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profileKeith Wyatt Miller, Dr.Phil.

TitleMallinckrodt Professor of Pharmacology in the Department of Anaesthesia
InstitutionMassachusetts General Hospital
DepartmentAnaesthesia
AddressMassachusetts General Hospital
Dept of Anaesthesia, Edwards 505
55 Fruit St
Boston MA 02114
Phone617/726-8985
Fax617/724-8644
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01GM069726     (MILLER, KEITH W)Jan 1, 2004 - Dec 31, 2008
NIH/NIGMS
General Anesthetic-Protein Interactions:Protein Kinase C
Role: Principal Investigator

U01AA014812     (MILLER, KEITH W)Sep 30, 2003 - Aug 31, 2008
NIH/NIAAA
Photolabeling of alcohol binding sites L1:
Role: Principal Investigator

P41RR015301     (EALICK, STEVEN E)Jun 15, 2001 - Mar 31, 2013
NIH/NCRR
An Undulator Resource for Structural Biology
Role: Co-Principal Investigator

P01GM058448     (MILLER, KEITH W)Dec 1, 1998 - Aug 31, 2019
NIH/NIGMS
General Anesthetic Sites on Ligand Gated Ion Channels
Role: Principal Investigator

R01AA007040     (MILLER, KEITH W)Jul 1, 1987 - Apr 30, 1999
NIH/NIAAA
ACTION OF ETHANOL ON NICOTINIC MEMBRANES
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Borenstein J, Herkert JR, Miller KW. Self-Driving Cars and Engineering Ethics: The Need for a System Level Analysis. Sci Eng Ethics. 2017 Nov 13. PMID: 29134429.
    View in: PubMed
  2. Ma C, Pejo E, McGrath M, Jayakar SS, Zhou X, Miller KW, Cohen JB, Raines DE. Competitive Antagonism of Anesthetic Action at the ?-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy. Anesthesiology. 2017 Nov; 127(5):824-837. PMID: 28857763.
    View in: PubMed
  3. Jounaidi Y, Cotten JF, Miller KW, Forman SA. Tethering IL2 to Its Receptor IL2Rß Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells. Cancer Res. 2017 Nov 01; 77(21):5938-5951. PMID: 28916655.
    View in: PubMed
  4. Nagasaka Y, Wepler M, Thoonen R, Sips PY, Allen K, Graw JA, Yao V, Burns SM, Muenster S, Brouckaert P, Miller K, Solt K, Buys ES, Ichinose F, Zapol WM. Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha. BMC Anesthesiol. 2017 Jun 14; 17(1):76. PMID: 28615047.
    View in: PubMed
  5. Savechenkov PY, Chiara DC, Desai R, Stern AT, Zhou X, Ziemba AM, Szabo AL, Zhang Y, Cohen JB, Forman SA, Miller KW, Bruzik KS. Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands. Eur J Med Chem. 2017 Aug 18; 136:334-347. PMID: 28505538.
    View in: PubMed
  6. Torlakovic EE, Cheung CC, D'Arrigo C, Dietel M, Francis GD, Gilks CB, Hall JA, Hornick JL, Ibrahim M, Marchetti A, Miller K, van Krieken JH, Nielsen S, Swanson PE, Vyberg M, Zhou X, Taylor CR. Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine. Part 3: Technical Validation of Immunohistochemistry (IHC) Assays in Clinical IHC Laboratories. Appl Immunohistochem Mol Morphol. 2017 Mar; 25(3):151-159. PMID: 28187030.
    View in: PubMed
  7. Torlakovic EE, Cheung CC, D'Arrigo C, Dietel M, Francis GD, Gilks CB, Hall JA, Hornick JL, Ibrahim M, Marchetti A, Miller K, van Krieken JH, Nielsen S, Swanson PE, Vyberg M, Zhou X, Taylor CR. Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine - Part 2: Immunohistochemistry Test Performance Characteristics. Appl Immunohistochem Mol Morphol. 2017 Feb; 25(2):79-85. PMID: 28182587.
