Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Patrick Joseph Brennan, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI143855 (BRENNAN, PATRICK JOSEPH) Feb 6, 2020 - Jan 31, 2025
    Lipid Antigens for iNKT Cells in the Gut Microenvironment
    Role: Principal Investigator
  2. K08AI102945 (BRENNAN, PATRICK JOSEPH) Jun 11, 2013 - Jan 31, 2018
    Self and dietary lipid antigens for invariant natural killer T cells
    Role: Principal Investigator
  3. U54AI065357 (BELISLE, JOHN T) Jun 1, 2005 - Apr 30, 2014
    Rocky Mountain Regional Center of Excellence or Biodefense and Emerging Infectiou
    Role: Co-Principal Investigator
  4. R01AI064798 (JACKSON, MARY) May 1, 2005 - Jun 30, 2021
    Biogenesis of Lipoarabinomannan in Mycobacteria
    Role: Co-Principal Investigator
  5. R01AI063054 (JACKSON, MARY) Dec 1, 2004 - Jun 30, 2014
    Mode of Action of Thiorcarlide in Mycobacterium Tuberculosis
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Foer D, Wien M, Karlson EW, Song W, Boyce JA, Brennan PJ. Patient Characteristics Associated With Reactions to Mrgprx2-Activating Drugs in an Electronic Health Record-Linked Biobank. J Allergy Clin Immunol Pract. 2022 Nov 07. PMID: 36356925.
    Citations:    Fields:    
  2. Klusaritz H, Paterson E, Summers C, Al-Ramahi N, Naseer N, Jeudin H, Sydnor Y, Enoch M, Dollard N, Young KD, Khan N, Henne J, Doubeni A, Kasbekar N, Gitelman Y, Brennan PJ, Bream K, Cannuscio CC, Wender RC, Feuerstein-Simon R. Community-Based COVID-19 Vaccine Clinics in Medically Underserved Neighborhoods to Improve Access and Equity, Philadelphia, 2021-2022. Am J Public Health. 2022 Dec; 112(12):1721-1725. PMID: 36302220; PMCID: PMC9670232.
    Citations:    Fields:    Translation:HumansPHPublic Health
  3. Richterman A, Behrman A, Brennan PJ, O'Donnell JA, Snider CK, Chaiyachati KH. Durability of SARS-CoV-2 mRNA Booster Vaccine Protection Against Omicron Among Health Care Workers with a Vaccine Mandate. Clin Infect Dis. 2022 Jun 06. PMID: 35666508; PMCID: PMC9214168.
    Citations:    Fields:    
  4. Green-McKenzie J, Shofer FS, Momplaisir F, Kuter BJ, Kruse G, Bialal U, Behta M, O'Donnell J, Al-Ramahi N, Kasbekar N, Sullivan P, Okala P, Brennan PJ. Factors Associated With COVID-19 Vaccine Receipt by Health Care Personnel at a Major Academic Hospital During the First Months of Vaccine Availability. JAMA Netw Open. 2021 12 01; 4(12):e2136582. PMID: 34851399; PMCID: PMC8637254.
    Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
  5. Aysola J, Clapp JT, Sullivan P, Brennan PJ, Higginbotham EJ, Kearney MD, Xu C, Thomas R, Griggs S, Abdirisak M, Hilton A, Omole T, Foster S, Mamtani M. Understanding Contributors to Racial/Ethnic Disparities in Emergency Department Throughput Times: a Sequential Mixed Methods Analysis. J Gen Intern Med. 2022 02; 37(2):341-350. PMID: 34341916; PMCID: PMC8811086.
    Citations:    Fields:    Translation:Humans
  6. Broyles AD, Banerji A, Barmettler S, Biggs CM, Blumenthal K, Brennan PJ, Breslow RG, Brockow K, Buchheit KM, Cahill KN, Cernadas J, Chiriac AM, Crestani E, Demoly P, Dewachter P, Dilley M, Farmer JR, Foer D, Fried AJ, Garon SL, Giannetti MP, Hepner DL, Hong DI, Hsu JT, Kothari PH, Kyin T, Lax T, Lee MJ, Lee-Sarwar K, Liu A, Logsdon S, Louisias M, MacGinnitie A, Maciag M, Minnicozzi S, Norton AE, Otani IM, Park M, Patil S, Phillips EJ, Picard M, Platt CD, Rachid R, Rodriguez T, Romano A, Stone CA, Torres MJ, Verdú M, Wang AL, Wickner P, Wolfson AR, Wong JT, Yee C, Zhou J, Castells M. Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs. J Allergy Clin Immunol Pract. 2020 10; 8(9S):S16-S116. PMID: 33039007.
    Citations: 28     Fields:    Translation:Humans
  7. Miller KE, Koboldt DC, Schieffer KM, Bedrosian TA, Crist E, Sheline A, Leraas K, Magrini V, Zhong H, Brennan P, Bush J, Fitch J, Bir N, Miller AR, Cottrell CE, Leonard J, Pindrik JA, Rusin JA, Shah SH, White P, Wilson RK, Mardis ER, Pierson CR, Ostendorf AP. Somatic SLC35A2 mosaicism correlates with clinical findings in epilepsy brain tissue. Neurol Genet. 2020 Aug; 6(4):e460. PMID: 32637635; PMCID: PMC7323482.
    Citations: 7     
  8. Donado CA, Cao AB, Simmons DP, Croker BA, Brennan PJ, Brenner MB. A Two-Cell Model for IL-1ß Release Mediated by Death-Receptor Signaling. Cell Rep. 2020 04 07; 31(1):107466. PMID: 32268091.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  9. Iweala OI, Choudhary SK, Addison CT, Batty CJ, Kapita CM, Amelio C, Schuyler AJ, Deng S, Bachelder EM, Ainslie KM, Savage PB, Brennan PJ, Commins SP. Glycolipid-mediated basophil activation in alpha-gal allergy. J Allergy Clin Immunol. 2020 08; 146(2):450-452. PMID: 32088306; PMCID: PMC7670280.
    Citations: 8     Fields:    Translation:HumansCells
  10. Nagai J, Balestrieri B, Fanning LB, Kyin T, Cirka H, Lin J, Idzko M, Zech A, Kim EY, Brennan PJ, Boyce JA. P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation. J Clin Invest. 2019 12 02; 129(12):5169-5186. PMID: 31638598; PMCID: PMC6877315.
