Harvard Catalyst Profiles

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Laurence A Turka, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI126143 (NEWTON, RYAN) Jun 1, 2016 - May 31, 2018
    NIH
    Control of regulatory T cell stability and function by the Foxo1 transcription factor
    Role: Principal Investigator
  2. R34AI116394 (TURKA, LAURENCE A) Jun 15, 2015 - Nov 30, 2016
    NIH
    Cellular Therapy with Allospecific Tregs in Liver Transplantation
    Role: Principal Investigator
  3. R21AI105607 (TURKA, LAURENCE A) Sep 1, 2013 - Aug 31, 2015
    NIH
    Control of Treg Homeostasis and Function by the Lipid Phosphatase PTEN
    Role: Principal Investigator
  4. R56AI083304 (TURKA, LAURENCE A) Aug 15, 2011 - Jul 31, 2012
    NIH
    The Control of T Cell Development in Responses by PTEN
    Role: Principal Investigator
  5. R01AI062789 (TURKA, LAURENCE A) Jan 1, 2006 - Dec 31, 2011
    NIH
    Expression and function of the TLRs on T cells
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shimozawa K, Contreras-Ruiz L, Sousa S, Zhang R, Bhatia U, Crisalli KC, Brennan LL, Turka LA, Markmann JF, Guinan EC. Ex vivo generation of regulatory T cells from liver transplant recipients using costimulation blockade. Am J Transplant. 2021 Sep 15. PMID: 34528383.
    Citations:    Fields:    
  2. Serrano OK, Turka L, Axelrod DA. Challenging the notion of conflict of interest in transplantation: Barriers at the intersection between innovation and clinical advancement. Am J Transplant. 2021 11; 21(11):3812-3813. PMID: 34254438.
    Citations:    Fields:    
  3. Levitsky J, Burrell BE, Kanaparthi S, Turka LA, Kurian S, Sanchez-Fueyo A, Lozano JJ, Demetris A, Lesniak A, Kirk AD, Stempora L, Yang GY, Mathew JM. Immunosuppression Withdrawal in Liver Transplant Recipients on Sirolimus. Hepatology. 2020 08; 72(2):569-583. PMID: 31721246.
    Citations: 7     Fields:    Translation:Humans
  4. Sawitzki B, Harden PN, Reinke P, Moreau A, Hutchinson JA, Game DS, Tang Q, Guinan EC, Battaglia M, Burlingham WJ, Roberts ISD, Streitz M, Josien R, Böger CA, Scottà C, Markmann JF, Hester JL, Juerchott K, Braudeau C, James B, Contreras-Ruiz L, van der Net JB, Bergler T, Caldara R, Petchey W, Edinger M, Dupas N, Kapinsky M, Mutzbauer I, Otto NM, Öllinger R, Hernandez-Fuentes MP, Issa F, Ahrens N, Meyenberg C, Karitzky S, Kunzendorf U, Knechtle SJ, Grinyó J, Morris PJ, Brent L, Bushell A, Turka LA, Bluestone JA, Lechler RI, Schlitt HJ, Cuturi MC, Schlickeiser S, Friend PJ, Miloud T, Scheffold A, Secchi A, Crisalli K, Kang SM, Hilton R, Banas B, Blancho G, Volk HD, Lombardi G, Wood KJ, Geissler EK. Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials. Lancet. 2020 05 23; 395(10237):1627-1639. PMID: 32446407.
    Citations: 47     Fields:    Translation:HumansCells
  5. Abdelsamed HA, Zebley CC, Nguyen H, Rutishauser RL, Fan Y, Ghoneim HE, Crawford JC, Alfei F, Alli S, Ribeiro SP, Castellaw AH, McGargill MA, Jin H, Boi SK, Speake C, Serti E, Turka LA, Busch ME, Stone M, Deeks SG, Sekaly RP, Zehn D, James EA, Nepom GT, Youngblood B. Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes. Nat Immunol. 2020 05; 21(5):578-587. PMID: 32231298.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  6. Tanimine N, Germana SK, Fan M, Hippen K, Blazar BR, Markmann JF, Turka LA, Priyadharshini B. Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets. PLoS One. 2019; 14(6):e0217761. PMID: 31170216.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  7. Paz K, Flynn R, Du J, Tannheimer S, Johnson AJ, Dong S, Stark AK, Okkenhaug K, Panoskaltsis-Mortari A, Sage PT, Sharpe AH, Luznik L, Ritz J, Soiffer RJ, Cutler CS, Koreth J, Antin JH, Miklos DB, MacDonald KP, Hill GR, Maillard I, Serody JS, Murphy WJ, Munn DH, Feser C, Zaiken M, Vanhaesebroeck B, Turka LA, Byrd JC, Blazar BR. Targeting PI3Kd function for amelioration of murine chronic graft-versus-host disease. Am J Transplant. 2019 06; 19(6):1820-1830. PMID: 30748099.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Glatigny S, Höllbacher B, Motley SJ, Tan C, Hundhausen C, Buckner JH, Smilek D, Khoury SJ, Ding L, Qin T, Pardo J, Nepom GT, Turka LA, Harris KM, Campbell DJ, Bettelli E. Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance. J Immunol. 2019 03 01; 202(5):1373-1382. PMID: 30683697.
    Citations: 16     Fields:    Translation:HumansCellsCTClinical Trials
  9. Weinberg SE, Singer BD, Steinert EM, Martinez CA, Mehta MM, Martínez-Reyes I, Gao P, Helmin KA, Abdala-Valencia H, Sena LA, Schumacker PT, Turka LA, Chandel NS. Mitochondrial complex III is essential for suppressive function of regulatory T cells. Nature. 2019 01; 565(7740):495-499. PMID: 30626970.
    Citations: 112     Fields:    Translation:AnimalsCells
  10. Savage TM, Shonts BA, Obradovic A, Dewolf S, Lau S, Zuber J, Simpson MT, Berglund E, Fu J, Yang S, Ho SH, Tang Q, Turka LA, Shen Y, Sykes M. Early expansion of donor-specific Tregs in tolerant kidney transplant recipients. JCI Insight. 2018 11 15; 3(22). PMID: 30429370.
    Citations: 18     Fields:    Translation:HumansCells
  11. Fan MY, Low JS, Tanimine N, Finn KK, Priyadharshini B, Germana SK, Kaech SM, Turka LA. Differential Roles of IL-2 Signaling in Developing versus Mature Tregs. Cell Rep. 2018 10 30; 25(5):1204-1213.e4. PMID: 30380412.
    Citations: 36     Fields:    Translation:AnimalsCells
  12. Priyadharshini B, Loschi M, Newton RH, Zhang JW, Finn KK, Gerriets VA, Huynh A, Rathmell JC, Blazar BR, Turka LA. Cutting Edge: TGF-ß and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets. J Immunol. 2018 10 15; 201(8):2215-2219. PMID: 30209190.
