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profileWilliam Francis Sewell, Ph.D.

TitleProfessor of Otolaryngology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOtolaryngology
AddressMassachusetts Eye & Ear Infrm
Otology & Laryngology
243 Charles St
Boston MA 02114
Phone617/573-3156
Fax617/720-4408
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01DC012838     (SEWELL, WILLIAM F)Sep 1, 2013 - Aug 31, 2018
NIH/NIDCD
Cochlear Neurotransmitters
Role: Principal Investigator

R01DC013138     (SEWELL, WILLIAM F)Feb 1, 2013 - Jan 31, 2018
NIH/NIDCD
Pharmacology of Rescue from Acoustic Trauma
Role: Principal Investigator

R21DC009651     (SEWELL, WILLIAM F)Jul 1, 2008 - Jun 30, 2011
NIH/NIDCD
Proteomic analysis of synaptic ribbons in the inner ear
Role: Principal Investigator

R01DC000767     (SEWELL, WILLIAM F)Dec 1, 1990 - Jun 30, 2012
NIH/NIDCD
Pharmacology of Neurotransmitters in Hair Cell Organs
Role: Principal Investigator

R01DC000202     (SEWELL, WILLIAM F)Apr 1, 1984 - Mar 31, 1991
NIH/NIDCD
IDENTIFICATION OF HAIR CELL TRANSMITTERS
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Jung DH, Kang WS, McKenna MJ, Sewell WF, Nguyen K, McKenna CE. Response to "Drug Diffusion to the Apex of the Human Cochlea?". Otol Neurotol. 2016 Oct; 37(9):1463-4. PMID: 27466891; PMCID: PMC5025361 [Available on 10/01/17].
  2. Kang WS, Nguyen K, McKenna CE, Sewell WF, McKenna MJ, Jung DH. Measurement of Ototoxicity Following Intracochlear Bisphosphonate Delivery. Otol Neurotol. 2016 Jul; 37(6):621-6. PMID: 27153329; PMCID: PMC4907848 [Available on 07/01/17].
  3. Tandon V, Kang WS, Robbins TA, Spencer AJ, Kim ES, McKenna MJ, Kujawa SG, Fiering J, Pararas EE, Mescher MJ, Sewell WF, Borenstein JT. Microfabricated reciprocating micropump for intracochlear drug delivery with integrated drug/fluid storage and electronically controlled dosing. Lab Chip. 2016 Mar 07; 16(5):829-46. PMID: 26778829; PMCID: PMC4766044 [Available on 02/23/17].
  4. Kang WS, Nguyen K, McKenna CE, Sewell WF, McKenna MJ, Jung DH. Intracochlear Drug Delivery Through the Oval Window in Fresh Cadaveric Human Temporal Bones. Otol Neurotol. 2016 Mar; 37(3):218-22. PMID: 26859540; PMCID: PMC4752383 [Available on 03/01/17].
  5. Kang WS, Sun S, Nguyen K, Kashemirov B, McKenna CE, Hacking SA, Quesnel AM, Sewell WF, McKenna MJ, Jung DH. Non-Ototoxic Local Delivery of Bisphosphonate to the Mammalian Cochlea. Otol Neurotol. 2015 Jul; 36(6):953-60. PMID: 25996080; PMCID: PMC4469560.
  6. Tandon V, Kang WS, Spencer AJ, Kim ES, Pararas EE, McKenna MJ, Kujawa SG, Mescher MJ, Fiering J, Sewell WF, Borenstein JT. Microfabricated infuse-withdraw micropump component for an integrated inner-ear drug-delivery platform. Biomed Microdevices. 2015 Apr; 17(2):37. PMID: 25686902.
    View in: PubMed
  7. Kantardzhieva A, Liberman MC, Sewell WF. Quantitative analysis of ribbons, vesicles, and cisterns at the cat inner hair cell synapse: correlations with spontaneous rate. J Comp Neurol. 2013 Oct 01; 521(14):3260-71. PMID: 23787810; PMCID: PMC4309284.
  8. Peppi M, Landa M, Sewell WF. Cochlear kainate receptors. J Assoc Res Otolaryngol. 2012 Apr; 13(2):199-208. PMID: 22231646; PMCID: PMC3298619.
