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Paul Alfred Boepple, M.D.

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  1. R01HD018169 (BOEPPLE, PAUL A) Jul 1, 1983 - Jun 30, 1999
    NIH
    NEUROENDOCRINE-GONADAL FUNCTION IN PUBERTY
    Role: Principal Investigator
  2. M01RR001066 (SLAVIN, PETER L) Feb 1, 1978 - May 31, 2008
    NIH
    General Clinical Research Center
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Stanford FC, Mushannen T, Cortez P, Campoverde Reyes KJ, Lee H, Gee DW, Pratt JS, Boepple PA, Bredella MA, Misra M, Singhal V. Comparison of Short and Long-Term Outcomes of Metabolic and Bariatric Surgery in Adolescents and Adults. Front Endocrinol (Lausanne). 2020; 11:157. PMID: 32265846; PMCID: PMC7105703.
    Citations: 6     Fields:    Translation:Humans
  2. Lin TY, Ebb DH, Boepple PA, Thiele EA, Rincon SP, Mordes DA. Case records of the Massachusetts General Hospital. Case 12-2015. A newborn boy with respiratory distress, lethargy, and hypernatremia. N Engl J Med. 2015 Apr 16; 372(16):1550-62. PMID: 25875261.
    Citations:    Fields:    Translation:Humans
  3. Dwyer AA, Sykiotis GP, Hayes FJ, Boepple PA, Lee H, Loughlin KR, Dym M, Sluss PM, Crowley WF, Pitteloud N. Trial of recombinant follicle-stimulating hormone pretreatment for GnRH-induced fertility in patients with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2013 Nov; 98(11):E1790-5. PMID: 24037890; PMCID: PMC3816270.
    Citations: 32     Fields:    Translation:Humans
  4. Sinha M, Stanley TL, Webb J, Scirica C, Corey K, Pratt J, Boepple PA, Hoppin A, Misra M. Metabolic effects of Roux-en-Y gastric bypass in obese adolescents and young adults. J Pediatr Gastroenterol Nutr. 2013 May; 56(5):528-31. PMID: 23274343.
    Citations: 3     Fields:    Translation:Humans
  5. Sidhoum VF, Chan YM, Lippincott MF, Balasubramanian R, Quinton R, Plummer L, Dwyer A, Pitteloud N, Hayes FJ, Hall JE, Martin KA, Boepple PA, Seminara SB. Reversal and relapse of hypogonadotropic hypogonadism: resilience and fragility of the reproductive neuroendocrine system. J Clin Endocrinol Metab. 2014 Mar; 99(3):861-70. PMID: 24423288; PMCID: PMC3942233.
    Citations: 61     Fields:    Translation:Humans
  6. Mannstadt M, Magen D, Segawa H, Stanley T, Sharma A, Sharma A, Sasaki S, Bergwitz C, Mounien L, Boepple P, Thorens B, Zelikovic I, Jüppner H. Fanconi-Bickel syndrome and autosomal recessive proximal tubulopathy with hypercalciuria (ARPTH) are allelic variants caused by GLUT2 mutations. J Clin Endocrinol Metab. 2012 Oct; 97(10):E1978-86. PMID: 22865906; PMCID: PMC3462928.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  7. Caronia LM, Martin C, Welt CK, Sykiotis GP, Quinton R, Thambundit A, Avbelj M, Dhruvakumar S, Plummer L, Hughes VA, Seminara SB, Boepple PA, Sidis Y, Crowley WF, Martin KA, Hall JE, Pitteloud N. A genetic basis for functional hypothalamic amenorrhea. N Engl J Med. 2011 Jan 20; 364(3):215-25. PMID: 21247312; PMCID: PMC3045842.
    Citations: 63     Fields:    Translation:Humans
  8. Katavetin P, Cheunsuchon P, Grant E, Boepple PA, Hedley-Whyte ET, Misra M, Levitsky LL. Rathke's cleft cysts in children and adolescents: association with female puberty. J Pediatr Endocrinol Metab. 2010 Nov; 23(11):1175-80. PMID: 21284332.
