Xandra Owens Breakefield, Ph.D.
This page shows the publications co-authored by Xandra Breakefield and Anat Stemmer-Rachamimov.
Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin. Sci Adv. 2021 Jan; 7(2).
Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1. Mol Ther Methods Clin Dev. 2019 Dec 13; 15:18-26.
Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain. Neuro Oncol. 2016 Jan; 18(1):58-69.
Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model. Neurobiol Dis. 2015 Oct; 82:22-31.
Stochastic model of Tsc1 lesions in mouse brain. PLoS One. 2013; 8(5):e64224.
miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways. Cancer Res. 2011 Feb 01; 71(3):852-61.
Imaging and therapy of experimental schwannomas using HSV amplicon vector-encoding apoptotic protein under Schwann cell promoter. Cancer Gene Ther. 2010 Apr; 17(4):266-74.
Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway. Mol Cell Biol. 2009 Nov; 29(21):5923-40.
Treatment of implantable NF2 schwannoma tumor models with oncolytic herpes simplex virus G47Delta. Cancer Gene Ther. 2007 May; 14(5):460-7.
Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery. Hum Gene Ther. 2005 Dec; 16(12):1367-76.
Update from the 2013 International Neurofibromatosis Conference. Am J Med Genet A. 2014 Dec; 164A(12):2969-78.
Regression of schwannomas induced by adeno-associated virus-mediated delivery of caspase-1. Hum Gene Ther. 2013 Feb; 24(2):152-62.
A novel imaging-compatible sciatic nerve schwannoma model. J Neurosci Methods. 2011 Jan 30; 195(1):75-7.
Preventing growth of brain tumors by creating a zone of resistance. Mol Ther. 2008 Oct; 16(10):1695-702.
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