Harvard Catalyst Profiles

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Sergey Viktorovich Kozin, D.Sc., Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gupta N, Ochiai H, Hoshino Y, Klein S, Zustin J, Ramjiawan RR, Kitahara S, Maimon N, Bazou D, Chiang S, Li S, Schanne DH, Jain RK, Munn LL, Huang P, Kozin SV, Duda DG. Inhibition of CXCR4 Enhances the Efficacy of Radiotherapy in Metastatic Prostate Cancer Models. Cancers (Basel). 2023 Feb 06; 15(4). PMID: 36831366; PMCID: PMC9954510.
    Citations:    
  2. Markin PA, Moskaleva NE, Lebedeva SA, Kozin SV, Grigorevskikh EM, Kolik LG, Gudasheva TA, Appolonova SA. LC-MS/MS determination of GTS-201, a dipeptide mimetic of the brain-derived neurotrophic factor, and neurotransmitter metabolites with application to a pharmacokinetic study in rats. J Pharm Biomed Anal. 2023 Jan 20; 223:115125. PMID: 36375394.
    Citations:    Fields:    Translation:Animals
  3. Taldaev A, Terekhov RP, Melnik EV, Belova MV, Kozin SV, Nedorubov AA, Pomerantseva TY, Ramenskaya GV. Insights into the Cardiotoxic Effects of Veratrum Lobelianum Alkaloids: Pilot Study. Toxins (Basel). 2022 07 15; 14(7). PMID: 35878228; PMCID: PMC9315652.
    Citations:    Fields:    Translation:HumansAnimals
  4. Kozin SV. Vascular damage in tumors: a key player in stereotactic radiation therapy? Trends Cancer. 2022 10; 8(10):806-819. PMID: 35835699.
    Citations:    Fields:    
  5. Melnik EV, Petukhov AE, Kozin SV, Pomerantseva TY, Ramenskaya GV. Validated HPLC-MS/MS method for quantification of ethylmethylhydroxypyridine succinate in rat brain and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Oct 01; 1096:180-186. PMID: 30176507.
    Citations: 1     Fields:    Translation:Animals
  6. Kozin SV, Maimon N, Wang R, Gupta N, Munn L, Jain RK, Garkavtsev I. Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers. Oncotarget. 2017 Dec 12; 8(65):108292-108302. PMID: 29312532.
    Citations: 11     Fields:    
  7. Ager EI, Kozin SV, Kirkpatrick ND, Seano G, Kodack DP, Askoxylakis V, Huang Y, Goel S, Snuderl M, Muzikansky A, Finkelstein DM, Dransfield DT, Devy L, Boucher Y, Fukumura D, Jain RK. Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy. J Natl Cancer Inst. 2015 Apr; 107(4). PMID: 25710962; PMCID: PMC4402365.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  8. Ivanov AS, Medvedev A, Ershov P, Molnar A, Mezentsev Y, Yablokov E, Kaluzhsky L, Gnedenko O, Buneeva O, Haidukevich I, Sergeev G, Lushchyk A, Yantsevich A, Medvedeva M, Kozin S, Popov I, Novikova S, Zgoda V, Gilep A, Usanov S, Lisitsa A, Archakov A. Protein interactomics based on direct molecular fishing on paramagnetic particles: practical realization and further SPR validation. Proteomics. 2014 Oct; 14(20):2261-74. PMID: 25044858.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  9. Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, Stylianopoulos T, Mousa AS, Han X, Adstamongkonkul P, Popovic Z, Huang P, Bawendi MG, Boucher Y, Jain RK. Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nat Commun. 2013; 4:2516. PMID: 24084631.
    Citations: 340     Fields:    Translation:HumansAnimalsCells
  10. Kozin SV, Duda DG, Munn LL, Jain RK. Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors? J Natl Cancer Inst. 2012 Jun 20; 104(12):899-905. PMID: 22572994.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  11. Kozin SV, Duda DG, Munn LL, Jain RK. Is vasculogenesis crucial for the regrowth of irradiated tumours? Nat Rev Cancer. 2011 Jun 24; 11(7):532. PMID: 21701514.
    Citations: 7     Fields:    Translation:HumansCells
  12. Duda DG, Kozin SV, Kirkpatrick ND, Xu L, Fukumura D, Jain RK. CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies? Clin Cancer Res. 2011 Apr 15; 17(8):2074-80. PMID: 21349998; PMCID: PMC3079023.