    Citations: 27     Fields:    Translation:AnimalsCells
  13. McDonald-Hyman C, Muller JT, Loschi M, Thangavelu G, Saha A, Kumari S, Reichenbach DK, Smith MJ, Zhang G, Koehn BH, Lin J, Mitchell JS, Fife BT, Panoskaltsis-Mortari A, Feser CJ, Kirchmeier AK, Osborn MJ, Hippen KL, Kelekar A, Serody JS, Turka LA, Munn DH, Chi H, Neubert TA, Dustin ML, Blazar BR. The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease. J Clin Invest. 2018 10 01; 128(10):4604-4621. PMID: 30106752.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  14. Newton RH, Shrestha S, Sullivan JM, Yates KB, Compeer EB, Ron-Harel N, Blazar BR, Bensinger SJ, Haining WN, Dustin ML, Campbell DJ, Chi H, Turka LA. Maintenance of CD4 T cell fitness through regulation of Foxo1. Nat Immunol. 2018 08; 19(8):838-848. PMID: 29988091.
    Citations: 19     Fields:    Translation:AnimalsCells
  15. Marangoni F, Zhang R, Mani V, Thelen M, Ali Akbar NJ, Warner RD, Äijö T, Zappulli V, Martinez GJ, Turka LA, Mempel TR. Tumor Tolerance-Promoting Function of Regulatory T Cells Is Optimized by CD28, but Strictly Dependent on Calcineurin. J Immunol. 2018 05 15; 200(10):3647-3661. PMID: 29661826.
    Citations: 5     Fields:    Translation:AnimalsCells
  16. Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA. Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. J Immunol. 2018 04 01; 200(7):2505-2506. PMID: 29475985.
    Citations:    Fields:    
  17. Newell KA, Adams AB, Turka LA. Biomarkers of operational tolerance following kidney transplantation - The immune tolerance network studies of spontaneously tolerant kidney transplant recipients. Hum Immunol. 2018 May; 79(5):380-387. PMID: 29448053.
    Citations: 7     Fields:    Translation:HumansCells
  18. Turka LA, Suthanthiran M. A tribute to Terry Strom. J Clin Invest. 2018 Mar 01; 128(3):891-892. PMID: 29400696.
    Citations:    Fields:    
  19. Harris KM, Lu T, Lim N, Turka LA. Challenges and Opportunities for Biomarkers of Clinical Response to AHSCT in Autoimmunity. Front Immunol. 2018; 9:100. PMID: 29456529.
    Citations: 2     Fields:    Translation:HumansCells
  20. Tanimine N, Turka LA, Priyadharshini B. Navigating T-Cell Immunometabolism in Transplantation. Transplantation. 2018 02; 102(2):230-239. PMID: 28930796.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  21. Fan MY, Turka LA. Immunometabolism and PI(3)K Signaling As a Link between IL-2, Foxp3 Expression, and Suppressor Function in Regulatory T Cells. Front Immunol. 2018; 9:69. PMID: 29434595.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  22. Asare A, Kanaparthi S, Lim N, Newell KA, Turka LA. Reply to Christakoudi and Hernandez-Fuentes: We agree-Let's move on. Am J Transplant. 2018 01; 18(1):273. PMID: 29087040.
    Citations: 1     Fields:    
  23. Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA. B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. J Immunol. 2017 12 15; 199(12):3972-3980. PMID: 29093061.
    Citations: 7     Fields:    Translation:AnimalsCells
  24. Uehara M, McGrath MM, Ohori S, Solhjou Z, Banouni N, Routray S, Evans C, DiNitto JP, Elkhal A, Turka LA, Strom TB, Tullius SG, Winkler DG, Azzi J, Abdi R. Regulation of T cell alloimmunity by PI3K? and PI3Kd. Nat Commun. 2017 10 16; 8(1):951. PMID: 29038423.
    Citations: 12     Fields:    Translation:AnimalsCells
  25. Asare A, Kanaparthi S, Lim N, Phippard D, Vincenti F, Friedewald J, Pavlakis M, Poggio E, Heeger P, Mannon R, Burrell BE, Morrison Y, Bridges N, Sanz I, Chandraker A, Newell KA, Turka LA. B Cell Receptor Genes Associated With Tolerance Identify a Cohort of Immunosuppressed Patients With Improved Renal Allograft Graft Function. Am J Transplant. 2017 Oct; 17(10):2627-2639. PMID: 28371372.
    Citations: 9     Fields:    Translation:HumansCells
  26. Sprangers B, DeWolf S, Savage TM, Morokata T, Obradovic A, LoCascio SA, Shonts B, Zuber J, Lau SP, Shah R, Morris H, Steshenko V, Zorn E, Preffer FI, Olek S, Dombkowski DM, Turka LA, Colvin R, Winchester R, Kawai T, Sykes M. Origin of Enriched Regulatory T Cells in Patients Receiving Combined Kidney-Bone Marrow Transplantation to Induce Transplantation Tolerance. Am J Transplant. 2017 Aug; 17(8):2020-2032. PMID: 28251801.
    Citations: 19     Fields:    Translation:HumansCells
  27. Kamphorst AO, Wieland A, Nasti T, Yang S, Zhang R, Barber DL, Konieczny BT, Daugherty CZ, Koenig L, Yu K, Sica GL, Sharpe AH, Freeman GJ, Blazar BR, Turka LA, Owonikoko TK, Pillai RN, Ramalingam SS, Araki K, Ahmed R. Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science. 2017 03 31; 355(6332):1423-1427. PMID: 28280249.
    Citations: 245     Fields:    Translation:HumansAnimalsCells
  28. Kean LS, Turka LA, Blazar BR. Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy. Immunol Rev. 2017 03; 276(1):192-212. PMID: 28258702.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  29. Danger R, Chesneau M, Paul C, Guérif P, Durand M, Newell KA, Kanaparthi S, Turka LA, Soulillou JP, Houlgatte R, Giral M, Ramstein G, Brouard S. A composite score associated with spontaneous operational tolerance in kidney transplant recipients. Kidney Int. 2017 06; 91(6):1473-1481. PMID: 28242033.
    Citations: 8     Fields:    Translation:HumansCells
  30. Alessandrini A, Turka LA. FOXP3-Positive Regulatory T Cells and Kidney Allograft Tolerance. Am J Kidney Dis. 2017 May; 69(5):667-674. PMID: 28049555.
    Citations: 5     Fields:    Translation:HumansCells
  31. Gerriets VA, Kishton RJ, Johnson MO, Cohen S, Siska PJ, Nichols AG, Warmoes MO, de Cubas AA, MacIver NJ, Locasale JW, Turka LA, Wells AD, Rathmell JC. Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nat Immunol. 2016 Dec; 17(12):1459-1466. PMID: 27695003.
