Harvard Catalyst Profiles

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Philip Reed Larsen, M.D.

Concepts

This page shows the publications Philip Larsen has written about Rats.
Connection Strength

0.535
  1. The imprinted gene neuronatin is regulated by metabolic status and associated with obesity. Obesity (Silver Spring). 2010 Jul; 18(7):1289-96.
    View in: PubMed
    Score: 0.030
  2. PYY(3-36) reduces food intake and body weight and improves insulin sensitivity in rodent models of diet-induced obesity. Am J Physiol Regul Integr Comp Physiol. 2006 Aug; 291(2):R367-75.
    View in: PubMed
    Score: 0.023
  3. Differential influences of peroxisome proliferator-activated receptors gamma and -alpha on food intake and energy homeostasis. Diabetes. 2003 Sep; 52(9):2249-59.
    View in: PubMed
    Score: 0.020
  4. Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency. Am J Physiol Endocrinol Metab. 2001 Jul; 281(1):E54-61.
    View in: PubMed
    Score: 0.017
  5. The human, but not rat, dio2 gene is stimulated by thyroid transcription factor-1 (TTF-1). Mol Endocrinol. 2001 Jan; 15(1):112-24.
    View in: PubMed
    Score: 0.016
  6. Thyroid hormone regulates hyperpolarization-activated cyclic nucleotide-gated channel (HCN2) mRNA in the rat heart. Circ Res. 1999 Sep 17; 85(6):498-503.
    View in: PubMed
    Score: 0.015
  7. Cloning and expression of the chicken type 2 iodothyronine 5'-deiodinase. J Biol Chem. 1999 May 14; 274(20):13768-76.
    View in: PubMed
    Score: 0.015
  8. Mutation of the Secys residue 266 in human type 2 selenodeiodinase alters 75Se incorporation without affecting its biochemical properties. Biochimie. 1999 May; 81(5):535-8.
    View in: PubMed
    Score: 0.015
  9. Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone. Endocrinology. 1999 Feb; 140(2):784-90.
    View in: PubMed
    Score: 0.014
  10. Studies of the hormonal regulation of type 2 5'-iodothyronine deiodinase messenger ribonucleic acid in pituitary tumor cells using semiquantitative reverse transcription-polymerase chain reaction. Endocrinology. 1998 Dec; 139(12):4895-905.
    View in: PubMed
    Score: 0.014
  11. Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes. J Clin Invest. 1998 Dec 01; 102(11):1895-9.
    View in: PubMed
    Score: 0.014
  12. The guanosine monophosphate reductase gene is conserved in rats and its expression increases rapidly in brown adipose tissue during cold exposure. J Biol Chem. 1998 Nov 20; 273(47):31092-6.
    View in: PubMed
    Score: 0.014
  13. The role of the active site cysteine in catalysis by type 1 iodothyronine deiodinase. Endocrinology. 1997 Dec; 138(12):5452-8.
    View in: PubMed
    Score: 0.013
  14. In vivo genomic footprinting of thyroid hormone-responsive genes in pituitary tumor cell lines. Mol Cell Biol. 1996 Aug; 16(8):4465-77.
    View in: PubMed
    Score: 0.012
  15. Is there a negative TRE in the luciferase reporter cDNA? Thyroid. 1996 Aug; 6(4):325-8.
    View in: PubMed
    Score: 0.012
  16. Structural features of thyroid hormone response elements that increase susceptibility to inhibition by an RTH mutant thyroid hormone receptor. Endocrinology. 1996 Jul; 137(7):2833-41.
    View in: PubMed
    Score: 0.012
  17. Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency. Mol Endocrinol. 1995 Aug; 9(8):969-80.
    View in: PubMed
    Score: 0.011
  18. Topological analysis of the integral membrane protein, type 1 iodothyronine deiodinase (D1). J Biol Chem. 1995 May 19; 270(20):12310-8.
    View in: PubMed
    Score: 0.011
  19. Pituitary cells respond to thyroid hormone by discrete, gene-specific pathways. Endocrinology. 1995 Apr; 136(4):1488-94.
    View in: PubMed
    Score: 0.011
  20. Nutritional and hormonal regulation of thyroid hormone deiodinases. Annu Rev Nutr. 1995; 15:323-52.
    View in: PubMed
    Score: 0.011
  21. Identification of critical amino acids for 3,5,3'-triiodothyronine deiodination by human type 1 deiodinase based on comparative functional-structural analyses of the human, dog, and rat enzymes. J Biol Chem. 1994 Aug 12; 269(32):20329-34.
    View in: PubMed
    Score: 0.010
  22. Recognition of UGA as a selenocysteine codon in eukaryotes: a review of recent progress. Biochem Soc Trans. 1993 Nov; 21(4):827-32.
    View in: PubMed
    Score: 0.010
  23. Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific. Mol Endocrinol. 1993 Oct; 7(10):1319-30.
    View in: PubMed
    Score: 0.010
  24. Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons. EMBO J. 1993 Aug; 12(8):3315-22.
    View in: PubMed
    Score: 0.010
  25. The type I iodothyronine 5'-deiodinase messenger ribonucleic acid is localized to the S3 segment of the rat kidney proximal tubule. Endocrinology. 1993 May; 132(5):2136-40.
    View in: PubMed
    Score: 0.010
  26. Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase. J Clin Endocrinol Metab. 1992 Oct; 75(4):1133-9.
