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Joseph Frank Cotten, M.D.,Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM128009 (COTTEN, JOSEPH F) Apr 1, 2018 - Mar 31, 2022
    Anesthetic activation of TASK-3 tandem pore potassium channels: molecular mechanisms and behavioral effects
    Role: Principal Investigator
  2. R21DA045231 (COTTEN, JOSEPH F) Mar 15, 2018 - Feb 28, 2021
    Safer, Non-addicting Pain Management: Identification and Expression of Cyclic Peptides with Analgesic and Breathing Stimulant Properties
    Role: Principal Investigator
  3. R01HL117871 (COTTEN, JOSEPH F) Jun 1, 2013 - Apr 30, 2019
    TASK Potassium Channel Antagonists to Treat Opioid Depression of Breathing
    Role: Principal Investigator
  4. K08GM083216 (COTTEN, JOSEPH F) Sep 1, 2008 - Aug 31, 2013
    Volatile Anesthetic Regulation of TASK Tandem Pore Potassium Channels
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Algera MH, Cotten JF, van Velzen M, Niesters M, Boon M, Shoham DS, Dandrea KE, van der Schrier R, Dahan A. Are thyrotropin-releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid-induced respiratory depression? Pharmacol Res Perspect. 2022 06; 10(3):e00974. PMID: 35621218; PMCID: PMC9137104.
    Citations: 1     Fields:    Translation:Animals
  2. Algera MH, Cotten JF, van Velzen M, Niesters M, Boon M, Shoham DS, Dandrea KE, van der Schrier R, Dahan A. Respiratory effects of thyrotropin-releasing hormone and its analogue taltirelin on opioid-induced respiratory depression. Br J Anaesth. 2022 07; 129(1):e4-e6. PMID: 35459532; PMCID: PMC9428912.
    Citations: 1     Fields:    Translation:Humans
  3. Dandrea KE, Cotten JF. A Comparison of Breathing Stimulants for Reversal of Synthetic Opioid-Induced Respiratory Depression in Conscious Rats. J Pharmacol Exp Ther. 2021 08; 378(2):146-156. PMID: 34021024; PMCID: PMC8686717.
    Citations: 1     Fields:    Translation:Animals
  4. Moody OA, Zhang ER, Arora V, Kato R, Cotten JF, Solt K. D-Amphetamine Accelerates Recovery of Consciousness and Respiratory Drive After High-Dose Fentanyl in Rats. Front Pharmacol. 2020; 11:585356. PMID: 33424595.
    Citations: 4     
  5. Thevathasan T, Grabitz SD, Santer P, Rostin P, Akeju O, Boghosian JD, Gill M, Isaacs L, Cotten JF, Eikermann M. Calabadion 1 selectively reverses respiratory and central nervous system effects of fentanyl in a rat model. Br J Anaesth. 2020 07; 125(1):e140-e147. PMID: 32241547.
    Citations: 7     Fields:    Translation:Animals
  6. Luethy A, Kindler CH, Cotten JF. Anesthetic pretreatment confers thermotolerance on Saccharomyces cerevisiae yeast. Biochem Biophys Res Commun. 2020 02 05; 522(2):479-484. PMID: 31780265.
    Citations: 1     Fields:    Translation:Animals
  7. Boghosian JD, Luethy A, Cotten JF. Intravenous and Intratracheal Thyrotropin Releasing Hormone and Its Analog Taltirelin Reverse Opioid-Induced Respiratory Depression in Isoflurane Anesthetized Rats. J Pharmacol Exp Ther. 2018 07; 366(1):105-112. PMID: 29674333; PMCID: PMC5987997.
    Citations: 6     Fields:    Translation:Animals
  8. Jounaidi Y, Cotten JF, Miller KW, Forman SA. Tethering IL2 to Its Receptor IL2Rß Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells. Cancer Res. 2017 11 01; 77(21):5938-5951. PMID: 28916655; PMCID: PMC6204197.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  9. Zhao H, Cotten JF, Long X, Feng HJ. The effect of atomoxetine, a selective norepinephrine reuptake inhibitor, on respiratory arrest and cardiorespiratory function in the DBA/1 mouse model of SUDEP. Epilepsy Res. 2017 11; 137:139-144. PMID: 28844345; PMCID: PMC5706652.
