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Joseph Frank Cotten, M.D.,Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM128009 (COTTEN, JOSEPH F) Apr 1, 2018 - Mar 31, 2022
    NIH/NIGMS
    Anesthetic activation of TASK-3 tandem pore potassium channels: molecular mechanisms and behavioral effects
    Role: Principal Investigator
  2. R21DA045231 (COTTEN, JOSEPH F) Mar 15, 2018 - Feb 29, 2020
    NIH/NIDA
    Safer, Non-addicting Pain Management: Identification and Expression of Cyclic Peptides with Analgesic and Breathing Stimulant Properties
    Role: Principal Investigator
  3. R01HL117871 (COTTEN, JOSEPH F) Jun 1, 2013 - Apr 30, 2018
    NIH/NHLBI
    TASK Potassium Channel Antagonists to Treat Opioid Depression of Breathing
    Role: Principal Investigator
  4. K08GM083216 (COTTEN, JOSEPH F) Sep 1, 2008 - Aug 31, 2013
    NIH/NIGMS
    Volatile Anesthetic Regulation of TASK Tandem Pore Potassium Channels
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Boghosian JD, Luethy A, Cotten JF. Intravenous and Intratracheal Thyrotropin Releasing Hormone and Its Analog Taltirelin Reverse Opioid-Induced Respiratory Depression in Isoflurane Anesthetized Rats. J Pharmacol Exp Ther. 2018 Jul; 366(1):105-112. PMID: 29674333.
    View in: PubMed
  2. Jounaidi Y, Cotten JF, Miller KW, Forman SA. Tethering IL2 to Its Receptor IL2Rß Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells. Cancer Res. 2017 11 01; 77(21):5938-5951. PMID: 28916655.
    View in: PubMed
  3. Zhao H, Cotten JF, Long X, Feng HJ. The effect of atomoxetine, a selective norepinephrine reuptake inhibitor, on respiratory arrest and cardiorespiratory function in the DBA/1 mouse model of SUDEP. Epilepsy Res. 2017 11; 137:139-144. PMID: 28844345.
    View in: PubMed
  4. Luethy A, Boghosian JD, Srikantha R, Cotten JF. Halogenated Ether, Alcohol, and Alkane Anesthetics Activate TASK-3 Tandem Pore Potassium Channels Likely through a Common Mechanism. Mol Pharmacol. 2017 06; 91(6):620-629. PMID: 28325748.
    View in: PubMed
  5. Kenny JD, Chemali JJ, Cotten JF, Van Dort CJ, Kim SE, Ba D, Taylor NE, Brown EN, Solt K. Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats. Anesth Analg. 2016 11; 123(5):1210-1219. PMID: 26991753.
    View in: PubMed
  6. Diaz-Gil D, Haerter F, Falcinelli S, Ganapati S, Hettiarachchi GK, Simons JC, Zhang B, Grabitz SD, Moreno Duarte I, Cotten JF, Eikermann-Haerter K, Deng H, Chamberlin NL, Isaacs L, Briken V, Eikermann M. A Novel Strategy to Reverse General Anesthesia by Scavenging with the Acyclic Cucurbit[n]uril-type Molecular Container Calabadion 2. Anesthesiology. 2016 08; 125(2):333-45. PMID: 27341276; PMCID: PMC4955735 [Available on 08/01/17].
  7. Zhang H, Zhao H, Yang X, Xue Q, Cotten JF, Feng HJ. 5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest. Epilepsia. 2016 08; 57(8):1228-35. PMID: 27302625.
    View in: PubMed
  8. Chokshi RH, Larsen AT, Bhayana B, Cotten JF. Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore. Mol Pharmacol. 2015 Nov; 88(5):926-34. PMID: 26268529; PMCID: PMC4613942 [Available on 11/01/16].
  9. Zeng C, Long X, Cotten JF, Forman SA, Solt K, Faingold CL, Feng HJ. Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice. Epilepsy Behav. 2015 Apr; 45:1-7. PMID: 25771493; PMCID: PMC4424071.
  10. Diaz-Gil D, Mueller N, Moreno-Duarte I, Lin H, Ayata C, Cusin C, Cotten JF, Eikermann M. Etomidate and Ketamine: Residual Motor and Adrenal Dysfunction that Persist beyond Recovery from Loss of Righting Reflex in Rats. Pharmaceuticals (Basel). 2014 Dec 29; 8(1):21-37. PMID: 25551398; PMCID: PMC4381199.