  9. Kantardzhieva A, Peppi M, Lane WS, Sewell WF. Protein composition of immunoprecipitated synaptic ribbons. J Proteome Res. 2012 Feb 03; 11(2):1163-74. PMID: 22103298; PMCID: PMC3274173.
  10. Pararas EE, Chen Z, Fiering J, Mescher MJ, Kim ES, McKenna MJ, Kujawa SG, Borenstein JT, Sewell WF. Kinetics of reciprocating drug delivery to the inner ear. J Control Release. 2011 Jun 10; 152(2):270-7. PMID: 21385596; PMCID: PMC3114251.
  11. Peppi M, Kujawa SG, Sewell WF. A corticosteroid-responsive transcription factor, promyelocytic leukemia zinc finger protein, mediates protection of the cochlea from acoustic trauma. J Neurosci. 2011 Jan 12; 31(2):735-41. PMID: 21228182; PMCID: PMC3274172.
  12. McCall AA, Swan EE, Borenstein JT, Sewell WF, Kujawa SG, McKenna MJ. Drug delivery for treatment of inner ear disease: current state of knowledge. Ear Hear. 2010 Apr; 31(2):156-65. PMID: 19952751; PMCID: PMC2836414.
  13. Chen Z, Kujawa SG, Sewell WF. Functional roles of high-affinity glutamate transporters in cochlear afferent synaptic transmission in the mouse. J Neurophysiol. 2010 May; 103(5):2581-6. PMID: 20220082; PMCID: PMC2867573.
  14. Sewell WF, Borenstein JT, Chen Z, Fiering J, Handzel O, Holmboe M, Kim ES, Kujawa SG, McKenna MJ, Mescher MM, Murphy B, Swan EE, Peppi M, Tao S. Development of a microfluidics-based intracochlear drug delivery device. Audiol Neurootol. 2009; 14(6):411-22. PMID: 19923811; PMCID: PMC2820330.
  15. Chen Z, Peppi M, Kujawa SG, Sewell WF. Regulated expression of surface AMPA receptors reduces excitotoxicity in auditory neurons. J Neurophysiol. 2009 Aug; 102(2):1152-9. PMID: 19515954; PMCID: PMC2724347.
  16. Fiering J, Mescher MJ, Leary Swan EE, Holmboe ME, Murphy BA, Chen Z, Peppi M, Sewell WF, McKenna MJ, Kujawa SG, Borenstein JT. Local drug delivery with a self-contained, programmable, microfluidic system. Biomed Microdevices. 2009 Jun; 11(3):571-8. PMID: 19089621; PMCID: PMC2935585.
  17. Mescher MJ, Swan EE, Fiering J, Holmboe ME, Sewell WF, Kujawa SG, McKenna MJ, Borenstein JT. Fabrication Methods and Performance of Low-Permeability Microfluidic Components for a Miniaturized Wearable Drug Delivery System. J Microelectromech Syst. 2009 Jun 01; 18(3):501-510. PMID: 20852729.
    View in: PubMed
  18. Swan EE, Peppi M, Chen Z, Green KM, Evans JE, McKenna MJ, Mescher MJ, Kujawa SG, Sewell WF. Proteomics analysis of perilymph and cerebrospinal fluid in mouse. Laryngoscope. 2009 May; 119(5):953-8. PMID: 19358201; PMCID: PMC2940114.
  19. Handzel O, Wang H, Fiering J, Borenstein JT, Mescher MJ, Swan EE, Murphy BA, Chen Z, Peppi M, Sewell WF, Kujawa SG, McKenna MJ. Mastoid cavity dimensions and shape: method of measurement and virtual fitting of implantable devices. Audiol Neurootol. 2009; 14(5):308-14. PMID: 19372649; PMCID: PMC2712579.
  20. Sewell W, Sparrow DB, Smith AJ, Gonzalez DM, Rappaport EF, Dunwoodie SL, Kusumi K. Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis. Dev Biol. 2009 May 15; 329(2):400-9. PMID: 19268448; PMCID: PMC2697309.
  21. Swan EE, Mescher MJ, Sewell WF, Tao SL, Borenstein JT. Inner ear drug delivery for auditory applications. Adv Drug Deliv Rev. 2008 Dec 14; 60(15):1583-99. PMID: 18848590; PMCID: PMC2657604.
