forman SA, Chiara DC, Miller KW. Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptors. Neuropharmacology. 2015 Sep; 96(Pt B):169-77. PMID: 25316107.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  33. Jayakar SS, Zhou X, Chiara DC, Dostalova Z, Savechenkov PY, Bruzik KS, Dailey WP, Miller KW, Eckenhoff RG, Cohen JB. Multiple propofol-binding sites in a ?-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog. J Biol Chem. 2014 Oct 03; 289(40):27456-68. PMID: 25086038.
    Citations: 44     Fields:    Translation:HumansCells
  34. Dostalova Z, Zhou X, Liu A, Zhang X, Zhang Y, Desai R, Forman SA, Miller KW. Human a1ß3?2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state. Protein Sci. 2014 Feb; 23(2):157-66. PMID: 24288268.
    Citations: 16     Fields:    Translation:HumansCells
  35. Olsen RW, Li GD, Wallner M, Trudell JR, Bertaccini EJ, Lindahl E, Miller KW, Alkana RL, Davies DL. Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol. Alcohol Clin Exp Res. 2014 Mar; 38(3):595-603. PMID: 24164436.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  36. Chiara DC, Jayakar SS, Zhou X, Zhang X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB. Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human a1ß3?2 ?-aminobutyric acid type A (GABAA) receptor. J Biol Chem. 2013 Jul 05; 288(27):19343-57. PMID: 23677991.
    Citations: 58     Fields:    Translation:HumansCells
  37. Shanmugasundararaj S, Zhou X, Neunzig J, Bernhardt R, Cotten JF, Ge R, Miller KW, Raines DE. Carboetomidate: an analog of etomidate that interacts weakly with 11ß-hydroxylase. Anesth Analg. 2013 Jun; 116(6):1249-56. PMID: 23492967.
    Citations: 8     Fields:    Translation:HumansCells
  38. Desai R, Miller KW, Raines DE. The pyrrole etomidate analog carboetomidate potently inhibits human 5-HT3A receptor function: comparisons with etomidate and potential implications for emetogenesis. Anesth Analg. 2013 Mar; 116(3):573-9. PMID: 23400978.
    Citations: 2     Fields:    Translation:HumansCells
  39. Shanmugasundararaj S, Das J, Sandberg WS, Zhou X, Wang D, Messing RO, Bruzik KS, Stehle T, Miller KW. Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cd*. Biophys J. 2012 Dec 05; 103(11):2331-40. PMID: 23283232.
    Citations: 10     Fields:    Translation:HumansCells
  40. Savechenkov PY, Zhang X, Chiara DC, Stewart DS, Ge R, Zhou X, Raines DE, Cohen JB, Forman SA, Miller KW, Bruzik KS. Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic. J Med Chem. 2012 Jul 26; 55(14):6554-65. PMID: 22734650.
    Citations: 27     Fields:    Translation:Humans
  41. Chiara DC, Dostalova Z, Jayakar SS, Zhou X, Miller KW, Cohen JB. Mapping general anesthetic binding site(s) in human a1ß3 ?-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue. Biochemistry. 2012 Jan 31; 51(4):836-47. PMID: 22243422.
    Citations: 54     Fields:    Translation:HumansCells
  42. Shanmugasundararaj S, Lehle S, Yamodo HI, Husain SS, Tseng C, Nguyen K, Addona GH, Miller KW. The location and nature of general anesthetic binding sites on the active conformation of firefly luciferase; a time resolved photolabeling study. PLoS One. 2012; 7(1):e29854. PMID: 22272253.
    Citations: 2     Fields:    Translation:AnimalsCells
  43. Stewart DS, Savechenkov PY, Dostalova Z, Chiara DC, Ge R, Raines DE, Cohen JB, Forman SA, Bruzik KS, Miller KW. p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol. J Med Chem. 2011 Dec 08; 54(23):8124-35. PMID: 22029276.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  44. Dou X, Menkari CE, Shanmugasundararaj S, Miller KW, Charness ME. Two alcohol binding residues interact across a domain interface of the L1 neural cell adhesion molecule and regulate cell adhesion. J Biol Chem. 2011 May 06; 286(18):16131-9. PMID: 21367865.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  45. Miller KW, Orser BA, Roth SH. Mechanisms of anesthesia: past, present, and a glimpse into the future. Can J Anaesth. 2011 Feb; 58(2):131-4, 134-8. PMID: 21165729.