  11. Cotten JF. The latest pharmacologic ventilator. Anesthesiology. 2014 Sep; 121(3):442-4. PMID: 25222671; PMCID: PMC4166568.
  12. Ge R, Pejo E, Gallin H, Jeffrey S, Cotten JF, Raines DE. The pharmacology of cyclopropyl-methoxycarbonyl metomidate: a comparison with propofol. Anesth Analg. 2014 Mar; 118(3):563-7. PMID: 24557104.
    View in: PubMed
  13. Shanmugasundararaj S, Zhou X, Neunzig J, Bernhardt R, Cotten JF, Ge R, Miller KW, Raines DE. Carboetomidate: an analog of etomidate that interacts weakly with 11ß-hydroxylase. Anesth Analg. 2013 Jun; 116(6):1249-56. PMID: 23492967; PMCID: PMC3836822.
  14. Cotten JF. TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats. Anesth Analg. 2013 Apr; 116(4):810-6. PMID: 23460565; PMCID: PMC3865919.
  15. Ge R, Pejo E, Cotten JF, Raines DE. Adrenocortical suppression and recovery after continuous hypnotic infusion: etomidate versus its soft analogue cyclopropyl-methoxycarbonyl metomidate. Crit Care. 2013 Jan 30; 17(1):R20. PMID: 23363638; PMCID: PMC4057162.
  16. Ge R, Pejo E, Husain SS, Cotten JF, Raines DE. Electroencephalographic and hypnotic recoveries after brief and prolonged infusions of etomidate and optimized soft etomidate analogs. Anesthesiology. 2012 Nov; 117(5):1037-43. PMID: 22929726; PMCID: PMC3509380.
  17. Wong KF, Gong JJ, Cotten JF, Solt K, Brown EN. Assessing the effects of pharmacological agents on respiratory dynamics using time-series modeling. IEEE Trans Biomed Eng. 2013 Apr; 60(4):1118-25. PMID: 23193230.
    View in: PubMed
  18. Pejo E, Ge R, Banacos N, Cotten JF, Husain SS, Raines DE. Electroencephalographic recovery, hypnotic emergence, and the effects of metabolite after continuous infusions of a rapidly metabolized etomidate analog in rats. Anesthesiology. 2012 May; 116(5):1057-65. PMID: 22417966; PMCID: PMC3351719.
  19. Pejo E, Feng Y, Chao W, Cotten JF, Le Ge R, Raines DE. Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia. Crit Care Med. 2012 Jan; 40(1):187-92. PMID: 21926608; PMCID: PMC3242859.
  20. Conway KE, Cotten JF. Covalent modification of a volatile anesthetic regulatory site activates TASK-3 (KCNK9) tandem-pore potassium channels. Mol Pharmacol. 2012 Mar; 81(3):393-400. PMID: 22147752; PMCID: PMC3286307.
  21. Solt K, Cotten JF, Cimenser A, Wong KF, Chemali JJ, Brown EN. Methylphenidate actively induces emergence from general anesthesia. Anesthesiology. 2011 Oct; 115(4):791-803. PMID: 21934407; PMCID: PMC3178041.
  22. Cotten JF, Le Ge R, Banacos N, Pejo E, Husain SS, Williams JH, Raines DE. Closed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical function. Anesthesiology. 2011 Oct; 115(4):764-73. PMID: 21572317; PMCID: PMC3534755.
  23. Pejo E, Cotten JF, Kelly EW, Le Ge R, Cuny GD, Laha JK, Liu J, Lin XJ, Raines DE. In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate. Anesth Analg. 2012 Aug; 115(2):297-304. PMID: 21965364; PMCID: PMC3252484.
  24. Gong JJ, Wong KF, Cotten JF, Solt K, Brown EN. Correcting for serial dependence in studies of respiratory dynamics. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:1721-4. PMID: 22254658; PMCID: PMC3767304.
  25. Husain SS, Stewart D, Desai R, Hamouda AK, Li SG, Kelly E, Dostalova Z, Zhou X, Cotten JF, Raines DE, Olsen RW, Cohen JB, Forman SA, Miller KW. p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels. J Med Chem. 2010 Sep 09; 53(17):6432-44. PMID: 20704351; PMCID: PMC3117435.
  26. Cotten JF, Forman SA, Laha JK, Cuny GD, Husain SS, Miller KW, Nguyen HH, Kelly EW, Stewart D, Liu A, Raines DE. Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function. Anesthesiology. 2010 Mar; 112(3):637-44. PMID: 20179500; PMCID: PMC2830733.
