Harvard Catalyst Profiles

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Caroline Erter Burns, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R35HL135831 (BURNS, CAROLINE E) Jan 1, 2017 - Jun 30, 2024
    NIH
    Change of Institution
    Role: Principal Investigator
  2. R01HL127067 (BURNS, C. GEOFFREY) Apr 1, 2015 - Mar 31, 2019
    NIH
    Deciphering the role of Notch signaling in zebrafish heart regeneration
    Role: Principal Investigator
  3. R01HL111179 (BURNS, CAROLINE E) Jan 1, 2012 - Dec 31, 2016
    NIH
    Cellular and Genetic Determinants of Great Vessel Morphogenesis
    Role: Principal Investigator
  4. K01DK067179 (BURNS, CAROLINE E) Feb 1, 2005 - Jan 31, 2010
    NIH
    Definitive Hematopoiesis in Zebrafish
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Akerberg AA, Trembley M, Butty V, Schwertner A, Zhao L, Beerens M, Liu X, Mahamdeh M, Yuan S, Boyer L, MacRae C, Nguyen C, Pu WT, Burns CE, Burns CG. RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function. Circ Res. 2022 12 02; 131(12):980-1000. PMID: 36367103; PMCID: PMC9770155.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Huang M, Akerberg AA, Zhang X, Yoon H, Joshi S, Hallinan C, Nguyen C, Pu WT, Haigis MC, Burns CG, Burns CE. Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome. Nat Commun. 2022 10 05; 13(1):5877. PMID: 36198703; PMCID: PMC9534849.
    Citations: 1     Fields:    Translation:HumansAnimals
  3. Abrial M, Basu S, Huang M, Butty V, Schwertner A, Jeffrey S, Jordan D, Burns CE, Burns CG. Latent TGFß-binding proteins 1 and 3 protect the larval zebrafish outflow tract from aneurysmal dilatation. Dis Model Mech. 2022 03 01; 15(3). PMID: 35098309; PMCID: PMC8990920.
    Citations:    Fields:    Translation:HumansAnimals
  4. Sharpe M, González-Rosa JM, Wranitz F, Jeffrey S, Copenhaver K, Burns CG, Burns CE. Ruvbl2 Suppresses Cardiomyocyte Proliferation During Zebrafish Heart Development and Regeneration. Front Cell Dev Biol. 2022; 10:800594. PMID: 35178388; PMCID: PMC8844374.
    Citations:    
  5. Yin HM, Burns CG, Burns CE. Innate Mechanisms of Heart Regeneration. Cold Spring Harb Perspect Biol. 2021 11 01; 13(11). PMID: 34187805; PMCID: PMC8559548.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Akerberg AA, Burns CE, Burns CG, Nguyen C. Deep learning enables automated volumetric assessments of cardiac function in zebrafish. Dis Model Mech. 2019 10 25; 12(10). PMID: 31548281.
    Citations: 12     Fields:    Translation:Animals
  7. Ben-Yair R, Butty VL, Busby M, Qiu Y, Levine SS, Goren A, Boyer LA, Burns CG, Burns CE. H3K27me3-mediated silencing of structural genes is required for zebrafish heart regeneration. Development. 2019 10 09; 146(19). PMID: 31427288; PMCID: PMC6803378.
    Citations: 14     Fields:    Translation:AnimalsCells
  8. Burns CG, Burns CE. Canonical Wnt Signaling Sets the Pace. Dev Cell. 2019 09 23; 50(6):675-676. PMID: 31550460.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  9. Akerberg AA, Burns CE, Burns CG. Exploring the Activities of RBPMS Proteins in Myocardial Biology. Pediatr Cardiol. 2019 Oct; 40(7):1410-1418. PMID: 31399780.