  22. Wang L, Sewell WF, Kim SD, Shin JT, MacRae CA, Zon LI, Seidman JG, Seidman CE. Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish. Development. 2008 Oct; 135(20):3425-34. PMID: 18799547.
    View in: PubMed
  23. Chen Z, Kujawa SG, Sewell WF. Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors. Nat Neurosci. 2007 Oct; 10(10):1238-40. PMID: 17828255.
    View in: PubMed
  24. William DA, Saitta B, Gibson JD, Traas J, Markov V, Gonzalez DM, Sewell W, Anderson DM, Pratt SC, Rappaport EF, Kusumi K. Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model. Dev Biol. 2007 May 01; 305(1):172-86. PMID: 17362910; PMCID: PMC1899184.
  25. Chen Z, Kujawa SG, McKenna MJ, Fiering JO, Mescher MJ, Borenstein JT, Swan EE, Sewell WF. Inner ear drug delivery via a reciprocating perfusion system in the guinea pig. J Control Release. 2005 Dec 10; 110(1):1-19. PMID: 16274830; PMCID: PMC2030590.
  26. Sewell WF, Mroz EA, Evans JE. Extracts of retina and brain that excite afferent fibers innervating hair cells contain a compound related to hydroxyphenylglycine-N-carbamoyl. Synapse. 2005 Nov; 58(2):129-40. PMID: 16088953; PMCID: PMC1989148.
  27. Avanesov A, Dahm R, Sewell WF, Malicki JJ. Mutations that affect the survival of selected amacrine cell subpopulations define a new class of genetic defects in the vertebrate retina. Dev Biol. 2005 Sep 01; 285(1):138-55. PMID: 16231865.
    View in: PubMed
  28. Chen Z, Mikulec AA, McKenna MJ, Sewell WF, Kujawa SG. A method for intracochlear drug delivery in the mouse. J Neurosci Methods. 2006 Jan 15; 150(1):67-73. PMID: 16043228.
    View in: PubMed
  29. Dawkins R, Keller SL, Sewell WF. Pharmacology of acetylcholine-mediated cell signaling in the lateral line organ following efferent stimulation. J Neurophysiol. 2005 May; 93(5):2541-51. PMID: 15615825; PMCID: PMC2001307.
  30. Dawkins R, Sewell WF. Afferent synaptic transmission in a hair cell organ: pharmacological and physiological analysis of the role of the extended refractory period. J Neurophysiol. 2004 Aug; 92(2):1105-15. PMID: 15056680.
    View in: PubMed
  31. Bang PI, Yelick PC, Malicki JJ, Sewell WF. High-throughput behavioral screening method for detecting auditory response defects in zebrafish. J Neurosci Methods. 2002 Aug 30; 118(2):177-87. PMID: 12204308.
    View in: PubMed
  32. Bang PI, Sewell WF, Malicki JJ. Morphology and cell type heterogeneities of the inner ear epithelia in adult and juvenile zebrafish (Danio rerio). J Comp Neurol. 2001 Sep 17; 438(2):173-90. PMID: 11536187.
    View in: PubMed
  33. Yoshida N, Liberman MC, Brown MC, Sewell WF. Fast, but not slow, effects of olivocochlear activation are resistant to apamin. J Neurophysiol. 2001 Jan; 85(1):84-8. PMID: 11152708.
    View in: PubMed
  34. Bailey GP, Sewell WF. Pharmacological characterization of the CGRP receptor in the lateral line organ of Xenopus laevis. J Assoc Res Otolaryngol. 2000 Aug; 1(1):82-8. PMID: 11548239; PMCID: PMC2504561.
  35. Bailey GP, Sewell WF. Calcitonin gene-related peptide suppresses hair cell responses to mechanical stimulation in the Xenopus lateral line organ. J Neurosci. 2000 Jul 01; 20(13):5163-9. PMID: 10864973.
    View in: PubMed
  36. Bailey GP, Sewell WF. Contribution of glutamate receptors to spontaneous and stimulus-evoked discharge in afferent fibers innervating hair cells of the Xenopus lateral line organ. Hear Res. 2000 Jun; 144(1-2):8-20. PMID: 10831861.
    View in: PubMed
  37. Yoshida N, Liberman MC, Brown MC, Sewell WF. Gentamicin blocks both fast and slow effects of olivocochlear activation in anesthetized guinea pigs. J Neurophysiol. 1999 Dec; 82(6):3168-74. PMID: 10601450.
