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Vadim Bolshakov, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH108665 (RESSLER, KERRY J.) Jul 1, 2016 - Apr 30, 2021
    NIH/NIMH
    Cell Type Specific Genomic and Functional Dissection of Fear Off Amygdala Pathways
    Role: Principal Investigator
  2. R21MH108022 (BOLSHAKOV, VADIM) Apr 1, 2016 - Feb 28, 2018
    NIH/NIMH
    PACAP-mediated modulation of amygdalar-BNST interactions: implications for control of anxiety states
    Role: Principal Investigator
  3. R01MH105851 (BOLSHAKOV, VADIM) Jul 1, 2015 - Mar 31, 2020
    NIH/NIMH
    TRPC-mediated control of anxiety
    Role: Principal Investigator
  4. R01MH090464 (BOLSHAKOV, VADIM) Apr 15, 2010 - Jan 31, 2015
    NIH/NIMH
    Synaptic mechanisms in extinction of conditioned fear
    Role: Principal Investigator
  5. R03MH087717 (BOLSHAKOV, VADIM) Mar 22, 2010 - Jan 31, 2013
    NIH/NIMH
    Functional role of vesicular zinc in synaptic mechanisms in the amygdala
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Li Y, Missig G, Finger BC, Landino SM, Alexander AJ, Mokler EL, Robbins JO, Manasian Y, Kim W, Kim KS, McDougle CJ, Carlezon WA, Bolshakov VY. Maternal and Early Postnatal Immune Activation Produce Dissociable Effects on Neurotransmission in mPFC-Amygdala Circuits. J Neurosci. 2018 Mar 28; 38(13):3358-3372. PMID: 29491010.
    View in: PubMed
  2. Lee SH, Lutz D, Mossalam M, Bolshakov VY, Frotscher M, Shen J. Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway. Mol Neurodegener. 2017 06 15; 12(1):48. PMID: 28619096.
    View in: PubMed
  3. Luchkina NV, Bolshakov VY. Diminishing fear: Optogenetic approach toward understanding neural circuits of fear control. Pharmacol Biochem Behav. 2017 May 11. PMID: 28502746.
    View in: PubMed
  4. Engin E, Smith KS, Gao Y, Nagy D, Foster RA, Tsvetkov E, Keist R, Crestani F, Fritschy JM, Bolshakov VY, Hajos M, Heldt SA, Rudolph U. Modulation of anxiety and fear via distinct intrahippocampal circuits. Elife. 2016 Mar 14; 5:e14120. PMID: 26971710.
    View in: PubMed
  5. Balu DT, Li Y, Takagi S, Presti KT, Ramikie TS, Rook JM, Jones CK, Lindsley CW, Conn PJ, Bolshakov VY, Coyle JT. An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia. Neuropsychopharmacology. 2016 07; 41(8):2052-61. PMID: 26741285; PMCID: PMC4908650 [Available on 07/01/17].
  6. Engin E, Zarnowska ED, Benke D, Tsvetkov E, Sigal M, Keist R, Bolshakov VY, Pearce RA, Rudolph U. Tonic Inhibitory Control of Dentate Gyrus Granule Cells by a5-Containing GABAA Receptors Reduces Memory Interference. J Neurosci. 2015 Oct 07; 35(40):13698-712. PMID: 26446222; PMCID: PMC4595621.
  7. Levy RJ, Kvajo M, Li Y, Tsvetkov E, Dong W, Yoshikawa Y, Kataoka T, Bolshakov VY, Karayiorgou M, Gogos JA. Deletion of Rapgef6, a candidate schizophrenia susceptibility gene, disrupts amygdala function in mice. Transl Psychiatry. 2015 Jun 09; 5:e577. PMID: 26057047; PMCID: PMC4490285.
  8. Xia D, Watanabe H, Wu B, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ. Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease. Neuron. 2015 Mar 04; 85(5):967-81. PMID: 25741723; PMCID: PMC4358812.
