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Xiqun Chen, M.D.


Available: 10/01/21, Expires: 10/30/24

Although Parkinson's disease (PD) and cancer are defined pathologically by neuron loss and cell overgrowth, respectively, they have been linked to some of the same gene alterations. LRRK2 mutations, the most common cause of autosomal dominant late-onset PD, are associated with an increased risk of cancer. Mutations of Parkin, a potent tumor suppressor gene, are the most common cause of autosomal recessive early-onset PD. While advances in cancer immunology are revolutionizing the treatment of cancer, there is a growing appreciation of the role of the immune system in PD. Previous and our preliminary studies support that PD and cancer-related LRRK2 and Parkin alterations can lead to dysregulated immune responses. The overall goal of the proposed study is to investigate whether and how the genetic connections between PD and cancer alter immune tolerance to dopaminergic neurons and contribute to dopaminergic neurodegeneration at the cellular, tissue, and systemic levels and in patient samples. Two specific aims will be pursued to determine whether 1) LRRK2 and Parkin alterations reprogram immune responses against dopaminergic neurons; 2) cancer-educated immune system alters dopaminergic-specific autoimmunity. Backed by exceptional expertise and resources from cancer research and neuroscience, two major disciplines that rarely crosstalk, the proposed work strikes a balance between high risk and high return to address issues relevant to both "Biology of PD-associated Genes" and "Neuro-immune Interactions". Its findings are expected to advance our understanding of the molecular events in the immune system leading to tumorigenesis in dividing cells and neurodegeneration as part of the systemic disorders in response to the same genetic triggers. These molecular insights would open new avenues for prevention and therapies for PD by offering a range of therapeutic targets, as well as the possibility that immune approaches developed in cancer will find applications in PD.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yu J, Xie N, Zhu J, Qian Y, Zheng S, Chen XM. Exploring impacts of COVID-19 on city-wide taxi and ride-sourcing markets: Evidence from Ningbo, China. Transp Policy (Oxf). 2022 Jan; 115:220-238. PMID: 34840441.
  2. Chen X, Burdett TC, Desjardins CA, Logan R, Cipriani S, Xu Y, Schwarzschild MA. Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):300-5. PMID: 23248282.
    Citations: 57     Fields:    Translation:AnimalsCells
  3. Chen X, Tagliaferro P, Kareva T, Yarygina O, Kholodilov N, Burke RE. Neurotrophic effects of serum- and glucocorticoid-inducible kinase on adult murine mesencephalic dopamine neurons. J Neurosci. 2012 Aug 15; 32(33):11299-308. PMID: 22895713; PMCID: PMC3433399.
    Citations: 9     Fields:    Translation:AnimalsCells
  4. Chen X, Wu G, Schwarzschild MA. Urate in Parkinson's disease: more than a biomarker? Curr Neurol Neurosci Rep. 2012 Aug; 12(4):367-75. PMID: 22580741.
    Citations: 30     Fields:    Translation:HumansAnimals
  5. Burdett TC, Desjardins CA, Logan R, McFarland NR, Chen X, Schwarzschild MA. Efficient determination of purine metabolites in brain tissue and serum by high-performance liquid chromatography with electrochemical and UV detection. Biomed Chromatogr. 2013 Jan; 27(1):122-9. PMID: 22674671.
    Citations: 9     Fields:    Translation:HumansAnimals
  6. Kim SR, Chen X, Oo TF, Kareva T, Yarygina O, Wang C, During M, Kholodilov N, Burke RE. Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration. Ann Neurol. 2011 Jul; 70(1):110-20. PMID: 21437936.
    Citations: 59     Fields:    Translation:AnimalsCells
  7. Cipriani S, Chen X, Schwarzschild MA. Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosis. Biomark Med. 2010 Oct; 4(5):701-12. PMID: 20945982.
    Citations: 55     Fields:    Translation:Humans
  8. Tank AW, Xu L, Chen X, Radcliffe P, Sterling CR. Post-transcriptional regulation of tyrosine hydroxylase expression in adrenal medulla and brain. Ann N Y Acad Sci. 2008 Dec; 1148:238-48. PMID: 19120116.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  9. Chen X, Xu L, Radcliffe P, Sun B, Tank AW. Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons. Mol Pharmacol. 2008 Jun; 73(6):1816-28. PMID: 18349104.
    Citations: 17     Fields:    Translation:AnimalsCells
  10. Chen X, Rzhetskaya M, Kareva T, Bland R, During MJ, Tank AW, Kholodilov N, Burke RE. Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo. J Neurosci. 2008 Jan 16; 28(3):672-80. PMID: 18199767; PMCID: PMC2896687.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  11. Xu L, Chen X, Sun B, Sterling C, Tank AW. Evidence for regulation of tyrosine hydroxylase mRNA translation by stress in rat adrenal medulla. Brain Res. 2007 Jul 16; 1158:1-10. PMID: 17543899; PMCID: PMC2756652.
    Citations: 11     Fields:    Translation:AnimalsCells
  12. Sun B, Chen X, Xu L, Sterling C, Tank AW. Chronic nicotine treatment leads to induction of tyrosine hydroxylase in locus ceruleus neurons: the role of transcriptional activation. Mol Pharmacol. 2004 Oct; 66(4):1011-21. PMID: 15258258.
    Citations: 12     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.