    View in: PubMed
  38. Lee KH, McKenna MJ, Sewell WF, Ung F. Ribonucleases may limit recovery of ribonucleic acids from archival human temporal bones. Laryngoscope. 1997 Sep; 107(9):1228-34. PMID: 9292608.
    View in: PubMed
  39. Sridhar TS, Brown MC, Sewell WF. Unique postsynaptic signaling at the hair cell efferent synapse permits calcium to evoke changes on two time scales. J Neurosci. 1997 Jan 01; 17(1):428-37. PMID: 8987768.
    View in: PubMed
  40. Sridhar TS, Liberman MC, Brown MC, Sewell WF. A novel cholinergic "slow effect" of efferent stimulation on cochlear potentials in the guinea pig. J Neurosci. 1995 May; 15(5 Pt 1):3667-78. PMID: 7751937.
    View in: PubMed
  41. Sewell WF, Mroz EA. Flavin adenine dinucleotide is a major endogenous fluorophore in the inner ear. Hear Res. 1993 Nov; 70(2):131-8. PMID: 7904988.
    View in: PubMed
  42. Davis RL, Sewell WF. Neurite regeneration from single primary-auditory neurons in vitro. Hear Res. 1992 Feb; 58(1):107-21. PMID: 1559901.
    View in: PubMed
  43. Sewell WF, Starr PA. Effects of calcitonin gene-related peptide and efferent nerve stimulation on afferent transmission in the lateral line organ. J Neurophysiol. 1991 May; 65(5):1158-69. PMID: 1651373.
    View in: PubMed
  44. Starr PA, Sewell WF. Neurotransmitter release from hair cells and its blockade by glutamate-receptor antagonists. Hear Res. 1991 Mar; 52(1):23-41. PMID: 1676396.
    View in: PubMed
  45. Sewell WF, Mroz EA. Purification of a low-molecular-weight excitatory substance from the inner ears of goldfish. Hear Res. 1990 Dec; 50(1-2):127-37. PMID: 1981769.
    View in: PubMed
  46. Sewell WF. Synaptic potentials in afferent fibers innervating hair cells of the lateral line organ in Xenopus laevis. Hear Res. 1990 Feb; 44(1):71-81. PMID: 2324020.
    View in: PubMed
  47. Mroz EA, Sewell WF. Pharmacological alterations of the activity of afferent fibers innervating hair cells. Hear Res. 1989 Mar; 38(1-2):141-62. PMID: 2565327.
    View in: PubMed
  48. Adams JC, Mroz EA, Sewell WF. A possible neurotransmitter role for CGRP in a hair-cell sensory organ. Brain Res. 1987 Sep 01; 419(1-2):347-51. PMID: 2890408.
    View in: PubMed
  49. Sewell WF, Mroz EA. Neuroactive substances in inner ear extracts. J Neurosci. 1987 Aug; 7(8):2465-75. PMID: 2886566.
    View in: PubMed
  50. Sweeney TK, Mroz EA, Sewell WF. Isolation and culture of auditory cells from the goldfish (Carassius auratus). Hear Res. 1987; 28(2-3):153-60. PMID: 3308802.
    View in: PubMed
  51. Kiang NY, Liberman MC, Sewell WF, Guinan JJ. Single unit clues to cochlear mechanisms. Hear Res. 1986; 22:171-82. PMID: 3733538.
    View in: PubMed
  52. Sewell WF. Furosemide selectively reduces one component in rate-level functions from auditory-nerve fibers. Hear Res. 1984 Jul; 15(1):69-72. PMID: 6480524.
    View in: PubMed
  53. Sewell WF. The effects of furosemide on the endocochlear potential and auditory-nerve fiber tuning curves in cats. Hear Res. 1984 Jun; 14(3):305-14. PMID: 6480516.
    View in: PubMed
  54. Sewell WF. The relation between the endocochlear potential and spontaneous activity in auditory nerve fibres of the cat. J Physiol. 1984 Feb; 347:685-96. PMID: 6707972; PMCID: PMC1199471.
  55. Sewell WF, Norris CH, Tachibana M, Guth PS. Detection of an auditory nerve--activating substance. Science. 1978 Nov 24; 202(4370):910-2. PMID: 30998.
    View in: PubMed
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