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George Liang King, M.D.

Concepts

This page shows the publications George King has written about Signal Transduction.
Connection Strength

0.875
  1. Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem. 2012 Feb 10; 287(7):4518-30.
    View in: PubMed
    Score: 0.088
  2. Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells. Arterioscler Thromb Vasc Biol. 2008 May; 28(5):919-24.
    View in: PubMed
    Score: 0.068
  3. Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5750-5.
    View in: PubMed
    Score: 0.067
  4. Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects. FASEB J. 2006 Oct; 20(12):2058-67.
    View in: PubMed
    Score: 0.061
  5. Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem. 2003 Aug 22; 278(34):31964-71.
    View in: PubMed
    Score: 0.049
  6. B-cell signaling: protein kinase Cdelta puts the brakes on. Curr Biol. 2002 Aug 20; 12(16):R554-6.
    View in: PubMed
    Score: 0.046
  7. Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes. Nat Commun. 2019 09 27; 10(1):4427.
    View in: PubMed
    Score: 0.038
  8. Retinol binding protein 3 is increased in the retina of patients with diabetes resistant to diabetic retinopathy. Sci Transl Med. 2019 07 03; 11(499).
    View in: PubMed
    Score: 0.037
  9. Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Diabetes. 1999 May; 48(5):1120-30.
    View in: PubMed
    Score: 0.037
  10. Letter by Rask-Madsen et al Regarding Article, "Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop". Circ Res. 2017 02 17; 120(4):e2-e3.
    View in: PubMed
    Score: 0.032
  11. Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture. Diabetes. 2016 06; 65(6):1462-71.
    View in: PubMed
    Score: 0.030
  12. Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCß activation in diabetes. Diabetes. 2012 Nov; 61(11):2967-79.
    View in: PubMed
    Score: 0.023
  13. Glomerular VEGF resistance induced by PKCd/SHP-1 activation and contribution to diabetic nephropathy. FASEB J. 2012 Jul; 26(7):2963-74.
    View in: PubMed
    Score: 0.023
  14. Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol. 2012 May; 32(5):1124-31.
    View in: PubMed
    Score: 0.022
  15. Glomerular-specific protein kinase C-ß-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity. Kidney Int. 2011 Apr; 79(8):883-96.
    View in: PubMed
    Score: 0.021
  16. Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice. Biomaterials. 2010 Dec; 31(34):9048-56.
    View in: PubMed
    Score: 0.020
  17. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab. 2010 May 05; 11(5):379-89.
    View in: PubMed
    Score: 0.020
  18. Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res. 2010 Apr 30; 106(8):1319-31.
    View in: PubMed
    Score: 0.020
  19. Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med. 2009 Nov; 15(11):1298-306.
    View in: PubMed
    Score: 0.019
  20. Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H566-72.
    View in: PubMed
    Score: 0.018
  21. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):787-93.
    View in: PubMed
    Score: 0.015
  22. The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest. 2003 May; 111(9):1373-80.
    View in: PubMed
    Score: 0.012
  23. Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA. 2002 Nov 27; 288(20):2579-88.
    View in: PubMed
    Score: 0.012
  24. Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):721-6.
    View in: PubMed
    Score: 0.011
  25. Protein kinase C and the development of diabetic vascular complications. Diabet Med. 2001 Dec; 18(12):945-59.
    View in: PubMed
    Score: 0.011
  26. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. Circulation. 2000 Feb 15; 101(6):676-81.
    View in: PubMed
    Score: 0.010
  27. Protein kinase C activation and its pharmacological inhibition in vascular disease. Vasc Med. 2000; 5(3):173-85.
    View in: PubMed
    Score: 0.010
  28. Overexpression of core 2 N-acetylglycosaminyltransferase enhances cytokine actions and induces hypertrophic myocardium in transgenic mice. FASEB J. 1999 Dec; 13(15):2329-37.
    View in: PubMed
    Score: 0.010
  29. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest. 1999 Aug; 104(4):447-57.
    View in: PubMed
    Score: 0.009
  30. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes. 1997 Sep; 46(9):1473-80.
    View in: PubMed
    Score: 0.008
  31. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest. 1996 Nov 01; 98(9):2018-26.
    View in: PubMed
    Score: 0.008
  32. Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells. J Clin Invest. 1995 Mar; 95(3):1353-62.
    View in: PubMed
    Score: 0.007
  33. Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation. J Biol Chem. 2005 Jun 24; 280(25):24135-42.
    View in: PubMed
    Score: 0.003
  34. Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci. 2005 Feb 02; 25(5):1240-8.
    View in: PubMed
    Score: 0.003
  35. Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J Clin Invest. 2003 Jun; 111(12):1835-42.
    View in: PubMed
    Score: 0.003
  36. Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. J Biol Chem. 2003 Feb 28; 278(9):6976-84.
    View in: PubMed
    Score: 0.003
  37. Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart. Circulation. 1999 Jan 26; 99(3):384-91.
    View in: PubMed
    Score: 0.002
  38. A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. Diabetes. 1998 Jul; 47(7):1074-85.
    View in: PubMed
    Score: 0.002
Connection Strength

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.