    Citations: 6     Fields:    Translation:AnimalsCells
  11. Reinink P, Buter J, Mishra VK, Ishikawa E, Cheng TY, Willemsen PTJ, Porwollik S, Brennan PJ, Heinz E, Mayfield JA, Dougan G, van Els CA, Cerundolo V, Napolitani G, Yamasaki S, Minnaard AJ, McClelland M, Moody DB, Van Rhijn I. Discovery of Salmonella trehalose phospholipids reveals functional convergence with mycobacteria. J Exp Med. 2019 04 01; 216(4):757-771. PMID: 30804000.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  12. Gutierrez-Arcelus M, Teslovich N, Mola AR, Polidoro RB, Nathan A, Kim H, Hannes S, Slowikowski K, Watts GFM, Korsunsky I, Brenner MB, Raychaudhuri S, Brennan PJ. Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions. Nat Commun. 2019 02 08; 10(1):687. PMID: 30737409; PMCID: PMC6368609.
    Citations: 41     Fields:    Translation:HumansCells
  13. Amin AG, De P, Spencer JS, Brennan PJ, Daum J, Andre BG, Joe M, Bai Y, Laurentius L, Porter MD, Honnen WJ, Choudhary A, Lowary TL, Pinter A, Chatterjee D. Detection of lipoarabinomannan in urine and serum of HIV-positive and HIV-negative TB suspects using an improved capture-enzyme linked immuno absorbent assay and gas chromatography/mass spectrometry. Tuberculosis (Edinb). 2018 07; 111:178-187. PMID: 30029905.
    Citations: 20     Fields:    Translation:Humans
  14. Lee-Sarwar K, Kelly RS, Lasky-Su J, Moody DB, Mola AR, Cheng TY, Comstock LE, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Laranjo N, Gold DR, Bunyavanich S, Savage JH, Weiss ST, Brennan PJ, Litonjua AA. Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy. J Allergy Clin Immunol. 2018 07; 142(1):335-338.e9. PMID: 29729303; PMCID: PMC6433125.
    Citations: 16     Fields:    Translation:HumansCells
  15. Brennan PJ, Cheng TY, Pellicci DG, Watts GFM, Veerapen N, Young DC, Rossjohn J, Besra GS, Godfrey DI, Brenner MB, Moody DB. Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface. Proc Natl Acad Sci U S A. 2017 08 01; 114(31):8348-8353. PMID: 28716901; PMCID: PMC5547638.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  16. Sedrak MS, Myers JS, Small DS, Nachamkin I, Ziemba JB, Murray D, Kurtzman GW, Zhu J, Wang W, Mincarelli D, Danoski D, Wells BP, Berns JS, Brennan PJ, Hanson CW, Dine CJ, Patel MS. Effect of a Price Transparency Intervention in the Electronic Health Record on Clinician Ordering of Inpatient Laboratory Tests: The PRICE Randomized Clinical Trial. JAMA Intern Med. 2017 07 01; 177(7):939-945. PMID: 28430829; PMCID: PMC5543323.
    Citations: 21     Fields:    Translation:Humans
  17. Witt SH, Streit F, Jungkunz M, Frank J, Awasthi S, Reinbold CS, Treutlein J, Degenhardt F, Forstner AJ, Heilmann-Heimbach S, Dietl L, Schwarze CE, Schendel D, Strohmaier J, Abdellaoui A, Adolfsson R, Air TM, Akil H, Alda M, Alliey-Rodriguez N, Andreassen OA, Babadjanova G, Bass NJ, Bauer M, Baune BT, Bellivier F, Bergen S, Bethell A, Biernacka JM, Blackwood DHR, Boks MP, Boomsma DI, Børglum AD, Borrmann-Hassenbach M, Brennan P, Budde M, Buttenschøn HN, Byrne EM, Cervantes P, Clarke TK, Craddock N, Cruceanu C, Curtis D, Czerski PM, Dannlowski U, Davis T, de Geus EJC, Di Florio A, Djurovic S, Domenici E, Edenberg HJ, Etain B, Fischer SB, Forty L, Fraser C, Frye MA, Fullerton JM, Gade K, Gershon ES, Giegling I, Gordon SD, Gordon-Smith K, Grabe HJ, Green EK, Greenwood TA, Grigoroiu-Serbanescu M, Guzman-Parra J, Hall LS, Hamshere M, Hauser J, Hautzinger M, Heilbronner U, Herms S, Hitturlingappa S, Hoffmann P, Holmans P, Hottenga JJ, Jamain S, Jones I, Jones LA, Juréus A, Kahn RS, Kammerer-Ciernioch J, Kirov G, Kittel-Schneider S, Kloiber S, Knott SV, Kogevinas M, Landén M, Leber M, Leboyer M, Li QS, Lissowska J, Lucae S, Martin NG, Mayoral-Cleries F, McElroy SL, McIntosh AM, McKay JD, McQuillin A, Medland SE, Middeldorp CM, Milaneschi Y, Mitchell PB, Montgomery GW, Morken G, Mors O, Mühleisen TW, Müller-Myhsok B, Myers RM, Nievergelt CM, Nurnberger JI, O'Donovan MC, Loohuis LMO, Ophoff R, Oruc L, Owen MJ, Paciga SA, Penninx BWJH, Perry A, Pfennig A, Potash JB, Preisig M, Reif A, Rivas F, Rouleau GA, Schofield PR, Schulze TG, Schwarz M, Scott L, Sinnamon GCB, Stahl EA, Strauss J, Turecki G, Van der Auwera S, Vedder H, Vincent JB, Willemsen G, Witt CC, Wray NR, Xi HS, Tadic A, Dahmen N, Schott BH, Cichon S, Nöthen MM, Ripke S, Mobascher A, Rujescu D, Lieb K, Roepke S, Schmahl C, Bohus M, Rietschel M. Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. Transl Psychiatry. 2017 06 20; 7(6):e1155. PMID: 28632202.
    Citations: 42     Fields:    Translation:Humans
  18. Clancy-Thompson E, Chen GZ, Tyler PM, Servos MM, Barisa M, Brennan PJ, Ploegh HL, Dougan SK. Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets. J Immunol. 2017 07 01; 199(1):159-171. PMID: 28576977; PMCID: PMC5518629.
    Citations: 19     Fields:    Translation:AnimalsCells
  19. Kohlgruber AC, Donado CA, LaMarche NM, Brenner MB, Brennan PJ. Activation strategies for invariant natural killer T cells. Immunogenetics. 2016 08; 68(8):649-63. PMID: 27457886.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  20. Sloane D, Govindarajulu U, Harrow-Mortelliti J, Barry W, Hsu FI, Hong D, Laidlaw T, Palis R, Legere H, Bunyavanich S, Breslow R, Wesemann D, Barrett N, Brennan P, Chong HJ, Liu A, Fernandez J, Fanning L, Kyin T, Cahill K, Bankova L, Lynch A, Berlin S, Campos S, Fuchs C, Mayer R, Matulonis U, Castells M. Safety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal Antibodies. J Allergy Clin Immunol Pract. 2016 May-Jun; 4(3):497-504. PMID: 26895621.