    View in: PubMed
  8. Cheung CC, D'Arrigo C, Dietel M, Francis GD, Gilks CB, Hall JA, Hornick JL, Ibrahim M, Marchetti A, Miller K, van Krieken JH, Nielsen S, Swanson PE, Taylor CR, Vyberg M, Zhou X, Torlakovic EE. Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine: Part 1: Fit-for-Purpose Approach to Classification of Clinical Immunohistochemistry Biomarkers. Appl Immunohistochem Mol Morphol. 2017 Jan; 25(1):4-11. PMID: 27922482.
    View in: PubMed
  9. Cheung CC, D'Arrigo C, Dietel M, Francis GD, Fulton R, Gilks CB, Hall JA, Hornick JL, Ibrahim M, Marchetti A, Miller K, van Krieken JH, Nielsen S, Swanson PE, Taylor CR, Vyberg M, Zhou X, Torlakovic EE. Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine: Part 4: Tissue Tools for Quality Assurance in Immunohistochemistry. Appl Immunohistochem Mol Morphol. 2016 Dec 09. PMID: 27941560.
    View in: PubMed
  10. Chiara DC, Jounaidi Y, Zhou X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB. General Anesthetic Binding Sites in Human a4ß3d ?-Aminobutyric Acid Type A Receptors (GABAARs). J Biol Chem. 2016 Dec 16; 291(51):26529-26539. PMID: 27821594.
    View in: PubMed
  11. Roth SH, Miller KW, Orser BA, Urban BW. Unlocking the Mechanisms of Anesthesia. Anesth Analg. 2016 Nov; 123(5):1070-1071. PMID: 27454067.
    View in: PubMed
  12. Amlong CA, Perkins MG, Houle TT, Miller KW, Pearce RA. Contrasting Effects of the ?-Aminobutyric Acid Type A Receptor ß3 Subunit N265M Mutation on Loss of Righting Reflexes Induced by Etomidate and the Novel Anesthetic Barbiturate R-mTFD-MPAB. Anesth Analg. 2016 Nov; 123(5):1241-1246. PMID: 27331778.
    View in: PubMed
  13. Forman SA, Miller KW. Mapping General Anesthetic Sites in Heteromeric ?-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes. Anesth Analg. 2016 Nov; 123(5):1263-1273. PMID: 27167687.
    View in: PubMed
  14. Miller KW, Wolf MJ, Grodzinsky F. This "Ethical Trap" Is for Roboticists, Not Robots: On the Issue of Artificial Agent Ethical Decision-Making. Sci Eng Ethics. 2017 Apr; 23(2):389-401. PMID: 27116039.
    View in: PubMed
  15. Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KW. Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the a1 ß3 ?2L GABAA receptor account for their in vivo effects. J Physiol. 2015 Nov 15; 593(22):4943-61. PMID: 26378885; PMCID: PMC4650410 [Available on 11/15/16].
  16. Jayakar SS, Zhou X, Savechenkov PY, Chiara DC, Desai R, Bruzik KS, Miller KW, Cohen JB. Positive and Negative Allosteric Modulation of an a1ß3?2 ?-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the ?+-ß- Interface. J Biol Chem. 2015 Sep 18; 290(38):23432-46. PMID: 26229099; PMCID: PMC4645599.
  17. Zhang X, Miller KW. Dodecyl maltopyranoside enabled purification of active human GABA type A receptors for deep and direct proteomic sequencing. Mol Cell Proteomics. 2015 Mar; 14(3):724-38. PMID: 25473089; PMCID: PMC4349990.
  18. Forman SA, Miller KW, Talmor D, Hickey P, Strichartz G, Wiener-Kronish J. Research at the Harvard Anesthesia Departments. Anesthesiology. 2014 Dec; 121(6):1141-3. PMID: 25299744; PMCID: PMC4493721 [Available on 12/01/15].
  19. Forman SA, Chiara DC, Miller KW. Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptors. Neuropharmacology. 2015 Sep; 96(Pt B):169-77. PMID: 25316107; PMCID: PMC4394016.