  9. Cunningham M, Cho JH, Leung A, Savvidis G, Ahn S, Moon M, Lee PK, Han JJ, Azimi N, Kim KS, Bolshakov VY, Chung S. hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice. Cell Stem Cell. 2014 Nov 06; 15(5):559-73. PMID: 25517465; PMCID: PMC4270101.
  10. Kim TG, Yao R, Monnell T, Cho JH, Vasudevan A, Koh A, Peeyush KT, Moon M, Datta D, Bolshakov VY, Kim KS, Chung S. Efficient specification of interneurons from human pluripotent stem cells by dorsoventral and rostrocaudal modulation. Stem Cells. 2014 Jul; 32(7):1789-804. PMID: 24648391; PMCID: PMC4147720.
  11. Riccio A, Li Y, Tsvetkov E, Gapon S, Yao GL, Smith KS, Engin E, Rudolph U, Bolshakov VY, Clapham DE. Decreased anxiety-like behavior and Gaq/11-dependent responses in the amygdala of mice lacking TRPC4 channels. J Neurosci. 2014 Mar 05; 34(10):3653-67. PMID: 24599464; PMCID: PMC3942581.
  12. Cho JH, Deisseroth K, Bolshakov VY. Synaptic encoding of fear extinction in mPFC-amygdala circuits. Neuron. 2013 Dec 18; 80(6):1491-507. PMID: 24290204; PMCID: PMC3872173.
  13. Balu DT, Li Y, Puhl MD, Benneyworth MA, Basu AC, Takagi S, Bolshakov VY, Coyle JT. Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):E2400-9. PMID: 23729812; PMCID: PMC3696825.
  14. Li Y, Meloni EG, Carlezon WA, Milad MR, Pitman RK, Nader K, Bolshakov VY. Learning and reconsolidation implicate different synaptic mechanisms. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):4798-803. PMID: 23487762; PMCID: PMC3607055.
  15. Li Y, Sacchi S, Pollegioni L, Basu AC, Coyle JT, Bolshakov VY. Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level. Nat Commun. 2013; 4:1760. PMID: 23612301; PMCID: PMC3641574.
  16. Cho JH, Zushida K, Shumyatsky GP, Carlezon WA, Meloni EG, Bolshakov VY. Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. J Neurosci. 2012 Oct 10; 32(41):14165-77. PMID: 23055486; PMCID: PMC3490216.
  17. Gisabella B, Bolshakov VY, Benes FM. Kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia. PLoS One. 2012; 7(3):e32483. PMID: 22396770; PMCID: PMC3291556.
  18. Benneyworth MA, Li Y, Basu AC, Bolshakov VY, Coyle JT. Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons. Cell Mol Neurobiol. 2012 May; 32(4):613-24. PMID: 22362148; PMCID: PMC4817353.
  19. Cho JH, Bayazitov IT, Meloni EG, Myers KM, Carlezon WA, Zakharenko SS, Bolshakov VY. Coactivation of thalamic and cortical pathways induces input timing-dependent plasticity in amygdala. Nat Neurosci. 2011 Dec 11; 15(1):113-22. PMID: 22158512; PMCID: PMC3245819.
  20. Chung S, Moon JI, Leung A, Aldrich D, Lukianov S, Kitayama Y, Park S, Li Y, Bolshakov VY, Lamonerie T, Kim KS. ES cell-derived renewable and functional midbrain dopaminergic progenitors. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9703-8. PMID: 21606375; PMCID: PMC3111266.
  21. Shin RM, Tully K, Li Y, Cho JH, Higuchi M, Suhara T, Bolshakov VY. Hierarchical order of coexisting pre- and postsynaptic forms of long-term potentiation at synapses in amygdala. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):19073-8. PMID: 20956319; PMCID: PMC2973868.
  22. Tully K, Bolshakov VY. Emotional enhancement of memory: how norepinephrine enables synaptic plasticity. Mol Brain. 2010 May 13; 3:15. PMID: 20465834; PMCID: PMC2877027.