    Citations: 37     Fields:    Translation:Humans
  21. Kim EY, Lynch L, Brennan PJ, Cohen NR, Brenner MB. The transcriptional programs of iNKT cells. Semin Immunol. 2015 Feb; 27(1):26-32. PMID: 25841627; PMCID: PMC6322908.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  22. Umscheid CA, Brennan PJ. Incentivizing "structures" over "outcomes" to bridge the knowing-doing gap. JAMA Intern Med. 2015 Mar; 175(3):354-5. PMID: 25561391.
    Citations: 4     Fields:    Translation:Humans
  23. Patel N, Brennan PJ, Metlay J, Bellini L, Shannon RP, Myers JS. Building the pipeline: the creation of a residency training pathway for future physician leaders in health care quality. Acad Med. 2015 Feb; 90(2):185-90. PMID: 25354070.
    Citations: 11     Fields:    Translation:Humans
  24. Wheat WH, Casali AL, Thomas V, Spencer JS, Lahiri R, Williams DL, McDonnell GE, Gonzalez-Juarrero M, Brennan PJ, Jackson M. Long-term survival and virulence of Mycobacterium leprae in amoebal cysts. PLoS Negl Trop Dis. 2014 Dec; 8(12):e3405. PMID: 25521850.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  25. Lynch L, Michelet X, Zhang S, Brennan PJ, Moseman A, Lester C, Besra G, Vomhof-Dekrey EE, Tighe M, Koay HF, Godfrey DI, Leadbetter EA, Sant'Angelo DB, von Andrian U, Brenner MB. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nat Immunol. 2015 Jan; 16(1):85-95. PMID: 25436972; PMCID: PMC4343194.
    Citations: 183     Fields:    Translation:AnimalsCells
  26. Mostafavi S, Ortiz-Lopez A, Bogue MA, Hattori K, Pop C, Koller D, Mathis D, Benoist C. Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains. J Immunol. 2014 Nov 01; 193(9):4485-96. PMID: 25267973; PMCID: PMC4201955.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  27. Brennan PJ, Tatituri RV, Heiss C, Watts GF, Hsu FF, Veerapen N, Cox LR, Azadi P, Besra GS, Brenner MB. Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13433-8. PMID: 25197085; PMCID: PMC4169973.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  28. Hu X, Kim H, Raj T, Brennan PJ, Trynka G, Teslovich N, Slowikowski K, Chen WM, Onengut S, Baecher-Allan C, De Jager PL, Rich SS, Stranger BE, Brenner MB, Raychaudhuri S. Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells. PLoS Genet. 2014 Jun; 10(6):e1004404. PMID: 24968232.
    Citations: 26     Fields:    Translation:HumansCells
  29. Rivoire BL, Groathouse NA, TerLouw S, Neupane KD, Ranjit C, Sapkota BR, Khadge S, Kunwar CB, Kunwar CB, Macdonald M, Hawksworth R, Thapa MB, Hagge DA, Tibbals M, Smith C, Dube T, She D, Wolff M, Zhou E, Makhene M, Mason R, Sizemore C, Brennan PJ. Safety and efficacy assessment of two new leprosy skin test antigens: randomized double blind clinical study. PLoS Negl Trop Dis. 2014; 8(5):e2811. PMID: 24874401.
    Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
  30. Rivoire BL, TerLouw S, Groathouse NA, Brennan PJ. The challenge of producing skin test antigens with minimal resources suitable for human application against a neglected tropical disease; leprosy. PLoS Negl Trop Dis. 2014; 8(5):e2791. PMID: 24874086.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  31. Bassiri H, Das R, Guan P, Barrett DM, Brennan PJ, Banerjee PP, Wiener SJ, Orange JS, Brenner MB, Grupp SA, Nichols KE. iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo . Cancer Immunol Res. 2014 Jan; 2(1):59-69. PMID: 24563871.
    Citations: 29     Fields:    Translation:AnimalsCells
  32. Hu X, Kim H, Brennan PJ, Han B, Baecher-Allan CM, De Jager PL, Brenner MB, Raychaudhuri S. Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19030-5. PMID: 24191009.
    Citations: 7     Fields:    Translation:HumansCells
  33. Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Nageswara Rao T, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S. The transcriptional landscape of aß T cell differentiation. Nat Immunol. 2013 Jun; 14(6):619-32. PMID: 23644507.
    Citations: 141     Fields:    Translation:AnimalsCells
  34. Jojic V, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemarte-Pelletier A, Malhotra D, Turley S. Identification of transcriptional regulators in the mouse immune system. Nat Immunol. 2013 Jun; 14(6):633-43. PMID: 23624555.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  35. Best JA, Blair DA, Knell J, Yang E, Mayya V, Doedens A, Dustin ML, Goldrath AW. Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation. Nat Immunol. 2013 Apr; 14(4):404-12. PMID: 23396170.
    Citations: 163     Fields:    Translation:AnimalsCells
  36. Sanderson JP, Brennan PJ, Mansour S, Matulis G, Patel O, Lissin N, Godfrey DI, Kawahara K, Zähringer U, Rossjohn J, Brenner MB, Gadola SD. CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells. Eur J Immunol. 2013 Mar; 43(3):815-25. PMID: 23280365.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  37. Brennan PJ, Brigl M, Brenner MB. Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nat Rev Immunol. 2013 Feb; 13(2):101-17. PMID: 23334244.
    Citations: 360     Fields:    Translation:HumansAnimalsCells
  38. Cohen NR, Brennan PJ, Shay T, Watts GF, Brigl M, Kang J, Brenner MB. Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells. Nat Immunol. 2013 Jan; 14(1):90-9. PMID: 23202270.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  39. Torrelles JB, Sieling PA, Zhang N, Keen MA, McNeil MR, Belisle JT, Modlin RL, Brennan PJ, Chatterjee D. Isolation of a distinct Mycobacterium tuberculosis mannose-capped lipoarabinomannan isoform responsible for recognition by CD1b-restricted T cells. Glycobiology. 2012 Aug; 22(8):1118-27. PMID: 22534567.
    Citations: 22     Fields:    Translation:HumansCells
  40. Horii T, Notake S, Tamai K, Yanagisawa H. Bacillus cereus from blood cultures: virulence genes, antimicrobial susceptibility and risk factors for blood stream infection. FEMS Immunol Med Microbiol. 2011 Nov; 63(2):202-9. PMID: 22077223.
    Citations: 7     Fields:    Translation:HumansCells
  41. Brennan PJ, Tatituri RV, Brigl M, Kim EY, Tuli A, Sanderson JP, Gadola SD, Hsu FF, Besra GS, Brenner MB. Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals. Nat Immunol. 2011 Oct 30; 12(12):1202-11. PMID: 22037601.