    Citations: 166     Fields:    Translation:AnimalsCells
  32. Lu Y, Hippen KL, Lemire AL, Gu J, Wang W, Ni X, Ranganathan P, Levine BL, Riley JL, June CH, Turka LA, Munn DH, Garzon R, Lu L, Blazar BR. miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency. Blood. 2016 09 08; 128(10):1424-35. PMID: 27485827.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  33. Feng S, Demetris AJ, Spain KM, Kanaparthi S, Burrell BE, Ekong UD, Alonso EM, Rosenthal P, Turka LA, Ikle D, Tchao NK. Five-year histological and serological follow-up of operationally tolerant pediatric liver transplant recipients enrolled in WISP-R. Hepatology. 2017 02; 65(2):647-660. PMID: 27302659.
    Citations: 12     Fields:    Translation:Humans
  34. McDonald-Hyman C, Flynn R, Panoskaltsis-Mortari A, Peterson N, MacDonald KP, Hill GR, Luznik L, Serody JS, Murphy WJ, Maillard I, Munn DH, Turka LA, Koreth J, Cutler CS, Soiffer RJ, Antin JH, Ritz J, Blazar BR. Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner. Blood. 2016 08 18; 128(7):1013-7. PMID: 27385791.
    Citations: 43     Fields:    Translation:AnimalsCells
  35. Borges CM, Reichenbach DK, Kim BS, Misra A, Blazar BR, Turka LA. Regulatory T cell expressed MyD88 is critical for prolongation of allograft survival. Transpl Int. 2016 Aug; 29(8):930-40. PMID: 27112509.
    Citations:    Fields:    Translation:AnimalsCells
  36. Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Tkachev V, Pawlicki JM, Furlan SN, Kean LS, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, Ranganathan P, Devine SM, Burrill JS, Guo L, Sacristan C, Snyder NW, Blair IA, Milone MC, Dustin ML, Riley JL, Bernlohr DA, Murphy WJ, Fife BT, Munn DH, Miller JS, Serody JS, Freeman GJ, Sharpe AH, Turka LA, Blazar BR. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest. 2016 07 01; 126(7):2642-60. PMID: 27294527.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  37. Newton R, Priyadharshini B, Turka LA. Immunometabolism of regulatory T cells. Nat Immunol. 2016 05 19; 17(6):618-25. PMID: 27196520.
    Citations: 105     Fields:    Translation:HumansAnimalsCells
  38. Kishnani PS, Dickson PI, Muldowney L, Lee JJ, Rosenberg A, Abichandani R, Bluestone JA, Burton BK, Dewey M, Freitas A, Gavin D, Griebel D, Hogan M, Holland S, Tanpaiboon P, Turka LA, Utz JJ, Wang YM, Whitley CB, Kazi ZB, Pariser AR. Immune response to enzyme replacement therapies in lysosomal storage diseases and the role of immune tolerance induction. Mol Genet Metab. 2016 Feb; 117(2):66-83. PMID: 26597321.
    Citations: 31     Fields:    Translation:HumansAnimals
  39. Zhang R, Borges CM, Fan MY, Harris JE, Turka LA. Requirement for CD28 in Effector Regulatory T Cell Differentiation, CCR6 Induction, and Skin Homing. J Immunol. 2015 Nov 01; 195(9):4154-61. PMID: 26408668.
    Citations: 11     Fields:    Translation:AnimalsCells
  40. Kim JI, Turka LA. Transplant tolerance: a new role for IL-34. J Clin Invest. 2015 Oct 01; 125(10):3751-3. PMID: 26389671.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  41. Newell KA, Turka LA. Tolerance signatures in transplant recipients. Curr Opin Organ Transplant. 2015 Aug; 20(4):400-5. PMID: 26107969.
    Citations: 7     Fields:    Translation:HumansCells
  42. DuPage M, Chopra G, Quiros J, Rosenthal WL, Morar MM, Holohan D, Zhang R, Turka L, Marson A, Bluestone JA. The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation. Immunity. 2015 Feb 17; 42(2):227-238. PMID: 25680271.
    Citations: 92     Fields:    Translation:AnimalsCells
  43. Priyadharshini B, Turka LA. T-cell energy metabolism as a controller of cell fate in transplantation. Curr Opin Organ Transplant. 2015 Feb; 20(1):21-8. PMID: 25563988.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  44. Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat Immunol. 2015 Feb; 16(2):188-96. PMID: 25559257.
    Citations: 190     Fields:    Translation:AnimalsCells
  45. Newton RH, Lu Y, Papa A, Whitcher GH, Kang YJ, Yan C, Pandolfi PP, Turka LA. Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity. Blood. 2015 Jan 29; 125(5):852-5. PMID: 25477498.
    Citations: 7     Fields:    Translation:AnimalsCells
  46. Gerriets VA, Kishton RJ, Nichols AG, Macintyre AN, Inoue M, Ilkayeva O, Winter PS, Liu X, Priyadharshini B, Slawinska ME, Haeberli L, Huck C, Turka LA, Wood KC, Hale LP, Smith PA, Schneider MA, MacIver NJ, Locasale JW, Newgard CB, Shinohara ML, Rathmell JC. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J Clin Invest. 2015 Jan; 125(1):194-207. PMID: 25437876.
    Citations: 243     Fields:    Translation:AnimalsCells
  47. Shamji MH, Layhadi JA, Scadding GW, Cheung DKM, Calderon MA, Turka LA, Phippard D, Durham SR. Basophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response. J Allergy Clin Immunol. 2015 Apr; 135(4):913-921.e9. PMID: 25457150.
    Citations: 27     Fields:    Translation:HumansCells
  48. Zwang NA, Turka LA. Homeostatic expansion as a barrier to lymphocyte depletion strategies. Curr Opin Organ Transplant. 2014 Aug; 19(4):357-62. PMID: 24926701.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  49. Kawai T, Leventhal J, Madsen JC, Strober S, Turka LA, Wood KJ. Tolerance: one transplant for life. Transplantation. 2014 Jul 27; 98(2):117-21. PMID: 24926829.