    Citations: 3     Fields:    Translation:Humans
  9. Pitteloud N, Thambundit A, Dwyer AA, Falardeau JL, Plummer L, Caronia LM, Hayes FJ, Lee H, Boepple PA, Crowley WF. Role of seminiferous tubular development in determining the FSH versus LH responsiveness to GnRH in early sexual maturation. Neuroendocrinology. 2009; 90(3):260-8. PMID: 19829004.
    Citations: 5     Fields:    Translation:Humans
  10. Levitsky LL, Misra M, Boepple PA, Hoppin AG. Adolescent obesity and bariatric surgery. Curr Opin Endocrinol Diabetes Obes. 2009 Feb; 16(1):37-44. PMID: 19104236.
    Citations: 1     Fields:    Translation:Humans
  11. Broder-Fingert S, Crowley WF, Boepple PA. Safety of frequent venous blood sampling in a pediatric research population. J Pediatr. 2009 Apr; 154(4):578-81. PMID: 19026428; PMCID: PMC2694723.
    Citations: 5     Fields:    Translation:Humans
  12. Pitteloud N, Dwyer AA, DeCruz S, Lee H, Boepple PA, Crowley WF, Hayes FJ. The relative role of gonadal sex steroids and gonadotropin-releasing hormone pulse frequency in the regulation of follicle-stimulating hormone secretion in men. J Clin Endocrinol Metab. 2008 Jul; 93(7):2686-92. PMID: 18445673; PMCID: PMC2453056.
    Citations: 22     Fields:    Translation:Humans
  13. Boepple PA, Hayes FJ, Dwyer AA, Raivio T, Lee H, Crowley WF, Pitteloud N. Relative roles of inhibin B and sex steroids in the negative feedback regulation of follicle-stimulating hormone in men across the full spectrum of seminiferous epithelium function. J Clin Endocrinol Metab. 2008 May; 93(5):1809-14. PMID: 18270253; PMCID: PMC2386680.
    Citations: 9     Fields:    Translation:Humans
  14. Pitteloud N, Dwyer AA, DeCruz S, Lee H, Boepple PA, Crowley WF, Hayes FJ. Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men. J Clin Endocrinol Metab. 2008 Mar; 93(3):784-91. PMID: 18073301; PMCID: PMC2266963.
    Citations: 31     Fields:    Translation:Humans
  15. Hughes VA, Boepple PA, Crowley WF, Seminara SB. Interplay between dose and frequency of GnRH administration in determining pituitary gonadotropin responsiveness. Neuroendocrinology. 2008; 87(3):142-50. PMID: 18063854.
    Citations: 5     Fields:    Translation:Humans
  16. Raivio T, Falardeau J, Dwyer A, Quinton R, Hayes FJ, Hughes VA, Cole LW, Pearce SH, Lee H, Boepple P, Crowley WF, Pitteloud N. Reversal of idiopathic hypogonadotropic hypogonadism. N Engl J Med. 2007 Aug 30; 357(9):863-73. PMID: 17761590.
    Citations: 117     Fields:    Translation:Humans
  17. Pitteloud N, Quinton R, Pearce S, Raivio T, Acierno J, Dwyer A, Plummer L, Hughes V, Seminara S, Cheng YZ, Li WP, Maccoll G, Eliseenkova AV, Olsen SK, Ibrahimi OA, Hayes FJ, Boepple P, Hall JE, Bouloux P, Mohammadi M, Crowley W. Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism. J Clin Invest. 2007 Feb; 117(2):457-63. PMID: 17235395; PMCID: PMC1765517.
    Citations: 170     Fields:    Translation:HumansCells
  18. Pitteloud N, Meysing A, Quinton R, Acierno JS, Dwyer AA, Plummer L, Fliers E, Boepple P, Hayes F, Seminara S, Hughes VA, Ma J, Bouloux P, Mohammadi M, Crowley WF. Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes. Mol Cell Endocrinol. 2006 Jul 25; 254-255:60-9. PMID: 16764984.
    Citations: 76     Fields:    Translation:Humans
  19. Pitteloud N, Hayes FJ, Dwyer A, Boepple PA, Lee H, Crowley WF. Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2002 Sep; 87(9):4128-36. PMID: 12213860.
