Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Login and Edit functionaility are currrently unavailable.

George Liang King, M.D.

Concepts

This page shows the publications George King has written about Isoenzymes.
Connection Strength

1.912
  1. Applications of inhibitors for protein kinase C and their isoforms. Methods Mol Biol. 2003; 233:397-422.
    View in: PubMed
    Score: 0.172
  2. Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes. Diabetes. 2002 Sep; 51(9):2709-18.
    View in: PubMed
    Score: 0.168
  3. Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):721-6.
    View in: PubMed
    Score: 0.161
  4. Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats. Invest Ophthalmol Vis Sci. 1997 Dec; 38(13):2711-20.
    View in: PubMed
    Score: 0.121
  5. Regulation of Macrophage Apoptosis and Atherosclerosis by Lipid-Induced PKCd Isoform Activation. Circ Res. 2017 Oct 27; 121(10):1153-1167.
    View in: PubMed
    Score: 0.119
  6. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science. 1996 May 03; 272(5262):728-31.
    View in: PubMed
    Score: 0.109
  7. Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-ß isoform in the endothelium. Circ Res. 2013 Aug 02; 113(4):418-27.
    View in: PubMed
    Score: 0.089
  8. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):11059-63.
    View in: PubMed
    Score: 0.085
  9. Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res. 2010 Apr 30; 106(8):1319-31.
    View in: PubMed
    Score: 0.072
  10. The role of protein kinase C activation in diabetic nephropathy. Kidney Int Suppl. 2007 Aug; (106):S49-53.
    View in: PubMed
    Score: 0.059
  11. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol Res. 2007 Jun; 55(6):498-510.
    View in: PubMed
    Score: 0.058
  12. Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium. J Biol Chem. 2005 Apr 22; 280(16):15719-26.
    View in: PubMed
    Score: 0.050
  13. Protein kinase C and the development of diabetic vascular complications. Diabet Med. 2001 Dec; 18(12):945-59.
    View in: PubMed
    Score: 0.040
  14. Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem. 2002 Feb 01; 277(5):3680-5.
    View in: PubMed
    Score: 0.040
  15. Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells. J Biol Chem. 2000 Dec 29; 275(52):40725-31.
    View in: PubMed
    Score: 0.037
  16. Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation. Diabetes. 2000 Jul; 49(7):1239-48.
    View in: PubMed
    Score: 0.036
  17. Protein kinase C and myocardial biology and function. Circ Res. 2000 Jun 09; 86(11):1104-6.
    View in: PubMed
    Score: 0.036
  18. Identification of PKC-isoform-specific biological actions using pharmacological approaches. Trends Pharmacol Sci. 2000 May; 21(5):181-7.
    View in: PubMed
    Score: 0.036
  19. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J. 2000 Mar; 14(3):439-47.
    View in: PubMed
    Score: 0.035
  20. Protein kinase C activation and its pharmacological inhibition in vascular disease. Vasc Med. 2000; 5(3):173-85.
    View in: PubMed
    Score: 0.035
  21. Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications? Diabetes Res Clin Pract. 1999 Sep; 45(2-3):169-82.
    View in: PubMed
    Score: 0.034
  22. d-Alpha-tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity. Diabetes Res Clin Pract. 1999 Sep; 45(2-3):183-90.
    View in: PubMed
    Score: 0.034
  23. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest. 1999 Jan; 103(2):185-95.
    View in: PubMed
    Score: 0.033
  24. The role of protein kinase C activation in the pathogenesis of diabetic vascular complications. Perit Dial Int. 1999; 19 Suppl 2:S222-7.
    View in: PubMed
    Score: 0.033
  25. In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts. J Clin Invest. 1998 Jul 01; 102(1):72-8.
    View in: PubMed
    Score: 0.032
  26. Prevention of diabetes-induced abnormal retinal blood flow by treatment with d-alpha-tocopherol. Biofactors. 1998; 7(1-2):55-67.
    View in: PubMed
    Score: 0.030
  27. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes. 1997 Sep; 46(9):1473-80.
    View in: PubMed
    Score: 0.030
  28. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest. 1996 Nov 01; 98(9):2018-26.
    View in: PubMed
    Score: 0.028
  29. Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues. Diabetes. 1996 Jul; 45 Suppl 3:S117-9.
    View in: PubMed
    Score: 0.027
  30. Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway. Am J Physiol. 1995 Aug; 269(2 Pt 1):E239-46.
    View in: PubMed
    Score: 0.026
  31. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol. 1993 Nov; 265(5 Pt 1):E783-93.
    View in: PubMed
    Score: 0.023
  32. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. 2007 Jun; 56(6):1551-8.
    View in: PubMed
    Score: 0.014
  33. Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart. Circulation. 1999 Jan 26; 99(3):384-91.
    View in: PubMed
    Score: 0.008
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.