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Zhicheng Lin, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AA026663 (LIN, ZHICHENG CARL) May 15, 2019 - Apr 30, 2021
    Modeling human alcohol abuse in mice with a common SLC6A3 regulatory variant
    Role: Principal Investigator
  2. R21DA031573 (LIN, ZHICHENG CARL) Mar 15, 2012 - Feb 28, 2015
    Monitoring DAT in Live Rats
    Role: Principal Investigator
  3. R01DA021409 (LIN, ZHICHENG CARL) Apr 1, 2006 - Jul 31, 2024
    Human dopamine transporter gene: variation and transcriptional regulation
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sheng Y, Filichia E, Shick E, Preston KL, Phillips KA, Cooperman L, Lin Z, Tesar P, Hoffer BJ, Luo Y. Lower Dopamine D2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs. Am J Psychiatry. 2016 Apr 01; 173(4):429-31. PMID: 27035534.
    Citations: 2     Fields:    Translation:HumansCells
  2. Onaivi ES, Schanz N, Lin ZC. Psychiatric disturbances regulate the innate immune system in CSF of conscious mice. Transl Psychiatry. 2014 Mar 04; 4:e367. PMID: 24594778.
    Citations: 3     Fields:    Translation:AnimalsCells
  3. Zhai D, Li S, Zhao Y, Lin Z. SLC6A3 is a risk factor for Parkinson's disease: a meta-analysis of sixteen years' studies. Neurosci Lett. 2014 Apr 03; 564:99-104. PMID: 24211691.
    Citations: 14     Fields:    Translation:Humans
  4. Zhao Y, Xiong N, Liu Y, Zhou Y, Li N, Qing H, Lin Z. Human dopamine transporter gene: differential regulation of 18-kb haplotypes. Pharmacogenomics. 2013 Sep; 14(12):1481-94. PMID: 24024899.
    Citations: 9     Fields:    Translation:HumansCells
  5. Won C, Lin Z, Kumar T P, Li S, Ding L, Elkhal A, Szabó G, Vasudevan A. Autonomous vascular networks synchronize GABA neuron migration in the embryonic forebrain. Nat Commun. 2013; 4:2149. PMID: 23857367.
    Citations: 34     Fields:    Translation:AnimalsCells
  6. Zhao Y, Zhou Y, Xiong N, Lin Z. Identification of an intronic cis-acting element in the human dopamine transporter gene. Mol Biol Rep. 2012 May; 39(5):5393-9. PMID: 22160470.
    Citations: 5     Fields:    Translation:HumansCells
  7. Zhou Y, Michelhaugh SK, Schmidt CJ, Liu JS, Bannon MJ, Lin Z. Ventral midbrain correlation between genetic variation and expression of the dopamine transporter gene in cocaine-abusing versus non-abusing subjects. Addict Biol. 2014 Jan; 19(1):122-31. PMID: 22026501.
    Citations: 16     Fields:    Translation:HumansCells
  8. Xiong N, Xiong J, Khare G, Chen C, Huang J, Zhao Y, Zhang Z, Qiao X, Feng Y, Reesaul H, Zhang Y, Sun S, Lin Z, Wang T. Edaravone guards dopamine neurons in a rotenone model for Parkinson's disease. PLoS One. 2011; 6(6):e20677. PMID: 21677777.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  9. Xiong N, Huang J, Chen C, Zhao Y, Zhang Z, Jia M, Zhang Z, Hou L, Yang H, Cao X, Liang Z, Zhang Y, Sun S, Lin Z, Wang T. Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson's disease. Neurobiol Aging. 2012 Aug; 33(8):1777-91. PMID: 21524431.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  10. Lin Z, Canales JJ, Björgvinsson T, Thomsen M, Qu H, Liu QR, Torres GE, Caine SB. Monoamine transporters: vulnerable and vital doorkeepers. Prog Mol Biol Transl Sci. 2011; 98:1-46. PMID: 21199769.
    Citations: 24     Fields:    Translation:HumansAnimals
  11. Xiong N, Zhang Z, Huang J, Chen C, Zhang Z, Jia M, Xiong J, Liu X, Wang F, Cao X, Liang Z, Sun S, Lin Z, Wang T. VEGF-expressing human umbilical cord mesenchymal stem cells, an improved therapy strategy for Parkinson's disease. Gene Ther. 2011 Apr; 18(4):394-402. PMID: 21107440.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  12. Xu M, Lin Z. Genetic influences of dopamine transport gene on alcohol dependence: a pooled analysis of 13 studies with 2483 cases and 1753 controls. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jul 01; 35(5):1255-60. PMID: 21078357.
