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Nora Amanda Barrett, M.D.

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Overview
Our lab is interested in defining the role of innate immunity in homeostasis, repair, and disease in the respiratory tract, where environmental determinants play a key role in both immunopathogenesis and health. Using biochemical, molecular, and genomic approaches, we focus on the cellular and molecular networks underlying the initiation and persistence of type 2 immunity at mucosal sites. Our ultimate goal is to understand innate immune sensing in the respiratory tract and key regulatory features that may treat or prevent diseases such as asthma.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U19AI095219, Project 2 (BARRETT, NORA AMANDA) Jul 1, 2021 - Apr 30, 2026
    NIH
    Basal Cell Dysplasia in Type 2 Immunopathology
    Role: Principal Investigator
  2. R01AI134989 (BARRETT, NORA AMANDA) Jan 1, 2019 - Dec 31, 2023
    NIH
    Type 2 Immunity Elicited Through an LTE4/GPR99-Dependent Pathway
    Role: Principal Investigator
  3. R56AI134989 (BARRETT, NORA AMANDA) Feb 1, 2018 - Dec 31, 2018
    NIH
    Type 2 Mucosal Inflammation Elicited Through an LTE4/GPR99-Dependent Pathway
    Role: Principal Investigator
  4. W81XWH-17-1-0527 (BARRETT, NORA AMANDA) Sep 1, 2017 - Aug 31, 2021
    Department of Defense
    Role of the Leukotriene E4 Receptor GPR99 in Asthma
    Role: Principal Investigator
  5. R01HL120952 (BARRETT, NORA AMANDA) Jan 1, 2014 - Dec 31, 2019
    NIH
    Allergic Pulmonary Inflammation Through the Dectin-2 Pathway
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ye Q, Barrett N, Balestrieri B. Bioactive lipids: Accessible indicators toward improved diagnosis and treatment of asthma. J Allergy Clin Immunol. 2022 10; 150(4):790-792. PMID: 36029891.
    Citations:    Fields:    Translation:Humans
  2. Ben-Baruch Morgenstern N, Ballaban AY, Wen T, Shoda T, Caldwell JM, Kliewer K, Felton JM, Abonia JP, Mukkada VA, Putnam PE, Bolton SM, Dwyer DF, Barrett NA, Rothenberg ME. Single-cell RNA sequencing of mast cells in eosinophilic esophagitis reveals heterogeneity, local proliferation, and activation that persists in remission. J Allergy Clin Immunol. 2022 06; 149(6):2062-2077. PMID: 35304158; PMCID: PMC9177790.
    Citations: 1     Fields:    Translation:HumansCells
  3. Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I. An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity. Cell. 2022 02 17; 185(4):614-629.e21. PMID: 35148840; PMCID: PMC8857056.
    Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
  4. Ye Q, Balestrieri B, Barrett NA. Protecting tissue integrity and enteric function: the case for type 2 inflammation and macrophages. Trends Parasitol. 2022 03; 38(3):191-192. PMID: 35078723.
    Citations:    Fields:    Translation:HumansCells
  5. Ualiyeva S, Lemire E, Aviles EC, Wong C, Boyd AA, Lai J, Liu T, Matsumoto I, Barrett NA, Boyce JA, Haber AL, Bankova LG. Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation. Sci Immunol. 2021 Dec 24; 6(66):eabj0474. PMID: 34932383; PMCID: PMC8750919.
    Citations: 5     Fields:    Translation:AnimalsCells
  6. Ualiyeva S, Boyd AA, Barrett NA, Bankova LG. Isolation of Nasal Brush Cells for Single-cell Preparations. Bio Protoc. 2021 Sep 20; 11(18):e4163. PMID: 34692913; PMCID: PMC8481025.
    Citations: 1     
  7. Kohanski MA, Cohen NA, Barrett NA. Epithelial dysregulation in chronic rhinosinusitis with nasal polyposis (CRSwNP) and aspirin-exacerbated respiratory disease (AERD). J Allergy Clin Immunol. 2021 11; 148(5):1161-1164. PMID: 34371082; PMCID: PMC9271844.
