Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Mustafa Sahin, Ph.D., M.D.

Concepts

This page shows the publications Mustafa Sahin has written about Animals.
Connection Strength

0.803
  1. Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia. Cell Rep. 2020 06 23; 31(12):107780.
    View in: PubMed
    Score: 0.023
  2. Tau: A Novel Entry Point for mTOR-Based Treatments in Autism Spectrum Disorder? Neuron. 2020 05 06; 106(3):359-361.
    View in: PubMed
    Score: 0.023
  3. Recent advances in human stem cell-based modeling of Tuberous Sclerosis Complex. Mol Autism. 2020 02 19; 11(1):16.
    View in: PubMed
    Score: 0.022
  4. Modeling Neurodevelopmental Deficits in Tuberous Sclerosis Complex with Stem Cell Derived Neural Precursors and Neurons. Adv Neurobiol. 2020; 25:1-31.
    View in: PubMed
    Score: 0.022
  5. Chronic mTORC1 inhibition rescues behavioral and biochemical deficits resulting from neuronal Depdc5 loss in mice. Hum Mol Genet. 2019 09 01; 28(17):2952-2964.
    View in: PubMed
    Score: 0.022
  6. Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors. Cell Rep. 2018 10 09; 25(2):357-367.e4.
    View in: PubMed
    Score: 0.020
  7. A unified circuit for social behavior. Neurobiol Learn Mem. 2019 11; 165:106920.
    View in: PubMed
    Score: 0.020
  8. Abnormal mTOR Activation in Autism. Annu Rev Neurosci. 2018 07 08; 41:1-23.
    View in: PubMed
    Score: 0.019
  9. mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex. Neuropsychopharmacology. 2018 05; 43(6):1457-1465.
    View in: PubMed
    Score: 0.019
  10. Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy. Cell Rep. 2017 07 25; 20(4):868-880.
    View in: PubMed
    Score: 0.019
  11. Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism. Mol Autism. 2017; 8:26.
    View in: PubMed
    Score: 0.019
  12. Translational use of event-related potentials to assess circuit integrity in ASD. Nat Rev Neurol. 2017 03; 13(3):160-170.
    View in: PubMed
    Score: 0.018
  13. Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex. J Exp Med. 2017 03 06; 214(3):681-697.
    View in: PubMed
    Score: 0.018
  14. Using tuberous sclerosis complex to understand the impact of MTORC1 signaling on mitochondrial dynamics and mitophagy in neurons. Autophagy. 2017 Apr 03; 13(4):754-756.
    View in: PubMed
    Score: 0.018
  15. Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex. Cell Rep. 2016 10 18; 17(4):1053-1070.
    View in: PubMed
    Score: 0.018
  16. Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference. Pediatr Neurol. 2016 07; 60:1-12.
    View in: PubMed
    Score: 0.017
  17. Cell-type-specific miR-431 dysregulation in a motor neuron model of spinal muscular atrophy. Hum Mol Genet. 2016 06 01; 25(11):2168-2181.
    View in: PubMed
    Score: 0.017
  18. Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders. Science. 2015 Nov 20; 350(6263).
    View in: PubMed
    Score: 0.017
  19. Cerebellar Development and Autism Spectrum Disorder in Tuberous Sclerosis Complex. J Child Neurol. 2015 Dec; 30(14):1954-62.
    View in: PubMed
    Score: 0.016
  20. The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex. J Neurosci. 2015 Jul 29; 35(30):10762-72.
    View in: PubMed
    Score: 0.016
  21. Developing therapies for spinal muscular atrophy. Ann N Y Acad Sci. 2016 02; 1366(1):5-19.
    View in: PubMed
    Score: 0.016
  22. Tuberous Sclerosis: A New Frontier in Targeted Treatment of Autism. Neurotherapeutics. 2015 Jul; 12(3):572-83.
    View in: PubMed
    Score: 0.016
  23. The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation. Cell. 2015 May 21; 161(5):1138-1151.
    View in: PubMed
    Score: 0.016
  24. Autism and the synapse: emerging mechanisms and mechanism-based therapies. Curr Opin Neurol. 2015 Apr; 28(2):91-102.
    View in: PubMed
    Score: 0.016
  25. A vascular model of Tsc1 deficiency accelerates renal tumor formation with accompanying hemangiosarcomas. Mol Cancer Res. 2015 Mar; 13(3):548-55.