    Citations: 12     Fields:    Translation:HumansCells
  13. Chung CY, Licznerski P, Alavian KN, Simeone A, Lin Z, Martin E, Vance J, Isacson O. The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain. 2010 Jul; 133(Pt 7):2022-31. PMID: 20573704.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  14. Xiong N, Cao X, Zhang Z, Huang J, Chen C, Zhang Z, Jia M, Xiong J, Liang Z, Sun S, Lin Z, Wang T. Long-term efficacy and safety of human umbilical cord mesenchymal stromal cells in rotenone-induced hemiparkinsonian rats. Biol Blood Marrow Transplant. 2010 Nov; 16(11):1519-29. PMID: 20542126.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  15. Xu M, Xing Q, Li S, Zheng Y, Wu S, Gao R, Yu L, Guo T, Yang Y, Liu J, Zhang A, Zhao X, He G, Zhou J, Wang L, Xuan J, Du J, Li X, Feng G, Lin Z, Xu Y, St Clair D, Lin Z, He L. Pharacogenetic effects of dopamine transporter gene polymorphisms on response to chlorpromazine and clozapine and on extrapyramidal syndrome in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16; 34(6):1026-32. PMID: 20580759.
    Citations: 23     Fields:    Translation:Humans
  16. Lin Z, Zhao Y, Chung CY, Zhou Y, Xiong N, Glatt CE, Isacson O. High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life. FASEB J. 2010 Jul; 24(7):2191-200. PMID: 20181938.
    Citations: 10     Fields:    Translation:HumansCells
  17. Xiong N, Huang J, Zhang Z, Zhang Z, Xiong J, Liu X, Jia M, Wang F, Chen C, Cao X, Liang Z, Sun S, Lin Z, Wang T. Stereotaxical infusion of rotenone: a reliable rodent model for Parkinson's disease. PLoS One. 2009 Nov 18; 4(11):e7878. PMID: 19924288.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  18. Madras BK, Xie Z, Lin Z, Jassen A, Panas H, Lynch L, Johnson R, Livni E, Spencer TJ, Bonab AA, Miller GM, Fischman AJ. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J Pharmacol Exp Ther. 2006 Nov; 319(2):561-9. PMID: 16885432.
    Citations: 118     Fields:    Translation:Animals
  19. Madras BK, Fahey MA, Goulet M, Lin Z, Bendor J, Goodrich C, Meltzer PC, Elmaleh DR, Livni E, Bonab AA, Fischman AJ. Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo. J Pharmacol Exp Ther. 2006 Nov; 319(2):570-85. PMID: 16885433.
    Citations: 9     Fields:    Translation:Animals
  20. Drgon T, Lin Z, Wang GJ, Fowler J, Pablo J, Mash DC, Volkow N, Uhl GR. Common human 5' dopamine transporter (SLC6A3) haplotypes yield varying expression levels in vivo. Cell Mol Neurobiol. 2006 Jul-Aug; 26(4-6):875-89. PMID: 16710758.
    Citations: 23     Fields:    Translation:HumansCells
  21. Lin Z, Madras BK. Human genetics and pharmacology of neurotransmitter transporters. Handb Exp Pharmacol. 2006; (175):327-71. PMID: 16722243.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  22. Uhl GR, Ishiguro H, Onaivi ES, Zhang PW, Akinshola BE, Lin Z, Hope B, Leonard CM, Liu QR. Molecular neurobiological methods in marijuana-cannabinoid research. Methods Mol Med. 2006; 123:1-17. PMID: 16506399.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  23. Lin Z, Uhl GR. Proline mutations induce negative-dosage effects on uptake velocity of the dopamine transporter. J Neurochem. 2005 Jul; 94(1):276-87. PMID: 15953370.
    Citations: 1     Fields:    Translation:AnimalsCells
  24. Lin Z, Walther D, Yu XY, Li S, Drgon T, Uhl GR. SLC18A2 promoter haplotypes and identification of a novel protective factor against alcoholism. Hum Mol Genet. 2005 May 15; 14(10):1393-404. PMID: 15829504.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  25. Lin Z, Walther D, Yu XY, Drgon T, Uhl GR. The human serotonin receptor 2B: coding region polymorphisms and association with vulnerability to illegal drug abuse. Pharmacogenetics. 2004 Dec; 14(12):805-11. PMID: 15608559.
    Citations: 10     Fields:    Translation:HumansCells
  26. Dohi T, Kitayama S, Morioka N, Kumagai K, Mitsuhata C, Morita K, Kozai K, Lin Z, Uhl GR. Regulation of dopamine and MPP+ transport by catecholamine transporters. Nihon Shinkei Seishin Yakurigaku Zasshi. 2004 Apr; 24(2):43-7. PMID: 15164608.
    Citations: 1     Fields:    Translation:HumansAnimals
  27. Liu QR, Zhang PW, Lin Z, Li QF, Woods AS, Troncoso J, Uhl GR. GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA. Biochem J. 2004 Jan 01; 377(Pt 1):171-81. PMID: 12974676.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  28. Uhl GR, Lin Z. The top 20 dopamine transporter mutants: structure-function relationships and cocaine actions. Eur J Pharmacol. 2003 Oct 31; 479(1-3):71-82. PMID: 14612139.