    Citations:    Fields:    Translation:Humans
  46. Forman SA, Miller KW. Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels. Can J Anaesth. 2011 Feb; 58(2):191-205. PMID: 21213095.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  47. Husain SS, Stewart D, Desai R, Hamouda AK, Li SG, Kelly E, Dostalova Z, Zhou X, Cotten JF, Raines DE, Olsen RW, Cohen JB, Forman SA, Miller KW. p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels. J Med Chem. 2010 Sep 09; 53(17):6432-44. PMID: 20704351.
    Citations: 12     Fields:    Translation:AnimalsCells
  48. Dostalova Z, Liu A, Zhou X, Farmer SL, Krenzel ES, Arevalo E, Desai R, Feinberg-Zadek PL, Davies PA, Yamodo IH, Forman SA, Miller KW. High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors. Protein Sci. 2010 Sep; 19(9):1728-38. PMID: 20662008.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  49. Cotten JF, Forman SA, Laha JK, Cuny GD, Husain SS, Miller KW, Nguyen HH, Kelly EW, Stewart D, Liu A, Raines DE. Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function. Anesthesiology. 2010 Mar; 112(3):637-44. PMID: 20179500.
    Citations: 28     Fields:    Translation:Animals
  50. Yamodo IH, Chiara DC, Cohen JB, Miller KW. Conformational changes in the nicotinic acetylcholine receptor during gating and desensitization. Biochemistry. 2010 Jan 12; 49(1):156-65. PMID: 19961216.
    Citations: 22     Fields:    Translation:AnimalsCells
  51. Cotten JF, Husain SS, Forman SA, Miller KW, Kelly EW, Nguyen HH, Raines DE. Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression. Anesthesiology. 2009 Aug; 111(2):240-9. PMID: 19625798.
    Citations: 35     Fields:    Translation:HumansAnimals
  52. Chiara DC, Hong FH, Arevalo E, Husain SS, Miller KW, Forman SA, Cohen JB. Time-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor. Mol Pharmacol. 2009 May; 75(5):1084-95. PMID: 19218367.
    Citations: 24     Fields:    Translation:AnimalsCells
  53. Ho C, Shanmugasundararaj S, Miller KW, Malinowski SA, Cook AC, Slater SJ. Interaction of anesthetics with the Rho GTPase regulator Rho GDP dissociation inhibitor. Biochemistry. 2008 Sep 09; 47(36):9540-52. PMID: 18702520.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  54. Arevalo E, Shanmugasundararaj S, Wilkemeyer MF, Dou X, Chen S, Charness ME, Miller KW. An alcohol binding site on the neural cell adhesion molecule L1. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):371-5. PMID: 18165316.
    Citations: 32     Fields:    Translation:AnimalsCells
  55. Williamson PT, Verhoeven A, Miller KW, Meier BH, Watts A. The conformation of acetylcholine at its target site in the membrane-embedded nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18031-6. PMID: 17989232.
    Citations: 11     Fields:    Translation:AnimalsCells
  56. Kumar A, Tyagi NK, Arevalo E, Miller KW, Kinne RK. A proteomic study of sodium/D-glucose cotransporter 1 (SGLT1): topology of loop 13 and coverage of other functionally important domains. Biochim Biophys Acta. 2007 Aug; 1774(8):968-74. PMID: 17588833.
    Citations: 1     Fields:    Translation:HumansCells
  57. Das J, Zhou X, Miller KW. Identification of an alcohol binding site in the first cysteine-rich domain of protein kinase Cdelta. Protein Sci. 2006 Sep; 15(9):2107-19. PMID: 16943444.
    Citations: 16     Fields:    Translation:AnimalsCells
  58. Husain SS, Nirthanan S, Ruesch D, Solt K, Cheng Q, Li GD, Arevalo E, Olsen RW, Raines DE, Forman SA, Cohen JB, Miller KW. Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels. J Med Chem. 2006 Aug 10; 49(16):4818-25. PMID: 16884293.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  59. Liao M, Sonner JM, Husain SS, Miller KW, Jurd R, Rudolph U, Eger EI. R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M point mutation in the gamma-aminobutyric acid receptor beta3 subunit. Anesth Analg. 2005 Jul; 101(1):131-5, table of contents. PMID: 15976219.
    Citations: 22     Fields:    Translation:Animals
  60. Arevalo E, Chiara DC, Forman SA, Cohen JB, Miller KW. Gating-enhanced accessibility of hydrophobic sites within the transmembrane region of the nicotinic acetylcholine receptor's {delta}-subunit. A time-resolved photolabeling study. J Biol Chem. 2005 Apr 08; 280(14):13631-40. PMID: 15664985.