    Citations:    Fields:    Translation:Humans
  8. Dwyer DF, Ordovas-Montanes J, Allon SJ, Buchheit KM, Vukovic M, Derakhshan T, Feng C, Lai J, Hughes TK, Nyquist SK, Giannetti MP, Berger B, Bhattacharyya N, Roditi RE, Katz HR, Nawijn MC, Berg M, van den Berge M, Laidlaw TM, Shalek AK, Barrett NA, Boyce JA. Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation. Sci Immunol. 2021 02 26; 6(56). PMID: 33637594; PMCID: PMC8362933.
    Citations: 15     Fields:    Translation:HumansCells
  9. Derakhshan T, Samuchiwal SK, Hallen N, Bankova LG, Boyce JA, Barrett NA, Austen KF, Dwyer DF. Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation. J Exp Med. 2021 01 04; 218(1). PMID: 32946563.
    Citations: 5     Fields:    Translation:AnimalsCells
  10. Liu T, Barrett NA, Nagai J, Lai J, Feng C, Boyce JA. Leukotriene D4 paradoxically limits LTC4-driven platelet activation and lung immunopathology. J Allergy Clin Immunol. 2021 07; 148(1):195-208.e5. PMID: 33285161; PMCID: PMC8175451.
    Citations: 3     Fields:    Translation:AnimalsCells
  11. Martin H, Barrett NA, Laidlaw T. Mepolizumab does not prevent all aspirin-induced reactions in patients with aspirin-exacerbated respiratory disease: A case series. J Allergy Clin Immunol Pract. 2021 03; 9(3):1384-1385. PMID: 32956852; PMCID: PMC9255360.
    Citations: 1     Fields:    Translation:Humans
  12. Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi LE, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. 2020 05 28; 181(5):1016-1035.e19. PMID: 32413319; PMCID: PMC7252096.
    Citations: 986     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  13. Buchheit KM, Dwyer DF, Ordovas-Montanes J, Katz HR, Lewis E, Vukovic M, Lai J, Bankova LG, Bhattacharyya N, Shalek AK, Barrett NA, Boyce JA, Laidlaw TM. IL-5Ra marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2020 06; 145(6):1574-1584. PMID: 32199912; PMCID: PMC7282948.
    Citations: 15     Fields:    Translation:HumansCells
  14. McGinty JW, Ting HA, Billipp TE, Nadjsombati MS, Khan DM, Barrett NA, Liang HE, Matsumoto I, von Moltke J. Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity. Immunity. 2020 03 17; 52(3):528-541.e7. PMID: 32160525.
    Citations: 57     Fields:    Translation:AnimalsCells
  15. Bankova LG, Barrett NA. Epithelial cell function and remodeling in nasal polyposis. Ann Allergy Asthma Immunol. 2020 04; 124(4):333-341. PMID: 32007569.
    Citations: 9     Fields:    Translation:Humans
  16. Ualiyeva S, Hallen N, Kanaoka Y, Ledderose C, Matsumoto I, Junger WG, Barrett NA, Bankova LG. Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2. Sci Immunol. 2020 01 17; 5(43). PMID: 31953256.
    Citations: 25     Fields:    Translation:AnimalsCells
  17. Barrett NA, Shalek AK. Revisiting airway epithelial remodeling in type 2 immunity: Beyond goblet cell metaplasia. J Allergy Clin Immunol. 2019 11; 144(5):1158-1160. PMID: 31600548.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  18. Ualiyeva S, Yoshimoto E, Barrett NA, Bankova LG. Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas. J Vis Exp. 2019 06 12; (148). PMID: 31259891.
    Citations: 3     Fields:    Translation:AnimalsCells
  19. Liu T, Barrett NA, Kanaoka Y, Buchheit K, Laidlaw TM, Garofalo D, Lai J, Katz HR, Feng C, Boyce JA. Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism. Mucosal Immunol. 2019 05; 12(3):679-690. PMID: 30664709; PMCID: PMC6462243.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  20. Bankova LG, Dwyer DF, Yoshimoto E, Ualiyeva S, McGinty JW, Raff H, von Moltke J, Kanaoka Y, Frank Austen K, Barrett NA. The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation. Sci Immunol. 2018 10 05; 3(28). PMID: 30291131; PMCID: PMC6599626.