  27. Solt K, Kelly EW, Cotten JF, Raines DE. Inhibition of human alpha4beta2 neuronal nicotinic acetylcholine receptors by volatile aromatic anesthetics depends on drug hydrophobicity. Anesth Analg. 2010 Feb 01; 110(2):455-60. PMID: 19917625; PMCID: PMC3534757.
  28. Cotten JF, Husain SS, Forman SA, Miller KW, Kelly EW, Nguyen HH, Raines DE. Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression. Anesthesiology. 2009 Aug; 111(2):240-9. PMID: 19625798; PMCID: PMC2739411.
  29. Brosnan R, Gong D, Cotten J, Keshavaprasad B, Yost CS, Eger EI, Sonner JM. Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers. Anesth Analg. 2006 Jul; 103(1):86-91, table of contents. PMID: 16790632.
    View in: PubMed
  30. Cotten JF, Keshavaprasad B, Laster MJ, Eger EI, Yost CS. The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Anesth Analg. 2006 Mar; 102(3):779-85. PMID: 16492828.
    View in: PubMed
  31. Keshavaprasad B, Liu C, Au JD, Kindler CH, Cotten JF, Yost CS. Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK. Anesth Analg. 2005 Oct; 101(4):1042-9, table of contents. PMID: 16192517.
    View in: PubMed
  32. Liu C, Cotten JF, Schuyler JA, Fahlman CS, Au JD, Bickler PE, Yost CS. Protective effects of TASK-3 (KCNK9) and related 2P K channels during cellular stress. Brain Res. 2005 Jan 21; 1031(2):164-73. PMID: 15649441.
    View in: PubMed
  33. Liu C, Au JD, Zou HL, Cotten JF, Yost CS. Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics. Anesth Analg. 2004 Dec; 99(6):1715-22, table of contents. PMID: 15562060.
    View in: PubMed
  34. Cotten JF, Zou HL, Liu C, Au JD, Yost CS. Identification of native rat cerebellar granule cell currents due to background K channel KCNK5 (TASK-2). Brain Res Mol Brain Res. 2004 Sep 28; 128(2):112-20. PMID: 15363886.
    View in: PubMed
  35. Callahan R, Labunskiy DA, Logvinova A, Abdallah M, Liu C, Cotten JF, Yost CS. Immunolocalization of TASK-3 (KCNK9) to a subset of cortical neurons in the rat CNS. Biochem Biophys Res Commun. 2004 Jun 25; 319(2):525-30. PMID: 15178438.
    View in: PubMed
  36. Cotten JF, In: Manuel Pardo & Ronald Miller, editors, . "Pulmonary Hypertension", "Acute Liver Failure", "Acute Hepatitis", and "Organ Harvest,". 2004.
  37. Baldursson O, Ostedgaard LS, Rokhlina T, Cotten JF, Welsh MJ. Cystic fibrosis transmembrane conductance regulator Cl- channels with R domain deletions and translocations show phosphorylation-dependent and -independent activity. J Biol Chem. 2001 Jan 19; 276(3):1904-10. PMID: 11038358.
    View in: PubMed
  38. Cotten JF. Cystic Fibrosis Transmembrane Conductance Regulator: Structure and Function . 1999.
  39. Cotten JF, Welsh MJ. Cystic fibrosis-associated mutations at arginine 347 alter the pore architecture of CFTR. Evidence for disruption of a salt bridge. J Biol Chem. 1999 Feb 26; 274(9):5429-35. PMID: 10026154.
    View in: PubMed
  40. Cotten JF, Welsh MJ. Covalent modification of the nucleotide binding domains of cystic fibrosis transmembrane conductance regulator. J Biol Chem. 1998 Nov 27; 273(48):31873-9. PMID: 9822656.
    View in: PubMed
  41. Cotten JF, Welsh MJ. Covalent modification of the regulatory domain irreversibly stimulates cystic fibrosis transmembrane conductance regulator. J Biol Chem. 1997 Oct 10; 272(41):25617-22. PMID: 9325282.
    View in: PubMed
  42. Cotten JF, Ostedgaard LS, Carson MR, Welsh MJ. Effect of cystic fibrosis-associated mutations in the fourth intracellular loop of cystic fibrosis transmembrane conductance regulator. J Biol Chem. 1996 Aug 30; 271(35):21279-84. PMID: 8702904.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.