    Citations: 58     Fields:    Translation:HumansCTClinical Trials
  20. Pitteloud N, Hayes FJ, Boepple PA, DeCruz S, Seminara SB, MacLaughlin DT, Crowley WF. The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2002 Jan; 87(1):152-60. PMID: 11788640.
    Citations: 51     Fields:    Translation:Humans
  21. Hayes FJ, Pitteloud N, DeCruz S, Crowley WF, Boepple PA. Importance of inhibin B in the regulation of FSH secretion in the human male. J Clin Endocrinol Metab. 2001 Nov; 86(11):5541-6. PMID: 11701733.
    Citations: 15     Fields:    Translation:HumansCTClinical Trials
  22. Palmert MR, Hayden DL, Mansfield MJ, Crigler JF, Crowley WF, Chandler DW, Boepple PA. The longitudinal study of adrenal maturation during gonadal suppression: evidence that adrenarche is a gradual process. J Clin Endocrinol Metab. 2001 Sep; 86(9):4536-42. PMID: 11549704.
    Citations: 32     Fields:    Translation:HumansCTClinical Trials
  23. Palmert MR, Boepple PA. Variation in the timing of puberty: clinical spectrum and genetic investigation. J Clin Endocrinol Metab. 2001 Jun; 86(6):2364-8. PMID: 11397824.
    Citations: 68     Fields:    Translation:Humans
  24. Pitteloud N, Boepple PA, DeCruz S, Valkenburgh SB, Crowley WF, Hayes FJ. The fertile eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the gonadotropin-releasing hormone receptor. J Clin Endocrinol Metab. 2001 Jun; 86(6):2470-5. PMID: 11397842.
    Citations: 32     Fields:    Translation:HumansCells
  25. Hayes FJ, DeCruz S, Seminara SB, Boepple PA, Crowley WF. Differential regulation of gonadotropin secretion by testosterone in the human male: absence of a negative feedback effect of testosterone on follicle-stimulating hormone secretion. J Clin Endocrinol Metab. 2001 Jan; 86(1):53-8. PMID: 11231978.
    Citations: 34     Fields:    Translation:Humans
  26. Hayes FJ, Seminara SB, Decruz S, Boepple PA, Crowley WF. Aromatase inhibition in the human male reveals a hypothalamic site of estrogen feedback. J Clin Endocrinol Metab. 2000 Sep; 85(9):3027-35. PMID: 10999781.
    Citations: 53     Fields:    Translation:HumansCTClinical Trials
  27. Palmert MR, Mansfield MJ, Crowley WF, Crigler JF, Crawford JD, Boepple PA. Is obesity an outcome of gonadotropin-releasing hormone agonist administration? Analysis of growth and body composition in 110 patients with central precocious puberty. J Clin Endocrinol Metab. 1999 Dec; 84(12):4480-8. PMID: 10599706.
    Citations: 25     Fields:    Translation:HumansCTClinical Trials
  28. Palmert MR, Malin HV, Boepple PA. Unsustained or slowly progressive puberty in young girls: initial presentation and long-term follow-up of 20 untreated patients. J Clin Endocrinol Metab. 1999 Feb; 84(2):415-23. PMID: 10022394.
    Citations: 24     Fields:    Translation:Humans
  29. Palmert MR, Radovick S, Boepple PA. Leptin levels in children with central precocious puberty. J Clin Endocrinol Metab. 1998 Jul; 83(7):2260-5. PMID: 9661592.
    Citations: 7     Fields:    Translation:HumansCells
  30. Hayes FJ, Hall JE, Boepple PA, Crowley WF. Clinical review 96: Differential control of gonadotropin secretion in the human: endocrine role of inhibin. J Clin Endocrinol Metab. 1998 Jun; 83(6):1835-41. PMID: 9626105.
    Citations: 12     Fields:    Translation:HumansAnimals
  31. Palmert MR, Radovick S, Boepple PA. The impact of reversible gonadal sex steroid suppression on serum leptin concentrations in children with central precocious puberty. J Clin Endocrinol Metab. 1998 Apr; 83(4):1091-6. PMID: 9543124.