    Citations: 48     Fields:    Translation:AnimalsCells
  21. Ordovas-Montanes J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M, Deb C, Wadsworth MH, Hughes TK, Kazer SW, Yoshimoto E, Cahill KN, Bhattacharyya N, Katz HR, Berger B, Laidlaw TM, Boyce JA, Barrett NA, Shalek AK. Allergic inflammatory memory in human respiratory epithelial progenitor cells. Nature. 2018 08; 560(7720):649-654. PMID: 30135581.
    Citations: 116     Fields:    Translation:HumansCells
  22. Liu T, Barrett NA, Kanaoka Y, Yoshimoto E, Garofalo D, Cirka H, Feng C, Boyce JA. Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity. J Immunol. 2018 02 01; 200(3):915-927. PMID: 29282304; PMCID: PMC5780246.
    Citations: 22     Fields:    Translation:AnimalsCells
  23. von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. J Exp Med. 2017 01; 214(1):27-37. PMID: 28011865; PMCID: PMC5206504.
    Citations: 67     Fields:    Translation:AnimalsCells
  24. Lee MJ, Yoshimoto E, Saijo S, Iwakura Y, Lin X, Katz HR, Kanaoka Y, Barrett NA. Phosphoinositide 3-Kinase d Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity. J Immunol. 2016 07 01; 197(1):278-87. PMID: 27194783; PMCID: PMC4912906.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  25. Bankova LG, Lai J, Yoshimoto E, Boyce JA, Austen KF, Kanaoka Y, Barrett NA. Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6242-7. PMID: 27185938; PMCID: PMC4896673.
    Citations: 47     Fields:    Translation:AnimalsCells
  26. Dwyer DF, Barrett NA, Austen KF. Expression profiling of constitutive mast cells reveals a unique identity within the immune system. Nat Immunol. 2016 Jul; 17(7):878-87. PMID: 27135604; PMCID: PMC5045264.
    Citations: 131     Fields:    Translation:AnimalsCells
  27. Sloane D, Govindarajulu U, Harrow-Mortelliti J, Barry W, Hsu FI, Hong D, Laidlaw T, Palis R, Legere H, Bunyavanich S, Breslow R, Wesemann D, Barrett N, Brennan P, Chong HJ, Liu A, Fernandez J, Fanning L, Kyin T, Cahill K, Bankova L, Lynch A, Berlin S, Campos S, Fuchs C, Mayer R, Matulonis U, Castells M. Safety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal Antibodies. J Allergy Clin Immunol Pract. 2016 May-Jun; 4(3):497-504. PMID: 26895621.
    Citations: 37     Fields:    Translation:Humans
  28. Barrett NA, Austen KF. Licensed to Ill: IL-9 Generation in Immature Mast Cells Permits Food-Elicited Anaphylaxis. Immunity. 2015 Oct 20; 43(4):626-8. PMID: 26488812.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  29. Liu T, Kanaoka Y, Barrett NA, Feng C, Garofalo D, Lai J, Buchheit K, Bhattacharya N, Laidlaw TM, Katz HR, Boyce JA. Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway. J Immunol. 2015 Oct 15; 195(8):3537-45. PMID: 26342029; PMCID: PMC4592820.
    Citations: 47     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  30. Boyce JA, Barrett NA. Cysteinyl leukotrienes: an innate system for epithelial control of airway smooth muscle proliferation? Am J Respir Crit Care Med. 2015 Mar 01; 191(5):496-7. PMID: 25723820; PMCID: PMC4384772.
    Citations: 2     Fields:    Translation:HumansAnimals
  31. Tjota MY, Hrusch CL, Blaine KM, Williams JW, Barrett NA, Sperling AI. Signaling through FcR?-associated receptors on dendritic cells drives IL-33-dependent TH2-type responses. J Allergy Clin Immunol. 2014 Sep; 134(3):706-713.e8. PMID: 25088053; PMCID: PMC4149927.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  32. Cardet JC, White AA, Barrett NA, Feldweg AM, Wickner PG, Savage J, Bhattacharyya N, Laidlaw TM. Alcohol-induced respiratory symptoms are common in patients with aspirin exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2014 Mar-Apr; 2(2):208-13.. PMID: 24607050.