  23. Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 2009 May 15; 137(4):761-72. PMID: 19450521; PMCID: PMC2719954.
  24. Li Y, Krupa B, Kang JS, Bolshakov VY, Liu G. Glycine site of NMDA receptor serves as a spatiotemporal detector of synaptic activity patterns. J Neurophysiol. 2009 Jul; 102(1):578-89. PMID: 19439669; PMCID: PMC2712282.
  25. Bolshakov VY. Nipping fear in the bud: inhibitory control in the amygdala. Neuron. 2009 Mar 26; 61(6):817-9. PMID: 19323992.
    View in: PubMed
  26. Gisabella B, Cunningham MG, Bolshakov VY, Benes FM. Amygdala-dependent regulation of electrical properties of hippocampal interneurons in a model of schizophrenia. Biol Psychiatry. 2009 Mar 15; 65(6):464-72. PMID: 19027103.
    View in: PubMed
  27. Pan BX, Vautier F, Ito W, Bolshakov VY, Morozov A. Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1. J Neurosci. 2008 Feb 27; 28(9):2089-98. PMID: 18305243.
    View in: PubMed
  28. Tully K, Li Y, Bolshakov VY. Keeping in check painful synapses in central amygdala. Neuron. 2007 Dec 06; 56(5):757-9. PMID: 18054852.
    View in: PubMed
  29. Tully K, Li Y, Tsvetkov E, Bolshakov VY. Norepinephrine enables the induction of associative long-term potentiation at thalamo-amygdala synapses. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):14146-50. PMID: 17709755; PMCID: PMC1955781.
  30. Bolshakov VY. SCOPing out proteases in long-term memory. Cell. 2007 Mar 23; 128(6):1029-30. PMID: 17382874.
    View in: PubMed
  31. Bi GQ, Bolshakov V, Bu G, Cahill CM, Chen ZF, Collingridge GL, Cooper RL, Coorssen JR, El-Husseini A, Galhardo V, Gan WB, Gu J, Inoue K, Isaac J, Iwata K, Jia Z, Kaang BK, Kawamata M, Kida S, Klann E, Kohno T, Li M, Li XJ, MacDonald JF, Nader K, Nguyen PV, Oh U, Ren K, Roder JC, Salter MW, Song W, Sugita S, Tang SJ, Tao Y, Wang YT, Woo N, Woodin MA, Yan Z, Yoshimura M, Xu M, Xu ZC, Zhang X, Zhen M, Zhuo M. Recent advances in basic neurosciences and brain disease: from synapses to behavior. Mol Pain. 2006 Dec 30; 2:38. PMID: 17196111; PMCID: PMC1769477.
  32. Shin RM, Tsvetkov E, Bolshakov VY. Spatiotemporal asymmetry of associative synaptic plasticity in fear conditioning pathways. Neuron. 2006 Dec 07; 52(5):883-96. PMID: 17145508; PMCID: PMC1764975.
  33. Kodirov SA, Takizawa S, Joseph J, Kandel ER, Shumyatsky GP, Bolshakov VY. Synaptically released zinc gates long-term potentiation in fear conditioning pathways. Proc Natl Acad Sci U S A. 2006 Oct 10; 103(41):15218-23. PMID: 17005717; PMCID: PMC1622803.
  34. Goussakov I, Chartoff EH, Tsvetkov E, Gerety LP, Meloni EG, Carlezon WA, Bolshakov VY. LTP in the lateral amygdala during cocaine withdrawal. Eur J Neurosci. 2006 Jan; 23(1):239-50. PMID: 16420433.
    View in: PubMed
  35. Shumyatsky GP, Malleret G, Shin RM, Takizawa S, Tully K, Tsvetkov E, Zakharenko SS, Joseph J, Vronskaya S, Yin D, Schubart UK, Kandel ER, Bolshakov VY. stathmin, a gene enriched in the amygdala, controls both learned and innate fear. Cell. 2005 Nov 18; 123(4):697-709. PMID: 16286011.