    Citations: 4     Fields:    Translation:Humans
  32. Nachtigall LB, Boepple PA, Pralong FP, Crowley WF. Adult-onset idiopathic hypogonadotropic hypogonadism--a treatable form of male infertility. N Engl J Med. 1997 Feb 06; 336(6):410-5. PMID: 9010147.
    Citations: 54     Fields:    Translation:Humans
  33. Waldstreicher J, Seminara SB, Jameson JL, Geyer A, Nachtigall LB, Boepple PA, Holmes LB, Crowley WF. The genetic and clinical heterogeneity of gonadotropin-releasing hormone deficiency in the human. J Clin Endocrinol Metab. 1996 Dec; 81(12):4388-95. PMID: 8954047.
    Citations: 28     Fields:    Translation:HumansCells
  34. Nachtigall LB, Boepple PA, Seminara SB, Khoury RH, Sluss PM, Lecain AE, Crowley WF. Inhibin B secretion in males with gonadotropin-releasing hormone (GnRH) deficiency before and during long-term GnRH replacement: relationship to spontaneous puberty, testicular volume, and prior treatment--a clinical research center study. J Clin Endocrinol Metab. 1996 Oct; 81(10):3520-5. PMID: 8855795.
    Citations: 7     Fields:    Translation:Humans
  35. Seminara SB, Boepple PA, Nachtigall LB, Pralong FP, Khoury RH, Sluss PM, Lecain AE, Crowley WF. Inhibin B in males with gonadotropin-releasing hormone (GnRH) deficiency: changes in serum concentration after shortterm physiologic GnRH replacement--a clinical research center study. J Clin Endocrinol Metab. 1996 Oct; 81(10):3692-6. PMID: 8855824.
    Citations: 5     Fields:    Translation:Humans
  36. Pralong FP, Boepple PA, Conn PM, Whitcomb RW, Butler JP, Schoenfeld D, Crowley WF. Contour of the GnRH pulse independently modulates gonadotropin secretion in the human male. Neuroendocrinology. 1996 Sep; 64(3):247-56. PMID: 8875443.
    Citations: 5     Fields:    Translation:Humans
  37. Habiby RL, Boepple P, Nachtigall L, Sluss PM, Crowley WF, Jameson JL. Adrenal hypoplasia congenita with hypogonadotropic hypogonadism: evidence that DAX-1 mutations lead to combined hypothalmic and pituitary defects in gonadotropin production. J Clin Invest. 1996 Aug 15; 98(4):1055-62. PMID: 8770879; PMCID: PMC507522.
    Citations: 47     Fields:    Translation:HumansCells
  38. Pralong FP, Pavlou SN, Waldstreicher J, Crowley WF, Boepple PA. Defective regulation of glycoprotein free alpha-subunit in males with isolated gonadotropin-releasing hormone deficiency--a clinical research center study. J Clin Endocrinol Metab. 1995 Dec; 80(12):3682-8. PMID: 8530620.
    Citations:    Fields:    Translation:Humans
  39. Boepple PA, Frisch LS, Wierman ME, Hoffman WH, Crowley WF. The natural history of autonomous gonadal function, adrenarche, and central puberty in gonadotropin-independent precocious puberty. J Clin Endocrinol Metab. 1992 Dec; 75(6):1550-5. PMID: 1464663.
    Citations: 2     Fields:    Translation:Humans
  40. Jay N, Mansfield MJ, Blizzard RM, Crowley WF, Schoenfeld D, Rhubin L, Boepple PA. Ovulation and menstrual function of adolescent girls with central precocious puberty after therapy with gonadotropin-releasing hormone agonists. J Clin Endocrinol Metab. 1992 Sep; 75(3):890-4. PMID: 1517382.
    Citations: 11     Fields:    Translation:Humans
  41. Frisch LS, Copeland KC, Boepple PA. Recurrent ovarian cysts in childhood: diagnosis of McCune-Albright syndrome by bone scan. Pediatrics. 1992 Jul; 90(1 Pt 1):102-4. PMID: 1614755.