  20. Jayakar SS, Zhou X, Chiara DC, Dostalova Z, Savechenkov PY, Bruzik KS, Dailey WP, Miller KW, Eckenhoff RG, Cohen JB. Multiple propofol-binding sites in a ?-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog. J Biol Chem. 2014 Oct 03; 289(40):27456-68. PMID: 25086038; PMCID: PMC4183786.
  21. Dostalova Z, Zhou X, Liu A, Zhang X, Zhang Y, Desai R, Forman SA, Miller KW. Human a1ß3?2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state. Protein Sci. 2014 Feb; 23(2):157-66. PMID: 24288268; PMCID: PMC3926741.
  22. Olsen RW, Li GD, Wallner M, Trudell JR, Bertaccini EJ, Lindahl E, Miller KW, Alkana RL, Davies DL. Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol. Alcohol Clin Exp Res. 2014 Mar; 38(3):595-603. PMID: 24164436; PMCID: PMC3959612.
  23. Chiara DC, Jayakar SS, Zhou X, Zhang X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB. Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human a1ß3?2 ?-aminobutyric acid type A (GABAA) receptor. J Biol Chem. 2013 Jul 05; 288(27):19343-57. PMID: 23677991; PMCID: PMC3707639.
  24. Shanmugasundararaj S, Zhou X, Neunzig J, Bernhardt R, Cotten JF, Ge R, Miller KW, Raines DE. Carboetomidate: an analog of etomidate that interacts weakly with 11ß-hydroxylase. Anesth Analg. 2013 Jun; 116(6):1249-56. PMID: 23492967; PMCID: PMC3836822.
  25. Desai R, Miller KW, Raines DE. The pyrrole etomidate analog carboetomidate potently inhibits human 5-HT3A receptor function: comparisons with etomidate and potential implications for emetogenesis. Anesth Analg. 2013 Mar; 116(3):573-9. PMID: 23400978; PMCID: PMC3582768.
  26. Shanmugasundararaj S, Das J, Sandberg WS, Zhou X, Wang D, Messing RO, Bruzik KS, Stehle T, Miller KW. Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cd*. Biophys J. 2012 Dec 05; 103(11):2331-40. PMID: 23283232; PMCID: PMC3514512.
  27. Savechenkov PY, Zhang X, Chiara DC, Stewart DS, Ge R, Zhou X, Raines DE, Cohen JB, Forman SA, Miller KW, Bruzik KS. Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic. J Med Chem. 2012 Jul 26; 55(14):6554-65. PMID: 22734650; PMCID: PMC3717557.
  28. Chiara DC, Dostalova Z, Jayakar SS, Zhou X, Miller KW, Cohen JB. Mapping general anesthetic binding site(s) in human a1ß3 ?-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue. Biochemistry. 2012 Jan 31; 51(4):836-47. PMID: 22243422; PMCID: PMC3274767.
  29. Shanmugasundararaj S, Lehle S, Yamodo HI, Husain SS, Tseng C, Nguyen K, Addona GH, Miller KW. The location and nature of general anesthetic binding sites on the active conformation of firefly luciferase; a time resolved photolabeling study. PLoS One. 2012; 7(1):e29854. PMID: 22272253; PMCID: PMC3260189.
  30. Stewart DS, Savechenkov PY, Dostalova Z, Chiara DC, Ge R, Raines DE, Cohen JB, Forman SA, Bruzik KS, Miller KW. p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol. J Med Chem. 2011 Dec 08; 54(23):8124-35. PMID: 22029276; PMCID: PMC3580944.
  31. Dou X, Menkari CE, Shanmugasundararaj S, Miller KW, Charness ME. Two alcohol binding residues interact across a domain interface of the L1 neural cell adhesion molecule and regulate cell adhesion. J Biol Chem. 2011 May 06; 286(18):16131-9. PMID: 21367865; PMCID: PMC3091222.
  32. Miller KW, Orser BA, Roth SH. Mechanisms of anesthesia: past, present, and a glimpse into the future. Can J Anaesth. 2011 Feb; 58(2):131-4, 134-8. PMID: 21165729.