    Citations: 10     Fields:    Translation:Animals
  10. Luethy A, Boghosian JD, Srikantha R, Cotten JF. Halogenated Ether, Alcohol, and Alkane Anesthetics Activate TASK-3 Tandem Pore Potassium Channels Likely through a Common Mechanism. Mol Pharmacol. 2017 06; 91(6):620-629. PMID: 28325748; PMCID: PMC5438130.
    Citations: 8     Fields:    Translation:AnimalsCells
  11. Kenny JD, Chemali JJ, Cotten JF, Van Dort CJ, Kim SE, Ba D, Taylor NE, Brown EN, Solt K. Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats. Anesth Analg. 2016 11; 123(5):1210-1219. PMID: 26991753; PMCID: PMC5026857.
    Citations: 17     Fields:    Translation:Animals
  12. Diaz-Gil D, Haerter F, Falcinelli S, Ganapati S, Hettiarachchi GK, Simons JC, Zhang B, Grabitz SD, Moreno Duarte I, Cotten JF, Eikermann-Haerter K, Deng H, Chamberlin NL, Isaacs L, Briken V, Eikermann M. A Novel Strategy to Reverse General Anesthesia by Scavenging with the Acyclic Cucurbit[n]uril-type Molecular Container Calabadion 2. Anesthesiology. 2016 08; 125(2):333-45. PMID: 27341276; PMCID: PMC4955735.
    Citations: 15     Fields:    Translation:Animals
  13. Zhang H, Zhao H, Yang X, Xue Q, Cotten JF, Feng HJ. 5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest. Epilepsia. 2016 08; 57(8):1228-35. PMID: 27302625.
    Citations: 14     Fields:    Translation:Animals
  14. Chokshi RH, Larsen AT, Bhayana B, Cotten JF. Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore. Mol Pharmacol. 2015 Nov; 88(5):926-34. PMID: 26268529; PMCID: PMC4613942.
    Citations: 15     Fields:    Translation:AnimalsCells
  15. Zeng C, Long X, Cotten JF, Forman SA, Solt K, Faingold CL, Feng HJ. Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice. Epilepsy Behav. 2015 Apr; 45:1-7. PMID: 25771493.
    Citations: 16     Fields:    Translation:Animals
  16. Diaz-Gil D, Mueller N, Moreno-Duarte I, Lin H, Ayata C, Cusin C, Cotten JF, Eikermann M. Etomidate and Ketamine: Residual Motor and Adrenal Dysfunction that Persist beyond Recovery from Loss of Righting Reflex in Rats. Pharmaceuticals (Basel). 2014 Dec 29; 8(1):21-37. PMID: 25551398; PMCID: PMC4381199.
    Citations: 3     
  17. Cotten JF. The latest pharmacologic ventilator. Anesthesiology. 2014 Sep; 121(3):442-4. PMID: 25222671; PMCID: PMC4166568.
    Citations: 1     Fields:    Translation:Humans
  18. Ge R, Pejo E, Gallin H, Jeffrey S, Cotten JF, Raines DE. The pharmacology of cyclopropyl-methoxycarbonyl metomidate: a comparison with propofol. Anesth Analg. 2014 Mar; 118(3):563-7. PMID: 24557104; PMCID: PMC6310170.
    Citations: 11     Fields:    Translation:Animals
  19. Shanmugasundararaj S, Zhou X, Neunzig J, Bernhardt R, Cotten JF, Ge R, Miller KW, Raines DE. Carboetomidate: an analog of etomidate that interacts weakly with 11ß-hydroxylase. Anesth Analg. 2013 Jun; 116(6):1249-56. PMID: 23492967; PMCID: PMC3836822.
    Citations: 11     Fields:    Translation:HumansCells
  20. Cotten JF. TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats. Anesth Analg. 2013 Apr; 116(4):810-6. PMID: 23460565; PMCID: PMC3865919.
    Citations: 27     Fields:    Translation:Animals
  21. Ge R, Pejo E, Cotten JF, Raines DE. Adrenocortical suppression and recovery after continuous hypnotic infusion: etomidate versus its soft analogue cyclopropyl-methoxycarbonyl metomidate. Crit Care. 2013 Jan 30; 17(1):R20. PMID: 23363638.