    Citations: 16     Fields:    Translation:Humans
  50. Stolp J, Turka LA, Wood KJ. B cells with immune-regulating function in transplantation. Nat Rev Nephrol. 2014 Jul; 10(7):389-97. PMID: 24846332.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  51. Papa A, Wan L, Bonora M, Salmena L, Song MS, Hobbs RM, Lunardi A, Webster K, Ng C, Newton RH, Knoblauch N, Guarnerio J, Ito K, Turka LA, Beck AH, Pinton P, Bronson RT, Wei W, Pandolfi PP. Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function. Cell. 2014 Apr 24; 157(3):595-610. PMID: 24766807.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  52. Vergani A, Gatti F, Lee KM, D'Addio F, Tezza S, Chin M, Bassi R, Tian Z, Wu E, Maffi P, Ben Nasr M, Kim JI, Secchi A, Markmann JF, Rothstein DM, Turka LA, Sayegh MH, Fiorina P. TIM4 Regulates the Anti-Islet Th2 Alloimmune Response. Cell Transplant. 2015; 24(8):1599-1614. PMID: 24612609.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  53. Huynh A, Zhang R, Turka LA. Signals and pathways controlling regulatory T cells. Immunol Rev. 2014 Mar; 258(1):117-31. PMID: 24517429.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  54. Muraro PA, Robins H, Malhotra S, Howell M, Phippard D, Desmarais C, de Paula Alves Sousa A, Griffith LM, Lim N, Nash RA, Turka LA. T cell repertoire following autologous stem cell transplantation for multiple sclerosis. J Clin Invest. 2014 Mar; 124(3):1168-72. PMID: 24531550.
    Citations: 91     Fields:    Translation:HumansCells
  55. Maltzman JS, Turka LA. T-cell costimulatory blockade in organ transplantation. Cold Spring Harb Perspect Med. 2013 Dec 01; 3(12):a015537. PMID: 24296352.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  56. Zhang R, Turka LA. A breath of fresh aire. Immunity. 2013 Sep 19; 39(3):427-9. PMID: 24054325.
    Citations:    Fields:    Translation:AnimalsCells
  57. Yeung MY, McGrath MM, Nakayama M, Shimizu T, Boenisch O, Magee CN, Abdoli R, Akiba H, Ueno T, Turka LA, Najafian N. Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival. J Immunol. 2013 Oct 15; 191(8):4447-55. PMID: 24038092.
    Citations: 15     Fields:    Translation:AnimalsCells
  58. Han D, Walsh MC, Cejas PJ, Dang NN, Kim YF, Kim J, Charrier-Hisamuddin L, Chau L, Zhang Q, Bittinger K, Bushman FD, Turka LA, Shen H, Reizis B, Defranco AL, Wu GD, Choi Y. Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity. 2013 Jun 27; 38(6):1211-22. PMID: 23791643.
    Citations: 40     Fields:    Translation:AnimalsCells
  59. Huynh A, Turka LA. Control of T cell tolerance by phosphatase and tensin homolog. Ann N Y Acad Sci. 2013 Mar; 1280:27-9. PMID: 23551099.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  60. Chang J, Burkett PR, Borges CM, Kuchroo VK, Turka LA, Chang CH. MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2270-5. PMID: 23341605.
    Citations: 39     Fields:    Translation:AnimalsCells
  61. Zhang R, Huynh A, Whitcher G, Chang J, Maltzman JS, Turka LA. An obligate cell-intrinsic function for CD28 in Tregs. J Clin Invest. 2013 Feb; 123(2):580-93. PMID: 23281398.
    Citations: 106     Fields:    Translation:AnimalsCells
  62. Hall AO, Beiting DP, Tato C, John B, Oldenhove G, Lombana CG, Pritchard GH, Silver JS, Bouladoux N, Stumhofer JS, Harris TH, Grainger J, Wojno ED, Wagage S, Roos DS, Scott P, Turka LA, Cherry S, Reiner SL, Cua D, Belkaid Y, Elloso MM, Hunter CA. The cytokines interleukin 27 and interferon-? promote distinct Treg cell populations required to limit infection-induced pathology. Immunity. 2012 Sep 21; 37(3):511-23. PMID: 22981537.
    Citations: 175     Fields:    Translation:AnimalsCells
  63. Scadding GW, Calderon MA, Bellido V, Koed GK, Nielsen NC, Lund K, Togias A, Phippard D, Turka LA, Hansel TT, Durham SR, Wurtzen PA. Optimisation of grass pollen nasal allergen challenge for assessment of clinical and immunological outcomes. J Immunol Methods. 2012 Oct 31; 384(1-2):25-32. PMID: 22759401.
    Citations: 32     Fields:    Translation:HumansAnimals
  64. Long SA, Rieck M, Sanda S, Bollyky JB, Samuels PL, Goland R, Ahmann A, Rabinovitch A, Aggarwal S, Phippard D, Turka LA, Ehlers MR, Bianchine PJ, Boyle KD, Adah SA, Bluestone JA, Buckner JH, Greenbaum CJ. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs ß-cell function. Diabetes. 2012 Sep; 61(9):2340-8. PMID: 22721971.
    Citations: 139     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  65. Newton RH, Turka LA. Regulation of T cell homeostasis and responses by pten. Front Immunol. 2012; 3:151. PMID: 22715338.
    Citations: 21     Fields:    
  66. Gupta S, Thornley TB, Gao W, Larocca R, Turka LA, Kuchroo VK, Strom TB. Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest. 2012 Jul; 122(7):2395-404. PMID: 22684103.
    Citations: 51     Fields:    Translation:AnimalsCells
  67. Lieberman SM, Kim JS, Corbo-Rodgers E, Kambayashi T, Maltzman JS, Behrens EM, Turka LA. Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer. Eur J Immunol. 2012 Jun; 42(6):1429-35. PMID: 22678899.
    Citations: 10     Fields:    Translation:AnimalsCells
  68. Turka LA. Plus ça change, plus c'est la même chose. J Clin Invest. 2012 Feb; 122(2):422-3. PMID: 22293179.
    Citations:    Fields:    Translation:HumansAnimals
  69. Feng S, Ekong UD, Lobritto SJ, Demetris AJ, Roberts JP, Rosenthal P, Alonso EM, Philogene MC, Ikle D, Poole KM, Bridges ND, Turka LA, Tchao NK. Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants. JAMA. 2012 Jan 18; 307(3):283-93. PMID: 22253395.
    Citations: 78     Fields:    Translation:Humans
  70. Caplan AL, Rockman HA, Turka LA. Editorial position on publishing articles on human organ transplantation. J Clin Invest. 2012 Jan; 122(1):2. PMID: 22214852.
    Citations: 3     Fields:    Translation:Humans
  71. Haynes LD, Jankowska-Gan E, Sheka A, Keller MR, Hernandez-Fuentes MP, Lechler RI, Seyfert-Margolis V, Turka LA, Newell KA, Burlingham WJ. Donor-specific indirect pathway analysis reveals a B-cell-independent signature which reflects outcomes in kidney transplant recipients. Am J Transplant. 2012 Mar; 12(3):640-8. PMID: 22151236.
    Citations: 29     Fields:    Translation:HumansCells
  72. Xiao X, Gong W, Demirci G, Liu W, Spoerl S, Chu X, Bishop DK, Turka LA, Li XC. New insights on OX40 in the control of T cell immunity and immune tolerance in vivo. J Immunol. 2012 Jan 15; 188(2):892-901. PMID: 22147766.