    Citations: 169     Fields:    Translation:HumansAnimalsCells
  42. Al-Mubarak R, Vander Heiden J, Broeckling CD, Balagon M, Brennan PJ, Vissa VD. Serum metabolomics reveals higher levels of polyunsaturated fatty acids in lepromatous leprosy: potential markers for susceptibility and pathogenesis. PLoS Negl Trop Dis. 2011 Sep; 5(9):e1303. PMID: 21909445.
    Citations: 30     Fields:    Translation:HumansCells
  43. Umscheid CA, Mitchell MD, Doshi JA, Agarwal R, Williams K, Brennan PJ. Estimating the proportion of healthcare-associated infections that are reasonably preventable and the related mortality and costs. Infect Control Hosp Epidemiol. 2011 Feb; 32(2):101-14. PMID: 21460463.
    Citations: 213     Fields:    Translation:HumansPHPublic Health
  44. Umscheid CA, Williams K, Brennan PJ. Hospital-based comparative effectiveness centers: translating research into practice to improve the quality, safety and value of patient care. J Gen Intern Med. 2010 Dec; 25(12):1352-5. PMID: 20697961; PMCID: PMC2988155.
    Citations: 12     Fields:    Translation:Humans
  45. Mitchell MD, Williams K, Brennan PJ, Umscheid CA. Integrating local data into hospital-based healthcare technology assessment: two case studies. Int J Technol Assess Health Care. 2010 Jul; 26(3):294-300. PMID: 20584358.
    Citations: 7     Fields:    
  46. Vaisitti T, Aydin S, Rossi D, Cottino F, Bergui L, D'Arena G, Bonello L, Horenstein AL, Brennan P, Pepper C, Gaidano G, Malavasi F, Deaglio S. CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells. Leukemia. 2010 May; 24(5):958-69. PMID: 20220774.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  47. Umscheid CA, Agarwal RK, Brennan PJ. Updating the guideline development methodology of the Healthcare Infection Control Practices Advisory Committee (HICPAC). Am J Infect Control. 2010 May; 38(4):264-73. PMID: 20116133.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  48. Brennan PJ, Rodriguez Bouza T, Hsu FI, Sloane DE, Castells MC. Hypersensitivity reactions to mAbs: 105 desensitizations in 23 patients, from evaluation to treatment. J Allergy Clin Immunol. 2009 Dec; 124(6):1259-66. PMID: 19910036.
    Citations: 56     Fields:    Translation:Humans
  49. Mascitti KB, Manaker S, Rohrbach J, Brennan PJ, Fishman NO. Limitations in using aspiration pneumonia as a quality measure. Infect Control Hosp Epidemiol. 2009 Dec; 30(12):1233-5. PMID: 19877817.
    Citations:    Fields:    Translation:Humans
  50. Chiba A, Cohen N, Brigl M, Brennan PJ, Besra GS, Brenner MB. Rapid and reliable generation of invariant natural killer T-cell lines in vitro. Immunology. 2009 Nov; 128(3):324-33. PMID: 20067532.
    Citations: 16     Fields:    Translation:AnimalsCells
  51. Gasink LB, Brennan PJ. Isolation precautions for antibiotic-resistant bacteria in healthcare settings. Curr Opin Infect Dis. 2009 Aug; 22(4):339-44. PMID: 19461513.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  52. Sakamuri RM, Kimura M, Li W, Kim HC, Lee H, Kiran MD, Black WC, Balagon M, Gelber R, Cho SN, Brennan PJ, Vissa V. Population-based molecular epidemiology of leprosy in Cebu, Philippines. J Clin Microbiol. 2009 Sep; 47(9):2844-54. PMID: 19571027.
    Citations: 15     Fields:    Translation:HumansCells
  53. Banerji AS, Brennan PJ, Hsu FI. Drug Desensitizations in the Management of Allergy and Anaphylaxis to Chemotherapeutic Agents and Monoclonal Antibodies. Anaphylaxis. 2009; in preparation.
  54. Wasserstein AG, Brennan PJ, Rubenstein AH. Institutional leadership and faculty response: fostering professionalism at the University of Pennsylvania School of Medicine. Acad Med. 2007 Nov; 82(11):1049-56. PMID: 17971690.
    Citations: 4     Fields:    Translation:Humans
  55. Kincaid EZ, Wolf AJ, Desvignes L, Mahapatra S, Crick DC, Brennan PJ, Pavelka MS, Ernst JD. Codominance of TLR2-dependent and TLR2-independent modulation of MHC class II in Mycobacterium tuberculosis infection in vivo. J Immunol. 2007 Sep 01; 179(5):3187-95. PMID: 17709534.
    Citations: 28     Fields:    Translation:AnimalsCells
  56. Li B, Samanta A, Song X, Iacono KT, Brennan P, Chatila TA, Roncador G, Banham AH, Riley JL, Wang Q, Shen Y, Saouaf SJ, Greene MI. FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease. Int Immunol. 2007 Jul; 19(7):825-35. PMID: 17586580.
    Citations: 66     Fields:    Translation:HumansCells
  57. Wittkowski M, Mittelstädt J, Brandau S, Reiling N, Lindner B, Torrelles J, Brennan PJ, Holst O. Capsular arabinomannans from Mycobacterium avium with morphotype-specific structural differences but identical biological activity. J Biol Chem. 2007 Jun 29; 282(26):19103-12. PMID: 17459879.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  58. Biet F, Angela de Melo Marques M, Grayon M, Xavier da Silveira EK, Brennan PJ, Drobecq H, Raze D, Vidal Pessolani MC, Locht C, Menozzi FD. Mycobacterium smegmatis produces an HBHA homologue which is not involved in epithelial adherence. Microbes Infect. 2007 Feb; 9(2):175-82. PMID: 17208488.
    Citations: 8     Fields:    Translation:HumansCells
  59. Martins MV, Lima MC, Duppre NC, Matos HJ, Spencer JS, Brennan PJ, Sarno EN, Fonseca L, Pereira GM, Pessolani MC. The level of PPD-specific IFN-gamma-producing CD4+ T cells in the blood predicts the in vivo response to PPD. Tuberculosis (Edinb). 2007 May; 87(3):202-11. PMID: 17049309.
    Citations: 4     Fields:    Translation:HumansCells
  60. Aráoz R, Honoré N, Banu S, Demangel C, Cissoko Y, Arama C, Uddin MK, Hadi SK, Monot M, Cho SN, Ji B, Brennan PJ, Sow S, Cole ST. Towards an immunodiagnostic test for leprosy. Microbes Infect. 2006 Jul; 8(8):2270-6. PMID: 16797206.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  61. White PC, Shore AM, Clement M, McLaren J, Soeiro I, Lam EW, Brennan P. Regulation of cyclin D2 and the cyclin D2 promoter by protein kinase A and CREB in lymphocytes. Oncogene. 2006 Apr 06; 25(15):2170-80. PMID: 16301994.