    View in: PubMed
  33. Forman SA, Miller KW. Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels. Can J Anaesth. 2011 Feb; 58(2):191-205. PMID: 21213095; PMCID: PMC3108180.
  34. Husain SS, Stewart D, Desai R, Hamouda AK, Li SG, Kelly E, Dostalova Z, Zhou X, Cotten JF, Raines DE, Olsen RW, Cohen JB, Forman SA, Miller KW. p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels. J Med Chem. 2010 Sep 09; 53(17):6432-44. PMID: 20704351; PMCID: PMC3117435.
  35. Dostalova Z, Liu A, Zhou X, Farmer SL, Krenzel ES, Arevalo E, Desai R, Feinberg-Zadek PL, Davies PA, Yamodo IH, Forman SA, Miller KW. High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors. Protein Sci. 2010 Sep; 19(9):1728-38. PMID: 20662008; PMCID: PMC2975136.
  36. Cotten JF, Forman SA, Laha JK, Cuny GD, Husain SS, Miller KW, Nguyen HH, Kelly EW, Stewart D, Liu A, Raines DE. Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function. Anesthesiology. 2010 Mar; 112(3):637-44. PMID: 20179500; PMCID: PMC2830733.
  37. Yamodo IH, Chiara DC, Cohen JB, Miller KW. Conformational changes in the nicotinic acetylcholine receptor during gating and desensitization. Biochemistry. 2010 Jan 12; 49(1):156-65. PMID: 19961216; PMCID: PMC2818735.
  38. Cotten JF, Husain SS, Forman SA, Miller KW, Kelly EW, Nguyen HH, Raines DE. Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression. Anesthesiology. 2009 Aug; 111(2):240-9. PMID: 19625798; PMCID: PMC2739411.
  39. Chiara DC, Hong FH, Arevalo E, Husain SS, Miller KW, Forman SA, Cohen JB. Time-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor. Mol Pharmacol. 2009 May; 75(5):1084-95. PMID: 19218367; PMCID: PMC2672814.
  40. Ho C, Shanmugasundararaj S, Miller KW, Malinowski SA, Cook AC, Slater SJ. Interaction of anesthetics with the Rho GTPase regulator Rho GDP dissociation inhibitor. Biochemistry. 2008 Sep 09; 47(36):9540-52. PMID: 18702520; PMCID: PMC4556268.
  41. Arevalo E, Shanmugasundararaj S, Wilkemeyer MF, Dou X, Chen S, Charness ME, Miller KW. An alcohol binding site on the neural cell adhesion molecule L1. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):371-5. PMID: 18165316; PMCID: PMC2224219.
  42. Williamson PT, Verhoeven A, Miller KW, Meier BH, Watts A. The conformation of acetylcholine at its target site in the membrane-embedded nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18031-6. PMID: 17989232; PMCID: PMC2084291.
  43. Kumar A, Tyagi NK, Arevalo E, Miller KW, Kinne RK. A proteomic study of sodium/D-glucose cotransporter 1 (SGLT1): topology of loop 13 and coverage of other functionally important domains. Biochim Biophys Acta. 2007 Aug; 1774(8):968-74. PMID: 17588833.
    View in: PubMed
  44. Das J, Zhou X, Miller KW. Identification of an alcohol binding site in the first cysteine-rich domain of protein kinase Cdelta. Protein Sci. 2006 Sep; 15(9):2107-19. PMID: 16943444; PMCID: PMC2242605.
  45. Husain SS, Nirthanan S, Ruesch D, Solt K, Cheng Q, Li GD, Arevalo E, Olsen RW, Raines DE, Forman SA, Cohen JB, Miller KW. Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels. J Med Chem. 2006 Aug 10; 49(16):4818-25. PMID: 16884293.
    View in: PubMed
  46. Liao M, Sonner JM, Husain SS, Miller KW, Jurd R, Rudolph U, Eger EI. R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M point mutation in the gamma-aminobutyric acid receptor beta3 subunit. Anesth Analg. 2005 Jul; 101(1):131-5, table of contents. PMID: 15976219.