    Citations: 2     Fields:    Translation:HumansAnimals
  10. Gálvez-Santisteban M, Chen D, Zhang R, Serrano R, Nguyen C, Zhao L, Nerb L, Masutani EM, Vermot J, Burns CG, Burns CE, Del Álamo JC, Chi NC. Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming. Elife. 2019 06 25; 8. PMID: 31237233.
    Citations: 13     Fields:    Translation:AnimalsCells
  11. Zhao L, Ben-Yair R, Burns CE, Burns CG. Endocardial Notch Signaling Promotes Cardiomyocyte Proliferation in the Regenerating Zebrafish Heart through Wnt Pathway Antagonism. Cell Rep. 2019 01 15; 26(3):546-554.e5. PMID: 30650349; PMCID: PMC6366857.
    Citations: 41     Fields:    Translation:AnimalsCells
  12. Guner-Ataman B, González-Rosa JM, Shah HN, Butty VL, Jeffrey S, Abrial M, Boyer LA, Burns CG, Burns CE. Failed Progenitor Specification Underlies the Cardiopharyngeal Phenotypes in a Zebrafish Model of 22q11.2 Deletion Syndrome. Cell Rep. 2018 07 31; 24(5):1342-1354.e5. PMID: 30067987.
    Citations: 8     Fields:    Translation:AnimalsCells
  13. González-Rosa JM, Sharpe M, Field D, Soonpaa MH, Field LJ, Burns CE, Burns CG. Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish. Dev Cell. 2018 02 26; 44(4):433-446.e7. PMID: 29486195; PMCID: PMC5830170.
    Citations: 98     Fields:    Translation:AnimalsCells
  14. Natarajan N, Abbas Y, Bryant DM, Gonzalez-Rosa JM, Sharpe M, Uygur A, Cocco-Delgado LH, Ho NN, Gerard NP, Gerard CJ, MacRae CA, Burns CE, Burns CG, Whited JL, Lee RT. Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Circulation. 2018 05 15; 137(20):2152-2165. PMID: 29348261; PMCID: PMC5953786.
    Citations: 28     Fields:    Translation:AnimalsCells
  15. Paffett-Lugassy N, Novikov N, Jeffrey S, Abrial M, Guner-Ataman B, Sakthivel S, Burns CE, Burns CG. Unique developmental trajectories and genetic regulation of ventricular and outflow tract progenitors in the zebrafish second heart field. Development. 2017 12 15; 144(24):4616-4624. PMID: 29061637.
    Citations: 19     Fields:    Translation:AnimalsCells
  16. González-Rosa JM, Burns CE, Burns CG. Zebrafish heart regeneration: 15 years of discoveries. Regeneration (Oxf). 2017 06; 4(3):105-123. PMID: 28979788.
    Citations: 66     
  17. Abrial M, Paffett-Lugassy N, Jeffrey S, Jordan D, O'Loughlin E, Frederick CJ, Burns CG, Burns CE. TGF-ß Signaling Is Necessary and Sufficient for Pharyngeal Arch Artery Angioblast Formation. Cell Rep. 2017 07 25; 20(4):973-983. PMID: 28746880.
    Citations: 9     Fields:    Translation:AnimalsCells
  18. Manalo T, May A, Quinn J, Lafontant DS, Shifatu O, He W, Gonzalez-Rosa JM, Burns GC, Burns CE, Burns AR, Lafontant PJ. Differential Lectin Binding Patterns Identify Distinct Heart Regions in Giant Danio ( Devario aequipinnatus) and Zebrafish ( Danio rerio) Hearts. J Histochem Cytochem. 2016 11; 64(11):687-714. PMID: 27680670; PMCID: PMC5084522.
    Citations: 7     Fields:    Translation:AnimalsCells
  19. Han P, Bloomekatz J, Ren J, Zhang R, Grinstein JD, Zhao L, Burns CG, Burns CE, Anderson RM, Chi NC. Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis. Nature. 2016 06 30; 534(7609):700-4. PMID: 27357797.