    Citations: 20     Fields:    Translation:HumansCells
  62. Groathouse NA, Brown SE, Knudson DL, Brennan PJ, Slayden RA. Isothermal amplification and molecular typing of the obligate intracellular pathogen Mycobacterium leprae isolated from tissues of unknown origins. J Clin Microbiol. 2006 Apr; 44(4):1502-8. PMID: 16597883; PMCID: PMC1448671.
    Citations: 8     Fields:    Translation:HumansCells
  63. Spencer JS, Dockrell HM, Kim HJ, Marques MA, Williams DL, Martins MV, Martins ML, Lima MC, Sarno EN, Pereira GM, Matos H, Fonseca LS, Sampaio EP, Ottenhoff TH, Geluk A, Cho SN, Stoker NG, Cole ST, Brennan PJ, Pessolani MC. Identification of specific proteins and peptides in Mycobacterium leprae suitable for the selective diagnosis of leprosy. J Immunol. 2005 Dec 15; 175(12):7930-8. PMID: 16339528.
    Citations: 28     Fields:    Translation:HumansCells
  64. Brennan PJ, Saouaf SJ, Van Dyken S, Marth JD, Li B, Bhandoola A, Greene MI. Sialylation regulates peripheral tolerance in CD4+ T cells. Int Immunol. 2006 May; 18(5):627-35. PMID: 16291658.
    Citations: 5     Fields:    Translation:AnimalsCells
  65. Linde CM, Grundström S, Nordling E, Refai E, Brennan PJ, Andersson M. Conserved structure and function in the granulysin and NK-lysin peptide family. Infect Immun. 2005 Oct; 73(10):6332-9. PMID: 16177304; PMCID: PMC1230960.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  66. McKibben L, Horan T, Tokars JI, Fowler G, Cardo DM, Pearson ML, Brennan PJ. Guidance on public reporting of healthcare-associated infections: recommendations of the Healthcare Infection Control Practices Advisory Committee. Am J Infect Control. 2005 May; 33(4):217-26. PMID: 15877016.
    Citations: 32     Fields:    Translation:HumansPHPublic Health
  67. Sieling PA, Torrelles JB, Stenger S, Chung W, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Porcelli SA, Modlin RL. The human CD1-restricted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens. J Immunol. 2005 Mar 01; 174(5):2637-44. PMID: 15728470.
    Citations: 9     Fields:    Translation:HumansCells
  68. Brennan, PJ. Mechanisms Regulating Peripheral T cell Tolerance. 2005.
  69. Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A, Porcelli SA, Modlin RL. Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. J Clin Invest. 2004 Mar; 113(5):701-8. PMID: 14991068; PMCID: PMC351318.
    Citations: 97     Fields:    Translation:HumansCells
  70. Henning KJ, Brennan PJ, Hoegg C, O'Rourke E, Dyer BD, Grace TL. Health system preparedness for bioterrorism: bringing the tabletop to the hospital. Infect Control Hosp Epidemiol. 2004 Feb; 25(2):146-55. PMID: 14994941.
    Citations: 9     Fields:    
  71. Coxon GD, Al Dulayymi JR, Morehouse C, Brennan PJ, Besra GS, Baird MS, Minnikin DE. Synthesis and properties of methyl 5-(1'R,2'S)-(2-octadecylcycloprop-1-yl)pentanoate and other omega-19 chiral cyclopropane fatty acids and esters related to mycobacterial mycolic acids. Chem Phys Lipids. 2004 Jan; 127(1):35-46. PMID: 14706739.
    Citations: 1     Fields:    Translation:Cells
  72. Saouaf SJ, Brennan PJ, Li B, Shen Y, Greene MI. Peripheral Tolerance Mechanism to Superantigen. . Extended abstract, 12th International Congress of Immunology. 2004.
  73. Phetsuksiri B, Jackson M, Scherman H, McNeil M, Besra GS, Baulard AR, Slayden RA, DeBarber AE, Barry CE, Baird MS, Crick DC, Brennan PJ. Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis. J Biol Chem. 2003 Dec 26; 278(52):53123-30. PMID: 14559907.
    Citations: 52     Fields:    Translation:Cells
  74. McGovern PC, Lautenbach E, Brennan PJ, Lustig RA, Fishman NO. Risk factors for postcraniotomy surgical site infection after 1,3-bis (2-chloroethyl)-1-nitrosourea (Gliadel) wafer placement. Clin Infect Dis. 2003 Mar 15; 36(6):759-65. PMID: 12627360.
    Citations: 15     Fields:    Translation:Humans
  75. Brennan PJ, Saouaf SJ, Greene MI, Shen Y. Anergy and suppression as coexistent mechanisms for the maintenance of peripheral T cell tolerance. Immunol Res. 2003; 27(2-3):295-302. PMID: 12857976.
    Citations:    Fields:    Translation:AnimalsCells
  76. Saouaf SJ, Brennan PJ, Shen Y, Greene MI. Mechanisms of peripheral immune tolerance: conversion of the immune to the unresponsive phenotype. Immunol Res. 2003; 28(3):193-9. PMID: 14713714.
    Citations:    Fields:    Translation:HumansAnimalsCells
  77. Hancock IC, Carman S, Besra GS, Brennan PJ, Waite E. Ligation of arabinogalactan to peptidoglycan in the cell wall of Mycobacterium smegmatis requires concomitant synthesis of the two wall polymers. Microbiology (Reading). 2002 Oct; 148(Pt 10):3059-3067. PMID: 12368439.
    Citations: 14     Fields:    Translation:Cells
  78. Gurcha SS, Baulard AR, Kremer L, Locht C, Moody DB, Muhlecker W, Costello CE, Crick DC, Brennan PJ, Besra GS. Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis. Biochem J. 2002 Jul 15; 365(Pt 2):441-50. PMID: 11931640; PMCID: PMC1222681.
    Citations: 44     Fields:    Translation:Cells
  79. Cooper HN, Gurcha SS, Nigou J, Brennan PJ, Belisle JT, Besra GS, Young D. Characterization of mycobacterial protein glycosyltransferase activity using synthetic peptide acceptors in a cell-free assay. Glycobiology. 2002 Jul; 12(7):427-34. PMID: 12122024.
    Citations: 2     Fields:    Translation:Cells
  80. Kremer L, Dover LG, Carrère S, Nampoothiri KM, Lesjean S, Brown AK, Brennan PJ, Minnikin DE, Locht C, Besra GS. Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis. Biochem J. 2002 Jun 01; 364(Pt 2):423-30. PMID: 12023885; PMCID: PMC1222587.
    Citations: 40     Fields:    Translation:Cells
  81. Kremer L, Gurcha SS, Bifani P, Hitchen PG, Baulard A, Morris HR, Dell A, Brennan PJ, Besra GS. Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis. Biochem J. 2002 May 01; 363(Pt 3):437-47. PMID: 11964144; PMCID: PMC1222496.