    Citations: 35     Fields:    Translation:AnimalsCells
  61. Das J, Addona GH, Sandberg WS, Husain SS, Stehle T, Miller KW. Identification of a general anesthetic binding site in the diacylglycerol-binding domain of protein kinase Cdelta. J Biol Chem. 2004 Sep 03; 279(36):37964-72. PMID: 15234976.
    Citations: 24     Fields:    Translation:AnimalsCells
  62. Ziebell MR, Nirthanan S, Husain SS, Miller KW, Cohen JB. Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic. J Biol Chem. 2004 Apr 23; 279(17):17640-9. PMID: 14761946.
    Citations: 39     Fields:    Translation:AnimalsCells
  63. Campagna JA, Miller KW, Forman SA. Mechanisms of actions of inhaled anesthetics. N Engl J Med. 2003 May 22; 348(21):2110-24. PMID: 12761368.
    Citations: 194     Fields:    Translation:HumansAnimalsCells
  64. Husain SS, Ziebell MR, Ruesch D, Hong F, Arevalo E, Kosterlitz JA, Olsen RW, Forman SA, Cohen JB, Miller KW. 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels. J Med Chem. 2003 Mar 27; 46(7):1257-65. PMID: 12646036.
    Citations: 49     Fields:    Translation:AnimalsCells
  65. Addona GH, Sandermann H, Kloczewiak MA, Miller KW. Low chemical specificity of the nicotinic acetylcholine receptor sterol activation site. Biochim Biophys Acta. 2003 Jan 31; 1609(2):177-82. PMID: 12543379.
    Citations: 15     Fields:    Translation:AnimalsCells
  66. Miller KW, Richards CD, Roth SH, Urban BW. Molecular and basic mechanisms of anaesthesia. Br J Anaesth. 2002 Jul; 89(1):1-2. PMID: 12173222.
    Citations:    Fields:    Translation:Humans
  67. Miller KW. The nature of sites of general anaesthetic action. Br J Anaesth. 2002 Jul; 89(1):17-31. PMID: 12173229.
    Citations: 22     Fields:    Translation:HumansCells
  68. Addona GH, Husain SS, Stehle T, Miller KW. Geometric isomers of a photoactivable general anesthetic delineate a binding site on adenylate kinase. J Biol Chem. 2002 Jul 12; 277(28):25685-91. PMID: 11976328.
    Citations: 7     Fields:    Translation:AnimalsCells
  69. Williamson PT, Watts JA, Addona GH, Miller KW, Watts A. Dynamics and orientation of N+(CD3)3-bromoacetylcholine bound to its binding site on the nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2346-51. PMID: 11226242.
    Citations: 7     Fields:    Translation:AnimalsCells
  70. Chiara DC, Kloczewiak MA, Addona GH, Yu JA, Cohen JB, Miller KW. Site of resting state inhibition of the nicotinic acetylcholine receptor by a hydrophobic inhibitor. Biochemistry. 2001 Jan 09; 40(1):296-304. PMID: 11141083.
    Citations: 4     Fields:    Translation:AnimalsCells
  71. Pratt MB, Husain SS, Miller KW, Cohen JB. Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic. J Biol Chem. 2000 Sep 22; 275(38):29441-51. PMID: 10859324.
    Citations: 35     Fields:    Translation:AnimalsCells
  72. Husain SS, Forman SA, Kloczewiak MA, Addona GH, Olsen RW, Pratt MB, Cohen JB, Miller KW. Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic. J Med Chem. 1999 Aug 26; 42(17):3300-7. PMID: 10464016.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  73. Addona GH, Kloczewiak MA, Miller KW. Time-resolved photolabeling of membrane proteins: application to the nicotinic acetylcholine receptor. Anal Biochem. 1999 Feb 01; 267(1):135-40. PMID: 9918665.
    Citations: 4     Fields:    Translation:AnimalsCells
  74. Miller KW, Addona GH, Kloczewiak MA. Approaches to proving there are general anesthetic sites on ligand gated ion channels. Toxicol Lett. 1998 Nov 23; 100-101:139-47. PMID: 10049134.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  75. Williamson PT, Watts J, Gröbner G, Miller KW, Watts A. Solid state NMR studies of ligands bound to the nicotinic acetylcholine receptor. Biochem Soc Trans. 1998 Aug; 26(3):S297. PMID: 9766016.