    Citations: 186     Fields:    Translation:HumansAnimalsCells
  13. Kozin SV, Kamoun WS, Huang Y, Dawson MR, Jain RK, Duda DG. Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation. Cancer Res. 2010 Jul 15; 70(14):5679-85. PMID: 20631066.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  14. Kozin SV, Niemierko A, Huang P, Silva J, Doppke KP, Suit HD. Inter- and intramouse heterogeneity of radiation response for a growing paired organ. Radiat Res. 2008 Aug; 170(2):264-7. PMID: 18666813.
    Citations: 4     Fields:    Translation:Animals
  15. Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D. Perivascular nitric oxide gradients normalize tumor vasculature. Nat Med. 2008 Mar; 14(3):255-7. PMID: 18278052.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  16. Kozin SV, Winkler F, Garkavtsev I, Hicklin DJ, Jain RK, Boucher Y. Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors. Cancer Res. 2007 Jun 01; 67(11):5076-82. PMID: 17545583.
    Citations: 13     Fields:    Translation:HumansAnimals
  17. Willett CG, Kozin SV, Duda DG, di Tomaso E, Kozak KR, Boucher Y, Jain RK. Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice. Semin Oncol. 2006 Oct; 33(5 Suppl 10):S35-40. PMID: 17145523; PMCID: PMC2686124.
    Citations: 27     Fields:    Translation:HumansAnimals
  18. Gerweck LE, Vijayappa S, Kozin S. Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics. Mol Cancer Ther. 2006 May; 5(5):1275-9. PMID: 16731760.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  19. Duda DG, Cohen KS, Kozin SV, Perentes JY, Fukumura D, Scadden DT, Jain RK. Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors. Blood. 2006 Apr 01; 107(7):2774-6. PMID: 16339405; PMCID: PMC1895376.
    Citations: 54     Fields:    Translation:HumansCells
  20. Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, Sahani DV, Kalva SP, Cohen KS, Scadden DT, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Shellito PC, Mino-Kenudson M, Lauwers GY. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J Clin Oncol. 2005 Nov 01; 23(31):8136-9. PMID: 16258121.
    Citations: 155     Fields:    Translation:HumansCTClinical Trials
  21. Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell. 2004 Dec; 6(6):553-63. PMID: 15607960.
    Citations: 526     Fields:    Translation:HumansAnimalsCells
  22. Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res. 2004 Jun 01; 64(11):3731-6. PMID: 15172975.
    Citations: 416     Fields:    Translation:HumansAnimalsCells
  23. Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Nature. 2004 Mar 18; 428(6980):328-32. PMID: 15029197.
    Citations: 129     Fields:    Translation:HumansAnimalsCells
  24. Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med. 2004 Feb; 10(2):145-7. PMID: 14745444; PMCID: PMC2693485.
    Citations: 554     Fields:    Translation:HumansCTClinical Trials
  25. Chastagner P, Kozin SV, Taghian A. Topotecan selectively enhances the radioresponse of human small-cell lung carcinoma and glioblastoma multiforme xenografts in nude mice. Int J Radiat Oncol Biol Phys. 2001 Jul 01; 50(3):777-82. PMID: 11395247.
    Citations: 7     Fields:    Translation:HumansAnimals
  26. Kozin SV, Shkarin P, Gerweck LE. The cell transmembrane pH gradient in tumors enhances cytotoxicity of specific weak acid chemotherapeutics. Cancer Res. 2001 Jun 15; 61(12):4740-3. PMID: 11406545.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  27. Kozin SV, Boucher Y, Hicklin DJ, Bohlen P, Jain RK, Suit HD. Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. Cancer Res. 2001 Jan 01; 61(1):39-44. PMID: 11196192.
    Citations: 54     Fields:    Translation:HumansAnimals
  28. Gerweck LE, Kozin SV, Stocks SJ. The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-pH-adapted cells. Br J Cancer. 1999 Feb; 79(5-6):838-42. PMID: 10070878; PMCID: PMC2362684.
    Citations: 21     Fields:    Translation:AnimalsCells
  29. Gerweck LE, Kozin SV. Relative biological effectiveness of proton beams in clinical therapy. Radiother Oncol. 1999 Feb; 50(2):135-42. PMID: 10368035.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  30. Kozin SV, Gerweck LE. Cytotoxicity of weak electrolytes after the adaptation of cells to low pH: role of the transmembrane pH gradient. Br J Cancer. 1998 May; 77(10):1580-5. PMID: 9635832; PMCID: PMC2150052.
    Citations: 7     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.