    View in: PubMed
  47. Arevalo E, Chiara DC, Forman SA, Cohen JB, Miller KW. Gating-enhanced accessibility of hydrophobic sites within the transmembrane region of the nicotinic acetylcholine receptor's {delta}-subunit. A time-resolved photolabeling study. J Biol Chem. 2005 Apr 08; 280(14):13631-40. PMID: 15664985.
    View in: PubMed
  48. Das J, Addona GH, Sandberg WS, Husain SS, Stehle T, Miller KW. Identification of a general anesthetic binding site in the diacylglycerol-binding domain of protein kinase Cdelta. J Biol Chem. 2004 Sep 03; 279(36):37964-72. PMID: 15234976.
    View in: PubMed
  49. Ziebell MR, Nirthanan S, Husain SS, Miller KW, Cohen JB. Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic. J Biol Chem. 2004 Apr 23; 279(17):17640-9. PMID: 14761946.
    View in: PubMed
  50. Campagna JA, Miller KW, Forman SA. Mechanisms of actions of inhaled anesthetics. N Engl J Med. 2003 May 22; 348(21):2110-24. PMID: 12761368.
    View in: PubMed
  51. Husain SS, Ziebell MR, Ruesch D, Hong F, Arevalo E, Kosterlitz JA, Olsen RW, Forman SA, Cohen JB, Miller KW. 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels. J Med Chem. 2003 Mar 27; 46(7):1257-65. PMID: 12646036.
    View in: PubMed
  52. Addona GH, Sandermann H, Kloczewiak MA, Miller KW. Low chemical specificity of the nicotinic acetylcholine receptor sterol activation site. Biochim Biophys Acta. 2003 Jan 31; 1609(2):177-82. PMID: 12543379.
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  53. Miller KW, Richards CD, Roth SH, Urban BW. Molecular and basic mechanisms of anaesthesia. Br J Anaesth. 2002 Jul; 89(1):1-2. PMID: 12173222.
    View in: PubMed
  54. Miller KW. The nature of sites of general anaesthetic action. Br J Anaesth. 2002 Jul; 89(1):17-31. PMID: 12173229.
    View in: PubMed
  55. Addona GH, Husain SS, Stehle T, Miller KW. Geometric isomers of a photoactivable general anesthetic delineate a binding site on adenylate kinase. J Biol Chem. 2002 Jul 12; 277(28):25685-91. PMID: 11976328.
    View in: PubMed
  56. Williamson PT, Watts JA, Addona GH, Miller KW, Watts A. Dynamics and orientation of N+(CD3)3-bromoacetylcholine bound to its binding site on the nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2346-51. PMID: 11226242; PMCID: PMC30141.
  57. Chiara DC, Kloczewiak MA, Addona GH, Yu JA, Cohen JB, Miller KW. Site of resting state inhibition of the nicotinic acetylcholine receptor by a hydrophobic inhibitor. Biochemistry. 2001 Jan 09; 40(1):296-304. PMID: 11141083.
    View in: PubMed
  58. Pratt MB, Husain SS, Miller KW, Cohen JB. Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic. J Biol Chem. 2000 Sep 22; 275(38):29441-51. PMID: 10859324.
    View in: PubMed
  59. Husain SS, Forman SA, Kloczewiak MA, Addona GH, Olsen RW, Pratt MB, Cohen JB, Miller KW. Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic. J Med Chem. 1999 Aug 26; 42(17):3300-7. PMID: 10464016.
    View in: PubMed
  60. Addona GH, Kloczewiak MA, Miller KW. Time-resolved photolabeling of membrane proteins: application to the nicotinic acetylcholine receptor. Anal Biochem. 1999 Feb 01; 267(1):135-40. PMID: 9918665.
    View in: PubMed
  61. Miller KW, Addona GH, Kloczewiak MA. Approaches to proving there are general anesthetic sites on ligand gated ion channels. Toxicol Lett. 1998 Nov 23; 100-101:139-47. PMID: 10049134.