    Citations: 16     Fields:    Translation:Humans
  33. Parsons MW, Li L, Wallace AM, Lee MJ, Katz HR, Fernandez JM, Saijo S, Iwakura Y, Austen KF, Kanaoka Y, Barrett NA. Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization. J Immunol. 2014 Feb 15; 192(4):1361-71. PMID: 24453247; PMCID: PMC4024442.
    Citations: 22     Fields:    Translation:AnimalsCells
  34. Barrett NA, Boyce JA. Activation of group 2 innate lymphoid cells: a new role for cysteinyl leukotrienes. J Allergy Clin Immunol. 2013 Jul; 132(1):214-6. PMID: 23810099; PMCID: PMC4024825.
    Citations: 2     Fields:    Translation:AnimalsCells
  35. Barrett NA, Fernandez JM, Maekawa A, Xing W, Li L, Parsons MW, Austen KF, Kanaoka Y. Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation. J Immunol. 2012 Nov 01; 189(9):4556-65. PMID: 23002438; PMCID: PMC3478400.
    Citations: 17     Fields:    Translation:AnimalsCells
  36. Barrett NA, Rahman OM, Fernandez JM, Parsons MW, Xing W, Austen KF, Kanaoka Y. Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes. J Exp Med. 2011 Mar 14; 208(3):593-604. PMID: 21357742.
    Citations: 83     Fields:    Translation:AnimalsCells
  37. Breslow RG, Rao JJ, Xing W, Hong DI, Barrett NA, Katz HR. Inhibition of Th2 adaptive immune responses and pulmonary inflammation by leukocyte Ig-like receptor B4 on dendritic cells. J Immunol. 2010 Jan 15; 184(2):1003-13. PMID: 19966208; PMCID: PMC2836496.
    Citations: 6     Fields:    Translation:AnimalsCells
  38. Barrett NA, Austen KF. Innate cells and T helper 2 cell immunity in airway inflammation. Immunity. 2009 Sep 18; 31(3):425-37. PMID: 19766085.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  39. Barrett NA, Maekawa A, Rahman OM, Austen KF, Kanaoka Y. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J Immunol. 2009 Jan 15; 182(2):1119-28. PMID: 19124755; PMCID: PMC3682801.
    Citations: 105     Fields:    Translation:AnimalsCells
  40. Castells MC, Tennant NM, Sloane DE, Hsu FI, Barrett NA, Hong DI, Laidlaw TM, Legere HJ, Nallamshetty SN, Palis RI, Rao JJ, Berlin ST, Campos SM, Matulonis UA. Hypersensitivity reactions to chemotherapy: outcomes and safety of rapid desensitization in 413 cases. J Allergy Clin Immunol. 2008 Sep; 122(3):574-80. PMID: 18502492.
    Citations: 101     Fields:    Translation:Humans
  41. Kim DC, Hsu FI, Barrett NA, Friend DS, Grenningloh R, Ho IC, Al-Garawi A, Lora JM, Lam BK, Austen KF, Kanaoka Y. Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation. J Immunol. 2006 Apr 01; 176(7):4440-8. PMID: 16547282.
    Citations: 55     Fields:    Translation:AnimalsCells
  42. Kim D, Hsu F, Barrett NA, Friend D, Grenningloh R, Ho I, Al-Garawi A, Lora J, Lam B, Austen K, Kanaoka Y. . Leukotrienes are required for development of Th2 Pulmonary Inflammation. Journal of Immunology. 2006; 176(7):4440-4448.
  43. Mannhalter JW, Pum M, Wolf HM, Küpcü Z, Barrett N, Dorner F, Eder G, Eibl MM. Immunization of chimpanzees with the HIV-1 glycoprotein gp160 induces long-lasting T-cell memory. AIDS Res Hum Retroviruses. 1991 May; 7(5):485-93. PMID: 1714748.
    Citations: 3     Fields:    Translation:AnimalsCellsPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.