    Citations: 38     Fields:    Translation:AnimalsCells
  20. Jahangiri L, Sharpe M, Novikov N, González-Rosa JM, Borikova A, Nevis K, Paffett-Lugassy N, Zhao L, Adams M, Guner-Ataman B, Burns CE, Burns CG. The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field. Development. 2016 Jan 01; 143(1):113-22. PMID: 26732840.
    Citations: 18     Fields:    Translation:AnimalsCells
  21. Mosimann C, Panáková D, Werdich AA, Musso G, Burger A, Lawson KL, Carr LA, Nevis KR, Sabeh MK, Zhou Y, Davidson AJ, DiBiase A, Burns CE, Burns CG, MacRae CA, Zon LI. Chamber identity programs drive early functional partitioning of the heart. Nat Commun. 2015 Aug 26; 6:8146. PMID: 26306682.
    Citations: 42     Fields:    Translation:AnimalsCells
  22. Mahmoud AI, O'Meara CC, Gemberling M, Zhao L, Bryant DM, Zheng R, Gannon JB, Cai L, Choi WY, Egnaczyk GF, Burns CE, Burns CG, MacRae CA, Poss KD, Lee RT. Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration. Dev Cell. 2015 Aug 24; 34(4):387-99. PMID: 26256209; PMCID: PMC4550513.
    Citations: 115     Fields:    Translation:AnimalsCells
  23. Harrison MR, Bussmann J, Huang Y, Zhao L, Osorio A, Burns CG, Burns CE, Sucov HM, Siekmann AF, Lien CL. Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish. Dev Cell. 2015 May 26; 33(4):442-54. PMID: 26017769; PMCID: PMC4448080.
    Citations: 70     Fields:    Translation:AnimalsCells
  24. Jang IH, Lu YF, Zhao L, Wenzel PL, Kume T, Datta SM, Arora N, Guiu J, Lagha M, Kim PG, Do EK, Kim JH, Schlaeger TM, Zon LI, Bigas A, Burns CE, Daley GQ. Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium. Blood. 2015 Feb 26; 125(9):1418-26. PMID: 25587036; PMCID: PMC4342355.
    Citations: 29     Fields:    Translation:AnimalsCells
  25. Burns CG, Burns CE. Development. A crowning achievement for deciphering coronary origins. Science. 2014 Jul 04; 345(6192):28-9. PMID: 24994633.
    Citations: 3     Fields:    Translation:Animals
  26. Zhao L, Borikova AL, Ben-Yair R, Guner-Ataman B, MacRae CA, Lee RT, Burns CG, Burns CE. Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1403-8. PMID: 24474765.
    Citations: 112     Fields:    Translation:AnimalsCells
  27. Paffett-Lugassy N, Singh R, Nevis KR, Guner-Ataman B, O'Loughlin E, Jahangiri L, Harvey RP, Burns CG, Burns CE. Heart field origin of great vessel precursors relies on nkx2.5-mediated vasculogenesis. Nat Cell Biol. 2013 Nov; 15(11):1362-9. PMID: 24161929.
    Citations: 35     Fields:    Translation:Animals
  28. Nevis K, Obregon P, Walsh C, Guner-Ataman B, Burns CG, Burns CE. Tbx1 is required for second heart field proliferation in zebrafish. Dev Dyn. 2013 May; 242(5):550-9. PMID: 23335360.
    Citations: 26     Fields:    Translation:AnimalsCells
  29. Guner-Ataman B, Paffett-Lugassy N, Adams MS, Nevis KR, Jahangiri L, Obregon P, Kikuchi K, Poss KD, Burns CE, Burns CG. Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function. Development. 2013 Mar; 140(6):1353-63. PMID: 23444361.
    Citations: 47     Fields:    Translation:AnimalsCells
  30. Taylor AM, Humphries JM, White RM, Murphey RD, Burns CE, Zon LI. Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation. Exp Hematol. 2012 Mar; 40(3):228-237.e5. PMID: 22120640; PMCID: PMC3310385.