    View in: PubMed
  62. Williamson PT, Watts J, Gröbner G, Miller KW, Watts A. Solid state NMR studies of ligands bound to the nicotinic acetylcholine receptor. Biochem Soc Trans. 1998 Aug; 26(3):S297. PMID: 9766016.
    View in: PubMed
  63. Williamson PT, Gröbner G, Spooner PJ, Miller KW, Watts A. Probing the agonist binding pocket in the nicotinic acetylcholine receptor: a high-resolution solid-state NMR approach. Biochemistry. 1998 Jul 28; 37(30):10854-9. PMID: 9692976.
    View in: PubMed
  64. Addona GH, Sandermann H, Kloczewiak MA, Husain SS, Miller KW. Where does cholesterol act during activation of the nicotinic acetylcholine receptor? Biochim Biophys Acta. 1998 Mar 13; 1370(2):299-309. PMID: 9545586.
    View in: PubMed
  65. Rankin SE, Addona GH, Kloczewiak MA, Bugge B, Miller KW. The cholesterol dependence of activation and fast desensitization of the nicotinic acetylcholine receptor. Biophys J. 1997 Nov; 73(5):2446-55. PMID: 9370438; PMCID: PMC1181146.
  66. Sandermann H, Addona GH, Miller KW. A thermodynamic analysis of the partitioning of cholesterol and related compounds between trioleoylglycerol and egg phosphatidylcholine bilayers. Biochim Biophys Acta. 1997 Jun 02; 1346(2):158-62. PMID: 9219898.
    View in: PubMed
  67. Wilson CJ, Husain SS, Stimson ER, Dangott LJ, Miller KW, Maggio JE. p-(4-Hydroxybenzoyl)phenylalanine: a photoreactive amino acid analog amenable to radioiodination for elucidation of peptide-protein interaction. Application to substance P receptor. Biochemistry. 1997 Apr 15; 36(15):4542-51. PMID: 9109663.
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  68. Forman SA, Miller KW, Yellen G. A discrete site for general anesthetics on a postsynaptic receptor. Mol Pharmacol. 1995 Oct; 48(4):574-81. PMID: 7476881.
    View in: PubMed
  69. Raines DE, Wu G, Dalton LA, Miller KW. Electron spin resonance studies of acyl chain motion in reconstituted nicotinic acetylcholine receptor membranes. Biophys J. 1995 Aug; 69(2):498-505. PMID: 8527664; PMCID: PMC1236275.
  70. Tonner PH, Miller KW. Molecular sites of general anaesthetic action on acetylcholine receptors. Eur J Anaesthesiol. 1995 Jan; 12(1):21-30. PMID: 7535690.
    View in: PubMed
  71. Raines DE, Rankin SE, Miller KW. General anesthetics modify the kinetics of nicotinic acetylcholine receptor desensitization at clinically relevant concentrations. Anesthesiology. 1995 Jan; 82(1):276-87; discussion 31A-32A. PMID: 7832311.
    View in: PubMed
  72. Wood SC, Tonner PH, de Armendi AJ, Bugge B, Miller KW. Channel inhibition by alkanols occurs at a binding site on the nicotinic acetylcholine receptor. Mol Pharmacol. 1995 Jan; 47(1):121-30. PMID: 7530805.
    View in: PubMed
  73. Wu G, Raines DE, Miller KW. A hydrophobic inhibitor of the nicotinic acetylcholine receptor acts on the resting state. Biochemistry. 1994 Dec 27; 33(51):15375-81. PMID: 7803400.
    View in: PubMed
  74. Raines DE, Miller KW. On the importance of volatile agents devoid of anesthetic action. Anesth Analg. 1994 Dec; 79(6):1031-3. PMID: 7677814.
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  75. Firestone LL, Alifimoff JK, Miller KW. Does general anesthetic-induced desensitization of the Torpedo acetylcholine receptor correlate with lipid disordering? Mol Pharmacol. 1994 Sep; 46(3):508-15. PMID: 7935332.