    View in: PubMed
  36. Gisabella B, Bolshakov VY, Benes FM. Regulation of synaptic plasticity in a schizophrenia model. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13301-6. PMID: 16131546; PMCID: PMC1201605.
  37. Dityatev AE, Bolshakov VY. Amygdala, long-term potentiation, and fear conditioning. Neuroscientist. 2005 Feb; 11(1):75-88. PMID: 15632280.
    View in: PubMed
  38. Tsvetkov E, Shin RM, Bolshakov VY. Glutamate uptake determines pathway specificity of long-term potentiation in the neural circuitry of fear conditioning. Neuron. 2004 Jan 08; 41(1):139-51. PMID: 14715141.
    View in: PubMed
  39. Feinmark SJ, Begum R, Tsvetkov E, Goussakov I, Funk CD, Siegelbaum SA, Bolshakov VY. 12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses. J Neurosci. 2003 Dec 10; 23(36):11427-35. PMID: 14673007.
    View in: PubMed
  40. Hinds HL, Goussakov I, Nakazawa K, Tonegawa S, Bolshakov VY. Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4275-80. PMID: 12629219; PMCID: PMC153083.
  41. Shumyatsky GP, Tsvetkov E, Malleret G, Vronskaya S, Hatton M, Hampton L, Battey JF, Dulac C, Kandel ER, Bolshakov VY. Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell. 2002 Dec 13; 111(6):905-18. PMID: 12526815.
    View in: PubMed
  42. Tsvetkov E, Carlezon WA, Benes FM, Kandel ER, Bolshakov VY. Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdala. Neuron. 2002 Apr 11; 34(2):289-300. PMID: 11970870.
    View in: PubMed
  43. Bolshakov VY, Carboni L, Cobb MH, Siegelbaum SA, Belardetti F. Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses. Nat Neurosci. 2000 Nov; 3(11):1107-12. PMID: 11036267.
    View in: PubMed
  44. Janz R, Südhof TC, Hammer RE, Unni V, Siegelbaum SA, Bolshakov VY. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron. 1999 Nov; 24(3):687-700. PMID: 10595519.
    View in: PubMed
  45. Bolshakov VY, Golan H, Kandel ER, Siegelbaum SA. Recruitment of new sites of synaptic transmission during the cAMP-dependent late phase of LTP at CA3-CA1 synapses in the hippocampus. Neuron. 1997 Sep; 19(3):635-51. PMID: 9331354.
    View in: PubMed
  46. McMahon HT, Bolshakov VY, Janz R, Hammer RE, Siegelbaum SA, Südhof TC. Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4760-4. PMID: 8643476; PMCID: PMC39352.
  47. Siegelbaum SA, Bolshakov VY. Response: Long-Term Potentiation in the CA1 Hippocampus. Science. 1996 Mar 15; 271(5255):1605-6. PMID: 17840522.
    View in: PubMed
  48. Bolshakov VY, Siegelbaum SA. Hippocampal long-term depression: arachidonic acid as a potential retrograde messenger. Neuropharmacology. 1995 Nov; 34(11):1581-7. PMID: 8606806.
    View in: PubMed
  49. Bolshakov VY, Siegelbaum SA. Regulation of hippocampal transmitter release during development and long-term potentiation. Science. 1995 Sep 22; 269(5231):1730-4. PMID: 7569903.
    View in: PubMed
  50. Geppert M, Bolshakov VY, Siegelbaum SA, Takei K, De Camilli P, Hammer RE, Südhof TC. The role of Rab3A in neurotransmitter release. Nature. 1994 Jun 09; 369(6480):493-7. PMID: 7911226.
    View in: PubMed
  51. Bolshakov VY, Siegelbaum SA. Postsynaptic induction and presynaptic expression of hippocampal long-term depression. Science. 1994 May 20; 264(5162):1148-52. PMID: 7909958.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.