    Citations: 31     Fields:    Translation:Cells
  82. Spencer JS, Marques MA, Lima MC, Junqueira-Kipnis AP, Gregory BC, Truman RW, Brennan PJ. Antigenic specificity of the Mycobacterium leprae homologue of ESAT-6. Infect Immun. 2002 Feb; 70(2):1010-3. PMID: 11796642.
    Citations: 16     Fields:    Translation:AnimalsCells
  83. Brennan PJ, Kumagai T, Berezov A, Murali R, Greene MI. HER2/Neu: mechanisms of dimerization/oligomerization. Oncogene. 2002 Jan 10; 21(2):328. PMID: 11840330.
    Citations: 9     Fields:    
  84. Brennan PJ and Greene MI. . Her2/neu. Encyclopedia of Cancer. 2002.
  85. Kremer L, Nampoothiri KM, Lesjean S, Dover LG, Graham S, Betts J, Brennan PJ, Minnikin DE, Locht C, Besra GS. Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II. J Biol Chem. 2001 Jul 27; 276(30):27967-74. PMID: 11373295.
    Citations: 36     Fields:    Translation:Cells
  86. Kremer L, Dover LG, Morehouse C, Hitchin P, Everett M, Morris HR, Dell A, Brennan PJ, McNeil MR, Flaherty C, Duncan K, Besra GS. Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferase. J Biol Chem. 2001 Jul 13; 276(28):26430-40. PMID: 11304545.
    Citations: 46     Fields:    Translation:Cells
  87. Brown JR, Field RA, Barker A, Guy M, Grewal R, Khoo KH, Brennan PJ, Besra GS, Chatterjec D. Synthetic mannosides act as acceptors for mycobacterial alpha1-6 mannosyltransferase. Bioorg Med Chem. 2001 Apr; 9(4):815-24. PMID: 11354664.
    Citations: 9     Fields:    Translation:Cells
  88. Chan ED, Morris KR, Belisle JT, Hill P, Remigio LK, Brennan PJ, Riches DW. Induction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK, and NF-kappaB signaling pathways. Infect Immun. 2001 Apr; 69(4):2001-10. PMID: 11254551; PMCID: PMC98123.
    Citations: 59     Fields:    Translation:AnimalsCells
  89. Brennan PJ, Kumagai T, Berezov A, Murali R, Greene MI, Kumogai T. HER2/neu: mechanisms of dimerization/oligomerization. Oncogene. 2000 Dec 11; 19(53):6093-101. PMID: 11156522.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  90. Mikusová K, Yagi T, Stern R, McNeil MR, Besra GS, Crick DC, Brennan PJ. Biosynthesis of the galactan component of the mycobacterial cell wall. J Biol Chem. 2000 Oct 27; 275(43):33890-7. PMID: 10934214.
    Citations: 31     Fields:    Translation:Cells
  91. Crick DC, Schulbach MC, Zink EE, Macchia M, Barontini S, Besra GS, Brennan PJ. Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis. J Bacteriol. 2000 Oct; 182(20):5771-8. PMID: 11004176.
    Citations: 23     Fields:    Translation:Cells
  92. Baulard AR, Betts JC, Engohang-Ndong J, Quan S, McAdam RA, Brennan PJ, Locht C, Besra GS. Activation of the pro-drug ethionamide is regulated in mycobacteria. J Biol Chem. 2000 Sep 08; 275(36):28326-31. PMID: 10869356.
    Citations: 107     Fields:    Translation:Cells
  93. Kremer L, Douglas JD, Baulard AR, Morehouse C, Guy MR, Alland D, Dover LG, Lakey JH, Jacobs WR, Brennan PJ, Minnikin DE, Besra GS. Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis. J Biol Chem. 2000 Jun 02; 275(22):16857-64. PMID: 10747933.
    Citations: 72     Fields:    Translation:Cells
  94. Chan ED, Reves R, Belisle JT, Brennan PJ, Hahn WE. Diagnosis of tuberculosis by a visually detectable immunoassay for lipoarabinomannan. Am J Respir Crit Care Med. 2000 May; 161(5):1713-9. PMID: 10806179.
    Citations: 18     Fields:    Translation:HumansCells
  95. Schaeffer ML, Khoo KH, Besra GS, Chatterjee D, Brennan PJ, Belisle JT, Inamine JM. The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis. J Biol Chem. 1999 Oct 29; 274(44):31625-31. PMID: 10531370.
    Citations: 29     Fields:    Translation:Cells
  96. Brightbill HD, Libraty DH, Krutzik SR, Yang RB, Belisle JT, Bleharski JR, Maitland M, Norgard MV, Plevy SE, Smale ST, Brennan PJ, Bloom BR, Godowski PJ, Modlin RL. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science. 1999 Jul 30; 285(5428):732-6. PMID: 10426995.
    Citations: 464     Fields:    Translation:HumansAnimalsCells
  97. Lautenbach E, Bilker WB, Brennan PJ. Enterococcal bacteremia: risk factors for vancomycin resistance and predictors of mortality. Infect Control Hosp Epidemiol. 1999 May; 20(5):318-23. PMID: 10349947.
    Citations: 31     Fields:    Translation:HumansCells
  98. Phetsuksiri B, Baulard AR, Cooper AM, Minnikin DE, Douglas JD, Besra GS, Brennan PJ. Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesis. Antimicrob Agents Chemother. 1999 May; 43(5):1042-51. PMID: 10223912; PMCID: PMC89109.
    Citations: 36     Fields:    Translation:Cells
  99. Strom BL, Schinnar R, Gibson GA, Brennan PJ, Berlin JA. Risk of bleeding and hypoprothrombinaemia associated with NMTT side chain antibiotics: using cefoperazone as a test case. Pharmacoepidemiol Drug Saf. 1999 Mar; 8(2):81-94. PMID: 15073933.
    Citations: 9     Fields:    
  100. Salman M, Lonsdale JT, Besra GS, Brennan PJ. Phosphatidylinositol synthesis in mycobacteria. Biochim Biophys Acta. 1999 Jan 04; 1436(3):437-50. PMID: 9989274.
    Citations: 12     Fields:    Translation:AnimalsCells
  101. Lautenbach E, Schuster MG, Bilker WB, Brennan PJ. The role of chloramphenicol in the treatment of bloodstream infection due to vancomycin-resistant Enterococcus. Clin Infect Dis. 1998 Nov; 27(5):1259-65. PMID: 9827280.
    Citations: 15     Fields:    Translation:HumansCells
  102. Lee RE, Brennan PJ, Besra GS. Synthesis of beta-D-arabinofuranosyl-1-monophosphoryl polyprenols: examination of their function as mycobacterial arabinosyl transferase donors. Bioorg Med Chem Lett. 1998 Apr 21; 8(8):951-4. PMID: 9871518.