    Citations: 12     Fields:    Translation:Animals
  22. Ge R, Pejo E, Husain SS, Cotten JF, Raines DE. Electroencephalographic and hypnotic recoveries after brief and prolonged infusions of etomidate and optimized soft etomidate analogs. Anesthesiology. 2012 Nov; 117(5):1037-43. PMID: 22929726; PMCID: PMC3509380.
    Citations: 12     Fields:    Translation:Animals
  23. Wong KF, Gong JJ, Cotten JF, Solt K, Brown EN. Assessing the effects of pharmacological agents on respiratory dynamics using time-series modeling. IEEE Trans Biomed Eng. 2013 Apr; 60(4):1118-25. PMID: 23193230.
    Citations:    Fields:    Translation:Animals
  24. Pejo E, Ge R, Banacos N, Cotten JF, Husain SS, Raines DE. Electroencephalographic recovery, hypnotic emergence, and the effects of metabolite after continuous infusions of a rapidly metabolized etomidate analog in rats. Anesthesiology. 2012 May; 116(5):1057-65. PMID: 22417966; PMCID: PMC3351719.
    Citations: 11     Fields:    Translation:Animals
  25. Pejo E, Feng Y, Chao W, Cotten JF, Le Ge R, Raines DE. Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia. Crit Care Med. 2012 Jan; 40(1):187-92. PMID: 21926608; PMCID: PMC3242859.
    Citations: 10     Fields:    Translation:Animals
  26. Conway KE, Cotten JF. Covalent modification of a volatile anesthetic regulatory site activates TASK-3 (KCNK9) tandem-pore potassium channels. Mol Pharmacol. 2012 Mar; 81(3):393-400. PMID: 22147752.
    Citations: 12     Fields:    Translation:AnimalsCells
  27. Cotten JF, Le Ge R, Banacos N, Pejo E, Husain SS, Williams JH, Raines DE. Closed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical function. Anesthesiology. 2011 Oct; 115(4):764-73. PMID: 21572317; PMCID: PMC3534755.
    Citations: 20     Fields:    Translation:Animals
  28. Solt K, Cotten JF, Cimenser A, Wong KF, Chemali JJ, Brown EN. Methylphenidate actively induces emergence from general anesthesia. Anesthesiology. 2011 Oct; 115(4):791-803. PMID: 21934407; PMCID: PMC3178041.
    Citations: 78     Fields:    Translation:Animals
  29. Pejo E, Cotten JF, Kelly EW, Le Ge R, Cuny GD, Laha JK, Liu J, Lin XJ, Raines DE. In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate. Anesth Analg. 2012 Aug; 115(2):297-304. PMID: 21965364; PMCID: PMC3252484.
    Citations: 19     Fields:    Translation:AnimalsCells
  30. Gong JJ, Wong KF, Cotten JF, Solt K, Brown EN. Correcting for serial dependence in studies of respiratory dynamics. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:1721-4. PMID: 22254658.
    Citations: 1     Fields:    Translation:Animals
  31. Husain SS, Stewart D, Desai R, Hamouda AK, Li SG, Kelly E, Dostalova Z, Zhou X, Cotten JF, Raines DE, Olsen RW, Cohen JB, Forman SA, Miller KW. p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels. J Med Chem. 2010 Sep 09; 53(17):6432-44. PMID: 20704351.
    Citations: 16     Fields:    Translation:AnimalsCells
  32. Cotten JF, Forman SA, Laha JK, Cuny GD, Husain SS, Miller KW, Nguyen HH, Kelly EW, Stewart D, Liu A, Raines DE. Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function. Anesthesiology. 2010 Mar; 112(3):637-44. PMID: 20179500; PMCID: PMC2830733.
    Citations: 33     Fields:    Translation:Animals
  33. Solt K, Kelly EW, Cotten JF, Raines DE. Inhibition of human alpha4beta2 neuronal nicotinic acetylcholine receptors by volatile aromatic anesthetics depends on drug hydrophobicity. Anesth Analg. 2010 Feb 01; 110(2):455-60. PMID: 19917625; PMCID: PMC3534757.