    Citations: 18     Fields:    Translation:HumansAnimals
  29. Morón JA, Zakharova I, Ferrer JV, Merrill GA, Hope B, Lafer EM, Lin ZC, Wang JB, Javitch JA, Galli A, Shippenberg TS. Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity. J Neurosci. 2003 Sep 17; 23(24):8480-8. PMID: 13679416.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  30. Lin Z, Zhang PW, Zhu X, Melgari JM, Huff R, Spieldoch RL, Uhl GR. Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. J Biol Chem. 2003 May 30; 278(22):20162-70. PMID: 12660249.
    Citations: 27     Fields:    Translation:AnimalsCells
  31. Lin Z, Uhl GR. Human dopamine transporter gene variation: effects of protein coding variants V55A and V382A on expression and uptake activities. Pharmacogenomics J. 2003; 3(3):159-68. PMID: 12815364.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  32. Itokawa M, Lin Z, Uhl GR. Dopamine efflux via wild-type and mutant dopamine transporters: alanine substitution for proline-572 enhances efflux and reduces dependence on extracellular dopamine, sodium and chloride concentrations. Brain Res Mol Brain Res. 2002 Dec; 108(1-2):71-80. PMID: 12480180.
    Citations: 3     Fields:    Translation:AnimalsCells
  33. Onaivi ES, Leonard CM, Ishiguro H, Zhang PW, Lin Z, Akinshola BE, Uhl GR. Endocannabinoids and cannabinoid receptor genetics. Prog Neurobiol. 2002 Apr; 66(5):307-44. PMID: 12015198.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  34. Lin Z, Uhl GR. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Mol Pharmacol. 2002 Apr; 61(4):885-91. PMID: 11901228.
    Citations: 17     Fields:    Translation:AnimalsCells
  35. Uhl GR, Li S, Takahashi N, Itokawa K, Lin Z, Hazama M, Sora I. The VMAT2 gene in mice and humans: amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins. FASEB J. 2000 Dec; 14(15):2459-65. PMID: 11099463.
    Citations: 18     Fields:    Translation:HumansAnimals
  36. Lin Z, Wang W, Uhl GR. Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains. Mol Pharmacol. 2000 Dec; 58(6):1581-92. PMID: 11093799.
    Citations: 12     Fields:    Translation:AnimalsCells
  37. Itokawa M, Lin Z, Cai NS, Wu C, Kitayama S, Wang JB, Uhl GR. Dopamine transporter transmembrane domain polar mutants: DeltaG and DeltaDeltaG values implicate regions important for transporter functions. Mol Pharmacol. 2000 Jun; 57(6):1093-103. PMID: 10825379.
    Citations: 10     Fields:    Translation:AnimalsCells
  38. Lin Z, Itokawa M, Uhl GR. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB J. 2000 Apr; 14(5):715-28. PMID: 10744628.
    Citations: 16     Fields:    Translation:AnimalsCells
  39. Lin Z, Wang W, Kopajtic T, Revay RS, Uhl GR. Dopamine transporter: transmembrane phenylalanine mutations can selectively influence dopamine uptake and cocaine analog recognition. Mol Pharmacol. 1999 Aug; 56(2):434-47. PMID: 10419565.
    Citations: 18     Fields:    Translation:AnimalsCells
  40. Lin Z, Mallavia LP. Functional analysis of the active partition region of the Coxiella burnetii plasmid QpH1. J Bacteriol. 1999 Mar; 181(6):1947-52. PMID: 10074095.
    Citations: 1     Fields:    Translation:Cells
  41. Lin Z, Mallavia LP. Membrane association of active plasmid partitioning protein A in Escherichia coli. J Biol Chem. 1998 May 01; 273(18):11302-12. PMID: 9556623.
    Citations: 3     Fields:    Translation:Cells
  42. Uhl G, Lin Z, Metzger T, Dar DE. Dopamine transporter mutants, small molecules, and approaches to cocaine antagonist/dopamine transporter disinhibitor development. Methods Enzymol. 1998; 296:456-65. PMID: 9779467.
    Citations: 2     Fields:    Translation:AnimalsCells
  43. Lin Z, Yang S, Mallavia LP. Codon usage and nucleotide composition in Coxiella burnetii. Gene. 1997 Oct 01; 198(1-2):171-80. PMID: 9370279.
    Citations:    Fields:    Translation:Cells
  44. Lin Z, Howe D, Mallavia LP. Roa307, a protein encoded on Coxiella burnetii plasmid QpH1, shows homology to proteins encoded in the replication origin region of bacterial chromosomes. Mol Gen Genet. 1995 Aug 30; 248(4):487-90. PMID: 7565613.
    Citations: 1     Fields:    Translation:Cells
  45. Lin Z, Mallavia LP. The partition region of plasmid QpH1 is a member of a family of two trans-acting factors as implied by sequence analysis. Gene. 1995 Jul 04; 160(1):69-74. PMID: 7628719.
    Citations: 3     Fields:    Translation:Cells
  46. Lin Z, Mallavia LP. Identification of a partition region carried by the plasmid QpH1 of Coxiella burnetii. Mol Microbiol. 1994 Aug; 13(3):513-23. PMID: 7997168.
    Citations: 5     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.