    Citations: 1     Fields:    Translation:Cells
  76. Williamson PT, Gröbner G, Spooner PJ, Miller KW, Watts A. Probing the agonist binding pocket in the nicotinic acetylcholine receptor: a high-resolution solid-state NMR approach. Biochemistry. 1998 Jul 28; 37(30):10854-9. PMID: 9692976.
    Citations: 6     Fields:    Translation:AnimalsCells
  77. Addona GH, Sandermann H, Kloczewiak MA, Husain SS, Miller KW. Where does cholesterol act during activation of the nicotinic acetylcholine receptor? Biochim Biophys Acta. 1998 Mar 13; 1370(2):299-309. PMID: 9545586.
    Citations: 15     Fields:    Translation:Animals
  78. Rankin SE, Addona GH, Kloczewiak MA, Bugge B, Miller KW. The cholesterol dependence of activation and fast desensitization of the nicotinic acetylcholine receptor. Biophys J. 1997 Nov; 73(5):2446-55. PMID: 9370438.
    Citations: 26     Fields:    Translation:Animals
  79. Sandermann H, Addona GH, Miller KW. A thermodynamic analysis of the partitioning of cholesterol and related compounds between trioleoylglycerol and egg phosphatidylcholine bilayers. Biochim Biophys Acta. 1997 Jun 02; 1346(2):158-62. PMID: 9219898.
    Citations: 2     Fields:    
  80. Wilson CJ, Husain SS, Stimson ER, Dangott LJ, Miller KW, Maggio JE. p-(4-Hydroxybenzoyl)phenylalanine: a photoreactive amino acid analog amenable to radioiodination for elucidation of peptide-protein interaction. Application to substance P receptor. Biochemistry. 1997 Apr 15; 36(15):4542-51. PMID: 9109663.
    Citations: 1     Fields:    Translation:AnimalsCells
  81. Forman SA, Miller KW, Yellen G. A discrete site for general anesthetics on a postsynaptic receptor. Mol Pharmacol. 1995 Oct; 48(4):574-81. PMID: 7476881.
    Citations: 35     Fields:    Translation:AnimalsCells
  82. Raines DE, Wu G, Dalton LA, Miller KW. Electron spin resonance studies of acyl chain motion in reconstituted nicotinic acetylcholine receptor membranes. Biophys J. 1995 Aug; 69(2):498-505. PMID: 8527664.
    Citations:    Fields:    Translation:AnimalsCells
  83. Tonner PH, Miller KW. Molecular sites of general anaesthetic action on acetylcholine receptors. Eur J Anaesthesiol. 1995 Jan; 12(1):21-30. PMID: 7535690.
    Citations: 6     Fields:    Translation:AnimalsCells
  84. Raines DE, Rankin SE, Miller KW. General anesthetics modify the kinetics of nicotinic acetylcholine receptor desensitization at clinically relevant concentrations. Anesthesiology. 1995 Jan; 82(1):276-87; discussion 31A-32A. PMID: 7832311.
    Citations: 3     Fields:    Translation:AnimalsCells
  85. Wood SC, Tonner PH, de Armendi AJ, Bugge B, Miller KW. Channel inhibition by alkanols occurs at a binding site on the nicotinic acetylcholine receptor. Mol Pharmacol. 1995 Jan; 47(1):121-30. PMID: 7530805.
    Citations: 8     Fields:    Translation:AnimalsCells
  86. Wu G, Raines DE, Miller KW. A hydrophobic inhibitor of the nicotinic acetylcholine receptor acts on the resting state. Biochemistry. 1994 Dec 27; 33(51):15375-81. PMID: 7803400.
    Citations: 3     Fields:    Translation:AnimalsCells
  87. Raines DE, Miller KW. On the importance of volatile agents devoid of anesthetic action. Anesth Analg. 1994 Dec; 79(6):1031-3. PMID: 7677814.
    Citations: 4     Fields:    Translation:Animals
  88. Firestone LL, Alifimoff JK, Miller KW. Does general anesthetic-induced desensitization of the Torpedo acetylcholine receptor correlate with lipid disordering? Mol Pharmacol. 1994 Sep; 46(3):508-15. PMID: 7935332.
    Citations: 9     Fields:    Translation:Animals
  89. Abadji V, Raines DE, Dalton LA, Miller KW. Lipid-protein interactions and protein dynamics in vesicles containing the nicotinic acetylcholine receptor: a study with ethanol. Biochim Biophys Acta. 1994 Aug 24; 1194(1):25-34. PMID: 8075138.