    Citations: 41     Fields:    Translation:AnimalsCells
  73. Friedman DJ, Turka LA, Robson SC. There's a goat behind door number 3: from Monty Hall to medicine. J Clin Invest. 2011 Oct; 121(10):3819-21. PMID: 21968106.
    Citations:    Fields:    Translation:HumansCells
  74. Auchincloss H, Turka LA. CTLA-4: not all costimulation is stimulatory. J Immunol. 2011 Oct 01; 187(7):3457-8. PMID: 21934096.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  75. Newell KA, Phippard D, Turka LA. Regulatory cells and cell signatures in clinical transplantation tolerance. Curr Opin Immunol. 2011 Oct; 23(5):655-9. PMID: 21982510.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  76. Hancock WW, Turka LA. Immunogenetics and transplantation. Curr Opin Immunol. 2011 Oct; 23(5):639-40. PMID: 21831621.
    Citations:    Fields:    Translation:HumansAnimalsCells
  77. Turka LA, Caplan A. What is the evidence for our standards of care? J Clin Invest. 2011 Jul; 121(7):2530. PMID: 21737884.
    Citations:    Fields:    Translation:Humans
  78. Schrum AG, Gil D, Turka LA, Palmer E. Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells. J Immunol. 2011 Jul 15; 187(2):870-8. PMID: 21666056.
    Citations: 8     Fields:    Translation:AnimalsCells
  79. Wojno ED, Hosken N, Stumhofer JS, O'Hara AC, Mauldin E, Fang Q, Turka LA, Levin SD, Hunter CA. A role for IL-27 in limiting T regulatory cell populations. J Immunol. 2011 Jul 01; 187(1):266-73. PMID: 21622862.
    Citations: 41     Fields:    Translation:AnimalsCells
  80. Murphy SP, Porrett PM, Turka LA. Innate immunity in transplant tolerance and rejection. Immunol Rev. 2011 May; 241(1):39-48. PMID: 21488888.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  81. Nepom GT, St Clair EW, Turka LA. Challenges in the pursuit of immune tolerance. Immunol Rev. 2011 May; 241(1):49-62. PMID: 21488889.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  82. Rahman AH, Zhang R, Blosser CD, Hou B, Defranco AL, Maltzman JS, Wherry EJ, Turka LA. Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Blood. 2011 Mar 17; 117(11):3123-30. PMID: 21233312.
    Citations: 15     Fields:    Translation:AnimalsCells
  83. Bluestone JA, Auchincloss H, Nepom GT, Rotrosen D, St Clair EW, Turka LA. The Immune Tolerance Network at 10 years: tolerance research at the bedside. Nat Rev Immunol. 2010 Nov; 10(11):797-803. PMID: 20972473.
    Citations: 24     Fields:    Translation:HumansAnimals
  84. Ramón HE, Cejas PJ, LaRosa D, Rahman A, Harris JE, Zhang J, Hunter C, Choi Y, Turka LA. EGR-2 is not required for in vivo CD4 T cell mediated immune responses. PLoS One. 2010 Sep 23; 5(9):e12904. PMID: 20886122.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  85. D'Addio F, Yuan X, Habicht A, Williams J, Ruzek M, Iacomini J, Turka LA, Sayegh MH, Najafian N, Ansari MJ. A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model. Transplantation. 2010 Aug 15; 90(3):260-9. PMID: 20712076.
    Citations: 18     Fields:    Translation:AnimalsCells
  86. Li XC, Turka LA. An update on regulatory T cells in transplant tolerance and rejection. Nat Rev Nephrol. 2010 Oct; 6(10):577-83. PMID: 20683480.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  87. Turka LA, Wood K, Bluestone JA. Bringing transplantation tolerance into the clinic: lessons from the ITN and RISET for the Establishment of Tolerance consortia. Curr Opin Organ Transplant. 2010 Aug; 15(4):441-8. PMID: 20631613.
    Citations: 6     Fields:    Translation:HumansAnimals
  88. Liu X, Karnell JL, Yin B, Zhang R, Zhang J, Li P, Choi Y, Maltzman JS, Pear WS, Bassing CH, Turka LA. Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. J Clin Invest. 2010 Jul; 120(7):2497-507. PMID: 20516645.
    Citations: 44     Fields:    Translation:HumansAnimals
  89. Newell KA, Asare A, Kirk AD, Gisler TD, Bourcier K, Suthanthiran M, Burlingham WJ, Marks WH, Sanz I, Lechler RI, Hernandez-Fuentes MP, Turka LA, Seyfert-Margolis VL. Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest. 2010 Jun; 120(6):1836-47. PMID: 20501946.
    Citations: 248     Fields:    Translation:HumansCells
  90. Cejas PJ, Walsh MC, Pearce EL, Han D, Harms GM, Artis D, Turka LA, Choi Y. TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. Blood. 2010 Jun 10; 115(23):4750-7. PMID: 20351308.
    Citations: 38     Fields:    Translation:AnimalsCells
  91. Bluestone JA, Krensky AM, Turka LA, Rotrosen D, Matthews JB. Ten years of the Immune Tolerance Network: an integrated clinical research organization. Sci Transl Med. 2010 Feb 17; 2(19):19cm7. PMID: 20371484.
    Citations: 1     Fields:    Translation:Humans
  92. Epstein JA, Turka LA, Birnbaum M, Koretzky G. The physician's voice in the health care debate. J Clin Invest. 2009 Oct; 119(10):2846. PMID: 20069703.
    Citations: 2     Fields:    Translation:Humans
  93. Turka LA. Top priority. J Clin Invest. 2009 Sep; 119(9):2436-7. PMID: 19729840.
    Citations:    Fields:    
  94. Turka LA, Lechler RI. Towards the identification of biomarkers of transplantation tolerance. Nat Rev Immunol. 2009 07; 9(7):521-6. PMID: 19483711.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  95. Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH, Sayegh MH. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10734-9. PMID: 19528638.
    Citations: 29     Fields:    Translation:AnimalsCells
  96. Turka LA. After further review. J Clin Invest. 2009 May; 119(5):1057. PMID: 19411763.
    Citations: 2     Fields:    
  97. Rahman AH, Taylor DK, Turka LA. The contribution of direct TLR signaling to T cell responses. Immunol Res. 2009; 45(1):25-36. PMID: 19597998.
    Citations: 56     Fields:    Translation:AnimalsCells
  98. Neill US, Turka LA. Bothered and bewildered, but not bewitched. J Clin Invest. 2008 Nov; 118(11):3516. PMID: 18982156.
    Citations: 1     Fields:    
  99. Rahman AH, Cui W, Larosa DF, Taylor DK, Zhang J, Goldstein DR, Wherry EJ, Kaech SM, Turka LA. MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. J Immunol. 2008 Sep 15; 181(6):3804-10. PMID: 18768833.
