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George Liang King, M.D.

Concepts

This page shows the publications George King has written about Rats.
Connection Strength

1.056
  1. Regulation of Macrophage Apoptosis and Atherosclerosis by Lipid-Induced PKCd Isoform Activation. Circ Res. 2017 Oct 27; 121(10):1153-1167.
    View in: PubMed
    Score: 0.053
  2. SHP-1 activation inhibits vascular smooth muscle cell proliferation and intimal hyperplasia in a rodent model of insulin resistance and diabetes. Diabetologia. 2017 03; 60(3):585-596.
    View in: PubMed
    Score: 0.050
  3. Obesity-associated Gingival Vascular Inflammation and Insulin Resistance. J Dent Res. 2014 Jun; 93(6):596-601.
    View in: PubMed
    Score: 0.042
  4. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol. 2013 Aug; 33(16):3227-41.
    View in: PubMed
    Score: 0.039
  5. Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Invest Ophthalmol Vis Sci. 2012 Dec 19; 53(13):8424-32.
    View in: PubMed
    Score: 0.038
  6. Glomerular VEGF resistance induced by PKCd/SHP-1 activation and contribution to diabetic nephropathy. FASEB J. 2012 Jul; 26(7):2963-74.
    View in: PubMed
    Score: 0.036
  7. Glomerular-specific protein kinase C-ß-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity. Kidney Int. 2011 Apr; 79(8):883-96.
    View in: PubMed
    Score: 0.033
  8. A complex interplay of factors causes diabetic nephropathy. Metabolism. 2011 May; 60(5):591-3.
    View in: PubMed
    Score: 0.033
  9. Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. J Biol Chem. 2008 Dec 05; 283(49):34327-36.
    View in: PubMed
    Score: 0.029
  10. Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Kidney Int. 2008 Dec; 74(11):1434-43.
    View in: PubMed
    Score: 0.028
  11. The role of protein kinase C activation in diabetic nephropathy. Kidney Int Suppl. 2007 Aug; (106):S49-53.
    View in: PubMed
    Score: 0.026
  12. Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes. 2007 May; 56(5):1410-20.
    View in: PubMed
    Score: 0.026
  13. Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain. FASEB J. 2006 Jun; 20(8):1203-5.
    View in: PubMed
    Score: 0.024
  14. Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes. 2006 Mar; 55(3):691-8.
    View in: PubMed
    Score: 0.024
  15. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):787-93.
    View in: PubMed
    Score: 0.024
  16. Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium. J Biol Chem. 2005 Apr 22; 280(16):15719-26.
    View in: PubMed
    Score: 0.022
  17. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes. 2003 Mar; 52(3):838-45.
    View in: PubMed
    Score: 0.019
  18. Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes. Diabetes. 2002 Sep; 51(9):2709-18.
    View in: PubMed
    Score: 0.019
  19. Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue. Circulation. 2002 Jan 22; 105(3):373-9.
    View in: PubMed
    Score: 0.018
  20. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. Circulation. 2000 Feb 15; 101(6):676-81.
    View in: PubMed
    Score: 0.016
  21. Overexpression of core 2 N-acetylglycosaminyltransferase enhances cytokine actions and induces hypertrophic myocardium in transgenic mice. FASEB J. 1999 Dec; 13(15):2329-37.
    View in: PubMed
    Score: 0.015
  22. d-Alpha-tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity. Diabetes Res Clin Pract. 1999 Sep; 45(2-3):183-90.
    View in: PubMed
    Score: 0.015
  23. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest. 1999 Aug; 104(4):447-57.
    View in: PubMed
    Score: 0.015
  24. Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Diabetes. 1999 May; 48(5):1120-30.
    View in: PubMed
    Score: 0.015
  25. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest. 1999 Jan; 103(2):185-95.
    View in: PubMed
    Score: 0.014
  26. Prevention of diabetes-induced abnormal retinal blood flow by treatment with d-alpha-tocopherol. Biofactors. 1998; 7(1-2):55-67.