    Citations: 1     Fields:    Translation:Animals
  90. Wu G, Miller KW. Ethanol enhances agonist-induced fast desensitization in nicotinic acetylcholine receptors. Biochemistry. 1994 Aug 09; 33(31):9085-91. PMID: 8049210.
    Citations: 3     Fields:    Translation:AnimalsCells
  91. Wu G, Tonner PH, Miller KW. Ethanol stabilizes the open channel state of the Torpedo nicotinic acetylcholine receptor. Mol Pharmacol. 1994 Jan; 45(1):102-8. PMID: 8302268.
    Citations: 10     Fields:    Translation:Animals
  92. Wood SC, Hill WA, Miller KW. Cycloalkanemethanols discriminate between volume- and length-dependent loss of activity of alkanols at the Torpedo nicotinic acetylcholine receptor. Mol Pharmacol. 1993 Dec; 44(6):1219-26. PMID: 8264559.
    Citations: 3     Fields:    Translation:Animals
  93. de Armendi AJ, Tonner PH, Bugge B, Miller KW. Barbiturate action is dependent on the conformational state of the acetylcholine receptor. Anesthesiology. 1993 Nov; 79(5):1033-41. PMID: 8238981.
    Citations: 6     Fields:    Translation:AnimalsCells
  94. Dalton LA, Miller KW. Trans-unsaturated lipid dynamics: modulation of dielaidoylphosphatidylcholine acyl chain motion by ethanol. Biophys J. 1993 Oct; 65(4):1620-31. PMID: 8274650.
    Citations:    Fields:    Translation:Animals
  95. Alifimoff JK, Bugge B, Forman SA, Miller KW. Stereoselectivity of channel inhibition by secondary alkanol enantiomers at nicotinic acetylcholine receptors. Anesthesiology. 1993 Jul; 79(1):122-8. PMID: 7688196.
    Citations: 1     Fields:    Translation:AnimalsCells
  96. Baenziger JE, Miller KW, Rothschild KJ. Fourier transform infrared difference spectroscopy of the nicotinic acetylcholine receptor: evidence for specific protein structural changes upon desensitization. Biochemistry. 1993 May 25; 32(20):5448-54. PMID: 8499448.
    Citations: 9     Fields:    Translation:AnimalsCells
  97. Raines DE, Korten SE, Hill AG, Miller KW. Anesthetic cutoff in cycloalkanemethanols. A test of current theories. Anesthesiology. 1993 May; 78(5):918-27. PMID: 8489064.
    Citations: 6     Fields:    Translation:Animals
  98. Abadji VC, Raines DE, Watts A, Miller KW. The effect of general anesthetics on the dynamics of phosphatidylcholine-acetylcholine receptor interactions in reconstituted vesicles. Biochim Biophys Acta. 1993 Apr 08; 1147(1):143-53. PMID: 8466926.
    Citations: 3     Fields:    Translation:Animals
  99. Raines DE, Miller KW. The role of charge in lipid selectivity for the nicotinic acetylcholine receptor. Biophys J. 1993 Mar; 64(3):632-41. PMID: 8386010.
    Citations: 1     Fields:    Translation:Animals
  100. Tonner PH, Poppers DM, Miller KW. The general anesthetic potency of propofol and its dependence on hydrostatic pressure. Anesthesiology. 1992 Nov; 77(5):926-31. PMID: 1443748.
    Citations: 12     Fields:    Translation:Animals
  101. Tonner PH, Wood SC, Miller KW. Can nicotine self-inhibition account for its low efficacy at the nicotinic acetylcholine receptor from Torpedo? Mol Pharmacol. 1992 Nov; 42(5):890-7. PMID: 1279379.
    Citations:    Fields:    Translation:Animals
  102. Baenziger JE, Miller KW, McCarthy MP, Rothschild KJ. Probing conformational changes in the nicotinic acetylcholine receptor by Fourier transform infrared difference spectroscopy. Biophys J. 1992 Apr; 62(1):64-6. PMID: 1600101.
    Citations: 6     Fields:    Translation:AnimalsCells
  103. Tonner PH, Miller KW. [Cholinergic receptors and anesthesia]. Anasthesiol Intensivmed Notfallmed Schmerzther. 1992 Apr; 27(2):109-14. PMID: 1382634.
