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Philip Reed Larsen, M.D.

Concepts

This page shows the publications Philip Larsen has written about Amino Acid Sequence.
Connection Strength

0.319
  1. The mRNA structure has potent regulatory effects on type 2 iodothyronine deiodinase expression. Mol Endocrinol. 2002 Jul; 16(7):1667-79.
    View in: PubMed
    Score: 0.024
  2. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev. 2002 Feb; 23(1):38-89.
    View in: PubMed
    Score: 0.023
  3. Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. Endocrinology. 2000 Mar; 141(3):1127-35.
    View in: PubMed
    Score: 0.020
  4. Cloning and expression of the chicken type 2 iodothyronine 5'-deiodinase. J Biol Chem. 1999 May 14; 274(20):13768-76.
    View in: PubMed
    Score: 0.019
  5. The guanosine monophosphate reductase gene is conserved in rats and its expression increases rapidly in brown adipose tissue during cold exposure. J Biol Chem. 1998 Nov 20; 273(47):31092-6.
    View in: PubMed
    Score: 0.019
  6. The role of the active site cysteine in catalysis by type 1 iodothyronine deiodinase. Endocrinology. 1997 Dec; 138(12):5452-8.
    View in: PubMed
    Score: 0.017
  7. Update on the human iodothyronine selenodeiodinases, the enzymes regulating the activation and inactivation of thyroid hormone. Biochem Soc Trans. 1997 May; 25(2):588-92.
    View in: PubMed
    Score: 0.017
  8. Molecular biological and biochemical characterization of the human type 2 selenodeiodinase. Endocrinology. 1996 Aug; 137(8):3308-15.
    View in: PubMed
    Score: 0.016
  9. Structural features of thyroid hormone response elements that increase susceptibility to inhibition by an RTH mutant thyroid hormone receptor. Endocrinology. 1996 Jul; 137(7):2833-41.
    View in: PubMed
    Score: 0.016
  10. The structure of the coding and 5'-flanking region of the type 1 iodothyronine deiodinase (dio1) gene is normal in a patient with suspected congenital dio1 deficiency. J Clin Endocrinol Metab. 1996 Jun; 81(6):2121-4.
    View in: PubMed
    Score: 0.016
  11. Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme. J Clin Invest. 1995 Nov; 96(5):2421-30.
    View in: PubMed
    Score: 0.015
  12. Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency. Mol Endocrinol. 1995 Aug; 9(8):969-80.
    View in: PubMed
    Score: 0.015
  13. Topological analysis of the integral membrane protein, type 1 iodothyronine deiodinase (D1). J Biol Chem. 1995 May 19; 270(20):12310-8.
    View in: PubMed
    Score: 0.015
  14. Nutritional and hormonal regulation of thyroid hormone deiodinases. Annu Rev Nutr. 1995; 15:323-52.
    View in: PubMed
    Score: 0.014
  15. Identification of critical amino acids for 3,5,3'-triiodothyronine deiodination by human type 1 deiodinase based on comparative functional-structural analyses of the human, dog, and rat enzymes. J Biol Chem. 1994 Aug 12; 269(32):20329-34.
    View in: PubMed
    Score: 0.014
  16. Type I iodothyronine deiodinase: unexpected complexities in a simple deiodination reaction. Thyroid. 1994; 4(3):357-62.
    View in: PubMed
    Score: 0.013
  17. Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase. J Clin Endocrinol Metab. 1992 Oct; 75(4):1133-9.
    View in: PubMed
    Score: 0.012
  18. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature. 1991 Jan 31; 349(6308):438-40.
    View in: PubMed
    Score: 0.011
  19. The thyroid hormone-inactivating deiodinase functions as a homodimer. Mol Endocrinol. 2008 Jun; 22(6):1382-93.
    View in: PubMed
    Score: 0.009
  20. The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure. J Biol Chem. 2003 Sep 19; 278(38):36887-96.
    View in: PubMed
    Score: 0.006
  21. Structure-activity relationships for thyroid hormone deiodination by mammalian type I iodothyronine deiodinases. Endocrinology. 1997 Jan; 138(1):213-9.
    View in: PubMed
    Score: 0.004
  22. Identification of a thyroid hormone receptor that is pituitary-specific. Science. 1989 Apr 07; 244(4900):76-9.
    View in: PubMed
    Score: 0.002
  23. Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5031-5.
    View in: PubMed
    Score: 0.002
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.