    View in: PubMed
    Score: 0.014
  27. d-alpha-tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein kinase C-diacylglycerol pathway. Biofactors. 1998; 7(1-2):69-76.
    View in: PubMed
    Score: 0.014
  28. Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats. Invest Ophthalmol Vis Sci. 1997 Dec; 38(13):2711-20.
    View in: PubMed
    Score: 0.013
  29. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes. 1997 Sep; 46(9):1473-80.
    View in: PubMed
    Score: 0.013
  30. Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. J Clin Invest. 1997 Jul 01; 100(1):115-26.
    View in: PubMed
    Score: 0.013
  31. Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol. J Am Soc Nephrol. 1997 Mar; 8(3):426-35.
    View in: PubMed
    Score: 0.013
  32. Regulation of retinal hemodynamics in diabetic rats by increased expression and action of endothelin-1. Invest Ophthalmol Vis Sci. 1996 Nov; 37(12):2504-18.
    View in: PubMed
    Score: 0.012
  33. Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues. Diabetes. 1996 Jul; 45 Suppl 3:S117-9.
    View in: PubMed
    Score: 0.012
  34. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science. 1996 May 03; 272(5262):728-31.
    View in: PubMed
    Score: 0.012
  35. Role of protein kinase C in glucose- and angiotensin II-induced plasminogen activator inhibitor expression. Contrib Nephrol. 1996; 118:180-7.
    View in: PubMed
    Score: 0.012
  36. Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue. J Clin Invest. 1995 Oct; 96(4):1759-67.
    View in: PubMed
    Score: 0.012
  37. Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2. J Clin Invest. 1995 Aug; 96(2):733-40.
    View in: PubMed
    Score: 0.011
  38. Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway. Am J Physiol. 1995 Aug; 269(2 Pt 1):E239-46.
    View in: PubMed
    Score: 0.011
  39. Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells. J Clin Invest. 1995 Mar; 95(3):1353-62.
    View in: PubMed
    Score: 0.011
  40. The in vivo effect of endothelins on retinal circulation in nondiabetic and diabetic rats. Invest Ophthalmol Vis Sci. 1995 Mar; 36(3):596-607.
    View in: PubMed
    Score: 0.011
  41. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes. 1994 Nov; 43(11):1372-7.
    View in: PubMed
    Score: 0.011
  42. Characterization of phorbol ester-stimulated serine phosphorylation of the human insulin receptor. Biochem J. 1994 Oct 01; 303 ( Pt 1):43-50.
    View in: PubMed
    Score: 0.011
  43. Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues. Am J Physiol. 1994 Sep; 267(3 Pt 1):E369-79.
    View in: PubMed
    Score: 0.011
  44. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes. 1994 Sep; 43(9):1122-9.
    View in: PubMed
    Score: 0.011
  45. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol. 1993 Nov; 265(5 Pt 1):E783-93.
    View in: PubMed
    Score: 0.010
  46. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):11059-63.
    View in: PubMed
    Score: 0.009
  47. Evaluating retinal circulation using video fluorescein angiography in control and diabetic rats. Curr Eye Res. 1992 Apr; 11(4):287-95.
    View in: PubMed
    Score: 0.009
  48. Modulation of the insulin growth factor II/mannose 6-phosphate receptor in microvascular endothelial cells by phorbol ester via protein kinase C. J Biol Chem. 1990 Aug 15; 265(23):13864-70.
    View in: PubMed
    Score: 0.008
  49. Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications. Proc Natl Acad Sci U S A. 1989 07; 86(13):5141-5.
    View in: PubMed
    Score: 0.007
  50. p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol. 2009 Aug; 23(8):1281-90.
    View in: PubMed
    Score: 0.007
  51. Insulin receptor recycling in vascular endothelial cells. Regulation by insulin and phorbol ester. J Biol Chem. 1989 Apr 05; 264(10):5916-23.
    View in: PubMed
    Score: 0.007
  52. Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H566-72.
    View in: PubMed
    Score: 0.007
  53. Identification of persistent defects in insulin receptor structure and function capillary endothelial cells from diabetic rats. J Clin Invest. 1989 Jan; 83(1):127-36.