    Citations: 44     Fields:    Translation:AnimalsCells
  100. Turka LA. Senator, what is your policy on "Other"? J Clin Invest. 2008 Sep; 118(9):2988. PMID: 18769628.
    Citations: 1     Fields:    Translation:Humans
  101. Porrett PM, Yuan X, LaRosa DF, Walsh PT, Yang J, Gao W, Li P, Zhang J, Ansari JM, Hancock WW, Sayegh MH, Koulmanda M, Strom TB, Turka LA. Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol. 2008 Aug 01; 181(3):1692-9. PMID: 18641305.
    Citations: 45     Fields:    Translation:AnimalsCells
  102. Buckler JL, Liu X, Turka LA. Regulation of T-cell responses by PTEN. Immunol Rev. 2008 Aug; 224:239-48. PMID: 18759931.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  103. Seyfert-Margolis V, Turka LA. Marking a path to transplant tolerance. J Clin Invest. 2008 Aug; 118(8):2684-6. PMID: 18654643.
    Citations: 4     Fields:    Translation:Humans
  104. Sawitzki B, Reinke P, Volk HD, Wood K, Turka LA. Autoimmunity and transplantation: a meeting at the crossroads in Berlin. Nat Immunol. 2008 May; 9(5):447-9. PMID: 18425094.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  105. Turka LA. Animal house. J Clin Invest. 2008 Mar; 118(3):822. PMID: 18317563.
    Citations: 2     Fields:    Translation:HumansAnimals
  106. LaRosa DF, Stumhofer JS, Gelman AE, Rahman AH, Taylor DK, Hunter CA, Turka LA. T cell expression of MyD88 is required for resistance to Toxoplasma gondii. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3855-60. PMID: 18308927.
    Citations: 55     Fields:    Translation:AnimalsCells
  107. Ueno T, Habicht A, Clarkson MR, Albin MJ, Yamaura K, Boenisch O, Popoola J, Wang Y, Yagita H, Akiba H, Ansari MJ, Yang J, Turka LA, Rothstein DM, Padera RF, Najafian N, Sayegh MH. The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest. 2008 Feb; 118(2):742-51. PMID: 18172549.
    Citations: 54     Fields:    Translation:AnimalsCells
  108. Turka LA, Walsh PT. IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells. Front Biosci. 2008 Jan 01; 13:1440-6. PMID: 17981641.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  109. King CG, Buckler JL, Kobayashi T, Hannah JR, Bassett G, Kim T, Pearce EL, Kim GG, Turka LA, Choi Y. Cutting edge: requirement for TRAF6 in the induction of T cell anergy. J Immunol. 2008 Jan 01; 180(1):34-8. PMID: 18097000.
    Citations: 20     Fields:    Translation:AnimalsCells
  110. Yang J, Brook MO, Carvalho-Gaspar M, Zhang J, Ramon HE, Sayegh MH, Wood KJ, Turka LA, Jones ND. Allograft rejection mediated by memory T cells is resistant to regulation. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):19954-9. PMID: 18042727.
    Citations: 83     Fields:    Translation:AnimalsCells
  111. Stumhofer JS, Silver JS, Laurence A, Porrett PM, Harris TH, Turka LA, Ernst M, Saris CJ, O'Shea JJ, Hunter CA. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol. 2007 Dec; 8(12):1363-71. PMID: 17994025.
    Citations: 369     Fields:    Translation:HumansAnimalsCells
  112. Tao R, de Zoeten EF, Ozkaynak E, Chen C, Wang L, Porrett PM, Li B, Turka LA, Olson EN, Greene MI, Wells AD, Hancock WW. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med. 2007 Nov; 13(11):1299-307. PMID: 17922010.
    Citations: 367     Fields:    Translation:AnimalsCells
  113. Dzierszinski F, Pepper M, Stumhofer JS, LaRosa DF, Wilson EH, Turka LA, Halonen SK, Hunter CA, Roos DS. Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells. Infect Immun. 2007 Nov; 75(11):5200-9. PMID: 17846116.
    Citations: 38     Fields:    Translation:AnimalsCells
  114. Turka LA. Lost in a dark wood. J Clin Invest. 2007 Jul; 117(7):1734-5. PMID: 17607347.
    Citations: 1     Fields:    Translation:Humans
  115. LaRosa DF, Rahman AH, Turka LA. The innate immune system in allograft rejection and tolerance. J Immunol. 2007 Jun 15; 178(12):7503-9. PMID: 17548582.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  116. LaRosa DF, Gelman AE, Rahman AH, Zhang J, Turka LA, Walsh PT. CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Immunol Lett. 2007 Feb 15; 108(2):183-8. PMID: 17270282.
    Citations: 40     Fields:    Translation:AnimalsCells
  117. Gelman AE, LaRosa DF, Zhang J, Walsh PT, Choi Y, Sunyer JO, Turka LA. The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity. 2006 Nov; 25(5):783-93. PMID: 17055754.
    Citations: 79     Fields:    Translation:AnimalsCells
  118. Buckler JL, Walsh PT, Porrett PM, Choi Y, Turka LA. Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J Immunol. 2006 Oct 01; 177(7):4262-6. PMID: 16982858.
    Citations: 42     Fields:    Translation:AnimalsCells
  119. Walsh PT, Buckler JL, Zhang J, Gelman AE, Dalton NM, Taylor DK, Bensinger SJ, Hancock WW, Turka LA. PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest. 2006 Sep; 116(9):2521-31. PMID: 16917540.
    Citations: 83     Fields:    Translation:AnimalsCells
  120. Hickman SP, Yang J, Thomas RM, Wells AD, Turka LA. Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4+CD25+ regulatory T cells. J Immunol. 2006 Aug 15; 177(4):2186-94. PMID: 16887978.
    Citations: 35     Fields:    Translation:AnimalsCells
  121. Taylor DK, Walsh PT, LaRosa DF, Zhang J, Burchill MA, Farrar MA, Turka LA. Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis. J Immunol. 2006 Aug 15; 177(4):2216-23. PMID: 16887981.
    Citations: 9     Fields:    Translation:AnimalsCells
  122. King CG, Kobayashi T, Cejas PJ, Kim T, Yoon K, Kim GK, Chiffoleau E, Hickman SP, Walsh PT, Turka LA, Choi Y. TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med. 2006 Sep; 12(9):1088-92. PMID: 16921377.
    Citations: 103     Fields:    Translation:AnimalsCells
  123. Neujahr DC, Chen C, Huang X, Markmann JF, Cobbold S, Waldmann H, Sayegh MH, Hancock WW, Turka LA. Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it. J Immunol. 2006 Apr 15; 176(8):4632-9. PMID: 16585554.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  124. Bluestone JA, St Clair EW, Turka LA. CTLA4Ig: bridging the basic immunology with clinical application. Immunity. 2006 Mar; 24(3):233-8. PMID: 16546089.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  125. Walsh PT, Benoit BM, Wysocka M, Dalton NM, Turka LA, Rook AH. A role for regulatory T cells in cutaneous T-Cell lymphoma; induction of a CD4 + CD25 + Foxp3+ T-cell phenotype associated with HTLV-1 infection. J Invest Dermatol. 2006 Mar; 126(3):690-2. PMID: 16410788.