    View in: PubMed
  76. Abadji V, Raines DE, Dalton LA, Miller KW. Lipid-protein interactions and protein dynamics in vesicles containing the nicotinic acetylcholine receptor: a study with ethanol. Biochim Biophys Acta. 1994 Aug 24; 1194(1):25-34. PMID: 8075138.
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  77. Wu G, Miller KW. Ethanol enhances agonist-induced fast desensitization in nicotinic acetylcholine receptors. Biochemistry. 1994 Aug 09; 33(31):9085-91. PMID: 8049210.
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  78. Wu G, Tonner PH, Miller KW. Ethanol stabilizes the open channel state of the Torpedo nicotinic acetylcholine receptor. Mol Pharmacol. 1994 Jan; 45(1):102-8. PMID: 8302268.
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  79. Wood SC, Hill WA, Miller KW. Cycloalkanemethanols discriminate between volume- and length-dependent loss of activity of alkanols at the Torpedo nicotinic acetylcholine receptor. Mol Pharmacol. 1993 Dec; 44(6):1219-26. PMID: 8264559.
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  80. de Armendi AJ, Tonner PH, Bugge B, Miller KW. Barbiturate action is dependent on the conformational state of the acetylcholine receptor. Anesthesiology. 1993 Nov; 79(5):1033-41. PMID: 8238981.
    View in: PubMed
  81. Dalton LA, Miller KW. Trans-unsaturated lipid dynamics: modulation of dielaidoylphosphatidylcholine acyl chain motion by ethanol. Biophys J. 1993 Oct; 65(4):1620-31. PMID: 8274650; PMCID: PMC1225888.
  82. Alifimoff JK, Bugge B, Forman SA, Miller KW. Stereoselectivity of channel inhibition by secondary alkanol enantiomers at nicotinic acetylcholine receptors. Anesthesiology. 1993 Jul; 79(1):122-8. PMID: 7688196.
    View in: PubMed
  83. Baenziger JE, Miller KW, Rothschild KJ. Fourier transform infrared difference spectroscopy of the nicotinic acetylcholine receptor: evidence for specific protein structural changes upon desensitization. Biochemistry. 1993 May 25; 32(20):5448-54. PMID: 8499448.
    View in: PubMed
  84. Raines DE, Korten SE, Hill AG, Miller KW. Anesthetic cutoff in cycloalkanemethanols. A test of current theories. Anesthesiology. 1993 May; 78(5):918-27. PMID: 8489064.
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  85. Abadji VC, Raines DE, Watts A, Miller KW. The effect of general anesthetics on the dynamics of phosphatidylcholine-acetylcholine receptor interactions in reconstituted vesicles. Biochim Biophys Acta. 1993 Apr 08; 1147(1):143-53. PMID: 8466926.
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  86. Raines DE, Miller KW. The role of charge in lipid selectivity for the nicotinic acetylcholine receptor. Biophys J. 1993 Mar; 64(3):632-41. PMID: 8386010; PMCID: PMC1262375.
  87. Tonner PH, Poppers DM, Miller KW. The general anesthetic potency of propofol and its dependence on hydrostatic pressure. Anesthesiology. 1992 Nov; 77(5):926-31. PMID: 1443748.
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  88. Tonner PH, Wood SC, Miller KW. Can nicotine self-inhibition account for its low efficacy at the nicotinic acetylcholine receptor from Torpedo? Mol Pharmacol. 1992 Nov; 42(5):890-7. PMID: 1279379.
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  89. Baenziger JE, Miller KW, McCarthy MP, Rothschild KJ. Probing conformational changes in the nicotinic acetylcholine receptor by Fourier transform infrared difference spectroscopy. Biophys J. 1992 Apr; 62(1):64-6. PMID: 1600101; PMCID: PMC1260486.
  90. Tonner PH, Miller KW. [Cholinergic receptors and anesthesia]. Anasthesiol Intensivmed Notfallmed Schmerzther. 1992 Apr; 27(2):109-14. PMID: 1382634.