    Citations:    Fields:    Translation:HumansAnimalsCells
  34. Cotten JF, Husain SS, Forman SA, Miller KW, Kelly EW, Nguyen HH, Raines DE. Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression. Anesthesiology. 2009 Aug; 111(2):240-9. PMID: 19625798; PMCID: PMC2739411.
    Citations: 44     Fields:    Translation:HumansAnimals
  35. Brosnan R, Gong D, Cotten J, Keshavaprasad B, Yost CS, Eger EI, Sonner JM. Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers. Anesth Analg. 2006 Jul; 103(1):86-91, table of contents. PMID: 16790632.
    Citations: 12     Fields:    Translation:AnimalsCells
  36. Cotten JF, Keshavaprasad B, Laster MJ, Eger EI, Yost CS. The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Anesth Analg. 2006 Mar; 102(3):779-85. PMID: 16492828.
    Citations: 32     Fields:    Translation:HumansAnimals
  37. Keshavaprasad B, Liu C, Au JD, Kindler CH, Cotten JF, Yost CS. Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK. Anesth Analg. 2005 Oct; 101(4):1042-1049. PMID: 16192517.
    Citations: 21     Fields:    Translation:Animals
  38. Liu C, Cotten JF, Schuyler JA, Fahlman CS, Au JD, Bickler PE, Yost CS. Protective effects of TASK-3 (KCNK9) and related 2P K channels during cellular stress. Brain Res. 2005 Jan 21; 1031(2):164-73. PMID: 15649441.
    Citations: 12     Fields:    Translation:AnimalsCells
  39. Liu C, Au JD, Zou HL, Cotten JF, Yost CS. Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics. Anesth Analg. 2004 Dec; 99(6):1715-1722. PMID: 15562060.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  40. Cotten JF, Zou HL, Liu C, Au JD, Yost CS. Identification of native rat cerebellar granule cell currents due to background K channel KCNK5 (TASK-2). Brain Res Mol Brain Res. 2004 Sep 28; 128(2):112-20. PMID: 15363886.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  41. Callahan R, Labunskiy DA, Logvinova A, Abdallah M, Liu C, Cotten JF, Yost CS. Immunolocalization of TASK-3 (KCNK9) to a subset of cortical neurons in the rat CNS. Biochem Biophys Res Commun. 2004 Jun 25; 319(2):525-30. PMID: 15178438.
    Citations: 5     Fields:    Translation:AnimalsCells
  42. Cotten JF, In: Manuel Pardo & Ronald Miller, editors, . "Pulmonary Hypertension", "Acute Liver Failure", "Acute Hepatitis", and "Organ Harvest,". 2004.
  43. Baldursson O, Ostedgaard LS, Rokhlina T, Cotten JF, Welsh MJ. Cystic fibrosis transmembrane conductance regulator Cl- channels with R domain deletions and translocations show phosphorylation-dependent and -independent activity. J Biol Chem. 2001 Jan 19; 276(3):1904-10. PMID: 11038358.
    Citations: 15     Fields:    Translation:Cells
  44. Cotten JF. Cystic Fibrosis Transmembrane Conductance Regulator: Structure and Function . 1999.
  45. Cotten JF, Welsh MJ. Cystic fibrosis-associated mutations at arginine 347 alter the pore architecture of CFTR. Evidence for disruption of a salt bridge. J Biol Chem. 1999 Feb 26; 274(9):5429-35. PMID: 10026154.
    Citations: 50     Fields:    Translation:Cells
  46. Cotten JF, Welsh MJ. Covalent modification of the nucleotide binding domains of cystic fibrosis transmembrane conductance regulator. J Biol Chem. 1998 Nov 27; 273(48):31873-9. PMID: 9822656.
    Citations: 15     Fields:    Translation:HumansCells
  47. Cotten JF, Welsh MJ. Covalent modification of the regulatory domain irreversibly stimulates cystic fibrosis transmembrane conductance regulator. J Biol Chem. 1997 Oct 10; 272(41):25617-22. PMID: 9325282.
    Citations: 23     Fields:    Translation:HumansCells
  48. Cotten JF, Ostedgaard LS, Carson MR, Welsh MJ. Effect of cystic fibrosis-associated mutations in the fourth intracellular loop of cystic fibrosis transmembrane conductance regulator. J Biol Chem. 1996 Aug 30; 271(35):21279-84. PMID: 8702904.
    Citations: 29     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.