    Citations: 13     Fields:    Translation:HumansCells
  126. Vu MD, Clarkson MR, Yagita H, Turka LA, Sayegh MH, Li XC. Critical, but conditional, role of OX40 in memory T cell-mediated rejection. J Immunol. 2006 Feb 01; 176(3):1394-401. PMID: 16424166.
    Citations: 43     Fields:    Translation:AnimalsCells
  127. Sánchez-Fueyo A, Sandner S, Habicht A, Mariat C, Kenny J, Degauque N, Zheng XX, Strom TB, Turka LA, Sayegh MH. Specificity of CD4+CD25+ regulatory T cell function in alloimmunity. J Immunol. 2006 Jan 01; 176(1):329-34. PMID: 16365425.
    Citations: 35     Fields:    Translation:AnimalsCells
  128. Krupnick AS, Gelman AE, Barchet W, Richardson S, Kreisel FH, Turka LA, Colonna M, Patterson GA, Kreisel D. Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol. 2005 Nov 15; 175(10):6265-70. PMID: 16272276.
    Citations: 63     Fields:    Translation:AnimalsCells
  129. Neumann AK, Yang J, Biju MP, Joseph SK, Johnson RS, Haase VH, Freedman BD, Turka LA. Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17071-6. PMID: 16286658.
    Citations: 43     Fields:    Translation:AnimalsCells
  130. Hickman SP, Turka LA. Homeostatic T cell proliferation as a barrier to T cell tolerance. Philos Trans R Soc Lond B Biol Sci. 2005 Sep 29; 360(1461):1713-21. PMID: 16147536.
    Citations: 17     Fields:    Translation:HumansCells
  131. Lechler RI, Sykes M, Thomson AW, Turka LA. Organ transplantation--how much of the promise has been realized? Nat Med. 2005 Jun; 11(6):605-13. PMID: 15937473.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  132. Schenk S, Kish DD, He C, El-Sawy T, Chiffoleau E, Chen C, Chen C, Wu Z, Sandner S, Gorbachev AV, Fukamachi K, Heeger PS, Sayegh MH, Turka LA, Fairchild RL. Alloreactive T cell responses and acute rejection of single class II MHC-disparate heart allografts are under strict regulation by CD4+ CD25+ T cells. J Immunol. 2005 Mar 15; 174(6):3741-8. PMID: 15749914.
    Citations: 34     Fields:    Translation:AnimalsCells
  133. Sandner SE, Clarkson MR, Salama AD, Sanchez-Fueyo A, Domenig C, Habicht A, Najafian N, Yagita H, Azuma M, Turka LA, Sayegh MH. Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. J Immunol. 2005 Mar 15; 174(6):3408-15. PMID: 15749874.
    Citations: 62     Fields:    Translation:AnimalsCells
  134. Schrum AG, Palmer E, Turka LA. Distinct temporal programming of naive CD4+ T cells for cell division versus TCR-dependent death susceptibility by antigen-presenting macrophages. Eur J Immunol. 2005 Feb; 35(2):449-59. PMID: 15682456.
    Citations: 7     Fields:    Translation:AnimalsCells
  135. Sandner SE, Clarkson MR, Salama AD, Sanchez-Fueyo A, Yagita H, Turka LA, Sayegh MH. Mechanisms of tolerance induced by donor-specific transfusion and ICOS-B7h blockade in a model of CD4+ T-cell-mediated allograft rejection. Am J Transplant. 2005 Jan; 5(1):31-9. PMID: 15636609.
    Citations: 9     Fields:    Translation:AnimalsCells
  136. Neujahr D, Turka LA. Lymphocyte depletion as a barrier to immunological tolerance. Contrib Nephrol. 2005; 146:65-72. PMID: 15567921.
    Citations: 4     Fields:    Translation:HumansCells
  137. Doyle AM, Lechler RI, Turka LA. Organ transplantation: halfway through the first century. J Am Soc Nephrol. 2004 Dec; 15(12):2965-71. PMID: 15579498.
    Citations: 6     Fields:    Translation:Humans
  138. Walsh PT, Taylor DK, Turka LA. Tregs and transplantation tolerance. J Clin Invest. 2004 Nov; 114(10):1398-403. PMID: 15545987.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  139. Biju MP, Neumann AK, Bensinger SJ, Johnson RS, Turka LA, Haase VH. Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol. 2004 Oct; 24(20):9038-47. PMID: 15456877.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  140. Taylor DK, Neujahr D, Turka LA. Heterologous immunity and homeostatic proliferation as barriers to tolerance. Curr Opin Immunol. 2004 Oct; 16(5):558-64. PMID: 15341999.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  141. Kreisel D, Krasinskas AM, Krupnick AS, Gelman AE, Balsara KR, Popma SH, Riha M, Rosengard AM, Turka LA, Rosengard BR. Vascular endothelium does not activate CD4+ direct allorecognition in graft rejection. J Immunol. 2004 Sep 01; 173(5):3027-34. PMID: 15322162.
    Citations: 20     Fields:    Translation:AnimalsCells
  142. Gelman AE, Zhang J, Choi Y, Turka LA. Toll-like receptor ligands directly promote activated CD4+ T cell survival. J Immunol. 2004 May 15; 172(10):6065-73. PMID: 15128790.
    Citations: 153     Fields:    Translation:AnimalsCells
  143. Bensinger SJ, Walsh PT, Zhang J, Carroll M, Parsons R, Rathmell JC, Thompson CB, Burchill MA, Farrar MA, Turka LA. Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol. 2004 May 01; 172(9):5287-96. PMID: 15100267.
    Citations: 109     Fields:    Translation:AnimalsCells
  144. Walsh PT, Strom TB, Turka LA. Routes to transplant tolerance versus rejection; the role of cytokines. Immunity. 2004 Feb; 20(2):121-31. PMID: 14975235.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  145. Mata M, Chiffoleau E, Adler SH, Gray T, Hancock W, Turka LA. Bcl-XL expression in stem cells facilitates engraftment and reduces the need for host conditioning during bone marrow transplantation. Am J Transplant. 2004 Jan; 4(1):58-64. PMID: 14678035.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  146. Burchill MA, Goetz CA, Prlic M, O'Neil JJ, Harmon IR, Bensinger SJ, Turka LA, Brennan P, Jameson SC, Farrar MA. Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol. 2003 Dec 01; 171(11):5853-64. PMID: 14634095.