    Citations: 8     Fields:    Translation:Cells
  103. Lee RE, Brennan PJ, Besra GS. Mycobacterial arabinan biosynthesis: the use of synthetic arabinoside acceptors in the development of an arabinosyl transfer assay. Glycobiology. 1997 Dec; 7(8):1121-8. PMID: 9455913.
    Citations: 20     Fields:    Translation:Cells
  104. van Soolingen D, Hoogenboezem T, de Haas PE, Hermans PW, Koedam MA, Teppema KS, Brennan PJ, Besra GS, Portaels F, Top J, Schouls LM, van Embden JD. A novel pathogenic taxon of the Mycobacterium tuberculosis complex, Canetti: characterization of an exceptional isolate from Africa. Int J Syst Bacteriol. 1997 Oct; 47(4):1236-45. PMID: 9336935.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  105. Besra GS, Brennan PJ. The mycobacterial cell wall: biosynthesis of arabinogalactan and lipoarabinomannan. Biochem Soc Trans. 1997 Aug; 25(3):845-50. PMID: 9388559.
    Citations: 15     Fields:    Translation:HumansCells
  106. Besra GS, Morehouse CB, Rittner CM, Waechter CJ, Brennan PJ. Biosynthesis of mycobacterial lipoarabinomannan. J Biol Chem. 1997 Jul 18; 272(29):18460-6. PMID: 9218490.
    Citations: 49     Fields:    Translation:Cells
  107. Lee RE, Armour JW, Takayama K, Brennan PJ, Besra GS. Mycolic acid biosynthesis: definition and targeting of the Claisen condensation step. Biochim Biophys Acta. 1997 Jun 23; 1346(3):275-84. PMID: 9219912.
    Citations: 1     Fields:    Translation:Cells
  108. Xin Y, Lee RE, Scherman MS, Khoo KH, Besra GS, Brennan PJ, McNeil M. Characterization of the in vitro synthesized arabinan of mycobacterial cell walls. Biochim Biophys Acta. 1997 Jun 06; 1335(3):231-4. PMID: 9202184.
    Citations: 4     Fields:    Translation:Cells
  109. Belisle JT, Vissa VD, Sievert T, Takayama K, Brennan PJ, Besra GS. Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science. 1997 May 30; 276(5317):1420-2. PMID: 9162010.
    Citations: 264     Fields:    Translation:Cells
  110. Brennan PJ, Besra GS. Structure, function and biogenesis of the mycobacterial cell wall. Biochem Soc Trans. 1997 Feb; 25(1):188-94. PMID: 9056869.
    Citations: 5     Fields:    Translation:Cells
  111. Slayden RA, Lee RE, Armour JW, Cooper AM, Orme IM, Brennan PJ, Besra GS. Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis. Antimicrob Agents Chemother. 1996 Dec; 40(12):2813-9. PMID: 9124847; PMCID: PMC163628.
    Citations: 43     Fields:    Translation:Cells
  112. Khoo KH, Douglas E, Azadi P, Inamine JM, Besra GS, Mikusová K, Brennan PJ, Chatterjee D. Truncated structural variants of lipoarabinomannan in ethambutol drug-resistant strains of Mycobacterium smegmatis. Inhibition of arabinan biosynthesis by ethambutol. J Biol Chem. 1996 Nov 08; 271(45):28682-90. PMID: 8910503.
    Citations: 22     Fields:    Translation:Cells
  113. Belanger AE, Besra GS, Ford ME, Mikusová K, Belisle JT, Brennan PJ, Inamine JM. The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11919-24. PMID: 8876238; PMCID: PMC38159.
    Citations: 133     Fields:    Translation:Cells
  114. Khoo KH, Suzuki R, Dell A, Morris HR, McNeil MR, Brennan PJ, Besra GS. Chemistry of the lyxose-containing mycobacteriophage receptors of Mycobacterium phlei/Mycobacterium smegmatis. Biochemistry. 1996 Sep 10; 35(36):11812-9. PMID: 8794763.
    Citations: 7     Fields:    Translation:Cells
  115. Murali R, Brennan PJ, Kieber-Emmons T, Greene MI. Structural analysis of p185c-neu and epidermal growth factor receptor tyrosine kinases: oligomerization of kinase domains. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6252-7. PMID: 8692801; PMCID: PMC39008.
    Citations: 17     Fields:    Translation:Cells
  116. Mikusová K, Mikus M, Besra GS, Hancock I, Brennan PJ. Biosynthesis of the linkage region of the mycobacterial cell wall. J Biol Chem. 1996 Mar 29; 271(13):7820-8. PMID: 8631826.
    Citations: 49     Fields:    Translation:Cells
  117. Lee RE, Brennan PJ, Besra GS. Mycobacterium tuberculosis cell envelope. Curr Top Microbiol Immunol. 1996; 215:1-27. PMID: 8791707.
    Citations: 18     Fields:    Translation:Cells
  118. Mikusová K, Slayden RA, Besra GS, Brennan PJ. Biogenesis of the mycobacterial cell wall and the site of action of ethambutol. Antimicrob Agents Chemother. 1995 Nov; 39(11):2484-9. PMID: 8585730.
    Citations: 83     Fields:    Translation:Cells
  119. Khoo KH, Suzuki R, Morris HR, Dell A, Brennan PJ, Besra GS. Structural definition of the glycopeptidolipids and the pyruvylated, glycosylated acyltrehalose from Mycobacterium butyricum. Carbohydr Res. 1995 Oct 23; 276(2):449-55. PMID: 8542612.
    Citations: 2     Fields:    Translation:Cells
  120. Sieling PA, Chatterjee D, Porcelli SA, Prigozy TI, Mazzaccaro RJ, Soriano T, Bloom BR, Brenner MB, Kronenberg M, Brennan PJ, et al. CD1-restricted T cell recognition of microbial lipoglycan antigens. Science. 1995 Jul 14; 269(5221):227-30. PMID: 7542404.
    Citations: 197     Fields:    Translation:HumansCells
  121. Hennessy S, Strom BL, Berlin JA, Brennan PJ. Predicting cutaneous hypersensitivity reactions to cotrimoxazole in HIV-infected individuals receiving primary Pneumocystis carinii pneumonia prophylaxis. J Gen Intern Med. 1995 Jul; 10(7):380-6. PMID: 7472686.
    Citations: 7     Fields:    Translation:Humans
  122. Roberts AD, Sonnenberg MG, Ordway DJ, Furney SK, Brennan PJ, Belisle JT, Orme IM. Characteristics of protective immunity engendered by vaccination of mice with purified culture filtrate protein antigens of Mycobacterium tuberculosis. Immunology. 1995 Jul; 85(3):502-8. PMID: 7558141.