    View in: PubMed
    Score: 0.007
  54. Receptors for and effects of insulin and IGF-I in rat glomerular mesangial cells. Am J Physiol. 1988 Mar; 254(3 Pt 1):C411-6.
    View in: PubMed
    Score: 0.007
  55. Regulation of insulin receptor internalization in vascular endothelial cells by insulin and phorbol ester. J Biol Chem. 1987 May 05; 262(13):6417-24.
    View in: PubMed
    Score: 0.006
  56. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. 2007 Jun; 56(6):1551-8.
    View in: PubMed
    Score: 0.006
  57. Processing and release of insulin and insulin-like growth factor I by macro- and microvascular endothelial cells. Endocrinology. 1986 Nov; 119(5):1904-13.
    View in: PubMed
    Score: 0.006
  58. Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J Biol Chem. 2004 Jul 16; 279(29):30369-74.
    View in: PubMed
    Score: 0.005
  59. Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes. 2003 Mar; 52(3):829-37.
    View in: PubMed
    Score: 0.005
  60. Interactions between the receptors for insulin and the insulin-like growth factors on adipocytes. J Biol Chem. 1982 Sep 10; 257(17):10001-6.
    View in: PubMed
    Score: 0.005
  61. Angiotensin AT(1) receptor stimulates heat shock protein 27 phosphorylation in vitro and in vivo. Hypertension. 2001 Dec 01; 38(6):1260-5.
    View in: PubMed
    Score: 0.004
  62. Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem. 2002 Feb 01; 277(5):3680-5.
    View in: PubMed
    Score: 0.004
  63. Endothelin-3 regulation of retinal hemodynamics in nondiabetic and diabetic rats. Invest Ophthalmol Vis Sci. 2000 Nov; 41(12):3955-62.
    View in: PubMed
    Score: 0.004
  64. Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulating activity (an insulinlike growth factor) using antibodies to the insulin receptor. J Clin Invest. 1980 Jul; 66(1):130-40.
    View in: PubMed
    Score: 0.004
  65. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J. 2000 Mar; 14(3):439-47.
    View in: PubMed
    Score: 0.004
  66. A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. Diabetes. 1998 Jul; 47(7):1074-85.
    View in: PubMed
    Score: 0.003
  67. Endothelin-1 action via endothelin receptors is a primary mechanism modulating retinal circulatory response to hyperoxia. Invest Ophthalmol Vis Sci. 1996 Sep; 37(10):2099-109.
    View in: PubMed
    Score: 0.003
  68. Reversal of abnormal retinal hemodynamics in diabetic rats by acarbose, an alpha-glucosidase inhibitor. Curr Eye Res. 1995 Sep; 14(9):741-9.
    View in: PubMed
    Score: 0.003
  69. Normalization of retinal blood flow in diabetic rats with primary intervention using insulin pumps. Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):981-90.
    View in: PubMed
    Score: 0.003
  70. Expression of a monoclonal antibody (3G5) defined ganglioside antigen in the renal cortex. Kidney Int. 1992 Jun; 41(6):1638-45.
    View in: PubMed
    Score: 0.002
  71. Characterization of a common high-affinity receptor for reovirus serotypes 1 and 3 on endothelial cells. J Virol. 1989 Mar; 63(3):1318-25.
    View in: PubMed
    Score: 0.002
  72. [B17-D-leucine]insulin and [B17-norleucine]insulin: synthesis and biological properties. Hoppe Seylers Z Physiol Chem. 1983 Nov; 364(11):1615-26.
    View in: PubMed
    Score: 0.001
  73. [B22-D-arginine]insulin: synthesis and biological properties. Hoppe Seylers Z Physiol Chem. 1982 Dec; 363(12):1449-60.
    View in: PubMed
    Score: 0.001
  74. Demonstration of receptors for insulin and insulin-like growth factors on Swarm rat chondrosarcoma chondrocytes. Evidence that insulin stimulates proteoglycan synthesis through the insulin receptor. J Biol Chem. 1982 Jan 25; 257(2):663-9.
    View in: PubMed
    Score: 0.001
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.