    Citations: 3     Fields:    Translation:Humans
  42. Waldhauser F, Boepple PA, Schemper M, Mansfield MJ, Crowley WF. Serum melatonin in central precocious puberty is lower than in age-matched prepubertal children. J Clin Endocrinol Metab. 1991 Oct; 73(4):793-6. PMID: 1909703.
    Citations: 18     Fields:    Translation:Humans
  43. Landy H, Boepple PA, Mansfield MJ, Whitcomb RW, Schneyer AL, Crawford JD, Crigler JF, Crowley WF. Altered patterns of pituitary secretion and renal excretion of free alpha-subunit during gonadotropin-releasing hormone agonist-induced pituitary desensitization. J Clin Endocrinol Metab. 1991 Mar; 72(3):711-7. PMID: 1997524.
    Citations: 3     Fields:    Translation:Humans
  44. Boepple PA, Crowley WF. Gonadotrophin-releasing hormone analogues as therapeutic probes in human growth and development: evidence from children with central precocious puberty. Acta Paediatr Scand Suppl. 1991; 372:33-8. PMID: 1927518.
    Citations: 1     Fields:    Translation:Humans
  45. Landy H, Boepple PA, Mansfield MJ, Charpie P, Schoenfeld DI, Link K, Romero G, Crawford JD, Crigler JF, Blizzard RM, et al. Sleep modulation of neuroendocrine function: developmental changes in gonadotropin-releasing hormone secretion during sexual maturation. Pediatr Res. 1990 Sep; 28(3):213-7. PMID: 2122402.
    Citations: 1     Fields:    Translation:Humans
  46. Boepple PA, Mansfield MJ, Crawford JD, Crigler JF, Blizzard RM, Crowley WF. Gonadotrophin-releasing hormone agonist treatment of central precocious puberty: an analysis of growth data in a developmental context. Acta Paediatr Scand Suppl. 1990; 367:38-43. PMID: 2220386.
    Citations: 4     Fields:    Translation:Humans
  47. Boepple PA, Mansfield MJ, Link K, Crawford JD, Crigler JF, Kushner DC, Blizzard RM, Crowley WF. Impact of sex steroids and their suppression on skeletal growth and maturation. Am J Physiol. 1988 Oct; 255(4 Pt 1):E559-66. PMID: 3052107.
    Citations: 3     Fields:    Translation:Humans
  48. Mansfield MJ, Rudlin CR, Crigler JF, Karol KA, Crawford JD, Boepple PA, Crowley WF. Changes in growth and serum growth hormone and plasma somatomedin-C levels during suppression of gonadal sex steroid secretion in girls with central precocious puberty. J Clin Endocrinol Metab. 1988 Jan; 66(1):3-9. PMID: 2961786.
    Citations: 15     Fields:    Translation:Humans
  49. Rivkees SA, Hall DA, Boepple PA, Crawford JD. Accuracy and reproducibility of clinical measures of testicular volume. J Pediatr. 1987 Jun; 110(6):914-7. PMID: 3295162.
    Citations: 14     Fields:    Translation:HumansAnimals
  50. Boepple PA, Mansfield MJ, Wierman ME, Rudlin CR, Bode HH, Crigler JF, Crawford JD, Crowley WF. Use of a potent, long acting agonist of gonadotropin-releasing hormone in the treatment of precocious puberty. Endocr Rev. 1986 Feb; 7(1):24-33. PMID: 2937629.
    Citations: 28     Fields:    Translation:Humans
  51. Wierman ME, Beardsworth DE, Crawford JD, Crigler JF, Mansfield MJ, Bode HH, Boepple PA, Kushner DC, Crowley WF. Adrenarche and skeletal maturation during luteinizing hormone releasing hormone analogue suppression of gonadarche. J Clin Invest. 1986 Jan; 77(1):121-6. PMID: 2935557; PMCID: PMC423317.
    Citations: 10     Fields:    Translation:Humans
  52. Gillum RF, Solomon HS, Kranz P, Boepple P, Creighton M. Improving hypertension detection and referral in an ambulatory setting. Arch Intern Med. 1978 May; 138(5):700-3. PMID: 646534.
    Citations: 4     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.