    Citations: 47     Fields:    Translation:AnimalsCellsPHPublic Health
  123. Sastry V, Brennan PJ. Cutaneous infections with rapidly growing mycobacteria. Clin Dermatol. 1995 May-Jun; 13(3):266-71. PMID: 8521368.
    Citations:    Fields:    Translation:HumansCells
  124. Besra GS, Khoo KH, McNeil MR, Dell A, Morris HR, Brennan PJ. A new interpretation of the structure of the mycolyl-arabinogalactan complex of Mycobacterium tuberculosis as revealed through characterization of oligoglycosylalditol fragments by fast-atom bombardment mass spectrometry and 1H nuclear magnetic resonance spectroscopy. Biochemistry. 1995 Apr 04; 34(13):4257-66. PMID: 7703239.
    Citations: 59     Fields:    Translation:Cells
  125. Sastry V, Brennan PJ, Levy MM, Fishman N, Friedman AL, Naji A, Barker CF, Brayman KL. Vancomycin-resistant enterococci: an emerging pathogen in immunosuppressed transplant recipients. Transplant Proc. 1995 Feb; 27(1):954-5. PMID: 7879244.
    Citations: 2     Fields:    Translation:HumansCells
  126. Shulkin DJ, Brennan PJ. The cost of caring for patients with tuberculosis: planning for a disease on the rise. Am J Infect Control. 1995 Feb; 23(1):1-4. PMID: 7762868.
    Citations: 3     Fields:    Translation:Humans
  127. Besra GS, Sievert T, Lee RE, Slayden RA, Brennan PJ, Takayama K. Identification of the apparent carrier in mycolic acid synthesis. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12735-9. PMID: 7809112; PMCID: PMC45514.
    Citations: 24     Fields:    Translation:Cells
  128. Besra GS, Gurcha SS, Khoo KH, Morris HR, Dell A, Hamid ME, Minnikin DE, Goodfellow M, Brennan PJ. Characterization of the specific antigenicity of representatives of M. senegalense and related bacteria. Zentralbl Bakteriol. 1994 Nov; 281(4):415-32. PMID: 7727889.
    Citations: 3     Fields:    Translation:AnimalsCells
  129. Besra GS, Khoo KH, Belisle JT, McNeil MR, Morris HR, Dell A, Brennan PJ. New pyruvylated, glycosylated acyltrehaloses from Mycobacterium smegmatis strains, and their implications for phage resistance in mycobacteria. Carbohydr Res. 1994 Jan 03; 251:99-114. PMID: 8149383.
    Citations: 7     Fields:    Translation:Cells
  130. Besra GS, McNeil MR, Khoo KH, Dell A, Morris HR, Brennan PJ. Trehalose-containing lipooligosaccharides of Mycobacterium gordonae: presence of a mono-O-methyltetra-O-acyltrehalose "core" and branching in the oligosaccharide backbone. Biochemistry. 1993 Nov 30; 32(47):12705-14. PMID: 8251490.
    Citations: 9     Fields:    Translation:Cells
  131. Wallace RJ, Tanner D, Brennan PJ, Brown BA. Clinical trial of clarithromycin for cutaneous (disseminated) infection due to Mycobacterium chelonae. Ann Intern Med. 1993 Sep 15; 119(6):482-6. PMID: 8357113.
    Citations: 38     Fields:    Translation:HumansCellsCTClinical Trials
  132. Besra GS, McNeil MR, Rivoire B, Khoo KH, Morris HR, Dell A, Brennan PJ. Further structural definition of a new family of glycopeptidolipids from Mycobacterium xenopi. Biochemistry. 1993 Jan 12; 32(1):347-55. PMID: 7678195.
    Citations: 5     Fields:    Translation:Cells
  133. Besra GS, Bolton RC, McNeil MR, Ridell M, Simpson KE, Glushka J, van Halbeek H, Brennan PJ, Minnikin DE. Structural elucidation of a novel family of acyltrehaloses from Mycobacterium tuberculosis. Biochemistry. 1992 Oct 13; 31(40):9832-7. PMID: 1390757.
    Citations: 24     Fields:    Translation:Cells
  134. Besra GS, McNeil MR, Brennan PJ. Characterization of the specific antigenicity of Mycobacterium fortuitum. Biochemistry. 1992 Jul 21; 31(28):6504-9. PMID: 1633162.
    Citations: 2     Fields:    Translation:Cells
  135. Orme IM, Miller ES, Roberts AD, Furney SK, Griffin JP, Dobos KM, Chi D, Rivoire B, Brennan PJ. T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens. J Immunol. 1992 Jan 01; 148(1):189-96. PMID: 1727865.
    Citations: 93     Fields:    Translation:AnimalsCells
  136. Besra GS, McNeil M, Minnikin DE, Portaels F, Ridell M, Brennan PJ. Structural elucidation and antigenicity of a novel phenolic glycolipid antigen from Mycobacterium haemophilum. Biochemistry. 1991 Aug 06; 30(31):7772-7. PMID: 1868054.
    Citations: 7     Fields:    Translation:AnimalsCells
  137. Brennan PJ, Zigmond SH, Schreiber AD, Smith ER, Southwick FS. Binding of IgG containing immune complexes to human neutrophil Fc gamma RII and Fc gamma RIII induces actin polymerization by a pertussis toxin-insensitive transduction pathway. J Immunol. 1991 Jun 15; 146(12):4282-8. PMID: 1828264.
    Citations: 7     Fields:    Translation:HumansCells
  138. Sada E, Brennan PJ, Herrera T, Torres M. Evaluation of lipoarabinomannan for the serological diagnosis of tuberculosis. J Clin Microbiol. 1990 Dec; 28(12):2587-90. PMID: 2126265.
    Citations: 36     Fields:    Translation:HumansCells
  139. Born W, Hall L, Dallas A, Boymel J, Shinnick T, Young D, Brennan P, O'Brien R. Recognition of a peptide antigen by heat shock--reactive gamma delta T lymphocytes. Science. 1990 Jul 06; 249(4964):67-9. PMID: 1695022.
    Citations: 82     Fields:    Translation:AnimalsCells
  140. Kobayashi K, Brown WR, Brennan PJ, Blaser MJ. Serum antibodies to mycobacterial antigens in active Crohn's disease. Gastroenterology. 1988 Jun; 94(6):1404-11. PMID: 2452116.
    Citations: 19     Fields:    Translation:HumansCells
  141. Mohagheghpour N, Gelber RH, Larrick JW, Sasaki DT, Brennan PJ, Engleman EG. Defective cell-mediated immunity in leprosy: failure of T cells from lepromatous leprosy patients to respond to Mycobacterium leprae is associated with defective expression of interleukin 2 receptors and is not reconstituted by interleukin 2. J Immunol. 1985 Aug; 135(2):1443-9. PMID: 2989366.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.