    View in: PubMed
    Score: 0.016
  26. The neurology of mTOR. Neuron. 2014 Oct 22; 84(2):275-91.
    View in: PubMed
    Score: 0.015
  27. Parkinson's disease: A disorder of axonal mitophagy? Mov Disord. 2014 Nov; 29(13):1582.
    View in: PubMed
    Score: 0.015
  28. SMN regulates axonal local translation via miR-183/mTOR pathway. Hum Mol Genet. 2014 Dec 01; 23(23):6318-31.
    View in: PubMed
    Score: 0.015
  29. Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1. Hum Mol Genet. 2014 Jul 15; 23(14):3865-74.
    View in: PubMed
    Score: 0.015
  30. Mechanism-based treatment in tuberous sclerosis complex. Pediatr Neurol. 2014 Apr; 50(4):290-6.
    View in: PubMed
    Score: 0.015
  31. Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice. Behav Genet. 2013 Jan; 43(1):51-9.
    View in: PubMed
    Score: 0.014
  32. Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature. 2012 Aug 30; 488(7413):647-51.
    View in: PubMed
    Score: 0.013
  33. Translational research: Rett syndrome and tuberous sclerosis complex. Curr Opin Pediatr. 2011 Dec; 23(6):633-9.
    View in: PubMed
    Score: 0.013
  34. Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10337-42.
    View in: PubMed
    Score: 0.012
  35. Mechanisms of neurocognitive dysfunction and therapeutic considerations in tuberous sclerosis complex. Curr Opin Neurol. 2011 Apr; 24(2):106-13.
    View in: PubMed
    Score: 0.012
  36. TSC1/TSC2 signaling in the CNS. FEBS Lett. 2011 Apr 06; 585(7):973-80.
    View in: PubMed
    Score: 0.012
  37. Eph receptor and mTOR pathway crosstalk: implications for cancer. . 2010 Jun 01; 9(11):2053-4.
    View in: PubMed
    Score: 0.011
  38. Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nat Neurosci. 2010 Feb; 13(2):163-72.
    View in: PubMed
    Score: 0.011
  39. Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner. J Neurosci. 2009 May 06; 29(18):5926-37.
    View in: PubMed
    Score: 0.011
  40. Induction and assessment methods used in experimental adhesion studies. Wound Repair Regen. 2005 Jul-Aug; 13(4):358-64.
    View in: PubMed
    Score: 0.008
  41. Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron. 2005 Apr 21; 46(2):191-204.
    View in: PubMed
    Score: 0.008
  42. Loss of ap4s1 in zebrafish leads to neurodevelopmental defects resembling spastic paraplegia 52. Ann Clin Transl Neurol. 2020 04; 7(4):584-589.
    View in: PubMed
    Score: 0.006
  43. Electrographic spikes are common in wildtype mice. Epilepsy Behav. 2018 12; 89:94-98.
    View in: PubMed
    Score: 0.005
  44. The mouse as a model for neuropsychiatric drug development. Curr Biol. 2018 09 10; 28(17):R909-R914.
    View in: PubMed
    Score: 0.005
  45. Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy. Sci Rep. 2018 05 21; 8(1):7907.
    View in: PubMed
    Score: 0.005
  46. A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility. Neurobiol Dis. 2018 03; 111:91-101.
    View in: PubMed
    Score: 0.005
  47. p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis. Cancer Res. 2017 06 15; 77(12):3255-3267.
    View in: PubMed
    Score: 0.005
  48. Direct current stimulation induces mGluR5-dependent neocortical plasticity. Ann Neurol. 2016 08; 80(2):233-46.
    View in: PubMed
    Score: 0.004
  49. Leveraging a Sturge-Weber Gene Discovery: An Agenda for Future Research. Pediatr Neurol. 2016 05; 58:12-24.
    View in: PubMed
    Score: 0.004
  50. Characterizing brain tissue by assessment of the distribution of anisotropic microstructural environments in diffusion-compartment imaging (DIAMOND). Magn Reson Med. 2016 09; 76(3):963-77.
    View in: PubMed
    Score: 0.004
  51. Expression of PTPH1, a rat protein tyrosine phosphatase, is restricted to the derivatives of a specific diencephalic segment. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):7859-63.
    View in: PubMed
    Score: 0.004
  52. Cerebellar associative sensory learning defects in five mouse autism models. Elife. 2015 Jul 09; 4:e06085.
    View in: PubMed
    Score: 0.004
  53. Comparison of therapeutic characteristics of islet cell transplantation simultaneous with pancreatic mesenchymal stem cell transplantation in rats with Type 1 diabetes mellitus. Stem Cell Rev Rep. 2015 Jun; 11(3):526-32.