    View in: PubMed
    Score: 0.009
  27. Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements. Mol Endocrinol. 1992 Apr; 6(4):502-14.
    View in: PubMed
    Score: 0.009
  28. Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region. Nature. 1991 Sep 19; 353(6341):273-6.
    View in: PubMed
    Score: 0.009
  29. Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase. J Biol Chem. 1991 Aug 05; 266(22):14155-8.
    View in: PubMed
    Score: 0.008
  30. Photoaffinity labeling of rat type I iodothyronine deiodinase. Endocrinology. 1991 Aug; 129(2):1042-8.
    View in: PubMed
    Score: 0.008
  31. Evidence that cysteine, not selenocysteine, is in the catalytic site of type II iodothyronine deiodinase. Endocrinology. 1991 Jul; 129(1):550-2.
    View in: PubMed
    Score: 0.008
  32. Antiestrogens stimulate expression of transiently transfected and endogenous genes in rat pituitary tumor cell lines. Mol Cell Endocrinol. 1991 May; 77(1-3):133-40.
    View in: PubMed
    Score: 0.008
  33. Effects of varying the position of thyroid hormone response elements within the rat growth hormone promoter: implications for positive and negative regulation by 3,5,3'-triiodothyronine. Mol Endocrinol. 1991 Apr; 5(4):542-8.
    View in: PubMed
    Score: 0.008
  34. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature. 1991 Jan 31; 349(6308):438-40.
    View in: PubMed
    Score: 0.008
  35. Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome. J Endocrinol. 2010 Sep; 206(3):287-96.
    View in: PubMed
    Score: 0.008
  36. Thyroid hormone regulates type I deiodinase messenger RNA in rat liver. Mol Endocrinol. 1990 May; 4(5):743-8.
    View in: PubMed
    Score: 0.008
  37. The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: comparison to sibutramine and rimonabant. Eur J Pharmacol. 2010 Jun 25; 636(1-3):88-95.
    View in: PubMed
    Score: 0.008
  38. Mutations of the rat growth hormone promoter which increase and decrease response to thyroid hormone define a consensus thyroid hormone response element. Mol Endocrinol. 1989 Dec; 3(12):1996-2004.
    View in: PubMed
    Score: 0.008
  39. Alpha 1- and beta-adrenergic agents cause synergistic stimulation of the iodothyronine deiodinase in rat brown adipocytes. Endocrinology. 1989 Nov; 125(5):2502-9.
    View in: PubMed
    Score: 0.008
  40. Characterization of beta-cell mass and insulin resistance in diet-induced obese and diet-resistant rats. Obesity (Silver Spring). 2010 Feb; 18(2):266-73.
    View in: PubMed
    Score: 0.007
  41. The pituitary-thyroid regulatory system. Adv Exp Med Biol. 1989; 261:11-26.
    View in: PubMed
    Score: 0.007
  42. Multihormonal regulation of the human, rat, and bovine growth hormone promoters: differential effects of 3',5'-cyclic adenosine monophosphate, thyroid hormone, and glucocorticoids. Mol Endocrinol. 1988 Sep; 2(9):792-8.
    View in: PubMed
    Score: 0.007
  43. Phorbol esters, protein kinase C, and thyroxine 5'-deiodinase in brown adipocytes. Am J Physiol. 1988 Mar; 254(3 Pt 1):E323-7.
    View in: PubMed
    Score: 0.007
  44. Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats. J Clin Invest. 2008 Mar; 118(3):975-83.
    View in: PubMed
    Score: 0.007
  45. The regional hypothalamic distribution of type II 5'-monodeiodinase in euthyroid and hypothyroid rats. Brain Res. 1987 Sep 08; 420(1):194-8.
    View in: PubMed
    Score: 0.006
  46. Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism. Endocrinology. 2006 Apr; 147(4):1735-43.
    View in: PubMed
    Score: 0.006
  47. Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. Endocrinology. 2004 Apr; 145(4):1649-55.
    View in: PubMed
    Score: 0.005
  48. DARPP-32 and CREB are present in type 2 iodothyronine deiodinase-producing tanycytes: implications for the regulation of type 2 deiodinase activity. Brain Res. 2000 Apr 17; 862(1-2):154-61.
    View in: PubMed
    Score: 0.004
  49. Comparison of thyroxine and 3,3',5'-triiodothyronine metabolism in rat kidney and liver homogenates. Metabolism. 1979 Nov; 28(11):1139-46.
    View in: PubMed
    Score: 0.004
  50. Characterization of the promoter of the rat sarcoplasmic endoplasmic reticulum Ca2+-ATPase 1 gene and analysis of thyroid hormone responsiveness. J Biol Chem. 1996 Dec 13; 271(50):32048-56.
    View in: PubMed
    Score: 0.003
  51. Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors. Mol Endocrinol. 1992 Oct; 6(10):1527-37.
    View in: PubMed
    Score: 0.002
  52. Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor. New Biol. 1989 Dec; 1(3):329-36.
    View in: PubMed
    Score: 0.002
  53. Identification of a thyroid hormone receptor that is pituitary-specific. Science. 1989 Apr 07; 244(4900):76-9.
    View in: PubMed
    Score: 0.002
  54. Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5031-5.
    View in: PubMed
    Score: 0.002
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.