    Citations: 2     Fields:    Translation:AnimalsCells
  104. Baenziger JE, Miller KW, Rothschild KJ. Incorporation of the nicotinic acetylcholine receptor into planar multilamellar films: characterization by fluorescence and Fourier transform infrared difference spectroscopy. Biophys J. 1992 Apr; 61(4):983-92. PMID: 1581507.
    Citations: 7     Fields:    Translation:AnimalsCells
  105. Wood SC, Forman SA, Miller KW. Short chain and long chain alkanols have different sites of action on nicotinic acetylcholine receptor channels from Torpedo. Mol Pharmacol. 1991 Mar; 39(3):332-8. PMID: 1706469.
    Citations: 14     Fields:    Translation:AnimalsCells
  106. Miller KW, Wood SC, Forman SA, Bugge B, Hill WA, Abadji V. The nicotinic acetylcholine receptor in its membrane environment. Ann N Y Acad Sci. 1991; 625:600-15. PMID: 1711816.
    Citations:    Fields:    Translation:Cells
  107. Dodson BA, Urh RR, Miller KW. Relative potencies for barbiturate binding to the Torpedo acetylcholine receptor. Br J Pharmacol. 1990 Nov; 101(3):710-4. PMID: 1963806.
    Citations: 4     Fields:    Translation:AnimalsCells
  108. Fraser DM, Louro SR, Horváath LI, Miller KW, Watts A. A study of the effect of general anesthetics on lipid-protein interactions in acetylcholine receptor enriched membranes from Torpedo nobiliana using nitroxide spin-labels. Biochemistry. 1990 Mar 20; 29(11):2664-9. PMID: 2161253.
    Citations: 6     Fields:    Translation:AnimalsCells
  109. Forman SA, Righi DL, Miller KW. Ethanol increases agonist affinity for nicotinic receptors from Torpedo. Biochim Biophys Acta. 1989 Dec 11; 987(1):95-103. PMID: 2597688.
    Citations: 6     Fields:    Translation:AnimalsCells
  110. Roth SH, Forman SA, Braswell LM, Miller KW. Actions of pentobarbital enantiomers on nicotinic cholinergic receptors. Mol Pharmacol. 1989 Dec; 36(6):874-80. PMID: 2481226.
    Citations: 7     Fields:    Translation:AnimalsCells
  111. Forman SA, Miller KW. Molecular sites of anesthetic action in postsynaptic nicotinic membranes. Trends Pharmacol Sci. 1989 Nov; 10(11):447-52. PMID: 2692257.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  112. Forman SA, Miller KW. Procaine rapidly inactivates acetylcholine receptors from Torpedo and competes with agonist for inhibition sites. Biochemistry. 1989 Feb 21; 28(4):1678-85. PMID: 2719927.
    Citations: 2     Fields:    Translation:AnimalsCells
  113. Miller KW, Firestone LL, Alifimoff JK, Streicher P. Nonanesthetic alcohols dissolve in synaptic membranes without perturbing their lipids. Proc Natl Acad Sci U S A. 1989 Feb; 86(3):1084-7. PMID: 2783782.
    Citations: 16     Fields:    Translation:AnimalsCells
  114. Alifimoff JK, Firestone LL, Miller KW. Anaesthetic potencies of primary alkanols: implications for the molecular dimensions of the anaesthetic site. Br J Pharmacol. 1989 Jan; 96(1):9-16. PMID: 2784337.
    Citations: 51     Fields:    Translation:AnimalsCells
  115. Forman SA, Miller KW. High acetylcholine concentrations cause rapid inactivation before fast desensitization in nicotinic acetylcholine receptors from Torpedo. Biophys J. 1988 Jul; 54(1):149-58. PMID: 3416024.
    Citations: 5     Fields:    Translation:Animals
  116. Dodson BA, Braswell LM, Miller KW. Barbiturates bind to an allosteric regulatory site on nicotinic acetylcholine receptor-rich membranes. Mol Pharmacol. 1987 Jul; 32(1):119-26. PMID: 3600612.
    Citations: 9     Fields:    Translation:AnimalsCells
  117. Forman SA, Firestone LL, Miller KW. Is agonist self-inhibition at the nicotinic acetylcholine receptor a nonspecific action? Biochemistry. 1987 May 19; 26(10):2807-14. PMID: 3038165.
    Citations: 5     Fields:    Translation:AnimalsCells
  118. Miller KW, Firestone LL, Forman SA. General anesthetic and specific effects of ethanol on acetylcholine receptors. Ann N Y Acad Sci. 1987; 492:71-87. PMID: 2440361.
    Citations: 5     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.