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  91. Baenziger JE, Miller KW, Rothschild KJ. Incorporation of the nicotinic acetylcholine receptor into planar multilamellar films: characterization by fluorescence and Fourier transform infrared difference spectroscopy. Biophys J. 1992 Apr; 61(4):983-92. PMID: 1581507; PMCID: PMC1260357.
  92. Wood SC, Forman SA, Miller KW. Short chain and long chain alkanols have different sites of action on nicotinic acetylcholine receptor channels from Torpedo. Mol Pharmacol. 1991 Mar; 39(3):332-8. PMID: 1706469.
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  93. Miller KW, Wood SC, Forman SA, Bugge B, Hill WA, Abadji V. The nicotinic acetylcholine receptor in its membrane environment. Ann N Y Acad Sci. 1991; 625:600-15. PMID: 1711816.
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  94. Dodson BA, Urh RR, Miller KW. Relative potencies for barbiturate binding to the Torpedo acetylcholine receptor. Br J Pharmacol. 1990 Nov; 101(3):710-4. PMID: 1963806; PMCID: PMC1917748.
  95. Fraser DM, Louro SR, Horváath LI, Miller KW, Watts A. A study of the effect of general anesthetics on lipid-protein interactions in acetylcholine receptor enriched membranes from Torpedo nobiliana using nitroxide spin-labels. Biochemistry. 1990 Mar 20; 29(11):2664-9. PMID: 2161253.
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  96. Forman SA, Righi DL, Miller KW. Ethanol increases agonist affinity for nicotinic receptors from Torpedo. Biochim Biophys Acta. 1989 Dec 11; 987(1):95-103. PMID: 2597688.
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  97. Roth SH, Forman SA, Braswell LM, Miller KW. Actions of pentobarbital enantiomers on nicotinic cholinergic receptors. Mol Pharmacol. 1989 Dec; 36(6):874-80. PMID: 2481226.
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  98. Forman SA, Miller KW. Molecular sites of anesthetic action in postsynaptic nicotinic membranes. Trends Pharmacol Sci. 1989 Nov; 10(11):447-52. PMID: 2692257.
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  99. Forman SA, Miller KW. Procaine rapidly inactivates acetylcholine receptors from Torpedo and competes with agonist for inhibition sites. Biochemistry. 1989 Feb 21; 28(4):1678-85. PMID: 2719927.
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  100. Miller KW, Firestone LL, Alifimoff JK, Streicher P. Nonanesthetic alcohols dissolve in synaptic membranes without perturbing their lipids. Proc Natl Acad Sci U S A. 1989 Feb; 86(3):1084-7. PMID: 2783782; PMCID: PMC286626.
  101. Alifimoff JK, Firestone LL, Miller KW. Anaesthetic potencies of primary alkanols: implications for the molecular dimensions of the anaesthetic site. Br J Pharmacol. 1989 Jan; 96(1):9-16. PMID: 2784337; PMCID: PMC1854325.
  102. Forman SA, Miller KW. High acetylcholine concentrations cause rapid inactivation before fast desensitization in nicotinic acetylcholine receptors from Torpedo. Biophys J. 1988 Jul; 54(1):149-58. PMID: 3416024; PMCID: PMC1330324.
  103. Dodson BA, Braswell LM, Miller KW. Barbiturates bind to an allosteric regulatory site on nicotinic acetylcholine receptor-rich membranes. Mol Pharmacol. 1987 Jul; 32(1):119-26. PMID: 3600612.
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  104. Forman SA, Firestone LL, Miller KW. Is agonist self-inhibition at the nicotinic acetylcholine receptor a nonspecific action? Biochemistry. 1987 May 19; 26(10):2807-14. PMID: 3038165.
    View in: PubMed
  105. Miller KW, Firestone LL, Forman SA. General anesthetic and specific effects of ethanol on acetylcholine receptors. Ann N Y Acad Sci. 1987; 492:71-87. PMID: 2440361.
    View in: PubMed
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