    Citations: 87     Fields:    Translation:AnimalsCells
  147. Schrum AG, Turka LA, Palmer E. Surface T-cell antigen receptor expression and availability for long-term antigenic signaling. Immunol Rev. 2003 Dec; 196:7-24. PMID: 14617194.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  148. Chiffoleau E, Kobayashi T, Walsh MC, King CG, Walsh PT, Hancock WW, Choi Y, Turka LA. TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease. J Immunol. 2003 Dec 01; 171(11):5751-9. PMID: 14634083.
    Citations: 25     Fields:    Translation:AnimalsCells
  149. Wu Z, Bensinger SJ, Zhang J, Chen C, Yuan X, Huang X, Markmann JF, Kassaee A, Rosengard BR, Hancock WW, Sayegh MH, Turka LA. Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med. 2004 Jan; 10(1):87-92. PMID: 14647496.
    Citations: 149     Fields:    Translation:AnimalsCells
  150. Sandner SE, Salama AD, Houser SL, Palmer E, Turka LA, Sayegh MH. New TCR transgenic model for tracking allospecific CD4 T-cell activation and tolerance in vivo. Am J Transplant. 2003 Oct; 3(10):1242-50. PMID: 14510697.
    Citations: 11     Fields:    Translation:AnimalsCells
  151. Adler SH, Chiffoleau E, Xu L, Dalton NM, Burg JM, Wells AD, Wolfe MS, Turka LA, Pear WS. Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol. 2003 Sep 15; 171(6):2896-903. PMID: 12960312.
    Citations: 70     Fields:    Translation:AnimalsCells
  152. Kobayashi T, Walsh PT, Walsh MC, Speirs KM, Chiffoleau E, King CG, Hancock WW, Caamano JH, Hunter CA, Scott P, Turka LA, Choi Y. TRAF6 is a critical factor for dendritic cell maturation and development. Immunity. 2003 Sep; 19(3):353-63. PMID: 14499111.
    Citations: 101     Fields:    Translation:AnimalsCells
  153. Chung JB, Wells AD, Adler S, Jacob A, Turka LA, Monroe JG. Incomplete activation of CD4 T cells by antigen-presenting transitional immature B cells: implications for peripheral B and T cell responsiveness. J Immunol. 2003 Aug 15; 171(4):1758-67. PMID: 12902475.
    Citations: 12     Fields:    Translation:AnimalsCells
  154. Kurtz J, Lie A, Griffith M, Eysaman S, Shaffer J, Anosova N, Turka L, Benichou G, Sykes M. Lack of role for CsA-sensitive or Fas pathways in the tolerization of CD4 T cells via BMT and anti-CD40L. Am J Transplant. 2003 Jul; 3(7):804-16. PMID: 12814472.
    Citations: 8     Fields:    Translation:AnimalsCells
  155. Chiffoleau E, Walsh PT, Turka L. Apoptosis and transplantation tolerance. Immunol Rev. 2003 Jun; 193:124-45. PMID: 12752677.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  156. Wells AD, Liu QH, Hondowicz B, Zhang J, Turka LA, Freedman BD. Regulation of T cell activation and tolerance by phospholipase C gamma-1-dependent integrin avidity modulation. J Immunol. 2003 Apr 15; 170(8):4127-33. PMID: 12682243.
    Citations: 8     Fields:    Translation:AnimalsCells
  157. Sayegh MH, Wu Z, Hancock WW, Langmuir PB, Mata M, Sandner S, Kishimoto K, Sho M, Palmer E, Mitchell RN, Turka LA. Allograft rejection in a new allospecific CD4+ TCR transgenic mouse. Am J Transplant. 2003 Apr; 3(4):381-9. PMID: 12694059.
    Citations: 21     Fields:    Translation:AnimalsCells
  158. Lechler RI, Garden OA, Turka LA. The complementary roles of deletion and regulation in transplantation tolerance. Nat Rev Immunol. 2003 Feb; 3(2):147-58. PMID: 12563298.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  159. Kreisel D, Krupnick AS, Balsara KR, Riha M, Gelman AE, Popma SH, Szeto WY, Turka LA, Rosengard BR. Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashion. J Immunol. 2002 Dec 01; 169(11):6154-61. PMID: 12444119.
    Citations: 20     Fields:    Translation:AnimalsCells
  160. Liu QH, Fleischmann BK, Hondowicz B, Maier CC, Turka LA, Yui K, Kotlikoff MI, Wells AD, Freedman BD. Modulation of Kv channel expression and function by TCR and costimulatory signals during peripheral CD4(+) lymphocyte differentiation. J Exp Med. 2002 Oct 07; 196(7):897-909. PMID: 12370252.
    Citations: 24     Fields:    Translation:AnimalsCells
  161. Adler SH, Turka LA. Immunotherapy as a means to induce transplantation tolerance. Curr Opin Immunol. 2002 Oct; 14(5):660-5. PMID: 12183169.
    Citations: 3     Fields:    Translation:HumansAnimals
  162. Krupnick AS, Kreisel D, Popma SH, Balsara KR, Szeto WY, Krasinskas AM, Riha M, Wells AD, Turka LA, Rosengard BR. Mechanism of T cell-mediated endothelial apoptosis. Transplantation. 2002 Sep 27; 74(6):871-6. PMID: 12364869.
    Citations: 10     Fields:    Translation:AnimalsCells
  163. Lechler RI, Sykes M, Thomson AW, Turka LA. Designer meetings. Nat Immunol. 2002 Sep; 3(9):791. PMID: 12205462.
    Citations:    Fields:    Translation:HumansAnimals
  164. Kishimoto K, Sandner S, Imitola J, Sho M, Li Y, Langmuir PB, Rothstein DM, Strom TB, Turka LA, Sayegh MH. Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance. J Clin Invest. 2002 Jun; 109(11):1471-9. PMID: 12045261.
    Citations: 26     Fields:    Translation:AnimalsCells
  165. Seo SJ, Fields ML, Buckler JL, Reed AJ, Mandik-Nayak L, Nish SA, Noelle RJ, Turka LA, Finkelman FD, Caton AJ, Erikson J. The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells. Immunity. 2002 Apr; 16(4):535-46. PMID: 11970877.
    Citations: 74     Fields:    Translation:AnimalsCells
  166. Kreisel D, Krupnick AS, Gelman AE, Engels FH, Popma SH, Krasinskas AM, Balsara KR, Szeto WY, Turka LA, Rosengard BR. Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: an alternative mechanism of allorecognition. Nat Med. 2002 Mar; 8(3):233-9. PMID: 11875493.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  167. Kreisel D, Sankaran D, Wells AD, Turka LA. Interleukin-2-mediated survival and proliferative signals are uncoupled in T lymphocytes that fail to divide after activation. Am J Transplant. 2002 Feb; 2(2):120-8. PMID: 12099513.
    Citations: 2     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.