    Citations: 44     Fields:    Translation:AnimalsCells
  31. Zhou Y, Cashman TJ, Nevis KR, Obregon P, Carney SA, Liu Y, Gu A, Mosimann C, Sondalle S, Peterson RE, Heideman W, Burns CE, Burns CG. Latent TGF-ß binding protein 3 identifies a second heart field in zebrafish. Nature. 2011 May 29; 474(7353):645-8. PMID: 21623370.
    Citations: 126     Fields:    Translation:AnimalsCells
  32. de Jong JL, Burns CE, Chen AT, Pugach E, Mayhall EA, Smith AC, Feldman HA, Zhou Y, Zon LI. Characterization of immune-matched hematopoietic transplantation in zebrafish. Blood. 2011 Apr 21; 117(16):4234-42. PMID: 21346254; PMCID: PMC3087475.
    Citations: 24     Fields:    Translation:Animals
  33. Deacon DC, Nevis KR, Cashman TJ, Zhou Y, Zhao L, Washko D, Guner-Ataman B, Burns CG, Burns CE. The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis. Development. 2010 Jun; 137(11):1887-96. PMID: 20460367.
    Citations: 44     Fields:    Translation:AnimalsCells
  34. Burns CE, Galloway JL, Smith AC, Keefe MD, Cashman TJ, Paik EJ, Mayhall EA, Amsterdam AH, Zon LI. A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood. 2009 Jun 04; 113(23):5776-82. PMID: 19332767; PMCID: PMC2700318.
    Citations: 54     Fields:    Translation:AnimalsCells
  35. Imamura S, Uchiyama J, Koshimizu E, Hanai J, Raftopoulou C, Murphey RD, Bayliss PE, Imai Y, Burns CE, Masutomi K, Gagos S, Zon LI, Roberts TM, Kishi S. A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS One. 2008; 3(10):e3364. PMID: 18846223.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  36. White RM, Sessa A, Burke C, Bowman T, LeBlanc J, Ceol C, Bourque C, Dovey M, Goessling W, Burns CE, Zon LI. Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell Stem Cell. 2008 Feb 07; 2(2):183-9. PMID: 18371439.
    Citations: 495     Fields:    Translation:AnimalsCells
  37. Peng CY, Yajima H, Burns CE, Zon LI, Sisodia SS, Pfaff SL, Sharma K. Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord. Neuron. 2007 Mar 15; 53(6):813-27. PMID: 17359917.
    Citations: 71     Fields:    Translation:AnimalsCells
  38. Burns CE, Zon LI. Homing sweet homing: odyssey of hematopoietic stem cells. Immunity. 2006 Dec; 25(6):859-62. PMID: 17174927.
    Citations: 9     Fields:    Translation:AnimalsCells
  39. Burns CE, Traver D, Mayhall E, Shepard JL, Zon LI. Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev. 2005 Oct 01; 19(19):2331-42. PMID: 16166372; PMCID: PMC1240042.
    Citations: 196     Fields:    Translation:AnimalsCells
  40. Ransom DG, Bahary N, Niss K, Traver D, Burns C, Trede NS, Paffett-Lugassy N, Saganic WJ, Lim CA, Hersey C, Zhou Y, Barut BA, Lin S, Kingsley PD, Palis J, Orkin SH, Zon LI. The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol. 2004 Aug; 2(8):E237. PMID: 15314655; PMCID: PMC509301.
    Citations: 53     Fields:    Translation:AnimalsCells
  41. Burns CE, DeBlasio T, Zhou Y, Zhang J, Zon L, Nimer SD. Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators. Exp Hematol. 2002 Dec; 30(12):1381-9. PMID: 12482499.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  42. Burns CE, Zon LI. Portrait of a stem cell. Dev Cell. 2002 Nov; 3(5):612-3. PMID: 12431368.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.