    View in: PubMed
    Score: 0.004
  54. Vigabatrin can enhance electroretinographic responses in pigmented and albino rats. Doc Ophthalmol. 2015 Aug; 131(1):1-11.
    View in: PubMed
    Score: 0.004
  55. Seven protein tyrosine phosphatases are differentially expressed in the developing rat brain. J Comp Neurol. 1995 Jan 23; 351(4):617-31.
    View in: PubMed
    Score: 0.004
  56. RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity. J Clin Invest. 2014 Jun; 124(6):2774-84.
    View in: PubMed
    Score: 0.004
  57. EphA7 signaling guides cortical dendritic development and spine maturation. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):4994-9.
    View in: PubMed
    Score: 0.004
  58. Protein tyrosine phosphatases expressed in the developing rat brain. J Neurosci. 1993 Nov; 13(11):4968-78.
    View in: PubMed
    Score: 0.004
  59. A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nat Cell Biol. 2013 Oct; 15(10):1186-96.
    View in: PubMed
    Score: 0.004
  60. The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models. J Neurosci. 2013 Apr 10; 33(15):6557-62.
    View in: PubMed
    Score: 0.003
  61. Graded loss of tuberin in an allelic series of brain models of TSC correlates with survival, and biochemical, histological and behavioral features. Hum Mol Genet. 2012 Oct 01; 21(19):4286-300.
    View in: PubMed
    Score: 0.003
  62. Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway. Angiogenesis. 2012 Sep; 15(3):457-68.
    View in: PubMed
    Score: 0.003
  63. Location of nicotinic and muscarinic cholinergic and mu-opiate receptors in rat cerebral neocortex: evidence from thalamic and cortical lesions. Brain Res. 1992 May 01; 579(1):135-47.
    View in: PubMed
    Score: 0.003
  64. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci U S A. 2011 Nov 08; 108(45):E1070-9.
    View in: PubMed
    Score: 0.003
  65. NMDA mediated contextual conditioning changes miRNA expression. PLoS One. 2011; 6(9):e24682.
    View in: PubMed
    Score: 0.003
  66. SMN deficiency reduces cellular ability to form stress granules, sensitizing cells to stress. Cell Mol Neurobiol. 2011 May; 31(4):541-50.
    View in: PubMed
    Score: 0.003
  67. Molecular identification of the Lugaro cell in the cat cerebellar cortex. J Comp Neurol. 1990 Nov 22; 301(4):575-84.
    View in: PubMed
    Score: 0.003
  68. Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice. Mol Psychiatry. 2012 Jan; 17(1):62-70.
    View in: PubMed
    Score: 0.003
  69. EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. Cell. 2010 Oct 29; 143(3):442-55.
    View in: PubMed
    Score: 0.003
  70. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4153-8.
    View in: PubMed
    Score: 0.003
  71. Murine Glut-1 transporter haploinsufficiency: postnatal deceleration of brain weight and reactive astrocytosis. Neurobiol Dis. 2009 Oct; 36(1):60-9.
    View in: PubMed
    Score: 0.003
  72. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science. 2008 Nov 07; 322(5903):963-6.
    View in: PubMed
    Score: 0.003
  73. Tuberous sclerosis complex proteins control axon formation. Genes Dev. 2008 Sep 15; 22(18):2485-95.
    View in: PubMed
    Score: 0.003
  74. Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome. Science. 2008 Aug 08; 321(5890):839-43.
    View in: PubMed
    Score: 0.003
  75. Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. J Neurosci. 2008 May 21; 28(21):5422-32.
    View in: PubMed
    Score: 0.002
  76. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell. 2008 Mar 14; 29(5):541-51.
    View in: PubMed
    Score: 0.002
  77. A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival. J Neurosci. 2007 May 23; 27(21):5546-58.
    View in: PubMed
    Score: 0.002
  78. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci. 2007 Jan; 10(1):67-76.
    View in: PubMed
    Score: 0.002
  79. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol Cell. 2006 Oct 20; 24(2):185-97.
    View in: PubMed
    Score: 0.002
  80. Regulation of EphA 4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function. Neuron. 2005 Aug 18; 47(4):515-28.
    View in: PubMed
    Score: 0.002
  81. Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron. 2005 Apr 21; 46(2):205-17.
    View in: PubMed
    Score: 0.002
  82. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell. 2001 Apr 20; 105(2):233-44.
    View in: PubMed
    Score: 0.002
  83. Kzf1 - a novel KRAB zinc finger protein encoding gene expressed during rat spermatogenesis. Biochim Biophys Acta. 1998 Jul 09; 1398(3):321-9.
    View in: PubMed
    Score: 0.001
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.